| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanyan Xuan, Dingting Wu, Qin Zhang, Zhiqiang Yu, Jingbo Yu, Dongdong Zho. Elevated ALT/AST ratio as a marker for NAFLD risk and severity: insights from a cross-sectional analysis in the United States. Frontiers in endocrinology. vol 15. 2024-09-10. PMID:39253584. |
the link between serum alanine aminotransferase (alt) to aspartate aminotransferase (ast) ratio and nafld remains unclear. |
2024-09-10 |
2024-09-13 |
Not clear |
| B Ma, Y Zheng, S Liu, Y Qiu, X Xing, M Gao, Z Cao, X Lua. Effect of goose-derived adiponectin peptide gADP3 on LPS-induced inflammatory injury in goose liver. British poultry science. 2024-09-09. PMID:39249992. |
the peptide gadp3 alleviated inflammatory cell infiltration and hepatic inflammatory changes, reversed the decrease in serum albumin (alb), total protein (tp), alanine aminotransferase (alt) and aspartate aminotransferase (ast) content or activity induced by lps and increased the activity of the antioxidant enzymes cat (catalase), sod (superoxide dismutase) and gsh-px (glutathione peroxidase).4. |
2024-09-09 |
2024-09-11 |
cat |
| Yan Yan, Haisheng Yuan, Fan Yang, Heiya Na, Xiuling Yu, Jingran Liu, Yuzhen Wan. Seabuckthorn polysaccharides mitigate hepatic steatosis by modulating the Nrf-2/HO-1 pathway and gut microbiota. AMB Express. vol 14. issue 1. 2024-09-09. PMID:39251509. |
results showed that hfd-induced alanine transaminase (alt) and aspartate aminotransferase (ast) levels decreased by 2.8-fold and 4.5-fold, respectively, after sp supplementation. |
2024-09-09 |
2024-09-13 |
Not clear |
| Lingling Wang, Zifeng Deng, Jieying Huang, Tingyuan Li, Jun Jiang, Wence Wang, Yu Sun, Yiqun Den. Zearalenone-induced hepatointestinal toxicity in laying hens: unveiling the role of gut microbiota and fecal metabolites. Poultry science. vol 103. issue 11. 2024-09-06. PMID:39241615. |
notably, zen induced significant hepatic damage, as evidenced by hepatocyte necrosis, inflammatory cell infiltrate, increased liver lipopolysaccharide (lps) and blood aspartate aminotransferase (ast) levels (p < 0.05). |
2024-09-06 |
2024-09-10 |
Not clear |
| Sijie Yu, Na Yang, Hongling Li, Xiaodan Hu, Li Zhang, Shibo L. Artemether ameliorates acetaminophen-induced liver injury through Nrf2 pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 179. 2024-09-05. PMID:39236474. |
additionally, art reduced serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) levels in apap-induced mice. |
2024-09-05 |
2024-09-08 |
mouse |
| Haoran Fang, Min Xu, Jiakai Zhang, Hong Qin, Hongwei Tang, Yuting He, Wenzhi Gu. JuA alleviates liver ischemia-reperfusion injury by activating AKT/NRF2/HO-1 pathways. Biochimica et biophysica acta. Molecular basis of disease. 2024-09-05. PMID:39237046. |
haematoxylin and eosin staining, serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) detection, and cell viability analysis were used to assess liver injury. |
2024-09-05 |
2024-09-08 |
mouse |
| Doru Morar, Cristina Văduva, Adriana Morar, Mirela Imre, Camelia Tulcan, Kálmán Imr. Paraclinical Changes Occurring in Dairy Cows with Spontaneous Subacute Ruminal Acidosis under Field Conditions. Animals : an open access journal from MDPI. vol 12. issue 18. 2024-09-04. PMID:36139324. |
serum aspartate aminotransferase (ast) and glutamate dehydrogenase (gldh) activity were significantly higher in the sara cows (p < 0.05) than in the group of healthy cows. |
2024-09-04 |
2024-09-06 |
Not clear |
| Jianhui Zhang, Xiaofei Ji, Shuzhen Liu, Zekun Sun, Xinying Cao, Bingxin Liu, Yizheng Li, Huilin Zha. Helicobacter pylori infection promotes liver injury through an exosome-mediated mechanism. Microbial pathogenesis. vol 195. 2024-09-02. PMID:39208956. |
using a mouse model established via tail vein injection of hp-ges-evs, exosome-driven liver injury was evidenced by slight hepatocellular erosion around the central hepatic vein and elevated serum levels of alanine aminotransferase (alt), aspartate aminotransferase (ast), and il-6. |
2024-09-02 |
2024-09-04 |
mouse |
| Junyang Fan, Hongyan Cui, Zhiying Mu, Chunxiao Yao, Mingfan Yang, Yue Jin, Changshen Ning, Hongying Zhan. Non-targeted metabolomics analysis of fermented traditional Chinese medicine and its impact on growth performance, serum biochemistry, and intestinal microbiome of weaned lambs. Scientific reports. vol 14. issue 1. 2024-09-02. PMID:39223216. |
in addition, fbq significantly increased the total protein level in the serum and the villus length of the jejunum and ileum in lambs, while significantly reduced the levels of aspartate aminotransferase (ast) and urea (p < 0.05). |
2024-09-02 |
2024-09-05 |
Not clear |
| Ya-Ling Yang, Yuan-Ting Chuang, Ying-Hsien Huan. MicroRNA 29a alleviates mitochondrial stress in diet-induced NAFLD by inhibiting the MAVS pathway. European journal of pharmacology. vol 982. 2024-08-30. PMID:39209098. |
our results have found that mice with increased mir-29a levels and fed a wd showed notably decreased serum aspartate aminotransferase (ast), alanine aminotransferase (alt), total cholesterol, and low-density lipoprotein cholesterol levels. |
2024-08-30 |
2024-09-04 |
mouse |
| M R Shrestha, A Basnet, P Joshi, D S Bhat, R Maharjan, R Thapa, R D Joshi, R Maharjan, R K Jh. Comparative Analyses of Clinical, Laboratory, and Radiological Findings between COVID-19 Deceased and Recovered Patients. Kathmandu University medical journal (KUMJ). vol 21. issue 84. 2024-08-30. PMID:39212018. |
compared to recovered covid-19 patients, deceased patients had increased median respiratory (20 versus 29.5 breaths/minute) and pulse (83 vs. 86 beats/minute) rates; multiple co-morbidities (≥ 2) (11.9% vs. 32.6%) (p < 0.001); significantly (p < 0.05) lowered alkaline phosphatase (alp), total protein (tp), albumin, lymphocytes, monocytes, eosinophil, hemoglobin and significantly (p < 0.05) elevated glucose, lactate dehydrogenase (ldh), alanine transaminase (alt), aspartate aminotransferase (ast), leucocytes, neutrophils, d-dimer and c-reactive protein (crp); and chest abnormalities including bilateral (p < 0.001), peripheral (p < 0.001) interstitial (p < 0.001) and ground glass opacity (ggo) (p=0.002). |
2024-08-30 |
2024-09-04 |
Not clear |
| Ananda Vitoria Silva Teixeira, Fernanda Torres Quitete, Bruna Cadete Martins, Thamara Cherem Peixoto, Mayara da Silva Ribeiro, Patricia Coelho de Velasco, Caroline Miranda, Angela de Castro Resende, Daniela Caldeira Costa, Geórgia Correa Atella, Daniela de Barros Mucci, Vanessa Souza-Mello, Fabiane Ferreira Martins, Julio Beltrame Dalepran. Metabolic consequences of interesterified palm oil and PCB-126 co-exposure in C57BL/6 mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 192. 2024-08-29. PMID:39197524. |
these liver changes included the presence of inflammatory cells, fibrosis, alterations in aspartate transaminase (ast) and alanine transaminase (alt) enzymes, and imbalance in gene expression related to fatty acid β-oxidation, de novo lipogenesis, mitochondrial dynamics, and endoplasmic reticulum stress. |
2024-08-29 |
2024-09-01 |
mouse |
| Li-Hsuan Li, Dur-Zong Hsu, Victor Raj Mohan Chandrasekaran, Ming-Yie Li. Inhibiting CD44-ICD Attenuates LPS-Induced Initiation of Hepatic Inflammation in Septic Mice. International journal of molecular sciences. vol 25. issue 16. 2024-08-29. PMID:39201593. |
inhibition of cd44-icd decreased the level of aspartate aminotransferase (ast), alanine aminotransferase (alt), hepatic necrosis, inflammatory cell infiltration, interleukin (il)-1β, inducible no synthase (inos), nitric oxide (no) production, nuclear factor (nf)κb signaling pathway proteins, and cd44 expression in mice. |
2024-08-29 |
2024-09-01 |
mouse |
| Meaad Nasser Hussein, Ali Noory Faje. In vivo Eevaluation of Antioxidant Activity of Chamomile Extract against Procyclidine-Induced Oxidative Stress: Potential Application in Cancer Prevention. Asian Pacific journal of cancer prevention : APJCP. vol 25. issue 8. 2024-08-29. PMID:39205591. |
afterward, blood samples were drawn to measure various biological parameters, including total oxidant status (tos), malondialdehyde (mda), aspartate aminotransferase (ast), alanine transaminase (alt), and acetylcholinesterase (ache) activity. |
2024-08-29 |
2024-09-04 |
rat |
| Jianming Su, Meiwen Tang, Qing Liu, Jian He, Tianjie Wang, Aiyun Yin, Jiangping Wang, Qing Li, Lihua Zhou, Hongyu Le. Trimethyltin chloride induces oxidative damage and apoptosis in chicken liver. Poultry science. vol 103. issue 11. 2024-08-27. PMID:39190995. |
in order to investigate the toxicity mechanism of tmt exposure on chicken liver, we established an in vivo experimental model by giving chickens oral administration of different concentrations of tmt dilution solution and vitro experiments of treating leghorn male hepatoma (lmh) cells for 12 h. the results showed that albumin (alb), total protein (tp) and alanine aminotransferase (alt) in the blood of tmt-treated chickens, as well as alt and aspartate aminotransferase (ast) in the liver, were dose-dependently increased, and different degrees of necrosis of hepatocytes were observed in histology. |
2024-08-27 |
2024-08-30 |
chicken |
| Sheila Kort, Jeffrey Wickliffe, Arti Shankar, Hannah H Covert, Maureen Lichtveld, Wilco Zijlman. Association between Liver and Kidney Function and Birth Outcomes in Pregnant Surinamese Women Exposed to Mercury and Lead in the Caribbean Consortium for Research in Environmental and Occupational Health (CCREOH) Environmental Epidemiologic Cohort Study. Journal of xenobiotics. vol 14. issue 3. 2024-08-27. PMID:39189174. |
liver function was assessed by measuring aspartate amino transferase (ast), alanine amino transferase (alt), and gamma-glutamyl transferase (ggt). |
2024-08-27 |
2024-08-30 |
Not clear |
| Yu Umeki, David Hala, Lene Hebsgaard Peterse. Optimization of an in situ liver perfusion method to evaluate hepatic function of juvenile American alligators (Alligator mississippiensis). Biology open. vol 13. issue 8. 2024-08-27. PMID:39189399. |
our results showed that in the normoxic perfusion, the aspartate transferase (ast) and lactate/pyruvate ratio in the perfusate remained stable and within an acceptable physiological range for 6 h. |
2024-08-27 |
2024-08-30 |
Not clear |
| Yong Wang, Ruo-Lin Tao, Dong-Sheng Yu, Kai-Wen Wu, Yang Bai, Dong-Jing Yang, Yue Gu, Wen-Zhi Guo, Shui-Jun Zhang, Yang Jin, Ji-Hua Sh. Air-ventilated normothermic mechanical perfusion improves susceptibility to donation after circulatory death and cold preservation-induced cholestatic liver injury through PPAR-γ/UGT1A1 axis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 16. 2024-08-26. PMID:39183544. |
here, metabolomics analysis revealed that air-ventilated nmp alleviated dcd- and cold preservation-induced cholestatic liver injury, as shown by the elevated release of alanine aminotransferase (alt), aspartate aminotransferase (ast), bilirubin, and γ-glutamyl transferase (ggt) in the perfusate (p < .05) and the reduction in the levels of bile acid metabolites, including ω-muricholic acid, glycohyodeoxycholic acid, glycocholic acid, and glycochenodeoxycholate (gcdc) in the perfused livers (p < .05). |
2024-08-26 |
2024-08-28 |
rat |
| Sheng-Han Lee, Ting-An Lin, Yuan-Horng Yan, Chu-Chun Chien, Tsun-Jen Chen. Hepatic and metabolic outcomes induced by sub-chronic exposure to polystyrene microplastics in mice. Archives of toxicology. 2024-08-25. PMID:39183192. |
simultaneously, increased levels of glucose, triglyceride, alanine transaminase (alt), aspartate transaminase (ast), superoxide dismutase, 4-hydroxy-2-nonenal-mercapturic acid (hne-ma), interleukin-6, and lipid droplets were found in the 0.5 µm mp exposure group, while the fewer responses, including elevated liver weight index, glucose, high-density lipoprotein, ast, and decreased hne-ma were observed in 5 µm mp exposure group. |
2024-08-25 |
2024-08-28 |
mouse |
| Mohammed H Zaid, Falah S Al-Fartusie, Yaghub Pazhang, Safaa Kade. Evaluation of lipid profile, liver function enzymes, and trace elements in Iraqi diabetic nephropathy patients. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2024-08-23. PMID:39179936. |
on the other hand, the mean values of aspartate aminotransferase (ast), alanine transferase (alt), alkaline phosphatase (alp), and γ- glutamyl transferase (ggt) were significantly greater in dn patients compared to the healthy controls. |
2024-08-23 |
2024-08-27 |
Not clear |