| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marco Paolino, Mariagrazia Rullo, Samuele Maramai, Modesto de Candia, Leonardo Pisani, Marco Catto, Claudia Mugnaini, Antonella Brizzi, Andrea Cappelli, Massimo Olivucci, Federico Corelli, Cosimo D Altomar. Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors. RSC medicinal chemistry. vol 13. issue 7. 2022-08-04. PMID:35923722. |
to this aim, we designed and synthesized a small library of cinnamic acid-inspired isomeric compounds with light modulated activity able to inhibit acetylcholinesterase (ache) and monoamine oxidase b (mao-b), with remarkable selectivity over butyrylcholinesterase (bche) and mao-a, which have been investigated as the enzyme targets related to alzheimer's disease (ad). |
2022-08-04 |
2023-08-14 |
Not clear |
| Selena P Maxwell, Meghan K Cash, Sultan Darves. Neuropathology and cholinesterase expression in the brains of octogenarians and older. Chemico-biological interactions. 2022-07-25. PMID:35872043. |
tissues from age- and sex-matched cnoo and alzheimer's disease (ad) rpfc and hippocampal formation were stained for β-amyloid (aβ), tau, α-synuclein, phosphorylated tar dna-binding protein 43 (ptdp-43), acetylcholinesterase (ache), and butyrylcholinesterase (bche). |
2022-07-25 |
2023-08-14 |
Not clear |
| Sidrah Tariq, Sadaf Mutahir, Muhammad Asim Khan, Zeeshan Mutahir, Safdar Hussain, Muhammad Ashraf, Xiaofang Bao, Baojing Zhou, Christian Bw Stark, Islam Ullah Kha. Synthesis, in vitro cholinesterase inhibition, molecular docking, DFT and ADME studies of novel 1,3,4-oxadiazole 2-thiol derivatives. Chemistry & biodiversity. 2022-06-29. PMID:35767725. |
a sequence of 1,3,4-oxadiazole 2-thiol derivatives bearing various alkyl or aryl moieties was designed, synthesized, and characterized by modern spectroscopic methods to yield 17 compounds ( 6a - 6q ) which were screened for acetylcholinesterase (ache) and butyrylcholinesterase (bche) enzymes in search of 'lead' compounds for the treatment of alzheimer disease (ad). |
2022-06-29 |
2023-08-14 |
Not clear |
| Tess Puopolo, Chang Liu, Hang Ma, Navindra P Seera. Inhibitory Effects of Cannabinoids on Acetylcholinesterase and Butyrylcholinesterase Enzyme Activities. Medical cannabis and cannabinoids. vol 5. issue 1. 2022-06-15. PMID:35702400. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are two cholinergic enzymes catalyzing the reaction of cleaving acetylcholine into acetate and choline at the neuromuscular junction. |
2022-06-15 |
2023-08-14 |
Not clear |
| Ferah Comert Onder, Kader Sahin, Murat Senturk, Serdar Durdagi, Mehmet A. Identifying highly effective coumarin-based novel cholinesterase inhibitors by in silico and in vitro studies. Journal of molecular graphics & modelling. vol 115. 2022-05-27. PMID:35623143. |
inhibition of high cholinesterase levels including acetylcholinesterase (ache) and butyrylcholinesterase (bche), is one of the most important strategies for the treatment of alzheimer's disease (ad). |
2022-05-27 |
2023-08-13 |
Not clear |
| Khadija Boukholda, Brahim Gargouri, Bakhta Aouey, Abdelraheim Attaai, Mohamed Abd Elkodous, Mohamed Najimi, Bernd L Fiebich, Michèle Bouchard, Hamadi Fetou. Subacute silica nanoparticle exposure induced oxidative stress and inflammation in rat hippocampus combined with disruption of cholinergic system and behavioral functions. NanoImpact. vol 24. 2022-05-13. PMID:35559817. |
sinps affected the cholinergic system as reflected by reduced acetylcholinesterase (ache) and butyrylcholinesterase (bche) activity. |
2022-05-13 |
2023-08-13 |
rat |
| b' Mehmet Koca, U\\xc4\\x9fur G\\xc3\\xbcller, P\\xc4\\xb1nar G\\xc3\\xbcller, Ziya Da\\xc4\\x9falan, Bilal Ni\\xc5\\x9fanc\\xc4\\xb. Design and Synthesis of Novel Dual Cholinesterase Inhibitors: In Vitro Inhibition Studies Supported with Molecular Docking. Chemistry & biodiversity. 2022-04-26. PMID:35470963.' |
the major cholinesterase enzymes, acetylcholinesterase (ache) and butyrylcholinesterase (bche), are important in the therapy of alzheimer's disease (ad) based on the cholinergic hypothesis. |
2022-04-26 |
2023-08-13 |
human |
| Hatice Esra Dura. Pyrimidines: Molecular docking and inhibition studies on carbonic anhydrase and cholinesterases. Biotechnology and applied biochemistry. 2022-02-03. PMID:35112394. |
cholinesterases (ches; ache, acetylcholinesterase and bche, butyrylcholinesterase) inhibitors and their benefits of cholinergic replacement in the treatment of ad have been researched and documented by scientists in various ways to date. |
2022-02-03 |
2023-08-13 |
human |
| Ankit Ganeshpurkar, Ravi Singh, Devendra Kumar, Pravin Gore, Shalini Shivhare, Divya Sardana, Swetha Rayala, Ashok Kumar, Sushil Kumar Sing. Identification of sulfonamide based butyrylcholinesterase inhibitors through scaffold hopping approach. International journal of biological macromolecules. 2022-01-29. PMID:35090939. |
butyrylcholinesterase (bche), a hydrolytic enzyme, is responsible for the termination of the action of acetylcholine besides acetylcholinesterase (ache) in the synaptic cleft of the brain. |
2022-01-29 |
2023-08-13 |
Not clear |
| Shuaizhang Li, Andrew J Li, Jameson Travers, Tuan Xu, Srilatha Sakamuru, Carleen Klumpp-Thomas, Ruili Huang, Menghang Xi. Identification of Compounds for Butyrylcholinesterase Inhibition. SLAS discovery : advancing life sciences R & D. vol 26. issue 10. 2021-12-04. PMID:34269114. |
bche plays a critical role in maintaining normal cholinergic function like acetylcholinesterase (ache) through hydrolyzing acetylcholine (ach). |
2021-12-04 |
2023-08-13 |
Not clear |
| b' Milena Mlaki\\xc4\\x87, Tena \\xc4\\x8cade\\xc5\\xbe, Danijela Bari\\xc4\\x87, Ivana Pu\\xc4\\x8dek, Ana Ratkovi\\xc4\\x87, \\xc5\\xbdeljko Marini\\xc4\\x87, Kornelija Lasi\\xc4\\x87, Zrinka Kovarik, Irena \\xc5\\xa0kori\\xc4\\x8. New Uncharged 2-Thienostilbene Oximes as Reactivators of Organophosphate-Inhibited Cholinesterases. Pharmaceuticals (Basel, Switzerland). vol 14. issue 11. 2021-11-30. PMID:34832929.' |
the inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche) by organophosphates (ops) as nerve agents and pesticides compromises normal cholinergic nerve signal transduction in the peripheral and central nervous systems (cns) leading to cholinergic crisis. |
2021-11-30 |
2023-08-13 |
Not clear |
| Muhammad Shahid Nadeem, Jalaluddin Azam Khan, Umer Rashi. Fluoxetine and sertraline based multitarget inhibitors of cholinesterases and monoamine oxidase-A/B for the treatment of Alzheimer's disease: Synthesis, pharmacology and molecular modeling studies. International journal of biological macromolecules. vol 193. issue Pt A. 2021-11-24. PMID:34687762. |
for the potential therapy of alzheimer's disease (ad), cholinesterases (che) and monoamine oxidase (mao) are key enzymes that regulate the level of acetylcholinesterase (ache)/butyrylcholinesterase (bche) and monoamines. |
2021-11-24 |
2023-08-13 |
mouse |
| Jason M Kinchen, Robert P Mohney, Kirk L Pappa. Long-Chain Acylcholines Link Butyrylcholinesterase to Regulation of Non-neuronal Cholinergic Signaling. Journal of proteome research. 2021-11-11. PMID:34758617. |
acylcholines are metabolized by a class of cholinesterases, including acetylcholinesterase (a specific regulator of acetylcholine levels) and butyrylcholinesterase (bche, an enigmatic enzyme whose function has not been resolved by genetic knockout models). |
2021-11-11 |
2023-08-13 |
Not clear |
| Jason M Kinchen, Robert P Mohney, Kirk L Pappa. Long-Chain Acylcholines Link Butyrylcholinesterase to Regulation of Non-neuronal Cholinergic Signaling. Journal of proteome research. 2021-11-11. PMID:34758617. |
bche provides reserve capacity to hydrolyze acetylcholine, but its importance is arguable given acetylcholinesterase is the most catalytically efficient enzyme characterized to date. |
2021-11-11 |
2023-08-13 |
Not clear |
| Rahim Ullah, Gowhar Ali, Fazal Subhan, Ajmal Khan, Sobia Ahsan Halim, Muhammad Naveed, Saima Kalsoom, Ahmed Al-Harras. Attenuation of spatial memory in 5xFAD mice by targeting cholinesterases, oxidative stress and inflammatory signaling using 2-(hydroxyl-(2-nitrophenyl)methyl)cyclopentanone. International immunopharmacology. vol 100. 2021-10-27. PMID:34478946. |
hippocampus (hc) and frontal cortex (fc) homogenates were examined for acetylcholinesterase (ache) and butyrylcholinesterase (bche) activities, 1,1-diphenyl-2-picrylhydrazyl (dpph) free radicals, glutathione s-transferase (gst), glutathione (gsh), and catalase. |
2021-10-27 |
2023-08-13 |
mouse |
| Noopur Khare, Sanjiv Kumar Maheshwari, Abhimanyu Kumar Jh. Screening and identification of secondary metabolites in the bark of Journal of biomolecular structure & dynamics. vol 39. issue 16. 2021-10-21. PMID:32720564. |
screening and identification of secondary metabolites in the bark of acetylcholinesterase (ache) and butyrylcholinesterase (bche) acts as a promising protein targets for which drug as an inhibitor can be designed to treat alzheimer's disease. |
2021-10-21 |
2023-08-13 |
Not clear |
| Saravanan Kandasamy, Chitra Loganathan, Penislusshiyan Sakayanathan, Subramani Karthikeyan, Arputharaj David Stephen, Dinesh Kumar Marimuthu, Saravanan Ravichandran, Vignesh Sivalingam, Palvannan Thayumanava. In silico, theoretical biointerface analysis and in vitro kinetic analysis of amine compounds interaction with acetylcholinesterase and butyrylcholinesterase. International journal of biological macromolecules. vol 185. 2021-08-16. PMID:34216669. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are considered important target for drug design against alzheimer's disease. |
2021-08-16 |
2023-08-13 |
Not clear |
| Suleyman Akocak, Parham Taslimi, Nebih Lolak, Mesut Işık, Mustafa Durgun, Yakup Budak, Cüneyt Türkeş, İlhami Gülçin, Şükrü Beydemi. Synthesis, Characterization, and Inhibition Study of Novel Substituted Phenylureido Sulfaguanidine Derivatives as α-Glycosidase and Cholinesterase Inhibitors. Chemistry & biodiversity. vol 18. issue 4. 2021-07-26. PMID:33620128. |
in vitro and in silico inhibitory effects of the novel ureido-substituted sulfaguanidine derivatives were investigated by spectrophotometric methods for α-glycosidase (α-gly), acetylcholinesterase (ache), and butyrylcholinesterase (bche) enzymes associated with diabetes mellitus (dm) and alzheimer's disease (ad). |
2021-07-26 |
2023-08-13 |
Not clear |
| Stephen A Adefegha, Bathlomew M Okeke, Ganiyu Obo. Antioxidant properties of eugenol, butylated hydroxylanisole, and butylated hydroxyl toluene with key biomolecules relevant to Alzheimer's diseases-In vitro. Journal of food biochemistry. vol 45. issue 3. 2021-07-08. PMID:32458455. |
this research work examined and likened effect of eugenol a natural phenolic compound with butylated hydroxylanisole (bha) and butylated hydroxyl toluene (bht) synthetic phenolic compounds with key biomolecules [acetylcholinesterase (ache), butyrylcholinesterase (bche), and monoamine oxidase (mao)] relevant to alzheimer's diseases (ad) in vitro. |
2021-07-08 |
2023-08-13 |
Not clear |
| Zhipeng Yu, Huizhuo Ji, Juntong Shen, Ruotong Kan, Wenzhu Zhao, Jianrong Li, Long Ding, Jingbo Li. Identification and molecular docking study of fish roe-derived peptides as potent BACE 1, AChE, and BChE inhibitors. Food & function. vol 11. issue 7. 2021-06-03. PMID:32656560. |
acetylcholinesterase (ache), butyrylcholinesterase (bche), and beta-secretase 1 (bace 1) play vital roles in the development and progression of alzheimer's disease (ad). |
2021-06-03 |
2023-08-13 |
Not clear |