| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ahmed A Elberry, Fathalla M Harraz, Salah A Ghareib, Ayman A Nagy, Salah A Gabr, Mansour I Suliaman, Essam Abdel-Satta. Antihepatotoxic effect of marrubium vulgare and withania somnifera extracts on carbon tetrachloride-induced hepatotoxicity in rats. Journal of basic and clinical pharmacy. vol 1. issue 4. 2014-05-14. PMID:24825994. |
the antihepatotoxic activity was assessed by measuring aspartate transaminase (ast), alanine transaminase (alt), lactate dehydrogenase (ldh), alkaline phosphatase (alp), glutathione peroxidase (gpx), glutathione reductase (gr), glutathione-s-transferase (gst), reduced glutathione (gsh), tissue content and malondialdehyde (mda) as well as histopathological examination. |
2014-05-14 |
2023-08-13 |
rat |
| B T Kavitha, S D Shruthi, S Padmalatha Rai, Y L Ramachandr. Phytochemical analysis and hepatoprotective properties of Tinospora cordifolia against carbon tetrachloride-induced hepatic damage in rats. Journal of basic and clinical pharmacy. vol 2. issue 3. 2014-05-14. PMID:24826014. |
ethanolic extract of all the parts showed significant hepatoprotective effect by reduction in serum enzymes alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase (alp) and total bilirubin (tbl) in the selected model which is followed by aqueous and pet ether extracts. |
2014-05-14 |
2023-08-13 |
rat |
| Victor Menezes Tunholi, Caio Oliveira Monteiro, Lidiane Cristina da Silva, Claudia de Melo Dolinski, Marcos Antônio José dos Santos, Maria de Lurdes de Azevedo Rodrigues, Vânia Rita Elias Pinheiro Bittencourt, Jairo Pinheiro, Vinícius Menezes Tunholi-Alve. Physiological alterations in Bradybaena similaris (Stylommatophora: Bradybaenidae) induced by the entomopathogenic nematode Heterorhabditis indica (Rhabditida: Heterorhabditidae) strain LPP1. Experimental parasitology. vol 139. 2014-05-13. PMID:24566044. |
after this period, the snails were dissected to collect the hemolymph to evaluate the possible physiological alterations, namely total proteins, uric acid and hemolymph urea, as well as the activities of alanine aminotransferase (alt) and aspartate aminotransferase (ast) as a result of the infection. |
2014-05-13 |
2023-08-12 |
Not clear |
| Tian-Tian Zhang, Xi-Lin Xu, Ming-Hua Jiang, Jian-Guo Jian. Hepatoprotective function of Penthorum chinense Pursh. Food & function. vol 4. issue 11. 2014-05-12. PMID:24056762. |
cell viability, levels of microsomal enzymes, alanine aminotransferase (alt) and aspartate aminotransferase (ast), and the concentration of malondialdehyde (mda) were determined in homogenates of the liver cells. |
2014-05-12 |
2023-08-12 |
Not clear |
| Cong Li, Huifan Ji, Yanjun Cai, Desalegn Admassu Ayana, Pin Lv, Maosheng Liu, Yanfang Jian. Serum interleukin-37 concentrations and HBeAg seroconversion in chronic HBV patients during telbivudine treatment. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 33. issue 10. 2014-05-08. PMID:23697556. |
anti-inflammatory cytokines such as il-2 and il-10 were measured using cytometric bead array, and the concentrations of clinical parameters such as serum hepatitis b surface antigen (hbsag), hepatitis b nucleocapsid antigen (hbeag), alanine transaminase (alt), aspartate transaminase (ast), hbv dna, and hepatitis c virus (hcv) rna loads were measured. |
2014-05-08 |
2023-08-12 |
Not clear |
| Y-H Chiu, S-K Hou, C-K How, L-H Li, W-F Kao, C-C Yang, S-L Chou, Y-T S Shiau, C Lam, R-J Che. Influence of a 100-km ultra-marathon on hepatitis B carrier runners. International journal of sports medicine. vol 34. issue 9. 2014-05-07. PMID:23444084. |
the results demonstrate a statistically significant increase in both immediate and 24-h post-race values for alanine aminotransferase (alt), aspartate aminotransferase (ast), lactate dehydrogenase (ldh), creatine kinase (ck), high-sensitivity c-reactive protein (hs-crp), interleukin-6 (il-6) and tumor necrosis factor-alpha (tnf-α), compared with pre-race values. |
2014-05-07 |
2023-08-12 |
Not clear |
| Takashi Nagano, Kazuma Higashisaka, Akiyoshi Kunieda, Yuki Iwahara, Kota Tanaka, Kazuya Nagano, Yasuhiro Abe, Haruhiko Kamada, Shin-ichi Tsunoda, Hiromi Nabeshi, Tomoaki Yoshikawa, Yasuo Yoshioka, Yasuo Tsutsum. Liver-specific microRNAs as biomarkers of nanomaterial-induced liver damage. Nanotechnology. vol 24. issue 40. 2014-05-06. PMID:24029385. |
in this study, we compared the effectiveness of serum levels of liver-specific or -enriched mirnas (mir-122, mir-192, and mir-194) with that of conventional hepatic biomarkers (alanine aminotransferase (alt) and aspartate aminotransferase (ast)) as biomarkers for nsp70. |
2014-05-06 |
2023-08-12 |
mouse |
| Jia-Hong Zhu, Chun-Yan Xu, Xin-Yi Mu, Jun Liu, Meng-Si Zhang, Dao-Yong Jia, Yan-Yan Zhang, Guo-Ning Huang, Ya-Ping Wan. [Effect of combined administration of Angelica polysaccharide and cytarabine on liver of human leukemia NOD/SCID mouse model]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 39. issue 1. 2014-05-06. PMID:24754180. |
compared to the human leukemia nod/scid mouse model group with the treatments of aps, ara-c and aps + ara-c, we found that severe liver damage and pathological changes of the liver were able to alleviate: first, the number of white blood cells in the peripheral blood was significantly lower and with less transplanted k562 leukemia cells; second, liver function damage was alleviated as liver function tests showed that alanine aminotransferase (alt), aspartate aminotransferase (ast) and total bilirubin (tbil) were significantly reduced, while the albumin (alb) was notably increased; third, liver antioxidant ability was improved as the activities of the antioxidant enzymes glutathione peroxidase (gsh-px) and superoxide dismutase (sod) were significantly increased, and the contents of gsh and malonaldehyde (mda) were decreased significantly in the liver; fourth, the inflammation of the liver was relieved as the level of il-1beta and il-6, the inflammatory cytokines, were decreased significantly in the liver. |
2014-05-06 |
2023-08-13 |
mouse |
| Tariq Helal Ashou. Therapy with interleukin-22 alleviates hepatic injury and hemostasis dysregulation in rat model of acute liver failure. Advances in hematology. vol 2014. 2014-05-06. PMID:24799907. |
the following parameters were investigated: (1) survival rate, (2) serum levels of liver function enzymes (aspartate aminotransferase (ast), alanine aminotransferase (alt), and alkaline phosphatase (alp)), total bilirubin (tbili), and total albumen (alb), (3) blood clotting tests (prothrombin time (pt), activated partial thromboplastin time (aptt), and fibrinogen level (fib)) and white blood cells (wbcs), red blood cells (rbcs), and platelet counts, (4) hepatic levels of tumor necrosis factor- α (tnf- α ) and cyclooxygenase-2 (cox-2), and (5) liver histopathology. |
2014-05-06 |
2023-08-13 |
rat |
| Jae-Young Cha, Hee-Young Ahn, Young-Su Cho, Jae-Young J. Protective effect of cordycepin-enriched Cordyceps militaris on alcoholic hepatotoxicity in Sprague-Dawley rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 60. 2014-05-05. PMID:23876821. |
alcohol administration resulted in a significant increase in the activities of aspartate aminotransferase (ast), alanine aminotransferase (alt), γ-glutamyl transpeptidase (γ-gtp), alkaline phosphatase (alp), and lactate dehydrogenase (ldh) and the levels of blood alcohol and acetaldehyde in serum. |
2014-05-05 |
2023-08-12 |
rat |
| Heung Bin Lim, Seung Hyung Ki. Inhallation of e-Cigarette Cartridge Solution Aggravates Allergen-induced Airway Inflammation and Hyper-responsiveness in Mice. Toxicological research. vol 30. issue 1. 2014-05-05. PMID:24795794. |
long-term e-cigarette inhalation elicited no remarkable changes in the activities of alanine aminotransferase (alt), aspartate aminotransferase (ast), lactate dehydrogenase enzymes in serum, however, increased infiltration of inflammatory cells including eosinophils, into airways from blood, aggravated the asthmatic ai and ahr, and stimulated the production of cytokines such as interleukin (il)-4, il-5 and il-13, and ova-specific ige production. |
2014-05-05 |
2023-08-13 |
mouse |
| Jung Hyu Shin, Chang Woo Lee, Soo Jin Oh, Jieun Yun, Moo Rim Kang, Sang-Bae Han, Heungsik Park, Jae Chul Jung, Yoon Hoo Chung, Jong Soon Kan. Hepatoprotective effect of aged black garlic extract in rodents. Toxicological research. vol 30. issue 1. 2014-05-05. PMID:24795800. |
abg inhibited carbon tetrachloride-induced elevation of aspartate transaminase (ast) and alanine transaminase (alt), which are markers of hepatocellular damage, in sd rats. |
2014-05-05 |
2023-08-13 |
mouse |
| Ross C Beier, J Allen Byrd, Leon F Kubena, Michael E Hume, Jackson L McReynolds, Robin C Anderson, David J Nisbe. Evaluation of linalool, a natural antimicrobial and insecticidal essential oil from basil: effects on poultry. Poultry science. vol 93. issue 2. 2014-05-01. PMID:24570447. |
linalool caused serum aspartate aminotransferase (ast) levels to increase, but it did not increase serum gamma-glutamyl transferase levels. |
2014-05-01 |
2023-08-12 |
chicken |
| M V Kharitonova, A A Zheltova, A A Spasov, A V Smirnov, N G Pan'shin, I N Iezhits. [Correction of isoproterenol-induced myocardial injury with magnesium salts in magnesium-deficient rats]. Voprosy pitaniia. vol 82. issue 5. 2014-05-01. PMID:24640156. |
twenty-four hours after second injection of isoproterenol, tests for activities of creatine kinase (ck), lactate dehydrogenase (ldh) and aspartate aminotransferase (ast) were run and histopathological study was carried out. |
2014-05-01 |
2023-08-12 |
rat |
| Runzhi Zhu, Guofang Zeng, Yinqin Chen, Qingyu Zhang, Bin Liu, Jie Liu, Hege Chen, Mingyi L. Oroxylin A accelerates liver regeneration in CCl₄-induced acute liver injury mice. PloS one. vol 8. issue 8. 2014-04-30. PMID:23951204. |
wild type (wt) mice were orally administrated with oroxylin a (60 mg/kg) for 4 days after ccl₄ injection, the anti-inflammatory effects of oroxylin a were assessed directly by hepatic histology and indirectly by measuring serum levels of aspartate aminotransferase (ast), alanine aminotransferase (alt) and albumin. |
2014-04-30 |
2023-08-12 |
mouse |
| Fatime Geyikoglu, Hasan Türkez, Tülay Ozhan Bakir, Mustafa Cice. The genotoxic, hepatotoxic, nephrotoxic, haematotoxic and histopathological effects in rats after aluminium chronic intoxication. Toxicology and industrial health. vol 29. issue 9. 2014-04-28. PMID:22421584. |
animals were killed and blood samples were analyzed for blood serum alkaline phosphatase (alp), aspartate aminotransferase (ast), alanine aminotransferase (alt) and lactate dehydrogenase (ldh) enzyme activities and creatinine, urea (u) and uric acid (ua) levels for evaluating hepatotoxicity and nephrotoxicity. |
2014-04-28 |
2023-08-12 |
rat |
| Tingting Li, Shaomei Zhu, Lifang Shuai, Yuxia Xu, Sen Yin, Yixin Bian, Yuanzhan Wang, Bingfeng Zuo, Wenjing Wang, Shuoxian Zhao, Ling Zhang, Jingang Zhang, George F Gao, Jean-Pierre Allain, Chengyao L. Infection of common marmosets with hepatitis C virus/GB virus-B chimeras. Hepatology (Baltimore, Md.). vol 59. issue 3. 2014-04-28. PMID:24123143. |
a moderate elevation of serum aspartate aminotransferase (ast) levels was observed in parallel with viral replication. |
2014-04-28 |
2023-08-12 |
Not clear |
| Monica A Konerman, Shruti H Mehta, Catherine G Sutcliffe, Trang Vu, Yvonne Higgins, Michael S Torbenson, Richard D Moore, David L Thomas, Mark S Sulkowsk. Fibrosis progression in human immunodeficiency virus/hepatitis C virus coinfected adults: prospective analysis of 435 liver biopsy pairs. Hepatology (Baltimore, Md.). vol 59. issue 3. 2014-04-28. PMID:24436062. |
between biopsies, elevated serum aspartate and alanine aminotransferase (ast, alt) (aor ast: 3.34, alt: 2.18 for >25% values >100 u/l versus <25% values >100 u/l) were strongly associated with fibrosis progression. |
2014-04-28 |
2023-08-12 |
human |
| Ying Wang, Li-Na Gao, Yuan-Lu Cui, Heng-Li Jian. Protective effect of danhong injection on acute hepatic failure induced by lipopolysaccharide and d-galactosamine in mice. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-04-28. PMID:24772178. |
we found that mice administrated with dhi displayed a higher survival rate, lower serum levels of alanine aminotransferase (alt), aspartate aminotransferase (ast), total bilirubin (tbil), glutathione s-transferase (gst), and tumor necrosis factor (tnf)- α . |
2014-04-28 |
2023-08-13 |
mouse |
| Alireza Hosseinnezhad, Rajakrishnan Vijayakrishnan, Mary Jo S Farme. Acute renal failure, thrombocytopenia, and elevated liver enzymes after concurrent abuse of alcohol and cocaine. Clinics and practice. vol 1. issue 2. 2014-04-25. PMID:24765297. |
laboratory investigations were significant for acute kidney failure with elevated serum creatinine (3.72 mg/dl), thrombocytopenia (platelet count 74,000/ul), elevated alanine and aspartate transaminases (alt 331 u/l; ast 462 u/l) and elevated creatine phosphokinase (cpk 5885 u/l). |
2014-04-25 |
2023-08-13 |
Not clear |