| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shanyong Yi, Tingting Mai, Ying Fang, Qishuo Tian, Shuquan Zha. Repeated Injection of Xylazine Causes Liver Injury Through the PPAR Signaling Pathway in Rats. Journal of biochemical and molecular toxicology. vol 39. issue 1. 2024-12-18. PMID:39692361. |
weight loss was observed in the 40 mg/kg group and elevated levels of aspartate aminotransferase (ast) and alanine aminotransferase (alt) were observed. |
2024-12-18 |
2024-12-21 |
rat |
| Azin Masroor, Abolfazl Gholipour, Milad Shahini Shams Abadi, Mohammad Mousavi, Moluk Hadi Alijanvand, Behnam Zamanza. Quantitative real-time PCR analysis of gut microbiota in rheumatoid arthritis patients compared to healthy controls. AMB Express. vol 14. issue 1. 2024-12-18. PMID:39694971. |
gut dysbiosis in patients with rheumatoid arthritis (ra) is identified alongside key serological and clinical markers such as c-reactive protein (crp), erythrocyte sedimentation rate (esr), immunofluorescence (if), anti-cyclic citrullinated peptide (anti-ccp), white blood cell count (wbc), mean corpuscular volume (mcv), aspartate aminotransferase (ast), alanine aminotransferase (alt), blood urea nitrogen (bun), platelet count (plt), thyroid-stimulating hormone (tsh), creatinine (cr), and hemoglobin (hb). |
2024-12-18 |
2024-12-21 |
Not clear |
| Yi Jiang, Ke Su, Han Li, Chenjie Wang, Zhenying Wu, Jiali Chen, Zhiyao Zhang, Kun He, Yunwei Ha. Efficacy and safety of the combination of envafolimab and lenvatinib in unresectable hepatocellular carcinoma: a single-arm, multicentre, exploratory phase II clinical study. Investigational new drugs. 2024-12-17. PMID:39690337. |
in terms of safety, 23 patients (76.7%) experienced at least one treatment-related adverse event (trae), of which the most common was elevated aspartate aminotransferase (ast, 23.3%). |
2024-12-17 |
2024-12-21 |
Not clear |
| Aimei Liao, Xiaoxiao Li, Yanbing Wang, Zhirui Ding, Long Pan, Yinchen Hou, Quanping Liu, Jianzheng Li, Menghui Shang, Jihong Huan. Wheat Embryo Albumin and Its Peptide Alleviate Acute Exercise Fatigue as Energy Supplement. Foods (Basel, Switzerland). vol 13. issue 23. 2024-12-17. PMID:39682937. |
fatigue-related biochemical indexes including lactate dehydrogenase (ldh), the level of blood urea nitrogen (bun), alanine transaminase (alt), aspartate transaminase (ast), liver glycogen (lg), and muscle glycogen (mg) were measured with commercial kits. |
2024-12-17 |
2024-12-21 |
Not clear |
| Muhammad Hassan Raza, Awais Mustafa, Muhammad Amir, Muhammad Khurram Saleem, Hifza Ishtiaq, Amna Akbar, Mohammad Saleem Kha. Association of Liver Biomarkers With Jaundice in Patients With Gastrointestinal Complications: An Observational Retrospective Cohort Study. Cureus. vol 16. issue 12. 2024-12-14. PMID:39669649. |
other tests regarding liver function are often used besides bilirubin as during any liver complications biomarkers such as alanine aminotransferase (alt), serum glutamic pyruvic transaminase (sgpt), aspartate aminotransferase (ast), serum glutamic-oxaloacetic transaminase (sgot), alkaline phosphatase (alp), and many other biomarkers even total protein metabolism might get disrupted and get released in the blood. |
2024-12-14 |
2024-12-21 |
Not clear |
| Daryna Mruga, Sergei Dzyadevych, Oleksandr Soldatki. Development and optimisation of the biosensor for aspartate aminotransferase blood level determination. Analytical and bioanalytical chemistry. 2024-12-12. PMID:39666000. |
this work presents the development and optimisation of an amperometric biosensor for determining aspartate aminotransferase (ast) activity in blood serum, using glutamate oxidase and platinum disc electrodes. |
2024-12-12 |
2024-12-14 |
Not clear |
| Nehal A Kamel, Dina W Bashir, Ebtihal M M El-Leithy, Adel F Tohamy, Maha M Rashad, Ghada E Ali, Abdel Aleem A El-Sab. "Polyethylene Terephthalate Nanoplastics Caused Hepatotoxicity in Mice Can be Prevented by Betaine: Molecular and Immunohistochemical Insights". Journal of biochemical and molecular toxicology. vol 38. issue 12. 2024-12-09. PMID:39651595. |
pet-nps induced a significant elevation in alanine aminotransferase (alt), aspartate aminotransferase (ast), and malondialdehyde (mda), as well as an increase in the inflammatory genes a proto-oncogene (c-fos) and cyclooxygenase 2 (cox2) (p ≤ 0.05), with a substantial decrease in glutathione (gsh) (p ≤ 0.05). |
2024-12-09 |
2024-12-12 |
mouse |
| Hesham M Hassan, Mahmoud El Safadi, Muhammad Faisal Hayat, Ahmed Al-Ema. Prevention of fenitrothion induced hepatic toxicity by saponarin via modulating TLR4/MYD88, JAK1/STAT3 and NF-κB signaling pathways. The international journal of biochemistry & cell biology. 2024-12-07. PMID:39645143. |
furthermore, fen administration notably escalated the concentrations of hepatic enzymes including alanine transaminase (alt), aspartate aminotransferase (ast), gamma-glutamyl transferase (ggt) and alkaline phosphatase (alp) whereas reduced the concentrations of total proteins and albumin. |
2024-12-07 |
2024-12-10 |
rat |
| Tianyu Liu, Ling Li, Yanchao Yang, Jiarou Li, Xutong Yang, Lei Li, Ziyao Zheng, Boyu Yang, Peiyu Zhang, Haiyan Li. Effects of chronic cold stress and thermal stress on growth performance, hepatic apoptosis, oxidative stress, immune response and gut microbiota of juvenile hybrid sturgeon (Acipenser baerii ♀ × A. schrenkii ♂). Fish & shellfish immunology. 2024-12-06. PMID:39642947. |
interestingly, cold stress increased hepatocyte apoptosis revealed by tunel staining, along with nuclear disappearance in h&e-stained sections and elevated serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) levels. |
2024-12-06 |
2024-12-10 |
Not clear |
| Shunwang Cao, Fei Zhong, Xueying Chen, Sikai Ke, Xiangrong Zhong, Tingting Li, Yanhua Sha, Chunmin Kang, Sheng Qin, Hongmei Wang, Yi Wang, Shuzhi Liao, Peifeng K. The combination of serum lncRNA PTTG3P and mRNA PTTG1 serves as a diagnostic and prognostic marker for hepatocellular carcinoma. Molecular medicine reports. vol 31. issue 2. 2024-12-05. PMID:39635828. |
spearman's correlation coefficient analysis showed that serum lncrna pttg3p was correlated with aspartate transaminase (ast). |
2024-12-05 |
2024-12-08 |
human |
| Zhikun Zhao, Xiaoxiao Ma, Mingyan Li, Guangyuan Chen, Libo Qi, Shuang Song, Zhenhao Li, Chunhong Ya. Alcoholic Extracts from the Ganoderma Lucidum Fermentation Product Alleviated Ethanol-Induced Liver Injury, Gut Leakiness, and Gut Dysbiosis in Mice. Plant foods for human nutrition (Dordrecht, Netherlands). vol 80. issue 1. 2024-12-05. PMID:39636452. |
gfe pretreatment significantly reduced the ethanol-induced elevated serum levels of aspartate aminotransferase (ast) and alanine transaminase (alt), hepatic steatosis, and increased triglyceride content. |
2024-12-05 |
2024-12-08 |
mouse |
| Tao Cheng, Jiandong Chen, Beiping Tan, Shuyan Ch. Effects of α-lipoic acid (LA) supplementation in high-fat diet on the growth, glycolipid metabolism and liver health of largemouth bass (Micropterus salmoides). Fish & shellfish immunology. 2024-12-05. PMID:39637953. |
compared to the fish fed hf diet, fish fed hl diets showed lower serum total triglyceride (tg), alanine aminotransferase (alt), aspartate aminotransferase (ast), hepatic malondialdehyde (mda) and glycogen levels, and higher hepatic catalase (cat) and glutathione peroxidase (gsh-px) activities. |
2024-12-05 |
2024-12-08 |
cat |
| Clarissa Gonzalez, Madelyn J Cohen, Juhee Hong, Daniel Calame, Kavitha Marri, Sanjiv Harpavat, Michael F Wangler, Krupa Mysor. Subacute Neuropathy Post-Liver Transplantation in Zellweger Spectrum Disorder: A Case Report. American journal of medical genetics. Part A. 2024-12-05. PMID:39632697. |
following olt, the patient's gamma-glutamyl transferase (ggt), aspartate aminotransferase (ast), alanine transaminase (alt), and albumin normalized; however, he developed a polyneuropathy, the cause of which was investigated with conditions such as inflammatory neuropathies (guillain barré syndrome: gbs/chronic inflammatory demyelinating polyneuropathy: cidp), drug effect, or underlying complication of pbd-zsd all considered possible. |
2024-12-05 |
2024-12-07 |
Not clear |
| Amir Mosayyeb Zadeh, Seyyed Ali Mirghelenj, Mohsen Daneshyar, Mohsen Eslami, Mohammad Amir Karimi Torshizi, Mahdi Zhandi, Touba Nadri, John Patrick Kastelic, Peyman Hasanloo, Mehdi Nabilo. Dietary supplementation with 15% tomato pomace (Solanum lycopersicum L.) improves sperm production and antioxidant status in aged male broiler breeders. Poultry science. vol 104. issue 1. 2024-12-04. PMID:39631284. |
additionally, serum of t-15 roosters had lower cholesterol and triglyceride (tg) concentrations, along with decreased aspartate aminotransferase (ast) activity (p<0.05). |
2024-12-04 |
2024-12-07 |
Not clear |
| Muhammad Asif, Muhammad Sohaib, Waleed Anwaar, Adeel Ahmed, Neha Tehreem Khalid, Hanzala Tariq, Muhammad Irfan Jami. Correlation Between Transient Elastography and Non-invasive Biomarker Scores for the Detection of Liver Fibrosis. Cureus. vol 16. issue 11. 2024-12-03. PMID:39624533. |
blood samples were collected for recording values of alanine aminotransferase (alt), aspartate aminotransferase (ast), and platelet count, and the appropriate formulas were applied to calculate the aspartate aminotransferase to platelet ratio index (apri), fibrosis-4 (fib-4), ast/alt-to-platelet ratio index (aarpri), and bard scores (a scoring system for nafld fibrosis that predicts the risk of advanced fibrosis in nafld patients; the components include body mass index (bmi), aspartate aminotransferase (ast)/alanine aminotransferase (alt) ratio, and diabetes status). |
2024-12-03 |
2024-12-06 |
Not clear |
| Tuoying Wen, Jinghong Liang, Yulan Wei, Weijun Lin, Liya Pa. Analysis of prognosis of neurological sequelae in children with carbon monoxide poisoning. Scientific reports. vol 14. issue 1. 2024-12-02. PMID:39623004. |
there were statistical differences in the admission co hemoglobin level, fibrinogen, d-dimer, high-sensitivity crp, neuron enolase, alanine aminotransferase or aspartate aminotransferase (alt or ast), lactate dehydrogenase, length of hospital stay, discharge and admission glasgow coma scale (gcs), seizure frequency, duration of consciousness disorders more than one day, cranial imaging changes, use of ventilators, presence of other system damage, the number of hyperbaric oxygen (hbo) treatments, and whether the patients were transferred to another hospital between the two groups of children. |
2024-12-02 |
2024-12-06 |
human |
| Ahmed S Ahmed, Liju S Mathew, Asim S Khan, Mark M Rohn, Omaima K Docmac, Pallav Sengupta, Ehab M Hantash, Rasha A Elsis. Potential of dehydroepiandrosterone and quercetin to ameliorate copper oxide nanoparticles induced hepatotoxicity in albino wistar rats. Journal of molecular histology. vol 56. issue 1. 2024-11-29. PMID:39614022. |
cuo nanoparticle-intoxicated rats exhibited a significant increase in serum alanine transaminase aspartate aminotransferase (ast), and bilirubin levels, coupled with a noteworthy reduction in serum albumin. |
2024-11-29 |
2024-12-02 |
rat |
| Anne S Maguire, Linh Ta, Amanda L Gross, Devin E Osterhoudt, Jessica S Cannon, Paige I Hall, Maninder Sandey, Thomas N Seyfried, Heather L Gray-Edwards, Miguel Sena-Esteves, Douglas R Marti. Intravenous gene therapy improves lifespan and clinical outcomes in feline Sandhoff Disease. bioRxiv : the preprint server for biology. 2024-11-28. PMID:39605340. |
cerebrospinal fluid levels of aspartate aminotransferase (ast) and lactate dehydrogenase (ldh) were decreased, indicating a reduction of cell damage within the central nervous system. |
2024-11-28 |
2024-11-30 |
Not clear |
| Ghazal Baghdadi, Farzad Shidfar, Marjan Mokhtare, Parvin Sarbakhsh, Shahram Aga. Effect of Pomegranate Peel Consumption on Liver Enzymes, Lipid Profile, Liver Steatosis, and Hs-CRP in Patients With Non-alcoholic Fatty Liver Disease: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial. Phytotherapy research : PTR. 2024-11-28. PMID:39608758. |
at the end of the trial, pomegranate peel group had significantly higher reduction in tg (triglycerides), alt(alanine aminotransferase), ast(aspartate transferase), hs-crp and also had higher significant increase in hdl-c(high-density lipoprotein cholesterol) compared to the control group (p = 0/02, p = 0/02, p = 0/01, p = 0/01, and p = 0/04, respectively). |
2024-11-28 |
2024-12-01 |
Not clear |
| Katayoon Karimzadeh, Suraj Unniappan, Asgar Zahmatkes. Spirulina platensis Peptide-Loaded Nanoliposomes Alleviate Hepatic Lipid Accumulation in Male Wistar Rats by Influencing Redox Homeostasis and Lipid Metabolism via the AMPK Signaling Pathway. Applied biochemistry and biotechnology. 2024-11-27. PMID:39601973. |
sp and sp-loaded nanoliposomes mitigated hepatic damage by lowering serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) and increasing hepatic antioxidant enzymes, which are manifested in improving histopathological findings. |
2024-11-27 |
2024-11-29 |
rat |