| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Łukasz Krupa, Robert Staroń, Dorota Dulko, Natalia Łozińska, Alan R Mackie, Neil M Rigby, Adam Macierzanka, Aleksandra Markiewicz, Christian Jungnicke. Importance of Bile Composition for Diagnosis of Biliary Obstructions. Molecules (Basel, Switzerland). vol 26. issue 23. 2021-12-10. PMID:34885858. |
the concentration of eight bile salts, specifically sodium cholate, sodium glycocholate, sodium taurocholate, sodium glycodeoxycholate, sodium chenodeoxycholate, sodium glycochenodeoxycholate, sodium taurodeoxycholate, and sodium taurochenodeoxycholate as well as bile cholesterol were determined by hplc-ms. serum alanine aminotransferase (alt), aspartate transaminase (ast), and bilirubin were measured before the ercp. |
2021-12-10 |
2023-08-13 |
Not clear |
| Xiangjun Fu, Jie He, Deliang Zheng, Xuefeng Yang, Pan Wang, FangXu Tuo, Lin Wang, Shixu Li, Jie Xu, Jie Y. Association of endocrine disrupting chemicals levels in serum, environmental risk factors, and hepatic function among 5- to 14-year-old children. Toxicology. vol 465. 2021-12-09. PMID:34715266. |
serum alanine aminotransferase (alt), aspartate aminotransferase (ast), ast/alt, total bilirubin (tbil), direct bilirubin (dbil) and indirect bilirubin (ibil) were detected with automatic biochemical analyzer. |
2021-12-09 |
2023-08-13 |
human |
| William R Treem, Melissa Palmer, Isabelle Lonjon-Domanec, Daniel Seekins, Lara Dimick-Santos, Mark I Avigan, John F Marcinak, Ajit Dash, Arie Regev, Eric Maller, Meenal Patwardhan, James H Lewis, Don C Rockey, Adrian M Di Bisceglie, James W Freston, Raul J Andrade, Naga Chalasan. Consensus Guidelines: Best Practices for Detection, Assessment and Management of Suspected Acute Drug-Induced Liver Injury During Clinical Trials in Adults with Chronic Viral Hepatitis and Adults with Cirrhosis Secondary to Hepatitis B, C and Nonalcoholic Steatohepatitis. Drug safety. vol 44. issue 2. 2021-12-08. PMID:33141341. |
key conclusions and recommendations include (1) the importance of establishing laboratory criteria that signal potential dili events and that fit the disease indication being studied in the clinical trial based on knowledge of the natural history of test fluctuations in that disease; (2) establishing a pretreatment value that is based on more than one screening determination, and revising that baseline during the trial if a new nadir is achieved during treatment; (3) basing rules for increased monitoring and for stopping drug for potential dili on multiples of baseline liver test values and/or a threshold value rather than multiples of the upper limit of normal (uln) for that test; (4) making use of more sensitive tests of liver function, including direct bilirubin (db) or combined parameters such as aspartate transaminase:alanine transaminase (ast:alt) ratio or model for end-stage liver disease (meld) to signal potential dili, especially in studies of patients with cirrhosis; and (5) being aware of potential confounders related to complications of the disease being studied that may masquerade as dili events. |
2021-12-08 |
2023-08-13 |
Not clear |
| Rebeka da Costa Alves, Cintia Giselle Martins Ferreira, Ismaela Maria Ferreira de Melo, Marina Gomes Pessoa Baptista, Yuri Mateus Lima de Albuquerque, Bruno José do Nascimento, Yasmim Barbosa Dos Santos, Valéria Wanderley-Teixeira, Álvaro Aguiar Coelho Teixeir. Renal and hepatic changes in the offspring of rats that received biological insecticides during pregnancy and lactation. Acta histochemica. vol 123. issue 8. 2021-12-08. PMID:34656827. |
in the animals of the groups whose matrices received the insecticides, there was a reduction in the levels of the biomarkers of toxicity alanine aminotransferase (alt), aspartate aminotransferase (ast), urea and creatinine, about the control group. |
2021-12-08 |
2023-08-13 |
rat |
| Hui Chen, Gang Li, Jianqiang Zhang, Ting Zheng, Qianglin Chen, Yanxiang Zhang, Fei Yang, Chao Wang, Hao Nie, Bing Zheng, Quan Gon. Sodium butyrate ameliorates Schistosoma japonicum-induced liver fibrosis by inhibiting HMGB1 expression. Experimental parasitology. vol 231. 2021-12-08. PMID:34736899. |
the activity of alanine aminotransferase (alt) and aspartate aminotransferase (ast), liver histopathology, hmgb1 expression, and the levels of interferon gamma (ifn-γ), transforming growth factor-β1 (tgf-β1), and interleukin-6 (il-6) in serum were analyzed. |
2021-12-08 |
2023-08-13 |
mouse |
| Donovan A McGrowder, Fabian Miller, Melisa Anderson Cross, Lennox Anderson-Jackson, Sophia Bryan, Lowell Dilwort. Abnormal Liver Biochemistry Tests and Acute Liver Injury in COVID-19 Patients: Current Evidence and Potential Pathogenesis. Diseases (Basel, Switzerland). vol 9. issue 3. 2021-12-07. PMID:34287285. |
liver biochemistry tests such as aspartate aminotransferase (ast), alanine aminotransferase (alt), gamma-glutamyl transferase (ggt) and alkaline phosphatase (alp) are deranged in covid-19 patients with liver injury. |
2021-12-07 |
2023-08-13 |
Not clear |
| Lirui Hou, Fang Liu, Chong Zhao, Lihong Fan, Hongbo Hu, Shutao Yi. Combination of oxytetracycline and quinocetone synergistically induces hepatotoxicity via generation of reactive oxygen species and activation of mitochondrial pathway. Toxicology mechanisms and methods. vol 32. issue 1. 2021-12-07. PMID:34348565. |
it also showed that the combination of otc (800 mg/kg, i.g., 5d) and qct (5000 mg/kg, i.g., 5d) resulted in significantly enhanced liver toxicity in c57bl/6n mice, the serum alanine transaminase (alt) and aspartate transaminase (ast) were significantly increased by the otc/qct. |
2021-12-07 |
2023-08-13 |
mouse |
| Ankita Kumari, Karuna Sing. Evaluation of prophylactic efficacy of cinnamaldehyde in murine model against Paradendryphiella arenariae mycotoxin tenuazonic acid-induced oxidative stress and organ toxicity. Scientific reports. vol 11. issue 1. 2021-12-07. PMID:34593834. |
sub-chronic intoxication of mice with tea showed elevated malondialdehyde (mda), reduced catalase (cat) and superoxide dismutase (sod) production; abnormal levels of aspartate transaminase (ast) and alanine transaminase (alt). |
2021-12-07 |
2023-08-13 |
mouse |
| Behnaz Amernia, Seyed Hamid Moosavy, Fatemeh Banookh, Ghazal Zogh. FIB-4, APRI, and AST/ALT ratio compared to FibroScan for the assessment of hepatic fibrosis in patients with non-alcoholic fatty liver disease in Bandar Abbas, Iran. BMC gastroenterology. vol 21. issue 1. 2021-12-07. PMID:34861841. |
in this study we aimed to compare fibrosis-4 (fib-4), aspartate aminotransferase (ast) to platelet ratio index (apri), and aspartate aminotransferase/alanine aminotransferase (ast/alt) ratio with fibroscan for the assessment of hepatic fibrosis in patients with nafld. |
2021-12-07 |
2023-08-13 |
Not clear |
| Yingchun Zhao, Xinglong Liu, Chuanbo Ding, Yan Gu, Wencong Li. Dihydromyricetin Reverses Thioacetamide-Induced Liver Fibrosis Through Inhibiting NF-κB-Mediated Inflammation and TGF-β1-Regulated of PI3K/Akt Signaling Pathway. Frontiers in pharmacology. vol 12. 2021-12-07. PMID:34867416. |
the results showed that dhm treatment significantly inhibited the activities of alanine aminotransferase (alt) (37.81 ± 7.62 u/l) and aspartate aminotransferase (ast) (55.18 ± 10.94 u/l) in serum of liver fibrosis mice, and increased the levels of superoxide dismutase (sod) and glutathione (gsh) while reversed the level of malondialdehyde (mda). |
2021-12-07 |
2023-08-13 |
mouse |
| Qiao Ling, Xiangnan Hu, Rong Jiang, Hailin Liu, Hongmei Qiu, Xuejun Jiang, Abdallah Zubreri, Hongda Zhu, Jingyuan Wan, Yingju Li. CQMUH-011 mitigates autoimmune hepatitis via inhibiting the function of T lymphocytes. Drug development research. vol 82. issue 8. 2021-12-06. PMID:33733518. |
in vivo, cqmuh-011 administration reduced the hepatic histopathological score and the infiltration of lymphocytes in the liver parenchyma; additionally, it downregulated the levels of alanine aminotransferase (alt), aspartate aminotransferase (ast) and pro-inflammatory cytokines interferon (ifn)-γ, tumor necrosis factor (tnf)-α, and interleukin (il)-6 in serum, as well as those of methane dicarboxylic aldehyde and myeloperoxidase in the liver tissues. |
2021-12-06 |
2023-08-13 |
mouse |
| Eman M El El-Sherbeny, Enas A Khoris, Samr Kasse. Assessment the efficacy of some various treatment methods, in vitro and in vivo, against Aeromonas hydrophila infection in fish with regard to side effects and residues. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 253. 2021-12-06. PMID:34801729. |
aspartate aminotransferase (ast), alanine aminotransferase (alt) and alkaline phosphatase (alp) decreased by lev and cnps than fos while all increased total protein (tp) and albumin than g2. |
2021-12-06 |
2023-08-13 |
Not clear |
| b' \\xc5\\xbd Jak\\xc5\\xa1i\\xc4\\x87, V Mrljak, A Horvati\\xc4\\x87, A Gelemanovi\\xc4\\x87, M Mi\\xc4\\x8di\\xc4\\x8. Loggerhead sea turtle Caretta caretta plasma biochemistry and proteome profile modulation during recovery. Journal of proteomics. vol 252. 2021-12-05. PMID:34839037.' |
the plasma biochemical parameters of total protein and glucose content, accompanied by aspartate aminotransferase (ast) and n-acetyl-cystein-activated creatinine kinase (ck-nac) are highlighted as valuable and potential biomarkers of turtle's health status and condition. |
2021-12-05 |
2023-08-13 |
Not clear |
| Junlin Ge, Rili Hao, Xue Rong, Q Ping Dou, Xintong Tan, Guannan Li, Feng Li, Dapeng L. Secoisolariciresinol diglucoside mitigates benzo[a]pyrene-induced liver and kidney toxicity in mice via miR-101a/MKP-1-mediated p38 and ERK pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021-12-05. PMID:34856318. |
results showed that the mice treated with sdg + bap had significantly (p < 0.05) higher body weight, lower organ-to-body weight ratio, alanine transaminase (alt), aspartate transaminase (ast), alkaline phosphatase (alp) activities, and less levels of serum creatinine (cre) and blood urea nitrogen (bun) than those treated with bap alone. |
2021-12-05 |
2023-08-13 |
mouse |
| Xiujuan Zhang, Yusheng Jie, Zemin Wan, Shanshan Lin, Yingxian Li, Ming Lin, Shuduo Wu, Xiaoju Wu, Meijie Shi, Huanming Xiao, Minling Cao, Jiao Gong, Xiaoling Ch. Prognostic Value of Inflammatory Indicators in Chronic Hepatitis B Patients With Significant Liver Fibrosis: A Multicenter Study in China. Frontiers in pharmacology. vol 12. 2021-12-04. PMID:34858162. |
inflammatory indicators, alanine aminotransferase (alt) and aspartate aminotransferase (ast), were significantly associated with significant liver fibrosis in chb patients but limited predictive performance, and then we combined them with prothrombin time activity percentage (pta) and liver stiffness measurement (lsm) were identified by multivariate logistic regression analysis. |
2021-12-04 |
2023-08-13 |
Not clear |
| Nathan G Briggs, Breno C Silva, Letícia A Godoi, Jon P Schoonmake. Effect of aspirin to intentionally induce leaky gut on performance, inflammation, and carcass characteristics of feedlot cattle. Journal of animal science. vol 99. issue 11. 2021-12-03. PMID:34741613. |
in experiment 2, ninety-six simmental × angus steers (355.0 ± 14.8 kg) were allotted by bw and breed composition and fed treatment diets for 159 d. weight was recorded monthly and serum was collected on day 159 and analyzed for lipopolysaccharide-binding protein (lbp), interleukin-6 (il-6), serum amyloid a (saa), haptoglobin, and aspartate aminotransferase (ast). |
2021-12-03 |
2023-08-13 |
cattle |
| Efrén Martínez-Quintana, Fayna Rodríguez-Gonzále. Blood test assessment of liver ultrasound findings in patients with Fontan surgery. American journal of cardiovascular disease. vol 11. issue 5. 2021-12-03. PMID:34849292. |
on the contrary, fontan patients showed higher liver enzymes [aspartate aminotransferase (ast) and alanine aminotransferase (alt), gamma-glutamyl transferase (ggt)], n-terminal pro-brain natriuretic peptide (nt-pro-bnp) and thyroid-stimulating hormone (tsh) concentrations than patients with restrictive vsd. |
2021-12-03 |
2023-08-13 |
Not clear |
| Xi Su, Huangping Chen, Zifei Zhu, Wanying Xie, Jianqiao Peng, Xinping Ma, Wenwen Jin, Wei Shi, Zhonghua Deng, Cunyan L. Clinical Diagnostic Value of Quantitative Hepatitis B Virus Core Antibody Test in Chronic Viral Hepatitis B. Bioinorganic chemistry and applications. vol 2021. 2021-12-03. PMID:34853582. |
the quantitative detection of hbcab, hepatitis b surface antigen (hbsag), hbv dna, alanine aminotransferase (alt), aspartate aminotransferase (ast), and platelet count (plt) were determined in the serum of 73 cases of low-replicative phase (lr), 46 cases of immune-tolerant phase (it), 44 cases of immune clearance phase (ic), and 57 cases of hbeag-negative hepatitis (enh). |
2021-12-03 |
2023-08-13 |
Not clear |
| Abdullah Alajaji, Faisal A Alrawaf, Saleh I Alosayli, Hana N Alqifari, Bader M Alhabdan, Majed A Alnasse. Laboratory Abnormalities in Acne Patients Treated With Oral Isotretinoin: A Retrospective Epidemiological Study. Cureus. vol 13. issue 10. 2021-12-03. PMID:34853752. |
at baseline, aspartate aminotransferase (ast) was elevated in 5.4% of patients and alanine aminotransferase (alt) was elevated in 12.7% of patients. |
2021-12-03 |
2023-08-13 |
Not clear |
| Sahar Sobhani, Reihaneh Aryan, Mina AkbariRad, Elahe Ebrahimi Miandehi, Maryam Alinezhad-Namaghi, Seyyed Reza Sobhani, Sara Raj. The Association between Anthropometry Indices and Serum Concentrations of Gamma-Glutamyl Transferase, Alkaline Phosphatase, Alanine Aminotransferase, and Aspartate Aminotransferase. BioMed research international. vol 2021. 2021-12-03. PMID:34853788. |
this study is aimed at investigating the association between anthropometric indices with gamma-glutamyl transferase (ggt), alkaline phosphatase (alp), alanine aminotransferase (alt), and aspartate aminotransferase (ast). |
2021-12-03 |
2023-08-13 |
Not clear |