| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anil Kumar, Lekha Sah. Colorectal cancer cell dormancy: An insight into pathways. World journal of gastroenterology. vol 30. issue 33. 2024-10-01. PMID:39351431. |
additionally, erk/p38α/β/mapk pathways, akt signalling pathway, and extracellular matrix metalloproteinase inducer, along with some potential less explored pathways such as stat/p53 switch and canonical and non-canonical wnt and smad signalling, are also involved in promoting colorectal ccd. |
2024-10-01 |
2024-10-03 |
Not clear |
| Guichen Huang, Minfeng Zhou, Damin Lu, Jinxiao Li, Qian Tang, Chutong Xiong, Fengxia Liang, Rui Che. The mechanism of ITGB4 in tumor migration and invasion. Frontiers in oncology. vol 14. 2024-08-22. PMID:39169946. |
this review provides a foundational description of the mechanisms by which itgb4 regulates tumor migration and invasion through pathways involving focal adhesion kinase (fak), protein kinase b (akt), and matrix metalloproteinases (mmps). |
2024-08-22 |
2024-08-24 |
Not clear |
| Yanhong Zheng, Yang Yang, Weiyan Zhu, Ruhao Liu, Aodong Liu, Runfeng Zhang, Weixing Lei, Shifeng Huang, Yongzhu Liu, Qinglan H. GSK3B inhibition reduced cervical cancer cell proliferation and migration by modulating the PI3K/Akt signaling pathway and epithelial-to-mesenchymal transition. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 57. 2024-08-21. PMID:39166606. |
transcriptomic sequencing revealed that gsk3b inhibition modulated the phosphatidylinositol 3-carboxykinase (pi3k)/protein kinase b (akt) and extracellular matrix (ecm)-receptor interaction signaling pathways. |
2024-08-21 |
2024-08-24 |
Not clear |
| Yuqin Xu, Zihan He, Zihan Rao, Zihan Li, Yuxin Hu, Zhongwei Zhang, Jianming Zhou, Tong Zhou, Huai Wan. The role of β2-AR/PI3K/AKT pathway in the proliferation, migration and invasion of THLE-2 cells induced by nicotine. Toxicology. 2024-08-15. PMID:39147091. |
besides, it also upregulated the intracellular levels of β2-ar, phosphoinositide 3-kinase (pi3k), akt, matrix metalloproteinase-2 (mmp-2) and cyclin d1, as well as downregulated the expression of p53. |
2024-08-15 |
2024-08-18 |
human |
| Hao-Fei Du, Jia-Min Jiang, Si-Han Wu, Yan-Fang Shi, Hai-Tian Liu, Zheng-Hao Hua, Cai-Sheng Wang, Guo-Ying Qian, Hao-Miao Din. Fucoxanthin Inhibits the Proliferation and Metastasis of Human Pharyngeal Squamous Cell Carcinoma by Regulating the PI3K/Akt/mTOR Signaling Pathway. Molecules (Basel, Switzerland). vol 29. issue 15. 2024-08-10. PMID:39125009. |
further studies indicated that fucoxanthin caused a significant reduction in the expression levels of proteins in the phosphoinositide 3-kinase (pi3k)/protein kinase b (akt)/mechanistic target of rapamycin (mtor) pathway, as well as the downstream proteins matrix metalloproteinase (mmp)-2 and mmp-9. |
2024-08-10 |
2024-08-13 |
human |
| Jiali Chen, Qinghe Zeng, Xu Wang, Rui Xu, Weidong Wang, Yuliang Huang, Qi Sun, Wenhua Yuan, Pinger Wang, Di Chen, Peijian Tong, Hongting Ji. Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signaling. eLife. vol 13. 2024-05-31. PMID:38819423. |
aberrant methylation and expression of tnxb promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via akt signaling. |
2024-05-31 |
2024-06-02 |
mouse |
| Xueping Wu, Jia Liang, Jinfeng Liu, Yijia Huang, Liyun Zhang, Xin Liu, Junhong Guo, Min Zhang, Yudong Chen, Jiantao Wan. Silibinin attenuates TGF-β2-induced fibrogenic changes in human trabecular meshwork cells by targeting JAK2/STAT3 and PI3K/AKT signaling pathways. Experimental eye research. 2024-05-24. PMID:38789021. |
rna sequencing indicated that sil interfered with the phosphoinositide 3-kinase (pi3k) /protein kinase b (pkb, also known as akt) signaling pathway, extracellular matrix (ecm)-receptor interaction, and focal adhesion in the tgf-β2-treated htm cells. |
2024-05-24 |
2024-05-27 |
human |
| Zhaofei Ye, Shuolin Zhu, Guoqi Li, Jie Lu, Shan Huang, Jie Du, Yihui Shao, Zhili Ji, Ping L. Early matrix softening contributes to vascular smooth muscle cell phenotype switching and aortic dissection through down-regulation of microRNA-143/145. Journal of molecular and cellular cardiology. vol 192. 2024-05-12. PMID:38718921. |
to understand this mechanism, we cultured vsmcs in a soft extracellular matrix and discovered that the expression of microrna (mir)-143/145, mediated by activation of the akt signalling pathway, decreased significantly. |
2024-05-12 |
2024-05-27 |
mouse |
| Qian Wang, Guoqiang Shao, Xiaoyi Zhao, Heidi H Wong, Kate Chin, Mackenzie Zhao, Audrey Bai, Michelle S Bloom, Zelda Z Love, Constance R Chu, Zhen Cheng, William H Robinso. Dysregulated fibrinolysis and plasmin activation promote the pathogenesis of osteoarthritis. JCI insight. 2024-03-19. PMID:38502232. |
we showed that upa and upar produced inflammatory and degradative mediators by activating the pi3k, pdk1, akt, and erk signaling cascades, and activates matrix metalloproteinases (pro-mmps) to degrade proteoglycan. |
2024-03-19 |
2024-03-23 |
mouse |
| Cininta Savitri, Sang Su Ha, Jae Won Kwon, Sung Hoon Kim, Young-Min Kim, Hyun Mee Park, Haejin Kwon, Mi Jung Ji, Kwideok Par. Human Fibroblast-Derived Matrix Hydrogel Accelerates Regenerative Wound Remodeling Through the Interactions with Macrophages. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-03-13. PMID:38476050. |
a mechanistic study demonstrated that macrophages-fdm interactions through cell surface integrins α5β1 and α1β1 resulted in significant production of vegf and bfgf, increased akt phosphorylation, and upregulated matrix metalloproteinase-9 activity. |
2024-03-13 |
2024-03-15 |
human |
| Ke Li, Yuzhan Zhang, Weihao Zhao, Rongrong Wang, Yan Li, Linting Wei, Li Wang, Xianghui Chen, Zhao Chen, Pengfei Liu, Na Nie, Xuefei Tian, Rongguo F. DPP8/9 inhibition attenuates the TGF-β1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathway. Toxicology letters. 2024-03-08. PMID:38458339. |
dpp8/9 inhibition attenuates the tgf-β1-induced excessive deposition of extracellular matrix (ecm) in human mesangial cells via smad and akt signaling pathway. |
2024-03-08 |
2024-03-11 |
human |
| Mohammad Arshad Javed Shaikh, Abdulmalik Saleh Alfawaz Altamimi, Muhammad Afzal, Gaurav Gupta, Neelam Singla, Ritu Gilhotra, Waleed Hassan Almalki, Imran Kazmi, Sami I Alzarea, Parteek Prasher, Sachin Kumar Singh, Kamal Du. Unraveling the impact of miR-21 on apoptosis regulation in glioblastoma. Pathology, research and practice. vol 254. 2024-01-23. PMID:38262269. |
the etiology of gbm may involve various cellular and molecular pathways, including egfr, pdcd4, nf-κb, mapk, matrix metalloproteinases, stat, and akt. |
2024-01-23 |
2024-01-26 |
Not clear |
| Takashi Yurube, William J Buchser, Zhongying Zhang, Prashanta Silwal, Michael T Lotze, James D Kang, Gwendolyn A Sowa, Nam V V. Rapamycin mitigates inflammation-mediated disc matrix homeostatic imbalance by inhibiting mTORC1 and inducing autophagy through Akt activation. JOR spine. vol 7. issue 1. 2024-01-15. PMID:38222800. |
rapamycin mitigates inflammation-mediated disc matrix homeostatic imbalance by inhibiting mtorc1 and inducing autophagy through akt activation. |
2024-01-15 |
2024-01-17 |
Not clear |
| Da-He Qi, Hua Ma, Yuan-Yuan Chen, Ke-Xin Wang, Meng-Meng Ding, Yun-Long Hao, Ye Guo, Ling-Bo Kon. [Research progress in mechanism of puerarin in treating vascular dementia]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 22. 2023-12-19. PMID:38114205. |
the pathways of action include activating nuclear factor erythroid 2-related factor 2(nrf2)/antioxidant response element(are), vascular endothelial growth factor(vegf), extracellular regulated protein kinases(erk), phosphatidylinositol-3-kinase(pi3k)/protein kinase b(akt), janus-activating kinase 2(jak2)/signal transducer and activator of transcription 3(stat3), amp-activated protein kinase(ampk), as well as inhibiting the tumor necrosis factor α(tnf-α), transient receptor potential melastatin 2(trpm2)/n-methyl-d-aspartate receptor(nmdar), p38 mitogen-activated protein kinase(p38 mapk), toll-like receptor 4(tlr4)/nuclear factor-kappab(nf-κb), early growth response 1(egr-1), and matrix metalloproteinase 9(mmp-9). |
2023-12-19 |
2023-12-23 |
Not clear |
| Xiangrong Liu, Wenqi Bai, Jianrong Li, Jinfeng Ma, Yan Liu, Zhixiang Wang, Linjie Hu, Zheng Li, Dimitri Papukashvili, Nino Rcheulishvili, Fusheng Wang, Xiaoqing L. MLLT11 siRNA Inhibits the Migration and Promotes the Apoptosis of MDA-MB-231 Breast Cancer Cells. The breast journal. vol 2023. 2023-12-11. PMID:38075552. |
moreover, cell migration and invasion, as well as the protein levels of phosphatidylinositol 3-kinase (pi3k), akt, matrix metalloproteinase (mmp) 2, and mmp9, were significantly lower in the groups treated with sirna while the apoptosis was augmented. |
2023-12-11 |
2023-12-17 |
Not clear |
| Xing He, Dongmei Li, Tianqing Che. Porcine Acellular Dermal Matrix Promotes Migration and Suppresses Inflammation of Keratinocytes by Mediating the AKT Signaling Pathway. Chemical & pharmaceutical bulletin. vol 71. issue 12. 2023-12-03. PMID:38044138. |
porcine acellular dermal matrix promotes migration and suppresses inflammation of keratinocytes by mediating the akt signaling pathway. |
2023-12-03 |
2023-12-10 |
Not clear |
| Hyeryeon Yang, Seongkyeong Bae, Du Hyeon Hwang, Ramachandran Loganathan Mohan Prakash, Jong-Hyun Kim, Il-Hwa Hong, Woo Hyun Kim, Il Rae Rho, Euikyung Kim, Changkeun Kan. Nemopilema nomurai jellyfish venom attenuates phenotypic modulation of PDGF BB-induced vascular smooth muscle cells and κ-carrageenan-induced rat tail thrombosis. Toxicon : official journal of the International Society on Toxinology. 2023-08-25. PMID:37625553. |
nnv inhibits on platelet-derived growth factor (pdgf)-bb-stimulated a7r5 cells migration and proliferation by decreasing matrix metalloproteinase 2 (mmp-2) level and phosphorylation of erk and akt in a dose-dependent manner, but not p38. |
2023-08-25 |
2023-09-07 |
rat |
| Mohamed S Abdel-Bakky, Anas S A Aldakhili, Hussein M Ali, Ali Y Babiker, Ahmad H Alhowail, Salman A A Mohamme. Evaluation of Cisplatin-Induced Acute Renal Failure Amelioration Using Fondaparinux and Alteplase. Pharmaceuticals (Basel, Switzerland). vol 16. issue 7. 2023-07-29. PMID:37513824. |
the fund + cis group showed significantly increased expression levels of platelet count, retinoid x receptor alpha (rxr-α) and phosphorylated akt (p-akt) in addition to decreased levels of urea, blood urea nitrogen (bun), uric acid, white blood cells (wbcs), red blood cells (rbcs), relative kidney body weight, kidney injury score, glucose, prothrombin (pt), a disintegrin and metalloproteinases-10 (adam10), extracellular matrix deposition, protease-activated receptor 2 (par-2), and fibrinogen expression when compared to the cis-only group. |
2023-07-29 |
2023-08-14 |
mouse |
| Xiaohua Zhang, Shan Shan Liu, Jingru Ma, Wei Q. Secretory leukocyte protease inhibitor (SLPI) in cancer pathophysiology: Mechanisms of action and clinical implications. Pathology, research and practice. vol 248. 2023-06-25. PMID:37356220. |
furthermore, slpi interacts intricately with other cancer-promoting factors, including matrix metalloproteinase-2 (mmp-2), mmp-9, the nf-κb and akt pathways, and the p53-upregulated modulator of apoptosis (puma). |
2023-06-25 |
2023-08-14 |
Not clear |
| Jianan Sun, Junjun Mou, Yunmei Zhang, Kang Yuan, Ying Yang, Qing Tan. Matrix metalloproteinase-2 delivery to extracellular vesicles produced by HPV-positive cervical cancer cells enhances metastasis via the Akt pathway. Cell biology international. 2023-06-05. PMID:37272289. |
matrix metalloproteinase-2 delivery to extracellular vesicles produced by hpv-positive cervical cancer cells enhances metastasis via the akt pathway. |
2023-06-05 |
2023-08-14 |
human |