| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Tozaki, Y Emi, E Horisaka, T Fujita, A Yamamoto, S Muranish. Degradation of insulin and calcitonin and their protection by various protease inhibitors in rat caecal contents: implications in peptide delivery to the colon. The Journal of pharmacy and pharmacology. vol 49. issue 2. 1997-05-22. PMID:9055189. |
both insulin and calcitonin were metabolized in suspensions of rat caecal contents, but the degradation of calcitonin was much faster than that of insulin. |
1997-05-22 |
2023-08-12 |
rat |
| H Tozaki, Y Emi, E Horisaka, T Fujita, A Yamamoto, S Muranish. Degradation of insulin and calcitonin and their protection by various protease inhibitors in rat caecal contents: implications in peptide delivery to the colon. The Journal of pharmacy and pharmacology. vol 49. issue 2. 1997-05-22. PMID:9055189. |
protease inhibitors such as camostat and aprotinin inhibited the degradation of insulin and calcitonin in rat caecal contents, which was consistent with the high chymotrypsin activity of these contents. |
1997-05-22 |
2023-08-12 |
rat |
| F Komada, S Iwakawa, N Yamamoto, H Sakakibara, K Okumur. Intratracheal delivery of peptide and protein agents: absorption from solution and dry powder by rat lung. Journal of pharmaceutical sciences. vol 83. issue 6. 1997-04-24. PMID:9120822. |
an aqueous solution and/or a dry powder of calcitonin, insulin, thyrotropin stimulating hormone (tsh), follicle stimulating hormone (fsh), and human chorionic gonadotropin (hcg) was delivered into the exposed trachea of anesthetized rats, and blood was sampled from the jugular vein at specified intervals. |
1997-04-24 |
2023-08-12 |
human |
| F Komada, S Iwakawa, N Yamamoto, H Sakakibara, K Okumur. Intratracheal delivery of peptide and protein agents: absorption from solution and dry powder by rat lung. Journal of pharmaceutical sciences. vol 83. issue 6. 1997-04-24. PMID:9120822. |
the bioavailabilities of calcitonin, insulin, tsh, fsh, and hcg, given intratracheally as a dry powder, were 11.5, 6.5, 1.6, 0.6, and 0.1%, respectively. |
1997-04-24 |
2023-08-12 |
human |
| V Ia Semke, O K Galaktionov, L I Dorofeeva, A V Avksentiuk, S A Kurilovic. [Search for biochemical factors implicated in the pathogenesis of alcoholism in different ethnic populations]. Vestnik Rossiiskoi akademii meditsinskikh nauk. issue 12. 1997-04-11. PMID:9102081. |
on the contrary, higher ca++ and ua concentrations directly or indirectly inhibit hormones and the functional activity of the adrenal cortex, testes and lower the levels of ee, some enzymes, and total protein, 2) calcitonin (ct) and parathyroid hormone (pth) seem to be factors favouring the activation of insulin that enhances the membranous transport not only of glucose, but some other saccharides together with ee. |
1997-04-11 |
2023-08-12 |
Not clear |
| R A Silvestre, M Salas, J Rodríguez-Gallardo, O García-Hermida, T Fontela, J Marc. Effect of (8-32) salmon calcitonin, an amylin antagonist, on insulin, glucagon and somatostatin release: study in the perfused pancreas of the rat. British journal of pharmacology. vol 117. issue 2. 1997-04-09. PMID:8789389. |
effect of (8-32) salmon calcitonin, an amylin antagonist, on insulin, glucagon and somatostatin release: study in the perfused pancreas of the rat. |
1997-04-09 |
2023-08-12 |
rat |
| R A Silvestre, M Salas, J Rodríguez-Gallardo, O García-Hermida, T Fontela, J Marc. Effect of (8-32) salmon calcitonin, an amylin antagonist, on insulin, glucagon and somatostatin release: study in the perfused pancreas of the rat. British journal of pharmacology. vol 117. issue 2. 1997-04-09. PMID:8789389. |
in the present study, we have studied the influence of (8-32) sct on the inhibitory effect of both amylin and its structural congener, calcitonin gene-related peptide (cgrp), on insulin secretion in the rat perfused pancreas. |
1997-04-09 |
2023-08-12 |
rat |
| S J Milstein, E N Barantsevitch, V A Grechanovski, D J Sarubb. pH-dependent microspheres from modified soybean protein hydrolysate. Journal of microencapsulation. vol 13. issue 6. 1997-02-20. PMID:8933351. |
formation of microspheres in solution containing either porcine insulin or salmon calcitonin resulted in the encapsulation of nearly 60% of the dissolved proteins. |
1997-02-20 |
2023-08-12 |
rat |
| S J Milstein, E N Barantsevitch, V A Grechanovski, D J Sarubb. pH-dependent microspheres from modified soybean protein hydrolysate. Journal of microencapsulation. vol 13. issue 6. 1997-02-20. PMID:8933351. |
oral gavage of encapsulated porcine insulin or salmon calcitonin into the stomach of rats resulted in significant titers of either protein in the systematic circulation. |
1997-02-20 |
2023-08-12 |
rat |
| A Khachatryan, S Guerder, F Palluault, G Cote, M Solimena, K Valentijn, I Millet, R A Flavell, A Vigner. Targeted expression of the neuropeptide calcitonin gene-related peptide to beta cells prevents diabetes in NOD mice. Journal of immunology (Baltimore, Md. : 1950). vol 158. issue 3. 1997-02-19. PMID:9013986. |
to investigate whether the immunosuppressive neuropeptide calcitonin gene-related peptide (cgrp) was a potential candidate for tissue-specific gene therapy, we engineered nonobese diabetic (nod) mice to produce cgrp in beta cells by placing the modified calcitonin gene under the control of the rat insulin promoter. |
1997-02-19 |
2023-08-12 |
mouse |
| J P Bai, L L Chang, J H Gu. Effects of polyacrylic polymers on the degradation of insulin and peptide drugs by chymotrypsin and trypsin. The Journal of pharmacy and pharmacology. vol 48. issue 1. 1997-02-11. PMID:8722488. |
the purpose of this study was to determine whether carbopol polymers, polyacrylic acid polymers, can inhibit lumenal degradation of insulin, calcitonin and insulin-like growth factor i (igf-i) by trypsin and chymotrypsin and to understand whether reducing the ph of the incubation medium by these polymers results in inhibition. |
1997-02-11 |
2023-08-12 |
rat |
| J P Bai, L L Chang, J H Gu. Effects of polyacrylic polymers on the degradation of insulin and peptide drugs by chymotrypsin and trypsin. The Journal of pharmacy and pharmacology. vol 48. issue 1. 1997-02-11. PMID:8722488. |
in 50 mm tris buffer, carbopol polymers, including 934p, 974p and 971p, at 0.1% only weakly inhibited degradation of calcitonin and insulin by both enzymes; however, as the polymer concentration increased to 0.4%, degradation of insulin, calcitonin, and igf-i by both enzymes was complete or almost complete. |
1997-02-11 |
2023-08-12 |
rat |
| A P Sayani, Y W Chie. Systemic delivery of peptides and proteins across absorptive mucosae. Critical reviews in therapeutic drug carrier systems. vol 13. issue 1-2. 1996-12-26. PMID:8853960. |
this article discusses the physiology of each of the mucosae used, the fundamentals of transmucosal delivery, and recent progress in systemic delivery of therapeutic peptides and proteins across each of the mucosae; in an effort to highlight principles of transmucosal delivery, it also discusses the transmucosal delivery of enkephalin, calcitonin, and insulin as case studies. |
1996-12-26 |
2023-08-12 |
Not clear |
| M F Le Bodic, M F Heymann, M Lecomte, N Berger, F Berger, A Louvel, C De Micco, M Patey, A De Mascarel, F Burtin, J P Saint-Andr. Immunohistochemical study of 100 pancreatic tumors in 28 patients with multiple endocrine neoplasia, type I. The American journal of surgical pathology. vol 20. issue 11. 1996-12-04. PMID:8898842. |
an immunohistochemical study was performed on deparaffinized sections using the following antibodies: neuron-specific enolase, chromogranin a or synaptophysin, insulin, glucagon, somatostatin, pancreatic polypeptide (pp), vasoactive intestinal peptide (vip), gastrin, adrenocorticotropic hormone, alpha-subunit of human chorionic gonadotropin, gonadotropin-releasing factor, serotonin, and calcitonin. |
1996-12-04 |
2023-08-12 |
human |
| T Clause. The Na+, K+ pump in skeletal muscle: quantification, regulation and functional significance. Acta physiologica Scandinavica. vol 156. issue 3. 1996-10-23. PMID:8729682. |
a variety of hormones (insulin, insulin-like growth factor i, adrenaline, noradrenaline, calcitonin gene-related peptide, calcitonin, amylin) increase the rate of active na+, k+ transport by 60-120% within a few minutes. |
1996-10-23 |
2023-08-12 |
human |
| A A Young, M W Wang, B Gedulin, T J Rink, R Pittner, K Beaumon. Diabetogenic effects of salmon calcitonin are attributable to amylin-like activity. Metabolism: clinical and experimental. vol 44. issue 12. 1996-09-24. PMID:8786728. |
like amylin, salmon calcitonin also inhibits the insulin response to 2 mmol infused glucose (insulin increments suppressed by 52% and 57% at 10 minutes for salmon calcitonin and amylin). |
1996-09-24 |
2023-08-12 |
rat |
| R A Wermers, V Fatourechi, A G Wynne, L K Kvols, R V Lloy. The glucagonoma syndrome. Clinical and pathologic features in 21 patients. Medicine. vol 75. issue 2. 1996-05-17. PMID:8606627. |
increased levels of secondary hormones, such as gastrin (4 patients), vasoactive intestinal peptide (1 patient), serotonin (5 patients), insulin (6 patients, clinically significant in 1 only), human pancreatic polypeptide (2 patients), calcitonin (2 patients) and adrenocorticotropic hormone (2 patients), contributed to clinical symptoms leading to the diagnosis of an islet cell tumor before the onset of the full glucagonoma syndrome in 2 patients. |
1996-05-17 |
2023-08-12 |
human |
| S P Cairns, J A Flatman, T Clause. Relation between extracellular [K+], membrane potential and contraction in rat soleus muscle: modulation by the Na+-K+ pump. Pflugers Archiv : European journal of physiology. vol 430. issue 6. 1996-04-09. PMID:8594543. |
salbutamol, insulin, or calcitonin gene-related peptide all stimulated the na+-k+ pump in muscles exposed to 11mm [k+]0 and induced an average 26-33% recovery of tetanic force. |
1996-04-09 |
2023-08-12 |
rat |
| J P Bai, L L Chang, J H Gu. Effects of polyacrylic polymers on the lumenal proteolysis of peptide drugs in the colon. Journal of pharmaceutical sciences. vol 84. issue 11. 1996-03-25. PMID:8587045. |
the in-vitro effectiveness of polyacrylic acid polymers in inhibiting degradation of insulin, calcitonin, and insulin-like growth factor-i by colonic lumenal contents was determined. |
1996-03-25 |
2023-08-12 |
rat |
| J P Bai, L L Chang, J H Gu. Effects of polyacrylic polymers on the lumenal proteolysis of peptide drugs in the colon. Journal of pharmaceutical sciences. vol 84. issue 11. 1996-03-25. PMID:8587045. |
the results revealed that carbopol 934p, 971p, and 974p all strongly inhibited microbial proteolytic activities against insulin, calcitonin, and insulin-like growth factor-i. |
1996-03-25 |
2023-08-12 |
rat |