| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Y Wang, T Kaneko, Y Wang, A Sat. Acarbose alone or in combination with ethanol potentiates the hepatotoxicity of carbon tetrachloride and acetaminophen in rats. Hepatology (Baltimore, Md.). vol 29. issue 1. 1999-02-03. PMID:9862862. |
the 40- or 80-mg/100 g acarbose diet alone potentiated ccl4 and ap hepatotoxicity, as evidenced by significantly increased levels of both alanine transaminase (alt) and aspartate transaminase (ast) in the plasma of rats pretreated with acarbose. |
1999-02-03 |
2023-08-12 |
rat |
| I Yeruham, Y Avidar, S Perl, B Yakobson, A Shlosberg, V Hanji, E Bogi. Probable toxicosis in cattle in Israel caused by the oak Quercus calliprinos. Veterinary and human toxicology. vol 40. issue 6. 1999-01-29. PMID:9830693. |
the clinical-pathological findings revealed increases in blood urea, creatinine, aspartate aminotransferase (ast), gamma-glutamyltransferase (ggt), creatine kinase (ck), lactate dehydrogenase (ldh) and inorganic phosphorus. |
1999-01-29 |
2023-08-12 |
cattle |
| F W Wong, W Y Chan, S S Le. Resistance to carbon tetrachloride-induced hepatotoxicity in mice which lack CYP2E1 expression. Toxicology and applied pharmacology. vol 153. issue 1. 1999-01-21. PMID:9875305. |
injection of 1 ml/kg (= 1.59 g/kg) ccl4 and 24 h later liver injury was assessed by elevations of serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) activities and histopathology. |
1999-01-21 |
2023-08-12 |
mouse |
| Z L Jiang, T Harada, M Yokokawa, M Kohzuki, T Sat. Muscle damage induced by experimental hypoglycemia. Metabolism: clinical and experimental. vol 47. issue 12. 1999-01-13. PMID:9867076. |
serum activity of alanine aminotransferase (alt), aspartate aminotransferase (ast), and lactate dehydrogenase (ldh) increased only in group b10. |
1999-01-13 |
2023-08-12 |
Not clear |
| K Atici, N Yamalik, K Eratalay, I Etika. Analysis of gingival crevicular fluid intracytoplasmic enzyme activity in patients with adult periodontitis and rapidly progressive periodontitis. A longitudinal study model with periodontal treatment. Journal of periodontology. vol 69. issue 10. 1999-01-12. PMID:9802716. |
in the present study, the activity of 3 functionally related enzymes, creatine kinase (ck), lactate dehydrogenase (ldh), and aspartate aminotransferase (ast) levels in the rest and flow gingival crevicular fluid (rgcf, fgcf) from patients with rapidly progressive periodontitis (rpp) and adult periodontitis (ap) were determined before and after periodontal treatment, including maintenance. |
1999-01-12 |
2023-08-12 |
Not clear |
| C J Waterfield, C Westmoreland, D S Asker, J C Murdock, E George, J A Timbrel. Ethionine toxicity in vitro: the correlation of data from rat hepatocyte suspensions and monolayers with in vivo observations. Archives of toxicology. vol 72. issue 9. 1999-01-07. PMID:9806431. |
the following markers were measured in the appropriate system: (1) neutral red uptake; 3-(4,5 dimethyl)thiazol-2-yl,-2,5-diphenyl tetrazolium bromide (mtt) reduction; lactate dehydrogenase (ldh), aspartate aminotransferase (ast) and alanine aminotransferase (alt) leakage (cytotoxicity). |
1999-01-07 |
2023-08-12 |
rat |
| S Nazifi, K Malek. Biochemical analysis of serum and cerebrospinal fluid in clinically normal adult camels (Camelus dromedarius). Research in veterinary science. vol 65. issue 1. 1998-12-18. PMID:9769078. |
the concentrations of total protein, glucose, cholesterol, triglyceride, urea nitrogen, creatinine, sodium, potassium, chloride, calcium, inorganic phosphorus, copper, magnesium, and iron and the activities of aspartate aminotransferase (ast), alanine aminotransferase, (alt), alkaline phosphatase (alp), lactate dehydrogenase (ld), creatine kinase (ck) and amylase were determined in cerebrospinal fluid (csf) and serum from 21 clinically healthy adult camels. |
1998-12-18 |
2023-08-12 |
Not clear |
| I Cepelak, T Zanić Grubisić, A Mandusić, B Rekić, J Lenice. Valproate and carbamazepine comedication changes hepatic enzyme activities in sera of epileptic children. Clinica chimica acta; international journal of clinical chemistry. vol 276. issue 2. 1998-12-17. PMID:9764730. |
this study compares alanine aminotransferase (alt), aspartate aminotransferase (ast) and gamma-glutamyltransferase (ggt) activities in sera of children treated with vpa (n=42), or cbz (n=36) taken as a monotherapy, with vpa + cbz combined therapy (n=36). |
1998-12-17 |
2023-08-12 |
Not clear |
| V Arndt, H Brenner, D Rothenbacher, B Zschenderlein, E Fraisse, T M Fliedne. Elevated liver enzyme activity in construction workers: prevalence and impact on early retirement and all-cause mortality. International archives of occupational and environmental health. vol 71. issue 6. 1998-12-10. PMID:9766914. |
gamma-glutamyl transferase (ggt), alanine transaminase (alt), and aspartate transaminase (ast) are widely used as markers of hepatobiliary disorders in occupational health surveillance. |
1998-12-10 |
2023-08-12 |
Not clear |
| D E Amacher, L M Fasulo, C Charuel, P Comby, K Beaumon. In vitro toxicity of zamifenacin (UK-76,654) and metabolites in primary hepatocyte cultures. Xenobiotica; the fate of foreign compounds in biological systems. vol 28. issue 9. 1998-12-03. PMID:9764931. |
the rapid onset of cytotoxicity indicated by elevations of alanine aminotransferase (alt), aspartate aminotransferase (ast) and other markers in the medium after uk-82,201 exposure, the delayed but substantial cytotoxic response to the parent drug which was suggestive of biotransformation to a reactive moiety, in vivo and in vitro drug metabolism results and subacute toxicology data suggest that dog may more effectively transform zamifenacin into uk-82,201, which is relatively hepatotoxic. |
1998-12-03 |
2023-08-12 |
rat |
| U Juárez, W Trejo, M Whente, G Contreras, M Cárdenas, P A Reye. [The usefulness of determining myoglobin, creatine phosphokinase MB isoenzyme, lactate dehydrogenase and aspartate aminotransferase in the diagnosis of acute myocardial infarct]. Archivos del Instituto de Cardiologia de Mexico. vol 68. issue 3. 1998-11-25. PMID:9810342. |
diagnosis of acute myocardial infarction is made with the aid of biomarkers such as structural myocardial proteins, myoglobin (mg) or specific enzymes, creatine phosphokinase isoenzyme mb (ck-mb) or non specific enzymes, lactic dehydrogenase (dhl) and aspartate aminotransferase (ast). |
1998-11-25 |
2023-08-12 |
Not clear |
| G Gavazzi, G Richallet, P Morand, O Bouchard, A Bosseray, P Leclercq, M Micou. [Effects of double and triple antiretroviral agents on the HCV viral load in patients coinfected with HIV and HCV]. Pathologie-biologie. vol 46. issue 6. 1998-11-20. PMID:9769871. |
hcv and hiv viral load, lymphocyte cd4 counts, alanine aminotransferase (alt) and aspartate amino transferase (ast) were measured before and 3 months after starting treatment in 2 groups: group 1 (n = 15) treated with 2 nucleoside analogues and group 2 (n = 15) treated with 2 nucleoside analogues and a protease inhibitor. |
1998-11-20 |
2023-08-12 |
Not clear |
| J Yang, W Denham, G Carter, K J Tracey, J Norma. Macrophage pacification reduces rodent pancreatitis-induced hepatocellular injury through down-regulation of hepatic tumor necrosis factor alpha and interleukin-1beta. Hepatology (Baltimore, Md.). vol 28. issue 5. 1998-11-20. PMID:9794913. |
tnf-, il-1beta, and inos gene expression (by reverse-transcription polymerase chain reaction) as well as aspartate transaminase (ast), alanine transaminase (alt), and lactic dehydrogenase (ldh) (but not alkaline phosphatase [alp]) increased following the development of pancreatitis (all p < .05). |
1998-11-20 |
2023-08-12 |
rat |
| T Takada, E Suzuki, M Nakano, H Kagamu, H Tsukada, T Hasegawa, M Satoh, M Haraguchi, T Ebe, M Arakaw. Clinical features of polymyositis/dermatomyositis with steroid-resistant interstitial lung disease. Internal medicine (Tokyo, Japan). vol 37. issue 8. 1998-11-19. PMID:9745852. |
the non-responder group revealed significantly high aspartate aminotransferase (ast), low ck, low white blood cell (wbc), and low absolute lymphocyte counts in their peripheral blood. |
1998-11-19 |
2023-08-12 |
Not clear |
| K H Janbaz, S A Saeed, A H Gilan. An assessment of the potential of protopine to inhibit microsomal drug metabolising enzymes and prevent chemical-induced hepatotoxicity in rodents. Pharmacological research. vol 38. issue 3. 1998-11-17. PMID:9782072. |
paracetamol at the dose of 640 mg kg-1 produced hepatic damage in rats as manifested by the rise in serum levels of aspartate transaminase (ast) and alanine transaminase (alt) to 972+/-186 and 624+/-131 iu (mean+/-sem; n=10), respectively, compared to respective control values of 101+/-29 and 64+/-18 iu. |
1998-11-17 |
2023-08-12 |
rat |
| I Yeruham, A Hadani, F Galker, Y Avidar, E Bogi. Clinical, clinico-pathological and serological studies of Babesia ovis in experimentally infected sheep. Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B. vol 45. issue 7. 1998-11-16. PMID:9780825. |
a marked increase in the enzymes of the transaminase groups, mainly aspartate aminotransferase (ast), was observed. |
1998-11-16 |
2023-08-12 |
Not clear |
| B Wang, Y Egashira, T Ohta, H Sanad. Effect of indigestible oligosaccharides on the hepatotoxic action of D-galactosamine in rats. Bioscience, biotechnology, and biochemistry. vol 62. issue 8. 1998-10-29. PMID:9757556. |
male wistar rats fed with 20% casein diets containing 10% oligosaccharide or d-galactose (gal) for 2 weeks were injected with galn (1,900 mg/kg of body weight), and the plasma aspartate aminotransferase (ast) and alanine aminotransferase (alt) activities and the hepatic glycogen concentration were examined 20 hours after the injection. |
1998-10-29 |
2023-08-12 |
rat |
| J Bowes, C Thiemerman. Effects of inhibitors of the activity of poly (ADP-ribose) synthetase on the liver injury caused by ischaemia-reperfusion: a comparison with radical scavengers. British journal of pharmacology. vol 124. issue 6. 1998-10-26. PMID:9720798. |
in the rat, ischaemia (30 or 60 min) and reperfusion (120 min) of the liver resulted in significant increases in the serum levels of aspartate aminotransferase (ast) and alanine aminotransferase (alt) indicating the development of liver injury. |
1998-10-26 |
2023-08-12 |
rat |
| N M Afifi, M S Abdel-Rahman, A M Nassa. Effect of alcohol and/or cocaine on blood glutathione and the ultrastructure of the liver of pregnant CF-1 mice. Toxicology letters. vol 98. issue 1-2. 1998-10-23. PMID:9776556. |
since alcohol and cocaine are hepatotoxic, pregnant mice were used to study the effect of alcohol and/or cocaine on alanine aminotransferase (alt) and aspartate aminotransferase (ast) and on liver ultrastructure. |
1998-10-23 |
2023-08-12 |
mouse |
| K Y Hung, R S Shyu, T J Tsai, W Y Che. Viral hepatitis infection should be considered for evaluating uremic pruritus in continuous ambulatory peritoneal dialysis patients. Blood purification. vol 16. issue 3. 1998-10-13. PMID:9681157. |
blood hemoglobin, ferritin, electrolytes, calcium, phosphate, albumin, urea, creatinine, aspartate transaminase (ast), alanine transaminase (alt), alkaline phosphatase, and bilirubin were analyzed by routine methods. |
1998-10-13 |
2023-08-12 |
Not clear |