| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nuriye Ezgi Bektur, Erhan Sahin, Cengiz Baycu, Gonul Unve. Protective effects of silymarin against acetaminophen-induced hepatotoxicity and nephrotoxicity in mice. Toxicology and industrial health. vol 32. issue 4. 2016-12-28. PMID:24193058. |
treatment of mice with overdose of apap resulted in the elevation of aspartate aminotransferase (ast), alanine transaminase (alt), blood urea nitrogen (bun), and serum creatinine (scr) levels in serum, liver, and kidney nitric oxide (no) levels and significant histological changes including decreased body weight, swelling of hepatocytes, cell infiltration, dilatation and congestion, necrosis and apoptosis in liver, and dilatation of bowman's capsular space and glomerular capillaries, pale-stained tubules epithelium, cell infiltration, and apoptosis in kidney. |
2016-12-28 |
2023-08-12 |
mouse |
| Naishun Liao, Fan Pan, Yingchao Wang, Youshi Zheng, Bo Xu, Wenwei Chen, Yunzhen Gao, Zhixiong Cai, Xiaolong Liu, Jingfeng Li. Adipose tissue-derived stem cells promote the reversion of non-alcoholic fatty liver disease: An in vivo study. International journal of molecular medicine. vol 37. issue 5. 2016-12-26. PMID:26986083. |
thereafter, gross liver morphology, the hepatosomatic (hsi) index and indicators of liver function, including alanine aminotransferase (alt), aspartate aminotransferase (ast) and total bilirubin (tbil) were evaluated. |
2016-12-26 |
2023-08-13 |
human |
| Lian-Yun Chen, Qin Chen, Yi-Feng Cheng, Huan-Huan Jin, De-Song Kong, Feng Zhang, Li Wu, Jiang-Juan Shao, Shi-Zhong Zhen. Diallyl trisulfide attenuates ethanol-induced hepatic steatosis by inhibiting oxidative stress and apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 79. 2016-12-26. PMID:27044810. |
our results demonstrated that dats prevented ethanol-induced injury, as indicated by the reduced activities of aspartate transaminase (ast) and alanine aminotransferase (alt) in the serum and culture medium, and inhibition of cell apoptosis. |
2016-12-26 |
2023-08-13 |
rat |
| Phetcharat Boonruamkaew, Pennapa Chonpathompikunlert, Yukio Nagasak. Redox Nanoparticle Therapeutics for Acetaminophen-Induced Hepatotoxicity in Mice. Oxidative medicine and cellular longevity. vol 2016. 2016-12-26. PMID:27073589. |
the effects of oral administration of rnp(n) to apap-treated mice were assessed for various biochemical liver function parameters: alanine transaminase (alt) activity, aspartate transaminase (ast) activity, alkaline phosphatase (alp) activity, prothrombin time, and serum albumin (alb) level. |
2016-12-26 |
2023-08-13 |
mouse |
| Michael Levine, Ayrn D O'Connor, Angela Padilla-Jones, Richard D Gerki. Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose. Journal of medical toxicology : official journal of the American College of Medical Toxicology. vol 12. issue 1. 2016-12-21. PMID:26341088. |
the primary objective of this study is to determine the test characteristics of the aspartate aminotransferase (ast) and the prothrombin time (pt) in patients with apap toxicity. |
2016-12-21 |
2023-08-13 |
human |
| Souad Elgengaihi, Abdel-Tawab H Mossa, Amel A Refaie, Doha Aboubake. Hepatoprotective Efficacy of Cichorium intybus L. Extract Against Carbon Tetrachloride-induced Liver Damage in Rats. Journal of dietary supplements. vol 13. issue 5. 2016-12-20. PMID:26913368. |
there were significant changes in serum biochemical parameters such as alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase (alp), bilirubin, albumin, total protein, and γ-glutamyl transferase (ggt) in carbon tetrachloride intoxicated rats, which were restored towards normal values in c. intybus-treated animals. |
2016-12-20 |
2023-08-13 |
rat |
| Zheng-Rong Wu, Zhong-Tian Bai, Ying Sun, Peng Chen, Zhi-Gang Yang, De-Juan Zhi, Yang Li, Xing Wang, Jing-Jing Du, Rui Yang, Peng Cui, Yu Zhang, Hong-Yu L. Protective effects of the bioactive natural product N-trans-Caffeoyldopamine on hepatotoxicity induced by isoniazid and rifampicin. Bioorganic & medicinal chemistry letters. vol 25. issue 22. 2016-12-16. PMID:26410075. |
results showed that serum aspartate aminotransferase (ast) and alanine aminotransferase (alt) levels and hepatic malondialdehyde (mda) content were reduced dramatically, and hepatic superoxide dismutase (sod) activity and glutathione (gsh) content were restored remarkably by n-trans-caffeoyldopamine co-administration, as compared to the inh-rfp treated rats (p<0.01). |
2016-12-16 |
2023-08-13 |
rat |
| Bing Han, Yang Gao, Yanli Wang, Lan Wang, Zuhui Shang, Shuang Wang, Jin Pe. Protective effect of a polysaccharide from Rhizoma Atractylodis Macrocephalae on acute liver injury in mice. International journal of biological macromolecules. vol 87. 2016-12-15. PMID:26820352. |
in vivo experiments confirmed that pram2 could reduce the liver weight, liver index, aspartate transaminase (ast) and alanine aminotransferase (alt) activities in the serum; meanwhile, pram2 could significantly reduce nitric oxide synthase (nos) activity, and nitric oxide (no) and malonaldehyde (mda) contents in the liver tissues, and increase superoxide dismutase (sod) and glutathione peroxidase (gsh-px) activities. |
2016-12-15 |
2023-08-13 |
mouse |
| Jia Fu, Dan Guo, Dandan Gao, Wenxiang Huang, Ziqiong Li, Bei Ji. Clinical analysis of patients suffering from chronic hepatitis B superinfected with other hepadnaviruses. Journal of medical virology. vol 88. issue 6. 2016-12-14. PMID:26509653. |
the tested biochemical indices and markers of liver function included serum alanine aminotransferase (alt), aspartate aminotransferase (ast), total bilirubin (tbil), prothrombin activity (pta), serum albumin (alb), and the serum levels of hbv dna. |
2016-12-14 |
2023-08-13 |
Not clear |
| Fei Liu, Hong-Zhuan Shi, Qiao-Sheng Guo, Ye-Bing Yu, Ai-Ming Wang, Fu Lv, Wen-Biao She. Effects of astaxanthin and emodin on the growth, stress resistance and disease resistance of yellow catfish (Pelteobagrus fulvidraco). Fish & shellfish immunology. vol 51. 2016-12-14. PMID:26899124. |
the combination group exhibited increases in alanine aminotransferase (alt) activity, aspartate aminotransferase (ast) activity, serum tp, hepatic sod activity and hepatic hsp70 mrna levels within 24 h after the initiation of crowding stress. |
2016-12-14 |
2023-08-13 |
cat |
| Xi-Dong Li, Bing-Hua Qiu, Fang-Cheng Su, Shao-Xia Su. Gender impacts on the correlations between nonalcoholic fatty liver disease and hypertension in a Chinese population aged 45-60 y. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 38. issue 7. 2016-12-14. PMID:27680771. |
body mass index (bmi), waist circumference (wc), waist-to-hip ratio (whr), fasting glucose, sbp, dbp, triglycerides (tg), serum uric acid (sua), alanine aminotransferase (alt), aspartate aminotransferase (ast), and the prevalence of hypertension and nafld were significantly higher in males than in females (p < 0.05). |
2016-12-14 |
2023-08-13 |
human |
| Peter Willeke, Bernhard Schlüter, Armend Limani, Heidemarie Becker, Heiko Schott. Liver involvement in ANCA-associated vasculitis. Clinical rheumatology. vol 35. issue 2. 2016-12-13. PMID:25633652. |
aspartate and alanine aminotransferase [ast, alt], gamma-glutamyl transpeptidase [gamma-gt], alkaline phosphatase [alp] and total bilirubin) were analysed at disease onset in therapy-naïve patients and during remission in patients with granulomatosis with polyangiitis (gpa, n = 67), microscopic polyangiitis (mpa, n = 28) and eosinophilic granulomatosis with polyangiitis (egpa, n = 14). |
2016-12-13 |
2023-08-13 |
Not clear |
| Amr H Farag, Sherif S Elghetany, Mohamed S Elkashi. Aspartate aminotransferase and free thyroid hormones in vaginal washing fluid as markers for preterm pre-labor rupture of membranes. The journal of obstetrics and gynaecology research. vol 41. issue 9. 2016-12-13. PMID:26014210. |
to evaluate the diagnostic value of vaginal fluid aspartate aminotransferase (ast), free triiodothyronine (t3) and free thyroxine (t4 ) in women with preterm pre-labor rupture of membranes (pprom). |
2016-12-13 |
2023-08-13 |
Not clear |
| T Sharapova, V Devanarayan, B LeRoy, M J Liguori, E Blomme, W Buck, J Mahe. Evaluation of miR-122 as a Serum Biomarker for Hepatotoxicity in Investigative Rat Toxicology Studies. Veterinary pathology. vol 53. issue 1. 2016-12-13. PMID:26123229. |
increases in circulating mir-122 levels highly correlated with serum elevations of liver enzymes, such as alanine aminotransferase (alt), aspartate aminotransferase (ast) and glutamate dehydrogenase (gldh). |
2016-12-13 |
2023-08-13 |
rat |
| Saliha Sena Karcioglu, Saziye Sezin Palabiyik, Yasin Bayir, Emre Karakus, Tolga Mercantepe, Zekai Halici, Abdulmecit Albayra. The Role of RAAS Inhibition by Aliskiren on Paracetamol-Induced Hepatotoxicity Model in Rats. Journal of cellular biochemistry. vol 117. issue 3. 2016-12-13. PMID:26280784. |
paracetamol toxicity increased alanine aminotransferases (alt), aspartate aminotransferases (ast), renin, and angiotensin ii levels in the serum samples. |
2016-12-13 |
2023-08-13 |
rat |
| Dinesh K Chellappan, Sivamalar Ganasen, Shaminiswary Batumalai, Mayuren Candasamy, Purushotham Krishnappa, Kamal Dua, Jestin Chellian, Gaurav Gupt. The Protective Action of the Aqueous Extract of Auricularia polytricha in Paracetamol Induced Hepatotoxicity in Rats. Recent patents on drug delivery & formulation. vol 10. issue 1. 2016-12-13. PMID:26517821. |
aspartate aminotransferase (ast), alanine transaminase (alt) and alkaline phosphatase (alp), lactate dehydrogenase (ldh), total bilirubin (tb), total protein (tp), triglycerides (tg) and cholesterol were measured to assess the effect of the extract on paracetamol-induced hepatic damage. |
2016-12-13 |
2023-08-13 |
rat |
| Nagla A El-Sherbeeny, Manar A Nade. The protective effect of vildagliptin in chronic experimental cyclosporine A-induced hepatotoxicity. Canadian journal of physiology and pharmacology. vol 94. issue 3. 2016-12-13. PMID:26632647. |
liver function was assessed by measuring serum levels of aspartate aminotransferase (ast), alanine aminotransferase (alt), gamma glutamyltransferase (γgt), lactate dehydrogenase (ldh), and albumin, and histopathological changes of liver were examined. |
2016-12-13 |
2023-08-13 |
rat |
| Abd El-Rahman M Khalaf-Allah, Souad E El-Gengaihi, Manal A Hamed, Hanan G Zahran, Mona A Mohamme. Chemical Composition of Golden Berry Leaves Against Hepato-renal Fibrosis. Journal of dietary supplements. vol 13. issue 4. 2016-12-13. PMID:26634867. |
liver function indices; aspartate and alanine aminotransferases (ast & alt), alkaline phosphatase (alp), gamma glutamyl transferase (ggt), bilirubin and total hepatic protein were also estimated. |
2016-12-13 |
2023-08-13 |
rat |
| Peter M Burch, David Greg Hall, Elizabeth G Walker, William Bracken, Richard Giovanelli, Richard Goldstein, Richard E Higgs, Nicholas M P King, Pamela Lane, John-Michael Sauer, Laura Michna, Nagaraja Muniappa, Michael L Pritt, Katerina Vlasakova, David E Watson, Debra Wescott, Tanja S Zabka, Warren E Glaa. Evaluation of the Relative Performance of Drug-Induced Skeletal Muscle Injury Biomarkers in Rats. Toxicological sciences : an official journal of the Society of Toxicology. vol 150. issue 1. 2016-12-13. PMID:26721300. |
novel skeletal muscle (skm) injury biomarkers that have recently been identified may outperform or add value to the conventional skm injury biomarkers aspartate transaminase (ast) and creatine kinase (ck). |
2016-12-13 |
2023-08-13 |
rat |
| Mardi M Algandaby, Ali M El-Halawany, Hossam M Abdallah, Abdulrahman M Alahdal, Ayman A Nagy, Osama M Ashour, Ashraf B Abdel-Nai. Gingerol protects against experimental liver fibrosis in rats via suppression of pro-inflammatory and profibrogenic mediators. Naunyn-Schmiedeberg's archives of pharmacology. vol 389. issue 4. 2016-12-13. PMID:26809353. |
gin significantly ameliorated the increase in serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) activities, albumin, total cholesterol (tc) and triglyceride (tg) concentrations, and liver index. |
2016-12-13 |
2023-08-13 |
rat |