| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M da Penha Berzaghi, J Cooper, E Castrén, F Zafra, M Sofroniew, H Thoenen, D Lindhol. Cholinergic regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) but not neurotrophin-3 (NT-3) mRNA levels in the developing rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 9. 1993-10-05. PMID:8366347. |
in previous experiments it has been demonstrated that the synthesis of bdnf (brain-derived neurotrophic factor) and ngf in neurons of the hippocampus is regulated by neuronal activity. |
1993-10-05 |
2023-08-12 |
rat |
| M da Penha Berzaghi, J Cooper, E Castrén, F Zafra, M Sofroniew, H Thoenen, D Lindhol. Cholinergic regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) but not neurotrophin-3 (NT-3) mRNA levels in the developing rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 9. 1993-10-05. PMID:8366347. |
partial transection of the fimbria fornix bundle in the second postnatal week resulted in a reduction of bdnf and ngf mrna levels in the hippocampus, suggesting that septal cholinergic input is involved in the regulation of hippocampal bdnf and ngf mrna levels. |
1993-10-05 |
2023-08-12 |
rat |
| M da Penha Berzaghi, J Cooper, E Castrén, F Zafra, M Sofroniew, H Thoenen, D Lindhol. Cholinergic regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) but not neurotrophin-3 (NT-3) mRNA levels in the developing rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 9. 1993-10-05. PMID:8366347. |
pilocarpine markedly increased hippocampal bdnf and ngf mrna levels in both early postnatal and adult rats. |
1993-10-05 |
2023-08-12 |
rat |
| M da Penha Berzaghi, J Cooper, E Castrén, F Zafra, M Sofroniew, H Thoenen, D Lindhol. Cholinergic regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) but not neurotrophin-3 (NT-3) mRNA levels in the developing rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 9. 1993-10-05. PMID:8366347. |
in situ hybridization experiments demonstrated that pilocarpine led to an increase in bdnf expression in the ca1-ca4 regions of the hippocampus and in the dentate gyrus. |
1993-10-05 |
2023-08-12 |
rat |
| K D Beck, F Lamballe, R Klein, M Barbacid, P E Schauwecker, T H McNeill, C E Finch, F Hefti, J R Da. Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 9. 1993-10-05. PMID:8396171. |
brain-derived neurotrophic factor (bdnf) and its signal transducing receptor, the trkb tyrosine protein kinase, are expressed at high levels in the hippocampus of the adult brain, suggesting a role for bdnf mechanisms in neuronal plasticity. |
1993-10-05 |
2023-08-12 |
Not clear |
| K D Beck, F Lamballe, R Klein, M Barbacid, P E Schauwecker, T H McNeill, C E Finch, F Hefti, J R Da. Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 9. 1993-10-05. PMID:8396171. |
at days 1, 3, and 6, the lesions decreased bdnf mrna expression ipsilaterally to approximately 50% of control, with complete recovery at 14 d. the lesions did not alter trkb mrna levels in neuronal layers of the hippocampus; however, they resulted in a pronounced induction of trkb mrna expression in hippocampal non-neuronal cells 6-14 d after lesioning. |
1993-10-05 |
2023-08-12 |
Not clear |
| N Y Ip, Y Li, G D Yancopoulos, R M Lindsa. Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 8. 1993-09-02. PMID:7688038. |
cultured hippocampal neurons show responses to bdnf, nt-3, and nt-4, but not ngf. |
1993-09-02 |
2023-08-12 |
rat |
| N Y Ip, Y Li, G D Yancopoulos, R M Lindsa. Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 8. 1993-09-02. PMID:7688038. |
cultures of embryonic day 18 (e18) hippocampal neurons were also found by northern analysis to express trkb and trkc but not trka, indicating potential responsiveness to brain-derived neurotrophic factor (bdnf), neurotrophin-3 (nt-3), and nt-4, but not ngf. |
1993-09-02 |
2023-08-12 |
rat |
| N Y Ip, Y Li, G D Yancopoulos, R M Lindsa. Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 8. 1993-09-02. PMID:7688038. |
phosphorylation experiments indeed showed that bdnf, nt-3, and nt-4 produced rapid tyrosine phosphorylation of trk proteins, as detected by immunoprecipitation using a pan-trk-specific antibody, whereas ngf produced no detectable tyrosine phosphorylation in hippocampal cultures. |
1993-09-02 |
2023-08-12 |
rat |
| N Y Ip, Y Li, G D Yancopoulos, R M Lindsa. Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 8. 1993-09-02. PMID:7688038. |
while we observed no major effect of any of the neurotrophins upon the survival of e18 hippocampal neurons, bdnf, nt-3, and nt-4, but not ngf, produced marked increases in the number of neurons expressing detectable levels of either calbindin or ache. |
1993-09-02 |
2023-08-12 |
rat |
| Z Kokaia, J Bengzon, M Metsis, M Kokaia, H Persson, O Lindval. Coexpression of neurotrophins and their receptors in neurons of the central nervous system. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 14. 1993-08-30. PMID:8341689. |
using double-label in situ hybridization, we demonstrate that mrnas for bdnf and its high-affinity receptor trkb are coexpressed in hippocampal and cortical neurons. |
1993-08-30 |
2023-08-12 |
Not clear |
| M Knipper, A Beck, J Rylett, H Bree. Neurotrophin induced second messenger responses in rat brain synaptosomes. Neuroreport. vol 4. issue 5. 1993-07-22. PMID:8390308. |
neurotrophins (ngf, bdnf) elicit significant elevation of camp as well as ip3-concentrations in either membrane preparations or intact isolated nerve endings from rat brain hippocampus. |
1993-07-22 |
2023-08-12 |
rat |
| C Cosi, P E Spoerri, M C Comelli, D Guidolin, S D Skape. Glucocorticoids depress activity-dependent expression of BDNF mRNA in hippocampal neurones. Neuroreport. vol 4. issue 5. 1993-07-22. PMID:8513132. |
glucocorticoids depress activity-dependent expression of bdnf mrna in hippocampal neurones. |
1993-07-22 |
2023-08-12 |
rat |
| C Cosi, P E Spoerri, M C Comelli, D Guidolin, S D Skape. Glucocorticoids depress activity-dependent expression of BDNF mRNA in hippocampal neurones. Neuroreport. vol 4. issue 5. 1993-07-22. PMID:8513132. |
here we show that dexamethasone, a synthetic glucocorticoid, prevents activity-dependent increases of brain-derived neurotrophic factor (bdnf) mrna in cultures of rat hippocampal neurones. |
1993-07-22 |
2023-08-12 |
rat |
| J B Pan, L M Monteggia, T Giordan. Altered levels and splicing of the amyloid precursor protein in the adult rat hippocampus after treatment with DMSO or retinoic acid. Brain research. Molecular brain research. vol 18. issue 3. 1993-06-24. PMID:7684485. |
on the abundance of app, the ratio of the three major isoforms, and the relative abundance of nerve growth factor (ngf), brain derived neurotrophic factor (bdnf), and neurotrophin-3 (nt-3) were determined by rtpcr in the hippocampus of aged rats. |
1993-06-24 |
2023-08-12 |
rat |
| P A Lapchak, D M Araujo, K D Beck, C E Finch, S A Johnson, F Heft. BDNF and trkB mRNA expression in the hippocampal formation of aging rats. Neurobiology of aging. vol 14. issue 2. 1993-06-10. PMID:8487914. |
northern blot analysis of hippocampal rna from male fischer 344 confirmed that neither bdnf mrna nor trkb mrna levels changed with age. |
1993-06-10 |
2023-08-12 |
rat |
| P A Lapchak, D M Araujo, K D Beck, C E Finch, S A Johnson, F Heft. BDNF and trkB mRNA expression in the hippocampal formation of aging rats. Neurobiology of aging. vol 14. issue 2. 1993-06-10. PMID:8487914. |
these findings suggest that age-related neurodegenerative changes, including the atrophy of the cholinergic septo-hippocampal pathway, are not the result of changes in hippocampal bdnf or trkb mrna expression. |
1993-06-10 |
2023-08-12 |
rat |
| P A Lapchak, D M Araujo, K D Beck, C E Finch, S A Johnson, F Heft. BDNF and trkB mRNA expression in the hippocampal formation of aging rats. Neurobiology of aging. vol 14. issue 2. 1993-06-10. PMID:8487914. |
these findings indicate that altered hippocampal synaptic plasticity which occurs in the aged rat brain is not a reflection of changes in the expression of bdnf or trkb receptor mrna. |
1993-06-10 |
2023-08-12 |
rat |
| P A Lapchak, D M Araujo, F Heft. BDNF and trkB mRNA expression in the rat hippocampus following entorhinal cortex lesions. Neuroreport. vol 4. issue 2. 1993-04-22. PMID:8453058. |
bdnf and trkb mrna expression in the rat hippocampus following entorhinal cortex lesions. |
1993-04-22 |
2023-08-12 |
rat |
| P A Lapchak, D M Araujo, F Heft. BDNF and trkB mRNA expression in the rat hippocampus following entorhinal cortex lesions. Neuroreport. vol 4. issue 2. 1993-04-22. PMID:8453058. |
our findings indicate that hippocampal neuron sprouting which occurs in response to ecls is not the result of changes in the expression of the bdnf or trkb mrna. |
1993-04-22 |
2023-08-12 |
rat |