| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Chen, T Nagayama, K Jin, R A Stetler, R L Zhu, S H Graham, R P Simo. Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 13. 1998-07-02. PMID:9634557. |
to determine whether caspase-3 serves to regulate neuronal death after cerebral ischemia, we have (1) cloned a cdna encoding the rat brain caspase-3; (2) examined caspase-3 mrna and protein expression in the brain using in situ hybridization, northern and western blot analyses, and double-labeled immunohistochemistry; (3) determined caspase-3-like activity in brain cell extracts; and (4) studied the effect of caspase-3 inhibition on cell survival and dna fragmentation in the hippocampus in a rat model of transient global ischemia. |
1998-07-02 |
2023-08-12 |
rat |
| C Olenik, H Barth, I Just, K Aktories, D K Meye. Gene expression of the small GTP-binding proteins RhoA, RhoB, Rac1, and Cdc42 in adult rat brain. Brain research. Molecular brain research. vol 52. issue 2. 1998-05-04. PMID:9495548. |
using western blot analysis, rhoa and cdc42 proteins were detected in hippocampus, cerebellum, thalamus and neocortex. |
1998-05-04 |
2023-08-12 |
rat |
| Y Dwivedi, G N Pande. Effects of subchronic administration of antidepressants and anxiolytics on levels of the alpha subunits of G proteins in the rat brain. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 6-7. 1998-03-10. PMID:9444573. |
the levels of alpha subunits of g proteins (gs, gi 1/2, gq/11) expressed in cortical, hippocampal, and cerebellar brain regions were studied by the western blot technique. |
1998-03-10 |
2023-08-12 |
rat |
| E Grigorenko, S Glazier, W Bell, M Tytell, E Nosel, T Pons, S A Deadwyle. Changes in glutamate receptor subunit composition in hippocampus and cortex in patients with refractory epilepsy. Journal of the neurological sciences. vol 153. issue 1. 1998-03-05. PMID:9455976. |
protein levels of the glur1 and glur4 subunits quantified by western blot analysis were also reduced in hippocampal and cortical tissue from epilepsy patients. |
1998-03-05 |
2023-08-12 |
human |
| J A Clemens, D T Stephenson, E P Dixon, E B Smalstig, R E Mincy, K S Rash, S P Littl. Global cerebral ischemia activates nuclear factor-kappa B prior to evidence of DNA fragmentation. Brain research. Molecular brain research. vol 48. issue 2. 1998-02-17. PMID:9332715. |
western blot analysis of hippocampus showed induction of p50 and p65. |
1998-02-17 |
2023-08-12 |
rat |
| N S Dejneka, C M Patanow, R Polavarapu, S M Toggas, J K Krady, M L Billingsle. Localization and characterization of stannin: relationship to cellular sensitivity to organotin compounds. Neurochemistry international. vol 31. issue 6. 1998-01-29. PMID:9413842. |
northern blot analysis showed that the stannin 3.0 kb mrna transcript was present, in decreasing amounts, in: spleen, hippocampus, neocortex, cerebellum, striatum, midbrain, kidney and lung. |
1998-01-29 |
2023-08-12 |
Not clear |
| J Chen, S R Ikeda, W Lang, C M Isales, X We. Molecular cloning of a putative tetrodotoxin-resistant sodium channel from dog nodose ganglion neurons. Gene. vol 202. issue 1-2. 1998-01-22. PMID:9427539. |
coupled transcription and translation of full-length cdna produced a 220-kda protein; based on northern blot and rt-pcr analysis, its expression is restricted to nodose ganglia, and not present in cortex, hippocampus, cerebellum, liver, heart or skeletal muscle. |
1998-01-22 |
2023-08-12 |
dog |
| M Y Zhou, M del Carmen Vila, E P Gomez-Sanchez, C E Gomez-Sanche. Cloning of two alternatively spliced 21-hydroxylase CDNAs from rat adrenal. The Journal of steroid biochemistry and molecular biology. vol 62. issue 4. 1998-01-13. PMID:9408081. |
reverse transcriptase-polymerase chain reaction (rt-pcr) combined with southern blot demonstrated expression of both transcripts in the kidney, aorta, liver, cerebellum, hypothalamus and brain stem, heart and cerebrum, but not the hippocampus, in addition to the adrenal. |
1998-01-13 |
2023-08-12 |
mouse |
| Y Nakashima, S Nishimura, A Maeda, E L Barsoumian, Y Hakamata, J Nakai, P D Allen, K Imoto, T Kit. Molecular cloning and characterization of a human brain ryanodine receptor. FEBS letters. vol 417. issue 1. 1998-01-07. PMID:9395096. |
northern blot analysis shows that the human ryr3 mrna is abundantly expressed in hippocampus, caudate nucleus and amygdala as well as in skeletal muscle. |
1998-01-07 |
2023-08-12 |
human |
| A Popa-Wagner, B Fischer, H Schmoll, D Platt, C Kessle. Increased expression of microtubule-associated protein 1B in the hippocampus, subiculum, and perforant path of rats treated with a high dose of pentylenetetrazole. Experimental neurology. vol 148. issue 1. 1998-01-07. PMID:9398451. |
using northern blot and in situ hybridization we show that the first increases in map1b mrna were detected at 15 h following ptz administration in the granule cells of the dentate gyrus and ca3 region of the hippocampus and reached a maximum at 44 h. the levels of map1b mrna in the subiculum peaked at later times (5 days). |
1998-01-07 |
2023-08-12 |
rat |
| R Yang, B Wang, J Chen. [Effect of electroacupuncture on cholecystokinin gene expression in rat hippocampus during penicillin-induced epileptic seizure]. Zhen ci yan jiu = Acupuncture research. vol 21. issue 2. 1997-12-23. PMID:9387377. |
northern blot and hybrization in situ techniques were used to investigate the effect of electroacupuncture (ea) on the changes of cholecystokinin (cck) mran levels of the hippocampus in rat penicillin-induced epilepsy model. |
1997-12-23 |
2023-08-12 |
rat |
| T Herdegen, A Blume, T Buschmann, E Georgakopoulos, C Winter, W Schmid, T F Hsieh, M Zimmermann, P Gas. Expression of activating transcription factor-2, serum response factor and cAMP/Ca response element binding protein in the adult rat brain following generalized seizures, nerve fibre lesion and ultraviolet irradiation. Neuroscience. vol 81. issue 1. 1997-11-06. PMID:9300412. |
two hours, but not 5 h or 24 h, following systemic application of kainic acid, an increase in srf was detectable by western blot analysis in hippocampal and cortical homogenates whereas the expression of atf-2 and creb did not change. |
1997-11-06 |
2023-08-12 |
rat |
| S Lee, J Williamson, E W Lothman, F G Szele, M F Chesselet, S Von Hagen, R M Sapolsky, M P Mattson, S Christako. Early induction of mRNA for calbindin-D28k and BDNF but not NT-3 in rat hippocampus after kainic acid treatment. Brain research. Molecular brain research. vol 47. issue 1-2. 1997-09-17. PMID:9221916. |
the influence of kainic acid (ka), which induces acute seizures, on expression of mrna for the calcium-binding protein, calbindin-d28k, brain-derived neurotrophic factor (bdnf), neurotrophin-3 (nt-3) and early-response genes [c-fos, zif268 (ngfi-a), nur77 (ngfi-b)] was examined in rat hippocampus by northern blot analysis. |
1997-09-17 |
2023-08-12 |
rat |
| G Bing, B Wilson, P Hudson, L Jin, Z Feng, W Zhang, R Bing, J S Hon. A single dose of kainic acid elevates the levels of enkephalins and activator protein-1 transcription factors in the hippocampus for up to 1 year. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 17. 1997-09-17. PMID:9256498. |
using northern blot analysis, immunocytochemistry, and western blot analysis, we have found a long-term elevation of the proconvulsive opioid peptide, enkephalin, in the rat hippocampus. |
1997-09-17 |
2023-08-12 |
rat |
| H C Kim, H W Suh, D Bronstein, G Bing, B Wilson, J S Hon. Dextromethorphan blocks opioid peptide gene expression in the rat hippocampus induced by kainic acid. Neuropeptides. vol 31. issue 2. 1997-08-18. PMID:9179861. |
both northern blot and in situ hybridization methods were used to examine the proenkephalin (penk) and prodynorphin (pdyn) mrna levels in the rat hippocampus. |
1997-08-18 |
2023-08-12 |
rat |
| C E Gomez-Sanchez, M Y Zhou, E N Cozza, H Morita, M F Foecking, E P Gomez-Sanche. Aldosterone biosynthesis in the rat brain. Endocrinology. vol 138. issue 8. 1997-08-15. PMID:9231789. |
expression of the mrna for the aldosterone synthase was demonstrated by rt-pcr/southern blot in adrenal, aorta, hypothalamus, hippocampus, amygdala, cerebrum, and cerebellum. |
1997-08-15 |
2023-08-12 |
rat |
| M Bergeron, D M Ferriero, H J Vreman, D K Stevenson, F R Shar. Hypoxia-ischemia, but not hypoxia alone, induces the expression of heme oxygenase-1 (HSP32) in newborn rat brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 17. issue 6. 1997-08-15. PMID:9236721. |
whereas ho enzymatic activity was unchanged in ipsilateral cortex and subcortical regions compared with the contralateral hemisphere or control brains, immunocytochemistry and western blot analysis showed increased ho-1 staining in ipsilateral cortex, hippocampus, and striatum at 12 to 24 hours up to 7 days after hi. |
1997-08-15 |
2023-08-12 |
rat |
| R A Hall, T R Soderlin. Quantitation of AMPA receptor surface expression in cultured hippocampal neurons. Neuroscience. vol 78. issue 2. 1997-08-01. PMID:9145793. |
to provide insight into this matter, western blot immunoreactivities for glutamate receptors 1 and 2/3, as well as binding of the specific ligand [3h]ampa, were quantified following three independent treatments modifying surface receptors in intact primary hippocampal cultures: (i) proteolysis of surface receptors by chymotrypsin, (ii) cross-linking of surface receptors with the membrane-impermeant reagent bis(sulfosuccinimidyl)suberate, and (iii) biotinylation of surface receptors with the membrane-impermeant reagent sulfosuccinimidyl-2(biotinamido)ethyl-1,3-dithiopropionate. |
1997-08-01 |
2023-08-12 |
Not clear |
| M Tokuda, B Y Ahmed, Y F Lu, H Matsui, O Miyamoto, F Yamaguchi, R Konishi, O Hatas. Involvement of calmodulin-dependent protein kinases-I and -IV in long-term potentiation. Brain research. vol 755. issue 1. 1997-07-16. PMID:9163554. |
ltp-induced and control hippocampal slices were studied by western blot and immunohistochemical analyses using camk-i, -ii and -iv antibodies. |
1997-07-16 |
2023-08-12 |
rat |
| M Tokuda, B Y Ahmed, Y F Lu, H Matsui, O Miyamoto, F Yamaguchi, R Konishi, O Hatas. Involvement of calmodulin-dependent protein kinases-I and -IV in long-term potentiation. Brain research. vol 755. issue 1. 1997-07-16. PMID:9163554. |
increased amounts of all three camks were found in ltp-induced hippocampal slices as indicated by western blot as well as by the density of their immunoreactivity. |
1997-07-16 |
2023-08-12 |
rat |