| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Naoko Kuzumaki, Daigo Ikegami, Rie Tamura, Nana Hareyama, Satoshi Imai, Michiko Narita, Kazuhiro Torigoe, Keiichi Niikura, Hideyuki Takeshima, Takayuki Ando, Katsuhide Igarashi, Jun Kanno, Toshikazu Ushijima, Tsutomu Suzuki, Minoru Narit. Hippocampal epigenetic modification at the brain-derived neurotrophic factor gene induced by an enriched environment. Hippocampus. vol 21. issue 2. 2011-05-06. PMID:20232397. |
exposure to an enriched environment for 3-4 weeks caused a dramatic increase in the mrna expression of bdnf, but not platelet-derived growth factor a (pdgf-a), pdgf-b, vascular endothelial growth factor (vegf), nerve growth factor (ngf), epidermal growth factor (egf), or glial fibrillary acidic protein (gfap), in the hippocampus of mice. |
2011-05-06 |
2023-08-12 |
mouse |
| Naoko Kuzumaki, Daigo Ikegami, Rie Tamura, Nana Hareyama, Satoshi Imai, Michiko Narita, Kazuhiro Torigoe, Keiichi Niikura, Hideyuki Takeshima, Takayuki Ando, Katsuhide Igarashi, Jun Kanno, Toshikazu Ushijima, Tsutomu Suzuki, Minoru Narit. Hippocampal epigenetic modification at the brain-derived neurotrophic factor gene induced by an enriched environment. Hippocampus. vol 21. issue 2. 2011-05-06. PMID:20232397. |
under these conditions, exposure to an enriched environment induced a significant increase in histone h3 lysine 4 (h3k4) trimethylation at the bdnf p3 and p6 promoters, in contrast to significant decreases in histone h3 lysine 9 (h3k9) trimethylation at the bdnf p4 promoter and histone h3 lysine 27 (h3k27) trimethylation at the bdnf p3 and p4 promoters without any changes in the expression of their associated histone methylases and demethylases in the hippocampus. |
2011-05-06 |
2023-08-12 |
mouse |
| Naoko Kuzumaki, Daigo Ikegami, Rie Tamura, Nana Hareyama, Satoshi Imai, Michiko Narita, Kazuhiro Torigoe, Keiichi Niikura, Hideyuki Takeshima, Takayuki Ando, Katsuhide Igarashi, Jun Kanno, Toshikazu Ushijima, Tsutomu Suzuki, Minoru Narit. Hippocampal epigenetic modification at the brain-derived neurotrophic factor gene induced by an enriched environment. Hippocampus. vol 21. issue 2. 2011-05-06. PMID:20232397. |
these results suggest that an enriched environment increases bdnf mrna expression via sustained epigenetic modification in the mouse hippocampus. |
2011-05-06 |
2023-08-12 |
mouse |
| J Rekha, L R Veena, Neethi Prem, P Kalaivani, Rupam Choudhury, Phalguni Anand Alladi, Maulishree Agrahari, T R Raju, Bindu M Kutt. NIH-3T3 fibroblast transplants enhance host regeneration and improve spatial learning in ventral subicular lesioned rats. Behavioural brain research. vol 218. issue 2. 2011-05-06. PMID:21074573. |
further, the vsl rats with fibroblast transplants showed enhanced expression of bdnf in the hippocampus and enhanced dendritic branching and increased spine density in the ca1 hippocampal pyramidal neurons. |
2011-05-06 |
2023-08-12 |
rat |
| Pablo C Muñoz, Mauricio A Aspé, Luis S Contreras, Adrián G Palacio. Correlations of recognition memory performance with expression and methylation of brain-derived neurotrophic factor in rats. Biological research. vol 43. issue 2. 2011-05-05. PMID:21031270. |
we found a significant correlation between performance on the novel object task and the expression of bdnf, negatively in hippocampal slices and positively in perirhinal cortical slices. |
2011-05-05 |
2023-08-12 |
rat |
| Pablo C Muñoz, Mauricio A Aspé, Luis S Contreras, Adrián G Palacio. Correlations of recognition memory performance with expression and methylation of brain-derived neurotrophic factor in rats. Biological research. vol 43. issue 2. 2011-05-05. PMID:21031270. |
by contrast, methylation of dna in cpg island 1 in the promoter of exon 1 in bdnf only correlated in hippocampal slices, but not in the pxc cortical slices from trained animals. |
2011-05-05 |
2023-08-12 |
rat |
| Pablo C Muñoz, Mauricio A Aspé, Luis S Contreras, Adrián G Palacio. Correlations of recognition memory performance with expression and methylation of brain-derived neurotrophic factor in rats. Biological research. vol 43. issue 2. 2011-05-05. PMID:21031270. |
these results suggest that dna methylation may be involved in the regulation of the bdnf gene during recognition memory, at least in the hippocampus. |
2011-05-05 |
2023-08-12 |
rat |
| Ewa Badowska-Szalewska, Edyta Spodnik, Ilona Klejbor, Janusz Mory. Effects of chronic forced swim stress on hippocampal brain-derived neutrophic factor (BDNF) and its receptor (TrkB) immunoreactive cells in juvenile and aged rats. Acta neurobiologiae experimentalis. vol 70. issue 4. 2011-05-03. PMID:21196945. |
effects of chronic forced swim stress on hippocampal brain-derived neutrophic factor (bdnf) and its receptor (trkb) immunoreactive cells in juvenile and aged rats. |
2011-05-03 |
2023-08-12 |
rat |
| Ewa Badowska-Szalewska, Edyta Spodnik, Ilona Klejbor, Janusz Mory. Effects of chronic forced swim stress on hippocampal brain-derived neutrophic factor (BDNF) and its receptor (TrkB) immunoreactive cells in juvenile and aged rats. Acta neurobiologiae experimentalis. vol 70. issue 4. 2011-05-03. PMID:21196945. |
a type of stress stimulation and age are claimed to affect the expression of brain-derived neurotrophic factor (bdnf) and its receptor - tyrosine kinase b (trkb) in the hippocampal regions differentially. |
2011-05-03 |
2023-08-12 |
rat |
| Chih C Chao, Yun L Ma, Eminy H Y Le. Brain-derived neurotrophic factor enhances Bcl-xL expression through protein kinase casein kinase 2-activated and nuclear factor kappa B-mediated pathway in rat hippocampus. Brain pathology (Zurich, Switzerland). vol 21. issue 2. 2011-04-28. PMID:20731656. |
these results demonstrate a novel bdnf signaling pathway and provide an alternative therapeutic strategy for the protective effect of bdnf on hippocampal neurons in vivo. |
2011-04-28 |
2023-08-12 |
rat |
| Hui Yu, Zhe-yu Che. The role of BDNF in depression on the basis of its location in the neural circuitry. Acta pharmacologica Sinica. vol 32. issue 1. 2011-04-25. PMID:21131999. |
here, we present an overview of the current knowledge concerning bdnf actions and associated intracellular signaling in hippocampus, prefrontal cortex, nucleus accumbens (nac) and amygdala as their relation to depression. |
2011-04-25 |
2023-08-12 |
Not clear |
| Yen-Ching Wu, Rebecca Williamson, Zhi Li, Annalisa Vicario, Jerry Xu, Masataka Kasai, Yijuang Chern, Enrico Tongiorgi, Jay M Baraba. Dendritic trafficking of brain-derived neurotrophic factor mRNA: regulation by translin-dependent and -independent mechanisms. Journal of neurochemistry. vol 116. issue 6. 2011-04-15. PMID:21198640. |
recently, we demonstrated that sirna-mediated knockdown of translin, an rna-binding protein, impairs kcl-induced dendritic trafficking of bdnf mrna in cultured hippocampal neurons. |
2011-04-15 |
2023-08-12 |
mouse |
| Yen-Ching Wu, Rebecca Williamson, Zhi Li, Annalisa Vicario, Jerry Xu, Masataka Kasai, Yijuang Chern, Enrico Tongiorgi, Jay M Baraba. Dendritic trafficking of brain-derived neurotrophic factor mRNA: regulation by translin-dependent and -independent mechanisms. Journal of neurochemistry. vol 116. issue 6. 2011-04-15. PMID:21198640. |
we have now assessed whether translin deletion impairs dendritic trafficking of bdnf mrna in hippocampal neurons in vivo. |
2011-04-15 |
2023-08-12 |
mouse |
| Yen-Ching Wu, Rebecca Williamson, Zhi Li, Annalisa Vicario, Jerry Xu, Masataka Kasai, Yijuang Chern, Enrico Tongiorgi, Jay M Baraba. Dendritic trafficking of brain-derived neurotrophic factor mRNA: regulation by translin-dependent and -independent mechanisms. Journal of neurochemistry. vol 116. issue 6. 2011-04-15. PMID:21198640. |
we have found that translin and its partner protein, trax, undergo dendritic translocation in response to treatment with pilocarpine, a pro-convulsant muscarinic agonist that increases dendritic trafficking of bdnf mrna in hippocampal neurons. |
2011-04-15 |
2023-08-12 |
mouse |
| Yen-Ching Wu, Rebecca Williamson, Zhi Li, Annalisa Vicario, Jerry Xu, Masataka Kasai, Yijuang Chern, Enrico Tongiorgi, Jay M Baraba. Dendritic trafficking of brain-derived neurotrophic factor mRNA: regulation by translin-dependent and -independent mechanisms. Journal of neurochemistry. vol 116. issue 6. 2011-04-15. PMID:21198640. |
consistent with this inference, we found that dendritic trafficking of bdnf mrna induced by bath application of recombinant bdnf in cultured hippocampal neurons, is not blocked by sirna-mediated knockdown of translin. |
2011-04-15 |
2023-08-12 |
mouse |
| Jin-Xiu Xu, Mu Yang, Ke-Jun Deng, Hong Zho. Antioxidant activities of Dracocephalum tanguticum maxim extract and its up-regulation on the expression of neurotrophic factors in a rat model of permanent focal cerebral ischemia. The American journal of Chinese medicine. vol 39. issue 1. 2011-04-15. PMID:21213399. |
dme was effective in stimulating bdnf mrna expression and protein synthesis in the ipsilateral frontal cortex (ifc) of both the sham-operated and pmcao rats and this effect was also observed in the hippocampus of the pmcao rats. |
2011-04-15 |
2023-08-12 |
rat |
| Tatiana Adasme, Paola Haeger, Andrea C Paula-Lima, Italo Espinoza, M Mercedes Casas-Alarcón, M Angélica Carrasco, Cecilia Hidalg. Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 7. 2011-04-14. PMID:21282625. |
along with calcium signals, brain-derived neurotrophic factor (bdnf) is a key signaling molecule for hippocampal synaptic plasticity and spatial memory. |
2011-04-14 |
2023-08-12 |
rat |
| Tatiana Adasme, Paola Haeger, Andrea C Paula-Lima, Italo Espinoza, M Mercedes Casas-Alarcón, M Angélica Carrasco, Cecilia Hidalg. Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 7. 2011-04-14. PMID:21282625. |
additionally, incubation with bdnf enhanced the expression of ryr2, ryr3, and pkmζ, an atypical protein kinase c isoform with key roles in hippocampal memory consolidation. |
2011-04-14 |
2023-08-12 |
rat |
| Tatiana Adasme, Paola Haeger, Andrea C Paula-Lima, Italo Espinoza, M Mercedes Casas-Alarcón, M Angélica Carrasco, Cecilia Hidalg. Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 7. 2011-04-14. PMID:21282625. |
intrahippocampal injection of bdnf or training rats in a spatial memory task enhanced pkmζ, ryr2, ryr3, and bdnf hippocampal protein content, while injection of ryanodine at concentrations that stimulate ryr-mediated calcium release improved spatial memory learning and enhanced memory consolidation. |
2011-04-14 |
2023-08-12 |
rat |
| Kirk I Erickson, Michelle W Voss, Ruchika Shaurya Prakash, Chandramallika Basak, Amanda Szabo, Laura Chaddock, Jennifer S Kim, Susie Heo, Heloisa Alves, Siobhan M White, Thomas R Wojcicki, Emily Mailey, Victoria J Vieira, Stephen A Martin, Brandt D Pence, Jeffrey A Woods, Edward McAuley, Arthur F Krame. Exercise training increases size of hippocampus and improves memory. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 7. 2011-04-14. PMID:21282661. |
we also demonstrate that increased hippocampal volume is associated with greater serum levels of bdnf, a mediator of neurogenesis in the dentate gyrus. |
2011-04-14 |
2023-08-12 |
Not clear |