| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ahmed S Ahmed, Liju S Mathew, Asim S Khan, Mark M Rohn, Omaima K Docmac, Pallav Sengupta, Ehab M Hantash, Rasha A Elsis. Potential of dehydroepiandrosterone and quercetin to ameliorate copper oxide nanoparticles induced hepatotoxicity in albino wistar rats. Journal of molecular histology. vol 56. issue 1. 2024-11-29. PMID:39614022. |
cuo nanoparticle-intoxicated rats exhibited a significant increase in serum alanine transaminase aspartate aminotransferase (ast), and bilirubin levels, coupled with a noteworthy reduction in serum albumin. |
2024-11-29 |
2024-12-02 |
rat |
| Anne S Maguire, Linh Ta, Amanda L Gross, Devin E Osterhoudt, Jessica S Cannon, Paige I Hall, Maninder Sandey, Thomas N Seyfried, Heather L Gray-Edwards, Miguel Sena-Esteves, Douglas R Marti. Intravenous gene therapy improves lifespan and clinical outcomes in feline Sandhoff Disease. bioRxiv : the preprint server for biology. 2024-11-28. PMID:39605340. |
cerebrospinal fluid levels of aspartate aminotransferase (ast) and lactate dehydrogenase (ldh) were decreased, indicating a reduction of cell damage within the central nervous system. |
2024-11-28 |
2024-11-30 |
Not clear |
| Ghazal Baghdadi, Farzad Shidfar, Marjan Mokhtare, Parvin Sarbakhsh, Shahram Aga. Effect of Pomegranate Peel Consumption on Liver Enzymes, Lipid Profile, Liver Steatosis, and Hs-CRP in Patients With Non-alcoholic Fatty Liver Disease: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial. Phytotherapy research : PTR. 2024-11-28. PMID:39608758. |
at the end of the trial, pomegranate peel group had significantly higher reduction in tg (triglycerides), alt(alanine aminotransferase), ast(aspartate transferase), hs-crp and also had higher significant increase in hdl-c(high-density lipoprotein cholesterol) compared to the control group (p = 0/02, p = 0/02, p = 0/01, p = 0/01, and p = 0/04, respectively). |
2024-11-28 |
2024-12-01 |
Not clear |
| Katayoon Karimzadeh, Suraj Unniappan, Asgar Zahmatkes. Spirulina platensis Peptide-Loaded Nanoliposomes Alleviate Hepatic Lipid Accumulation in Male Wistar Rats by Influencing Redox Homeostasis and Lipid Metabolism via the AMPK Signaling Pathway. Applied biochemistry and biotechnology. 2024-11-27. PMID:39601973. |
sp and sp-loaded nanoliposomes mitigated hepatic damage by lowering serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) and increasing hepatic antioxidant enzymes, which are manifested in improving histopathological findings. |
2024-11-27 |
2024-11-29 |
rat |
| Hesham M Hassan, Mahmoud El Safadi, Warda Mustfa, Shahaba Tehreem, Giorgio Antoniolli, Arifa Mehreen, Adnan Ali, Ahmed Al-Ema. Pharmacotherapeutic potential of pratensein to avert metribuzin instigated hepatotoxicity via regulating TGF-β1, PI3K/Akt, Nrf-2/Keap-1 and NF-κB pathway. Tissue & cell. vol 91. 2024-11-27. PMID:39603025. |
the levels of albumin and total proteins were reduced whereas the levels of alkaline phosphatase (alp), gamma-glutamyl transferase (ggt), aspartate aminotransferase (ast) and alanine aminotransferase (alt) were enhanced following the mbn administration. |
2024-11-27 |
2024-11-30 |
rat |
| Yang Huang, Anque Liao, Liangliang Xu, Hui Li, Mingqing Xu, Li Jian. The Prognostic Values of Serum Liver Enzymes in Intrahepatic Cholangiocarcinoma Patients After Liver Resection: A Multi-Institutional Analysis of 605 Patients. Cancer management and research. vol 16. 2024-11-26. PMID:39588157. |
the value of liver enzymes, such as alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase (alp) and gamma-glutamyl transferase (ggt), in predicting the prognosis of intrahepatic cholangiocarcinoma (icc) patients who underwent curative resection has not been elucidated. |
2024-11-26 |
2024-11-28 |
Not clear |
| Ziyi Sheng, Hua Song, Xianzhi Gao, Bian Shu, Yu You, Zuojin Li. Exosomal miR-146a-5p Derived from HSCs Accelerates Sepsis-induced Liver Injury by Suppressing KLF-4. Inflammation. 2024-11-26. PMID:39589633. |
liver injury was evaluated using he staining, and alanine aminotransferase (alt) and aspartate aminotransferase (ast) levels were measured. |
2024-11-26 |
2024-11-28 |
mouse |
| Zhe Bai, Hui Li, Baoping Jia. Potential Therapeutic Effect of Sinigrin on Diethylnitrosamine-Induced Liver Cancer in Mice: Exploring the Involvement of Nrf-2/HO-1, PI3K-Akt-mTOR Signaling Pathways, and Apoptosis. ACS omega. vol 9. issue 46. 2024-11-25. PMID:39583716. |
sinigrin reduced the serum level of alanine aminotransferase (alt), aspartate aminotransferase (ast), gamma-glutamyl transferase (ggt), alkaline phosphatase (alp), lactate dehydrogenase (ldh), alpha-fetoprotein (afp), and bilirubin but increased total protein, and albumin, levels. |
2024-11-25 |
2024-11-27 |
mouse |
| Miwako Minami, Tomohiro Imamura, Ayako Takamori, Hiromu Minagawa, Rina Matsuo, Junko Miyakawa, Kenichi Izumi, Shoichiro Ohta, Kohei Yamanouchi, Nobuya Souta, Kyosuke Yamamoto, Sadatosi Tsuji, Tsukuru Umemura, Keizo Anzai, Yuji Hirai, Kazuma Fujimoto, Takuya Kish. Characterized factors of subjects who were first time diagnosed as hyperglycemia more than 126 mg/dl during annual or biannual medical checkups: a case-control study in Japan. Journal of clinical biochemistry and nutrition. vol 75. issue 3. 2024-11-25. PMID:39583976. |
blood test results indicated that triglyceride, low-density lipoprotein (ldl) cholesterol, aspartate aminotransferase (ast), alanine aminotransferase (alt), and γ-glutamyl transpeptidase (γ-gtp), were significantly enhanced in cases. |
2024-11-25 |
2024-11-27 |
human |
| Jie Tian, Xianghong Ke, Yinjing Zhang, Jingjing Qu, Shaohua Fu, Ying Xia, Wenxiang Yang, Yanhua Zeng, Jun Fan, Yanmei Li, Bolin Fa. Safety evaluation of alpha- glycerylphosphorylcholine as a novel food. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-11-22. PMID:39577616. |
in 90-day oral toxicity, female high-dose group (2,000mg/kg) had lower body weight, body weight gain, empty stomach body weight, total protein (tp), albumin (alb), and higher alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase (alp) in contrast to control group. |
2024-11-22 |
2024-11-25 |
rat |
| Amna Qureshi, Javeria Junaid, Niaz Shaikh, Ayesha Siddiqa, Arshee Kha. Relationship of Biochemical and Hematological Markers With Alcohol Withdrawal Severity. Cureus. vol 16. issue 10. 2024-11-21. PMID:39564011. |
sixteen other blood markers were also analyzed, including hemoglobin, mean corpuscular volume, white blood cell (wbc), platelets, alanine transaminase, aspartate aminotransferase, aspartate aminotransferase (ast)/alanine aminotransferase (alt) ratio, gamma-glutamyl transferase, albumin, international normalized ratio, lactate dehydrogenase, sodium, potassium, magnesium, phosphate, and creatinine. |
2024-11-21 |
2024-11-23 |
Not clear |
| Jianxiu Zhang, Yilin Yuan, Xiaoyan Gao, Hui Li, Fengxia Yuan, Di Wu, Qinglong Cui, Guangchun Piao, Haidan Yua. Scopoletin ameliorates hyperlipidemia and hepatic steatosis via AMPK, Nrf2/HO-1 and NF-κB signaling pathways. Biochemical pharmacology. 2024-11-21. PMID:39571916. |
our results showed that ty injection significantly increased serum levels of alanine aminotransferase (alt), aspartate aminotransferase (ast), interleukin-1β (il-1β), tumor necrosis factor-α (tnf-α), triglyceride (tg), total cholesterol (tc), low density lipoprotein (ldl-c) as well as malondialdehyde (mda) in the livers of the mice (p < 0.001, respectively), and decreased serum levels of high density lipoprotein (hdl-c), il-10 levels as well as superoxide dismutase (sod) in the livers (p < 0.001, respectively). |
2024-11-21 |
2024-11-24 |
mouse |
| Chen Chen, Jing Wang, Tian Tian Huo, Bai Lin Zhu, Xin Jin, Zai Hao Zhao, Mei Hua Lin, Jun Xian Liu, Zhen Yi Guo, Wen Hu Xu, Lan Cui, Xiao Nan He, Yin Hua Zhan. Peripheral microvessel area better predicts the severity of coronary stenosis of acute myocardial infarction patients over pulse wave velocity. Scientific reports. vol 14. issue 1. 2024-11-20. PMID:39562600. |
creatine kinase, ck; creatine kinase muscle brain, ckmb; lactate dehydrogenase, ldh; hydroxybutyrate dehydrogenase, hdbh; aspartate aminotransferase, ast; alanine aminotransferase, alt) or with inflammatory markers (neutrophil, neutrophil/lymphocyte ratio, neu, neu/lym (nlr); systemic immune inflammation index, sii and system inflammation response index, siri), indicating clinical significance of oma. |
2024-11-20 |
2024-11-23 |
Not clear |
| Jing Yang, Jingcheng Zhao, Te Zheng, Jiashuo Zhou, Huiwen Zhang, Yun Zhan. A Rapid Quantitative Assessment Method for Liver Damage Effects of Compounds Based on Zebrafish Liver Partition Area Ratio. Journal of applied toxicology : JAT. 2024-11-18. PMID:39558222. |
the pearson correlation coefficient was used to analyze the correlation between the liver partition area ratio, total liver area, and alanine aminotransferase (alt) and aspartate aminotransferase (ast). |
2024-11-18 |
2024-11-22 |
zebrafish |
| Ling Jiang, Cai-Bo Tian, Rui-Han Ye, Nian Shi, Xing-Chao He, Yun-Li Zhao, Xiao-Dong Lu. Kakuol and asarinin protecting liver injury via HSP90AA1/CDK2/mTOR signaling pathway. Fitoterapia. 2024-11-17. PMID:39551106. |
in this investigation, kakuol and asarinin reduced the levels of serum alanine transaminase (alt), aspartate transaminase (ast) and malondialdehyde (mda) dramatically, and ameliorated the pathological damage of liver tissues in apap-induced mice. |
2024-11-17 |
2024-11-22 |
mouse |
| Kang Chen, Yi-Hui Jia, Zheng He, Pei-Yu Xie, Hong Liu, Ze-Xia Gao, Huan-Ling Wan. Regulation mechanism of oxidative status, immunity and apoptosis induced by hypoxia and heat exposure via PI3K/Akt signaling pathway in Megalobrama amblycephala. Fish & shellfish immunology. 2024-11-17. PMID:39551115. |
furthermore, m. amblycephala suffering from hypoxia and heat exposure exhibited several changes in liver tissues, with the most severe lesions and up-regulation of alanine aminotransferase (alt) and aspartate aminotransferase (ast) observed in those subjected to simultaneous exposure. |
2024-11-17 |
2024-11-22 |
cat |
| Zeping Luo, Liwei Pa. Synthesis of Formononetin Derivatives and Cardioprotective Effects. Chemical & pharmaceutical bulletin. vol 72. issue 11. 2024-11-17. PMID:39551522. |
further mechanistic investigations revealed that c4 could mitigate apoptosis rates, reduce the activity of myocardial enzyme (such as aspartate aminotransferase (ast), lactate dehydrogenase (ldh), and ck), diminish the number of autophagic vesicles, and restore excessive autophagy. |
2024-11-17 |
2024-11-22 |
Not clear |
| Milad Shokuhi Nia, Dormohammad Kordi Tamandani, Mohammad Kazem Momeni, Zakaria Bamer. Mitochondrial Pathogenic Mutations and Expression Pattern of Oxidative Phosphorylation Genes in COVID-19 Patients. Iranian journal of allergy, asthma, and immunology. vol 23. issue 4. 2024-11-16. PMID:39549291. |
correlations between gene expression levels, clinical parameters, including leukocyte, lymphocyte, neutrophil, and platelet count, as well as creatinine, alanine transaminase (alt), aspartate transaminase (ast), and blood urea nitrogen (bun) levels, and disease severity were analyzed. |
2024-11-16 |
2024-11-20 |
Not clear |
| Kai Wang, Lu Zhang, Hualiang Liang, Mingchun Ren, Haifeng Mi, Dongyu Huang, Jiaze G. Effects of Dietary Ferroporphyrin Supplementation on Growth Performance, Antioxidant Capacity, Immune Response, and Oxygen-Carrying Capacity in Gibel Carp ( Animals : an open access journal from MDPI. vol 14. issue 21. 2024-11-15. PMID:39518827. |
the addition of 0.03% and 0.04% fpr significantly increased alanine aminotransferase (alt) and aspartate aminotransferase (ast) levels, respectively, while the glucose (glu), tc, and total triglyceride (tg) levels showed opposite trends. |
2024-11-15 |
2024-11-17 |
Not clear |
| Fadwa M Arafa, Nehal Nassef Hezema, Ateyatallah Aljuhani, Mohamed R Aouad, Mohamed Hagar, Ahmed Zakaria, Nadjet Rezki, Marwa M Shaaban, Sara Ahmed Abdel Sala. Isatin-1,2,3-triazole derivatives: synthesis, molecular docking and evaluation against acute experimental toxoplasmosis. Acta tropica. 2024-11-14. PMID:39542154. |
furthermore, the serum levels of liver enzymes (aspartate transaminase (ast) and alanine transaminase (alt), and renal function tests (urea and creatinine) in mice were within normal limits which makes them more appealing candidates with proven safety. |
2024-11-14 |
2024-11-17 |
mouse |