| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohamed K Hankir, Christelle Le Fol. Central nervous system pathways targeted by amylin in the regulation of food intake. Biochimie. 2024-10-19. PMID:39426704. |
in this review, we discuss the evidence derived from preclinical studies showing that amylin and the related peptide salmon calcitonin (sct) directly or indirectly target genetically distinct neurons in the caudal hindbrain (nucleus tractus solitarius and area postrema), rostral hindbrain (lateral parabrachial nucleus), midbrain (lateral dorsal tegmentum and ventral tegmental area) and hypothalamus (arcuate nucleus and parasubthalamic nucleus) via activation of amylin and/or calcitonin receptors. |
2024-10-19 |
2024-10-22 |
Not clear |
| Kirsten Dahl, Kirsten Raun, Jakob Lerche Hansen, Christian Poulsen, Charlotta D de la Cour, Trine Ryberg Clausen, Ann Maria Kruse Hansen, Linu M John, Annette Plesner, Gao Sun, Morten Schlein, Rikke Bjerring Skyggebjerg, Thomas Krus. NN1213 - A Potent, Long-Acting, and Selective Analog of Human Amylin. Journal of medicinal chemistry. 2024-07-03. PMID:38960379. |
amylin, a member of the calcitonin family, acts via amylin receptors in the hindbrain and hypothalamus to suppress appetite. |
2024-07-03 |
2024-07-10 |
human |
| Jingwei Yuan, Elizabeth R Gilbert, Mark A Clin. The central anorexigenic mechanism of amylin in Japanese quail (Coturnix japonica) involves pro-opiomelanocortin, calcitonin receptor, and the arcuate nucleus of the hypothalamus. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 210. 2017-07-24. PMID:28552562. |
the central anorexigenic mechanism of amylin in japanese quail (coturnix japonica) involves pro-opiomelanocortin, calcitonin receptor, and the arcuate nucleus of the hypothalamus. |
2017-07-24 |
2023-08-13 |
Not clear |
| Jingwei Yuan, Elizabeth R Gilbert, Mark A Clin. The central anorexigenic mechanism of amylin in Japanese quail (Coturnix japonica) involves pro-opiomelanocortin, calcitonin receptor, and the arcuate nucleus of the hypothalamus. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 210. 2017-07-24. PMID:28552562. |
central amylin injection increased the mrna abundance of calcitonin receptor (calcr), receptor activity modifying protein 1 (ramp1), pro-opiomelanocortin (pomc), and aromatic l-amino acid decarboxylase (aadc) in the hypothalamus and individual hypothalamic nuclei. |
2017-07-24 |
2023-08-13 |
Not clear |
| Sho Matsui, Takumi Yamane, Kazuo Kobayashi-Hattori, Yuichi Oish. Ultraviolet B irradiation reduces the expression of adiponectin in ovarial adipose tissues through endocrine actions of calcitonin gene-related peptide-induced serum amyloid A. PloS one. vol 9. issue 5. 2015-01-15. PMID:24845824. |
additionally, in the liver, hypothalamus, and epidermis, uvb irradiation increased the expression of calcitonin gene-related peptide (cgrp), which upregulates saa in the liver. |
2015-01-15 |
2023-08-13 |
mouse |
| C-J Yang, H-P Tan, Y-J D. The developmental disruptions of serotonin signaling may involved in autism during early brain development. Neuroscience. vol 267. 2014-12-09. PMID:24583042. |
the increased serotonin causes a decrease of oxytocin in the paraventricular nucleus of the hypothalamus and an increase in calcitonin gene-related peptide (cgrp) in the central nucleus of the amygdale, which are associated with social interactions and vital in autism. |
2014-12-09 |
2023-08-12 |
Not clear |
| K L Sewel. Calcitonin. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. vol 3. issue 2 Suppl. 2012-10-02. PMID:19078152. |
these receptors are distributed in calcium-responsive tissues, gut, and hypothalamus and mediate calcitonin's known clinical effects of hypocalcemia, enhanced gastric motility, and analgesia. |
2012-10-02 |
2023-08-12 |
Not clear |
| G Fin. The external layer of the median eminence: A neurovascular synapse. Neurochemistry international. vol 9. issue 1. 2012-10-02. PMID:20493112. |
in addition to the "established" neurohormones, attention is also focused on a recently discovered hypothalamic pituitary system that controls the release of plasminogen activator and on thyrocalcitonin and the calcitonin gene related peptide which demonstrate the way in which studies of the hypothalamus have led to the discovery of new neural control mechanisms. |
2012-10-02 |
2023-08-12 |
Not clear |
| S Michinaga, A Hisatsune, Y Isohama, H Katsuk. Orexin neurons in hypothalamic slice cultures are vulnerable to endoplasmic reticulum stress. Neuroscience. vol 190. 2012-07-05. PMID:21712074. |
here we found that application of endoplasmic reticulum stress inducers such as tunicamycin (that prevents protein n-glycosylation) and thapsigargin (that inhibits ca²⁺-atpase) to organotypic slice cultures of the hypothalamus caused preferential loss of orexin-immunoreactive neurons, as compared to melanin-concentrating hormone- or calcitonin gene-related peptide-immunoreactive neurons. |
2012-07-05 |
2023-08-12 |
Not clear |
| H Nakayama, T Takahashi, W Funaki, K Nakagawa-Mizuyachi, M Kawashim. Calcitonin receptor bindings in the hen hypothalamus before and after oviposition. Poultry science. vol 90. issue 3. 2011-04-19. PMID:21325236. |
calcitonin receptor bindings in the hen hypothalamus before and after oviposition. |
2011-04-19 |
2023-08-12 |
Not clear |
| H Nakayama, T Takahashi, W Funaki, K Nakagawa-Mizuyachi, M Kawashim. Calcitonin receptor bindings in the hen hypothalamus before and after oviposition. Poultry science. vol 90. issue 3. 2011-04-19. PMID:21325236. |
to demonstrate the presence of a receptor for calcitonin (ct) in the hen hypothalamus and to determine when ct acts on this tissue during the oviposition cycle, bindings of (125)i labeled ct in the plasma membrane fraction of the hen hypothalamus were measured by radioligand binding assay. |
2011-04-19 |
2023-08-12 |
Not clear |
| Jessica E Layne, Kara E Hunt, Tyler True, Ravinder S Gill, Veronica E Combos, Mark A Clin. Central calcitonin exerts anorectic effects via the hypothalamus in chicks. Pharmacology, biochemistry, and behavior. vol 92. issue 3. 2009-08-05. PMID:19344671. |
central calcitonin exerts anorectic effects via the hypothalamus in chicks. |
2009-08-05 |
2023-08-12 |
chicken |
| Xia Li, Liang Li, Lin-Lin Shen, Yuan Qian, Yin-Xiang Cao, Da-Nian Zh. Changes of adrenomedullin and its receptor components mRNAs expression in the brain stem and hypothalamus-pituitary-adrenal axis of stress-induced hypertensive rats. Sheng li xue bao : [Acta physiologica Sinica]. vol 56. issue 6. 2006-07-21. PMID:15614422. |
in this study, reverse transcription-polymerase chain reaction (rt-pcr) was used to detect the changes in mrnas levels of preproadrenomedullin (ppadm) gene encoding adrenomedullin (adm) and the essential receptor components of adm, calcitonin receptor-like receptor (crlr), and the receptor activity modifying protein 2 and 3 (ramp2 and ramp3) in the medulla oblongata, hypothalamus, midbrain, pituitary gland and adrenal gland of the stress-induced hypertensive rats. |
2006-07-21 |
2023-08-12 |
rat |
| Takeshi Katafuchi, Kazumasa Hamano, Katsuro Kikumoto, Naoto Minamin. Identification of second and third calcitonin receptor-stimulating peptides in porcine brain. Biochemical and biophysical research communications. vol 308. issue 3. 2003-09-26. PMID:12914769. |
we identified two cdnas encoding new calcitonin receptor-stimulating peptides (crsps) in porcine hypothalamus cdna library by cross-hybridization with the crsp cdna, and designated the second and third peptides as crsp-2 and crsp-3. |
2003-09-26 |
2023-08-12 |
Not clear |
| S de Lacalle, C B Sape. Calcitonin gene-related peptide-like immunoreactivity marks putative visceral sensory pathways in human brain. Neuroscience. vol 100. issue 1. 2000-11-06. PMID:10996463. |
in addition, scattered calcitonin gene-related peptide-like immunoreactive cells were found in the periventricular hypothalamus. |
2000-11-06 |
2023-08-12 |
human |
| O Rugarn, M Hammar, A Theodorsson, E Theodorsson, C Stenfor. Sex differences in neuropeptide distribution in the rat brain. Peptides. vol 20. issue 1. 1999-06-29. PMID:10098627. |
immunoreactive neurotensin (nt), neurokinin a (nka), galanin (gal), calcitonin gene-related peptide (cgrp), substance p (sp) and neuropeptide y (npy) were measured by radioimmunoassay in frontal cortex, occipital cortex, hippocampus, striatum, hypothalamus and pituitary in male and female pre- and postpubertal rats. |
1999-06-29 |
2023-08-12 |
rat |
| V Bucinskaite, G Brodda-Jansen, C Stenfors, E Theodorsson, T Lundeber. Increased concentrations of calcitonin gene-related peptide-like immunoreactivity in rat brain and peripheral tissue after ischaemia: correlation to flap survival. Neuropeptides. vol 32. issue 2. 1998-08-20. PMID:9639258. |
the effects of experimentally induced ischaemia after free-flap surgery on concentrations of neuropeptide y (npy), neurokinin a (nka), substance p (sp) and calcitonin gene-related peptide (cgrp)-like immunoreactivity (-li) were studied in flap tissue and in different regions of the rat brain (striatum, hippocampus, pituitary, hypothalamus, frontal and occipital cortex). |
1998-08-20 |
2023-08-12 |
rat |
| S Moussaoul, P Duval, V Lenoir, C Garret, B Kerdelhu. CGRP in the trigeminal nucleus, spinal cord and hypothalamus: effect of gonadal steroids. Neuropeptides. vol 30. issue 6. 1997-06-17. PMID:9004252. |
calcitonin gene-related peptide (cgrp) contents were assayed in cervical spinal cord, trigeminal nucleus and hypothalamus throughout the estrous cycle and in male and ovariectomized rats. |
1997-06-17 |
2023-08-12 |
rat |
| T A Lantos, T J Görcs, M Palkovit. Immunohistochemical localization of calcitonin gene-related peptide in the terete nucleus of the rat hypothalamus. Neurobiology (Budapest, Hungary). vol 4. issue 1-2. 1997-04-22. PMID:9116696. |
immunohistochemical localization of calcitonin gene-related peptide in the terete nucleus of the rat hypothalamus. |
1997-04-22 |
2023-08-12 |
rat |
| G M Taylor, K Meeran, D O'Shea, D M Smith, M A Ghatei, S R Bloo. Adrenomedullin inhibits feeding in the rat by a mechanism involving calcitonin gene-related peptide receptors. Endocrinology. vol 137. issue 8. 1996-12-18. PMID:8754748. |
adrenomedullin shares sequence homology with calcitonin gene-related peptide (cgrp), a central anorectic agent, and binding sites for both are present in the hypothalamus. |
1996-12-18 |
2023-08-12 |
rat |