| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| U R Nilsson, R J Mandle, J A McConnell-Mape. Human C3 and C5: subunit structure and modifications by trypsin and C42-C423. Journal of immunology (Baltimore, Md. : 1950). vol 114. issue 2 pt 2. 1975-05-09. PMID:1112981. |
the approximate molecular weights for the alpha and beta subunits of c3 as well as c5 were 140,000 and 80,000 respectively. |
1975-05-09 |
2023-08-11 |
human |
| K K Yabusaki, M A Well. Binding of calcium to phosphatidylcholines as determined by proton magnetic resonance and infrared spectroscopy. Biochemistry. vol 14. issue 1. 1975-04-21. PMID:1109586. |
the calcium-induced chemical shifts for the various protons of phosphatidylcholine were c alpha choline greater than c beta choline greater than n(ch3)3 greater than c3 glycerol. |
1975-04-21 |
2023-08-11 |
Not clear |
| S H Orkin, P D Buchanan, W J Yount, H Reisner, J W Littlefiel. Lambda-chain production in human lymphoblast-mouse fibroblast hybrids. Proceedings of the National Academy of Sciences of the United States of America. vol 70. issue 8. 1974-08-27. PMID:4599625. |
as in both parental lines, no human immunoglobulin heavy chains, complements c3 or c4, or alpha(1)-antitrypsin, or mouse immunoglobulin chains or complement c5 were detectable in the hybrids. |
1974-08-27 |
2023-08-11 |
mouse |
| S Fujit. Oxygen equilibrium characteristics of abnormal hemoglobins. Hirose (alpha-2-beta-2-37Ser), L Ferrara (alpha-2-47-Gly-beta-2), Broussais (alpha-2-90-Asn-beta-2), and Dhofar (alpha-2-beta-2-58Arg). The Journal of clinical investigation. vol 51. issue 10. 1972-10-25. PMID:5056652. |
hemoglobin hirose, in which the tryptophan at c3 (37)beta is replaced by serine, showed abnormalities of all oxygen equilibrium characteristics; i.e., increased oxygen affinity, diminished heme-heme interaction, and reduced bohr effect.these results suggest that aspartic acid at cd5(47)alpha and lysine at fg2(90)alpha are involved in the function of the hemoglobin molecule, despite the fact that these positions are not located directly in the heme or the alpha-beta-contact regions. |
1972-10-25 |
2023-08-11 |
Not clear |
| S Fujit. Oxygen equilibrium characteristics of abnormal hemoglobins. Hirose (alpha-2-beta-2-37Ser), L Ferrara (alpha-2-47-Gly-beta-2), Broussais (alpha-2-90-Asn-beta-2), and Dhofar (alpha-2-beta-2-58Arg). The Journal of clinical investigation. vol 51. issue 10. 1972-10-25. PMID:5056652. |
tryptophan at c3(37)beta is located at contact between alpha(1)- and beta(2)-subunits. |
1972-10-25 |
2023-08-11 |
Not clear |
| E H Vallota, J Forristal, R E Spitzer, N C Davis, C D Wes. Continuing C3 breakdown after bilateral nephrectomy in patients with membrano-proliferative glomerulonephritis. The Journal of clinical investigation. vol 50. issue 3. 1971-04-06. PMID:5101779. |
in both patients, low levels of c3 and high levels of preformed alpha 2d, a c3 breakdown product, were present before nephrectomy and remained essentially unchanged during the anephric period. |
1971-04-06 |
2023-08-11 |
Not clear |
| E H Vallota, J Forristal, R E Spitzer, N C Davis, C D Wes. Continuing C3 breakdown after bilateral nephrectomy in patients with membrano-proliferative glomerulonephritis. The Journal of clinical investigation. vol 50. issue 3. 1971-04-06. PMID:5101779. |
with transplantation, c3 levels rose towards normal and alpha 2d disappeared from the serum. |
1971-04-06 |
2023-08-11 |
Not clear |
| E H Vallota, J Forristal, R E Spitzer, N C Davis, C D Wes. Continuing C3 breakdown after bilateral nephrectomy in patients with membrano-proliferative glomerulonephritis. The Journal of clinical investigation. vol 50. issue 3. 1971-04-06. PMID:5101779. |
the serum of both patients contained detectable amounts of c3nef, a factor which has been shown to react with a cofactor found in normal serum to form an enzyme, designated c3 lytic nephritic factor (c3lynef), which will cleave c3 to form the breakdown products, beta1a and alpha 2d. |
1971-04-06 |
2023-08-11 |
Not clear |
| E H Vallota, J Forristal, R E Spitzer, N C Davis, C D Wes. Continuing C3 breakdown after bilateral nephrectomy in patients with membrano-proliferative glomerulonephritis. The Journal of clinical investigation. vol 50. issue 3. 1971-04-06. PMID:5101779. |
the high levels of alpha 2d during the anephric period and the disappearance of this protein as c3 levels approach normal at the time of transplantation indicate that the low c3 levels were largely the result of c3 breakdown rather than diminished synthesis. |
1971-04-06 |
2023-08-11 |
Not clear |
| E H Vallota, J Forristal, R E Spitzer, N C Davis, C D Wes. Continuing C3 breakdown after bilateral nephrectomy in patients with membrano-proliferative glomerulonephritis. The Journal of clinical investigation. vol 50. issue 3. 1971-04-06. PMID:5101779. |
finally, the lack of effect of nephrectomy on c3, alpha 2d, and c3nef levels indicate that the site of c3 breakdown was extrarenal and that c3nef and cofactor are at least in large part of extrarenal origin. |
1971-04-06 |
2023-08-11 |
Not clear |