| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L C Harte-Hargrove, N J Maclusky, H E Scharfma. Brain-derived neurotrophic factor-estrogen interactions in the hippocampal mossy fiber pathway: implications for normal brain function and disease. Neuroscience. vol 239. 2013-10-17. PMID:23276673. |
here we focus on the mossy fiber (mf) pathway of the hippocampus, a critical pathway in normal hippocampal function, and a prime example of a location where numerous studies support an interaction between bdnf and estrogen in the rodent brain. |
2013-10-17 |
2023-08-12 |
Not clear |
| L C Harte-Hargrove, N J Maclusky, H E Scharfma. Brain-derived neurotrophic factor-estrogen interactions in the hippocampal mossy fiber pathway: implications for normal brain function and disease. Neuroscience. vol 239. 2013-10-17. PMID:23276673. |
then we consider the results of studies that suggest that 17β-estradiol alters hippocampal function by its influence on bdnf expression in the mf pathway. |
2013-10-17 |
2023-08-12 |
Not clear |
| L C Harte-Hargrove, N J Maclusky, H E Scharfma. Brain-derived neurotrophic factor-estrogen interactions in the hippocampal mossy fiber pathway: implications for normal brain function and disease. Neuroscience. vol 239. 2013-10-17. PMID:23276673. |
we also address the hypothesis that estrogen influences the hippocampus by mechanisms related not only to the mature form of bdnf, acting at trkb receptors, but also by regulating the precursor, probdnf, acting at p75ntr. |
2013-10-17 |
2023-08-12 |
Not clear |
| L C Harte-Hargrove, N J Maclusky, H E Scharfma. Brain-derived neurotrophic factor-estrogen interactions in the hippocampal mossy fiber pathway: implications for normal brain function and disease. Neuroscience. vol 239. 2013-10-17. PMID:23276673. |
we suggest that the interactions between bdnf and 17β-estradiol in the mfs are potentially important in the normal function of the hippocampus, and have implications for sex differences in functions that depend on the mfs and in diseases where mf plasticity has been suggested to play an important role, alzheimer's disease, epilepsy and addiction. |
2013-10-17 |
2023-08-12 |
Not clear |
| Sylvie Burnouf, Alberto Martire, Maxime Derisbourg, Cyril Laurent, Karim Belarbi, Antoine Leboucher, Francisco J Fernandez-Gomez, Laetitia Troquier, Sabiha Eddarkaoui, Marie-Eve Grosjean, Dominique Demeyer, Anne Muhr-Tailleux, Alain Buisson, Nicolas Sergeant, Malika Hamdane, Sandrine Humez, Patrizia Popoli, Luc Buée, David Blu. NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model. Aging cell. vol 12. issue 1. 2013-09-30. PMID:23082852. |
when applied on hippocampal slices, bdnf is able to enhance ampa receptor-dependent hippocampal basal synaptic transmission through a mechanism involving trkb and n-methyl-d-aspartate receptors (nmdar). |
2013-09-30 |
2023-08-12 |
mouse |
| Sylvie Burnouf, Alberto Martire, Maxime Derisbourg, Cyril Laurent, Karim Belarbi, Antoine Leboucher, Francisco J Fernandez-Gomez, Laetitia Troquier, Sabiha Eddarkaoui, Marie-Eve Grosjean, Dominique Demeyer, Anne Muhr-Tailleux, Alain Buisson, Nicolas Sergeant, Malika Hamdane, Sandrine Humez, Patrizia Popoli, Luc Buée, David Blu. NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model. Aging cell. vol 12. issue 1. 2013-09-30. PMID:23082852. |
using thy-tau22 transgenic mice, we demonstrated that hippocampal tau pathology is associated with loss of synaptic enhancement normally induced by exogenous bdnf. |
2013-09-30 |
2023-08-12 |
mouse |
| Gabriele Baj, Domenico Del Turco, Jessica Schlaudraff, Lucio Torelli, Thomas Deller, Enrico Tongiorg. Regulation of the spatial code for BDNF mRNA isoforms in the rat hippocampus following pilocarpine-treatment: a systematic analysis using laser microdissection and quantitative real-time PCR. Hippocampus. vol 23. issue 5. 2013-09-30. PMID:23436435. |
regulation of the spatial code for bdnf mrna isoforms in the rat hippocampus following pilocarpine-treatment: a systematic analysis using laser microdissection and quantitative real-time pcr. |
2013-09-30 |
2023-08-12 |
rat |
| Gabriele Baj, Domenico Del Turco, Jessica Schlaudraff, Lucio Torelli, Thomas Deller, Enrico Tongiorg. Regulation of the spatial code for BDNF mRNA isoforms in the rat hippocampus following pilocarpine-treatment: a systematic analysis using laser microdissection and quantitative real-time PCR. Hippocampus. vol 23. issue 5. 2013-09-30. PMID:23436435. |
in this study, using laser microdissection of hippocampal laminae and reverse transcription-quantitative real-time pcr (rt-qpcr), we analyzed all known bdnf mrna variants at resting conditions or following 3 h pilocarpine-induced status epilepticus. |
2013-09-30 |
2023-08-12 |
rat |
| Florian Duclot, Mohamed Kabba. Individual differences in novelty seeking predict subsequent vulnerability to social defeat through a differential epigenetic regulation of brain-derived neurotrophic factor expression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 27. 2013-09-30. PMID:23825410. |
here, we show that such individual differences are critically regulated by hippocampal bdnf. |
2013-09-30 |
2023-08-12 |
rat |
| Florian Duclot, Mohamed Kabba. Individual differences in novelty seeking predict subsequent vulnerability to social defeat through a differential epigenetic regulation of brain-derived neurotrophic factor expression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 27. 2013-09-30. PMID:23825410. |
this difference in hippocampal bdnf expression promoted the vulnerability of hr and the resilience of lr rats. |
2013-09-30 |
2023-08-12 |
rat |
| Florian Duclot, Mohamed Kabba. Individual differences in novelty seeking predict subsequent vulnerability to social defeat through a differential epigenetic regulation of brain-derived neurotrophic factor expression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 27. 2013-09-30. PMID:23825410. |
indeed, preventing activation of bdnf signaling by infusing the bdnf scavenger trkb-fc into the dentate gyrus of the hippocampus of lr rats led to social defeat-induced social avoidance, whereas its activation in hr rats by the trkb agonist 7,8-dihydroxyflavone promoted social approach. |
2013-09-30 |
2023-08-12 |
rat |
| Florian Duclot, Mohamed Kabba. Individual differences in novelty seeking predict subsequent vulnerability to social defeat through a differential epigenetic regulation of brain-derived neurotrophic factor expression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 27. 2013-09-30. PMID:23825410. |
altogether, our data support the importance of hippocampal bdnf regulation in response to stressful events. |
2013-09-30 |
2023-08-12 |
rat |
| Florian Duclot, Mohamed Kabba. Individual differences in novelty seeking predict subsequent vulnerability to social defeat through a differential epigenetic regulation of brain-derived neurotrophic factor expression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 27. 2013-09-30. PMID:23825410. |
moreover, we identify a specific and adaptive regulation of bdnf exon vi in the hippocampus as a critical regulator of stress resilience, and strengthen the importance of epigenetic factors in mediating stress-induced adaptive and maladaptive responses in different individuals. |
2013-09-30 |
2023-08-12 |
rat |
| C V Melo, S Okumoto, J R Gomes, M S Baptista, B A Bahr, W B Frommer, C B Duart. Spatiotemporal resolution of BDNF neuroprotection against glutamate excitotoxicity in cultured hippocampal neurons. Neuroscience. vol 237. 2013-09-23. PMID:23384605. |
spatiotemporal resolution of bdnf neuroprotection against glutamate excitotoxicity in cultured hippocampal neurons. |
2013-09-23 |
2023-08-12 |
rat |
| C V Melo, S Okumoto, J R Gomes, M S Baptista, B A Bahr, W B Frommer, C B Duart. Spatiotemporal resolution of BDNF neuroprotection against glutamate excitotoxicity in cultured hippocampal neurons. Neuroscience. vol 237. 2013-09-23. PMID:23384605. |
brain-derived neurotrophic factor (bdnf) protects hippocampal neurons from glutamate excitotoxicity as determined by analysis of chromatin condensation, through activation of extracellular signal-regulated kinase (erk) and phosphatidylinositol 3-kinase (pi3-k) signaling pathways. |
2013-09-23 |
2023-08-12 |
rat |
| Rachel A Hill, Yee-Wen Candace Wu, Andrea Gogos, Maarten van den Buus. Sex-dependent alterations in BDNF-TrkB signaling in the hippocampus of reelin heterozygous mice: a role for sex steroid hormones. Journal of neurochemistry. vol 126. issue 3. 2013-09-20. PMID:23414458. |
we found significantly increased levels of bdnf in the ventral hippocampus (vhp) of female, but not male rln(+/-) compared to wild-type (wt) controls. |
2013-09-20 |
2023-08-12 |
mouse |
| Rachel A Hill, Yee-Wen Candace Wu, Andrea Gogos, Maarten van den Buus. Sex-dependent alterations in BDNF-TrkB signaling in the hippocampus of reelin heterozygous mice: a role for sex steroid hormones. Journal of neurochemistry. vol 126. issue 3. 2013-09-20. PMID:23414458. |
no changes in bdnf, trkb, ptrkb or perk1/2 were observed in the dorsal hippocampus of rln(+/-) mice. |
2013-09-20 |
2023-08-12 |
mouse |
| Rachel A Hill, Yee-Wen Candace Wu, Andrea Gogos, Maarten van den Buus. Sex-dependent alterations in BDNF-TrkB signaling in the hippocampus of reelin heterozygous mice: a role for sex steroid hormones. Journal of neurochemistry. vol 126. issue 3. 2013-09-20. PMID:23414458. |
these data may provide a better understanding of the interaction of reelin and bdnf in the hippocampus, which may be involved in schizophrenia. |
2013-09-20 |
2023-08-12 |
mouse |
| Lauren L Orefice, Emily G Waterhouse, John G Partridge, Rupa R Lalchandani, Stefano Vicini, Baoji X. Distinct roles for somatically and dendritically synthesized brain-derived neurotrophic factor in morphogenesis of dendritic spines. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 28. 2013-09-20. PMID:23843530. |
in this study, using rat hippocampal neuronal cultures, we found that knocking down long 3' utr bdnf mrna blocked spine head enlargement and spine elimination, whereas overexpressing long 3' utr bdnf mrna had the opposite effect. |
2013-09-20 |
2023-08-12 |
mouse |
| K Suijo, S Inoue, Y Ohya, Y Odagiri, T Takamiya, H Ishibashi, M Itoh, Y Fujieda, T Shimomits. Resistance exercise enhances cognitive function in mouse. International journal of sports medicine. vol 34. issue 4. 2013-09-19. PMID:23041964. |
however, it remains unknown whether plasticity molecules, such as brain-derived neurotrophic factor (bdnf) and cyclic amp response element-binding protein (creb), are expressed in the hippocampus following resistance exercise. |
2013-09-19 |
2023-08-12 |
mouse |