| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bin Zhao, Hong Zha. Incidence and risk of regorafenib-induced hepatotoxicity. Oncotarget. vol 8. issue 48. 2019-11-20. PMID:29137408. |
eligible studies include subjects with solid tumors treated with 160 mg of regorafenib daily during the first three week of each four-week cycle, and adequate safety data reporting the elevation of aspartate transaminase (ast), alanine aminotransferase (alt), alkaline phosphatase (alp) and bilirubin. |
2019-11-20 |
2023-08-13 |
human |
| Satomi Minato, Kaori Kitaoka, Mika Takeuchi, Ayaka Tsuboi, Miki Kurata, Shigehiro Tanaka, Tsutomu Kazumi, Keisuke Fuku. Appendicular muscle mass and fasting triglycerides predict serum liver aminotransferases in young female collegiate athletes. BMJ open diabetes research & care. vol 6. issue 1. 2019-11-20. PMID:29527310. |
we test the hypothesis that aspartate aminotransferase (ast) may be associated inversely with serum triglycerides (tg) and positively with high density lipoprotein (hdl) cholesterol in young athletes because athletes have larger amounts of muscle mass. |
2019-11-20 |
2023-08-13 |
Not clear |
| Michele Paolantonio, Giacinto Di Placido, Vincenzo Tumini, Mauro Di Stilio, Alessandro Contento, Giuseppe Spot. A spartate Aminotransferase Activity in Crevicular Fluid From Dental Impiants. Journal of periodontology. vol 71. issue 7. 2019-11-20. PMID:29537530. |
aspartate aminotransferase (ast) is an enzyme normally confined to the cytoplasm of cells, but released to the exracellular environment upon cell death. |
2019-11-20 |
2023-08-13 |
Not clear |
| Wycliffe Mbagaya, Joanne Foo, Ahai Luvai, Claire King, Sarah Mapplebeck, Andrew Gough, Nuthar Jassa. Persistently raised aspartate aminotransferase (AST) due to macro-AST in a rheumatology clinic. Diagnosis (Berlin, Germany). vol 2. issue 2. 2019-11-20. PMID:29540021. |
persistently raised aspartate aminotransferase (ast) due to macro-ast in a rheumatology clinic. |
2019-11-20 |
2023-08-13 |
Not clear |
| Wycliffe Mbagaya, Joanne Foo, Ahai Luvai, Claire King, Sarah Mapplebeck, Andrew Gough, Nuthar Jassa. Persistently raised aspartate aminotransferase (AST) due to macro-AST in a rheumatology clinic. Diagnosis (Berlin, Germany). vol 2. issue 2. 2019-11-20. PMID:29540021. |
macrocomplexes between immunoglobins and aspartate aminotransferase (macro-ast) may result in persistently increased ast concentration. |
2019-11-20 |
2023-08-13 |
Not clear |
| Hanan S Zaky, Amany M Gad, Ekram Nemr, Wedad Hassan, Ola M Abd El-Raouf, Aza A Al. Modulatory effects of some natural products on hepatotoxicity induced by combination of sodium valproate and paracetamol in rats. Journal of biochemical and molecular toxicology. 2019-11-20. PMID:29799656. |
sv and/or paracetamol significantly increased aspartate aminotransferase (ast), alanine aminotransferase (alt), alkaline phosphatase (alp), total bilirubin, relative liver/body weight ratio, malondialdehyde (mda), tumor necrosis factor alpha (tnf-α), and caspase-3 (casp-3) while significantly decreased albumin, total protein, glutathione (gsh) reduced, gsh peroxidase, and superoxide dismutase (sod). |
2019-11-20 |
2023-08-13 |
rat |
| Atypical clinical manifestations of hepatitis a among children aged 1-16 years in South-Eastern Region of Turkey. The Turkish journal of pediatrics. vol 57. issue 4. 2019-11-20. PMID:30346119. |
children with atypical features of hepatitis a statistically had higher initial and peak values of alanine aminotransferase (alt), aspartate aminotransferase (ast), international normalized ratio (inr), serum total and direct bilirubin than typical manifested group. |
2019-11-20 |
2023-08-13 |
Not clear |
| Nashwa Fathy Gamal El-Tahawy, Samah Mohammed Mahmoud Abozai. The possible structural changes in the adrenal gland cortex after induction of hepatic ischemia-reperfusion injury in male albino rats: Light and electron microscopic study. Journal of cellular physiology. 2019-11-20. PMID:30684267. |
sera were estimated for the following: aspartate transaminase (ast), alanine transaminase (alt), lactic dehydrogenase (ldh), and corticosterone levels. |
2019-11-20 |
2023-08-13 |
rat |
| Ming-Shan Jiang, Xue-Feng Luo, Zhu Wang, Xiao L. The transjugular approach is a safe and effective alternative for performing portal vein embolization. Medicine. vol 98. issue 45. 2019-11-20. PMID:31702644. |
liver function, including total bilirubin (tb), aspartate aminotransferase (ast), alanine aminotransferase (alt) and international normalized ratio (inr), was assessed before and after pve. |
2019-11-20 |
2023-08-13 |
Not clear |
| Seyit Ali Büyüktuna, Halef Okan Doğan, Meltem Unlusavuran, Mehmet Baki. An evaluation of the different biomarkers to discriminate bleeding in Crimean-Congo Hemorrhagic Fever. Ticks and tick-borne diseases. vol 10. issue 5. 2019-11-19. PMID:31151923. |
serum iron, unsaturated iron binding capacity (uibc), alanine aminotransferase (alt), and aspartate aminotransferase (ast) levels were determined using the colorimetric method. |
2019-11-19 |
2023-08-13 |
human |
| Umarah Zahoor Banday, Sadiya Binte Swaleh, Nazura Usman. Insights into the heavy metal-induced immunotoxic and genotoxic alterations as health indicators of Clarias gariepinus inhabiting a rivulet. Ecotoxicology and environmental safety. vol 183. 2019-11-19. PMID:31446173. |
serum enzymes (hepatic and renal markers) viz., aspartate aminotransferase (ast), alanine aminotransferase (alt) and alkaline phosphatase (alp) were higher than the normal, whereas, creatine kinase (ck) was considerably low in both male and female fish. |
2019-11-19 |
2023-08-13 |
human |
| Zhengyu Jiang, Lulong Bo, Yan Meng, Chen Wang, Tianxing Chen, Changli Wang, Xiya Yu, Xiaoming Den. Overexpression of homeodomain-interacting protein kinase 2 (HIPK2) attenuates sepsis-mediated liver injury by restoring autophagy. Cell death & disease. vol 9. issue 9. 2019-11-15. PMID:30154452. |
hipk2 expression was reduced in sepsis-induced liver injury, and hipk2 overexpression increased the survival rate and improved caecal ligation and puncture (clp)-induced liver injury by reducing serum and liver aspartate transaminase (ast), alanine transaminase (alt), and alkaline phosphatase (alp) levels in mice with sepsis. |
2019-11-15 |
2023-08-13 |
mouse |
| Bingning Gu, Wei Liang, Tiezhu Yang, Zhongjun Hu, Heding She. Metallothionein, hemocyte status and superoxide dismutase/aspartate aminotransferase activity are sensitive biomarkers of cadmium stress in Onchidium reevesii. Aquatic toxicology (Amsterdam, Netherlands). vol 215. 2019-11-14. PMID:31479758. |
cellular immunity (in the hemolymph) and enzyme activity (in the hepatopancreas) were investigated along with hemocyte viability, hemocyte phagocytosis, and superoxide dismutase (sod) and aspartate aminotransferase (ast) activities. |
2019-11-14 |
2023-08-13 |
Not clear |
| Rumeng Tan, Hongzhe Tian, Bo Yang, Bo Zhang, Chen Dai, Zhenyi Han, Meixi Wang, Yakun Li, Lai Wei, Dong Chen, Guangyao Wang, Huifang Yang, Fan He, Zhishui Che. Autophagy and Akt in the protective effect of erythropoietin helix B surface peptide against hepatic ischaemia/reperfusion injury in mice. Scientific reports. vol 8. issue 1. 2019-11-13. PMID:30279567. |
we assessed alanine aminotransferase (alt), aspartate aminotransferase (ast) and lactate dehydrogenase (ldh) levels in mouse sera, and performed haematoxylin/eosin (he) staining, immunohistochemistry, electron microscopy, immunofluorescence microscopy, and western blotting on liver tissue to detect the degree of liver injury, liver apoptosis, autophagy, and the expression of microtubule associated protein 1 light chain 3 alpha (map1lc3, or lc3), beclin 1, phospho-mtor, mtor, phospho-akt (p-akt), and akt. |
2019-11-13 |
2023-08-13 |
mouse |
| Deng-Fa Yang, Ying-Ling Shen, Changwei Wu, Yu-Sheng Huang, Po-Ying Lee, Ng Xin Er, Wen-Ching Huang, Yu-Tang Tun. Sleep deprivation reduces the recovery of muscle injury induced by high-intensity exercise in a mouse model. Life sciences. vol 235. 2019-11-12. PMID:31493480. |
according to the tnf-α level and aspartate aminotransferase (ast), and creatine phosphokinase (ck) activities, only the ex+sd group exhibited muscle impairment. |
2019-11-12 |
2023-08-13 |
mouse |
| Roni Lehmann-Werman, Judith Magenheim, Joshua Moss, Daniel Neiman, Ofri Abraham, Sheina Piyanzin, Hai Zemmour, Ilana Fox, Talya Dor, Markus Grompe, Giora Landesberg, Bao-Li Loza, Abraham Shaked, Kim Olthoff, Benjamin Glaser, Ruth Shemer, Yuval Do. Monitoring liver damage using hepatocyte-specific methylation markers in cell-free circulating DNA. JCI insight. vol 3. issue 12. 2019-11-06. PMID:29925683. |
furthermore, patients with sepsis had high levels of hepatocyte cfdna, which correlated with levels of liver enzymes aspartate aminotransferase (ast) and alanine aminotransferase (alt). |
2019-11-06 |
2023-08-13 |
human |
| Jung-Ran Noh, Yong-Hoon Kim, Don-Kyu Kim, Jung Hwan Hwang, Kyoung-Shim Kim, Dong-Hee Choi, Seon-Jin Lee, Hee Gu Lee, Tae Geol Lee, Hong-Lei Weng, Steven Dooley, Hueng-Sik Choi, Chul-Ho Le. Small heterodimer partner negatively regulates C-X-C motif chemokine ligand 2 in hepatocytes during liver inflammation. Scientific reports. vol 8. issue 1. 2019-11-04. PMID:30323351. |
accordingly, plasma alanine aminotransferase (alt) and aspartate aminotransferase (ast) levels, and inflammatory cytokine expressions were significantly higher in the ko recipients than in the wt recipients regardless of donor genotype. |
2019-11-04 |
2023-08-13 |
Not clear |
| Qiang Li, Yu Zhou, Chenlu Huang, Weixia Li, Liang Che. A novel diagnostic algorithm to predict significant liver inflammation in chronic hepatitis B virus infection patients with detectable HBV DNA and persistently normal alanine transaminase. Scientific reports. vol 8. issue 1. 2019-11-04. PMID:30337643. |
in the training set, the area under the receiver operating characteristic curve (auroc) of aagp was higher than that of alt and aspartate transaminase (ast), to diagnose significant liver inflammation (0.77, 0.67, and 0.59, respectively, p < 0.001). |
2019-11-04 |
2023-08-13 |
Not clear |
| Yaojie Shi, Qianqian Wang, Juan Rong, Jing Ren, Xuejiao Song, Xiaoli Fan, Mengyi Shen, Yong Xia, Ningyu Wang, Zhihao Liu, Quanfang Hu, Tinghong Ye, Luoting Y. Synthesis and biological evaluation of (1,2,4)triazole[4,3-a]pyridine derivatives as potential therapeutic agents for concanavalin A-induced hepatitis. European journal of medicinal chemistry. vol 179. 2019-11-04. PMID:31254920. |
more importantly, 8d also exhibited potent efficacy, alleviating con a-induced hepatitis by downregulating the levels of plasma alanine transaminase (alt), aspartate transaminase (ast) and inflammatory infiltration in a mouse autoimmune hepatitis (aih) model. |
2019-11-04 |
2023-08-13 |
mouse |
| Mio Yamashima, Hisamitsu Miyaaki, Satoshi Miuma, Hidetaka Shibata, Ryu Sasaki, Masafumi Haraguchi, Masanori Fukushima, Kazuhiko Naka. The Long-term Efficacy of Sodium Glucose Co-transporter 2 Inhibitor in Patients with Non-alcoholic Fatty Liver Disease. Internal medicine (Tokyo, Japan). vol 58. issue 14. 2019-11-01. PMID:31308341. |
results body weight and aspartate aminotransferase (ast) and alanine aminotransferase (alt) levels were significantly decreased at 12 and 24 months after sglt-2i treatment. |
2019-11-01 |
2023-08-13 |
Not clear |