| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana Matošević, Dejan M Opsenica, Marta Spasić, Nikola Maraković, Antonio Zandona, Suzana Žunec, Marija Bartolić, Zrinka Kovarik, Anita Bosa. Evaluation of 4-aminoquinoline derivatives with an n-octylamino spacer as potential multi-targeting ligands for the treatment of Alzheimer's disease. Chemico-biological interactions. 2023-07-05. PMID:37406982. |
the most successful therapeutic strategy in the treatment of alzheimer's disease (ad) is directed toward increasing levels of the neurotransmitter acetylcholine (ach) by inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche), the enzymes responsible for its hydrolysis. |
2023-07-05 |
2023-08-14 |
human |
| Jonathan Godinez, Catherine Y Lee, Jason P Schwan. Synthesis and Evaluation of Fmoc-Amino Esters and Amides Bearing a Substrate Like Quaternary Ammonium Group as Selective Butyrylcholinesterase Inhibitors. Bioorganic & medicinal chemistry letters. 2023-06-26. PMID:37364726. |
for the two major cholinesterases, butyrylcholinesterase (bche) and acetylcholinesterase (ache), increased bche activity observed in individuals with ad has been suggested to deplete acetylcholine levels. |
2023-06-26 |
2023-08-14 |
Not clear |
| Muslum Gok, Cigdem Cicek, Ebru Bodu. Butyrylcholinesterase in lipid metabolism: A new outlook. Journal of neurochemistry. 2023-05-02. PMID:37129444. |
cholinesterase enzymes acetylcholinesterase (ache) and butyrylcholinesterase (bche) are traditionally associated with the termination of acetylcholine mediated neural signaling. |
2023-05-02 |
2023-08-14 |
Not clear |
| Hina Rehman, Waqar Ali, Mohammad Ali, Nadir Zaman Khan, Muhammad Aasim, Ayaz Ali Khan, Tariq Khan, Muhammad Ali, Ashaq Ali, Muhammad Ayaz, Muzamil Shah, Syed Salman Hashm. Delpinium uncinatum mediated green synthesis of AgNPs and its antioxidant, enzyme inhibitory, cytotoxic and antimicrobial potentials. PloS one. vol 18. issue 4. 2023-04-04. PMID:37014921. |
the agnps exhibited efficient antioxidant activities and considerable enzyme inhibition potential against alpha amylase, acetylcholinesterase (ache) and butyrylcholinesterase (bche) enzymes. |
2023-04-04 |
2023-08-14 |
human |
| Tuan Xu, Shuaizhang Li, Andrew J Li, Jinghua Zhao, Srilatha Sakamuru, Wenwei Huang, Menghang Xia, Ruili Huan. Identification of Potent and Selective Acetylcholinesterase/Butyrylcholinesterase Inhibitors by Virtual Screening. Journal of chemical information and modeling. 2023-04-03. PMID:37011147. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) play important roles in human neurodegenerative disorders such as alzheimer's disease. |
2023-04-03 |
2023-08-14 |
human |
| Ignazio Schino, Mariangela Cantore, Modesto de Candia, Cosimo D Altomare, Catarina Maria, João Barros, Vasco Cachatra, Patrícia Calado, Karina Shimizu, Adilson A Freitas, Maria C Oliveira, Maria J Ferreira, José N C Lopes, Nicola A Colabufo, Amélia P Raute. Exploring Mannosylpurines as Copper Chelators and Cholinesterase Inhibitors with Potential for Alzheimer's Disease. Pharmaceuticals (Basel, Switzerland). vol 16. issue 1. 2023-01-21. PMID:36678552. |
alzheimer's disease (ad) is characterized by a progressive cholinergic neurotransmission imbalance, with a decrease of acetylcholinesterase (ache) activity followed by a significant increase of butyrylcholinesterase (bche) in the later ad stages. |
2023-01-21 |
2023-08-14 |
Not clear |
| Ashraf K El-Damasy, Jong Eun Park, Hyun Ji Kim, Jinhyuk Lee, Eun-Kyoung Bang, Hoon Kim, Gyochang Keu. Identification of New Pharmaceuticals (Basel, Switzerland). vol 16. issue 1. 2023-01-21. PMID:36678580. |
identification of new monoamine oxidase-b (mao-b), acetylcholinesterase (ache), and butyrylcholinesterase (bche) have been considered target enzymes of depression and neurodegenerative diseases, including alzheimer's disease (ad). |
2023-01-21 |
2023-08-14 |
Not clear |
| Melvin Selim Atay, Suat Sari, Ebru Bodu. Molecular and Computational Analysis Identify Statins as Selective Inhibitors of Human Butyrylcholinesterase. The protein journal. 2023-01-17. PMID:36648628. |
cholinesterase enzyme family consists of acetylcholinesterase (ache, 3.1.1.7), the major enzyme responsible for hydrolysis of acetylcholine at cholinergic synapses, and butyrylcholinesterase (bche, 3.1.1.8) a detoxification enzyme of plasma. |
2023-01-17 |
2023-08-14 |
human |
| Asma Gholami, Dariush Minai-Tehrani, Leif A Eriksso. In silico and in vitro studies confirm Ondansetron as a novel acetylcholinesterase and butyrylcholinesterase inhibitor. Scientific reports. vol 13. issue 1. 2023-01-12. PMID:36635365. |
studies show that a lack of acetylcholine and butyrylcholine due to the overexpression of enzymes acetylcholinesterase (ache) and butyrylcholinesterase (bche) may lead to reduced communication between neuron cells. |
2023-01-12 |
2023-08-14 |
Not clear |
| Esra Palabıyık, Ayşe Nurseli Sulumer, Handan Uguz, Bahri Avcı, Seda Askın, Hakan Askın, Yeliz Demi. Assessment of hypolipidemic and anti-inflammatory properties of Walnut (Juglans regia) Seed Coat Extract and Modulates Some Metabolic Enzymes Activity In Triton WR-1339-Induced Hyperlipidemia In Rat Kidney, Liver and Heart. Journal of molecular recognition : JMR. 2022-12-20. PMID:36537558. |
hence, the purpose of this study was to investigate the possible amendatory impact of ethanol extract walnut (juglans regia) seed coat (e-wsc) on some metabolic enzymes (glutathione reductase (gr), paraoxonase-1 (pon1), aldose reductase (ar), sorbitol dehydrogenase (sdh), acetylcholinesterase (ache), glutathione s-transferase (gst) and butyrylcholinesterase (bche)) activity in the liver, kidney and heart of rats with triton wr-1339-induced hyperlipidemia. |
2022-12-20 |
2023-08-14 |
rat |
| Itam Ako Hogan, Yu-Cheng Kuo, Asmau N Abubakar, Bashir Lawal, Abdulhakeem R Agboola, Halimat Yusuf Lukman, Sunday Amos Onikanni, Femi Olawale, Adewale Oluwaseun Fadaka, Yunusa O Ibrahim, Shukurat B Babalola, Gaber El-Saber Batiha, Sarah M Albogami, Mohammed Alorabi, Michel De Waard, Hsu-Shan Huan. Attenuation of hyperglycemia-associated dyslipidemic, oxidative, cognitive, and inflammatory crises via modulation of neuronal ChEs/NF-κB/COX-2/NOx, and hepatorenal functional deficits by the Tridax procumbens extract. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 158. 2022-12-16. PMID:36525818. |
the tpme also improved the antioxidant status as evidenced by increased superoxide dismutase (sod), catalase (cat), glutathione (gsh), and decreased malondialdehyde (mda); and decreased levels of cholinesterases (acetylcholinesterase (ache) and butyrylcholinesterase (bche)), and proinflammatory mediators including nuclear factor (nf)-κb, cyclooxygenase (cox)- 2, and nitrogen oxide (nox) in the brain of rats with stz-induced diabetes compared to rats with stz-induced diabetes that received distilled water. |
2022-12-16 |
2023-08-14 |
rat |
| Saritha S L Silva, Luciane V Tureck, Leonardo C Souza, João V M Hortega, Ana Luiza Piumbini, Mayza D Teixeira, Lupe Furtado-Alle Writing-Reviewing, Maria A B F Vital, Ricardo L R Souz. Animal model of Alzheimer's disease induced by streptozotocin: new insights about cholinergic pathway. Brain research. 2022-11-27. PMID:36436686. |
disorders of the cholinergic system are well known to be involved in the pathogenesis of ad, characterized by increased acetylcholinesterase (ache) and butyrylcholinesterase (bche) and decreased acetyltransferase (chat) enzymatic activities. |
2022-11-27 |
2023-08-14 |
human |
| Ana Matošević, Anamarija Knežević, Antonio Zandona, Nikola Maraković, Zrinka Kovarik, Anita Bosa. Design, Synthesis and Biological Evaluation of Biscarbamates as Potential Selective Butyrylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease. Pharmaceuticals (Basel, Switzerland). vol 15. issue 10. 2022-10-27. PMID:36297332. |
as butyrylcholinesterase (bche) plays a role in the progression of symptoms and pathophysiology of alzheimer's disease (ad), selective inhibition of bche over acetylcholinesterase (ache) can represent a promising pathway in treating ad. |
2022-10-27 |
2023-08-14 |
Not clear |
| Ilkay Erdogan Orhan, F Sezer Senol Deniz, Ramin Ekhteiari Salmas, Sule Irmak, Ozden Ozgun Acar, Gurbet Celik Turgut, Alaattin Sen, Ana-Maria Zbancioc, Simon Vlad Luca, Adrianna Skiba, Krystyna Skalicka Wozniak, Gabriela Tataring. Evaluation of anti-Alzheimer activity of synthetic coumarins by combination of in vitro and in silico approaches. Chemistry & biodiversity. 2022-10-25. PMID:36282001. |
series of synthetic coumarin derivatives (1-16) were tested against acetylcholinesterase (ache) and butyrylcholinesterase (bche), two enzymes linked to the pathology of alzheimer's disease (ad). |
2022-10-25 |
2023-08-14 |
human |
| Muslum Gok, Cigdem Cicek, Suat Sari, Ebru Bodu. Novel activity of human BChE: Lipid hydrolysis. Biochimie. 2022-09-20. PMID:36126749. |
acetylcholinesterase and butyrylcholinesterase (bche) typically hydrolyze the neurotransmitter acetylcholine. |
2022-09-20 |
2023-08-14 |
human |
| Muslum Gok, Nimrod Madrer, Tamara Zorbaz, Estelle R Bennett, David Greenberg, David A Bennett, Hermona Sore. Altered levels of variant cholinesterase transcripts contribute to the imbalanced cholinergic signaling in Alzheimer's and Parkinson's disease. Frontiers in molecular neuroscience. vol 15. 2022-09-19. PMID:36117917. |
acetylcholinesterase and butyrylcholinesterase (ache and bche) are involved in modulating cholinergic signaling, but their roles in alzheimer's and parkinson's diseases (ad and pd) remain unclear. |
2022-09-19 |
2023-08-14 |
Not clear |
| Hafiz Muhammad Abdullah Asif, Shagufta Kamal, Aziz-Ur Rehman, Shahid Rasool, Muhammad Sajid Hamid Akas. Synthesis, Characterization, and Enzyme Inhibition Properties of 1,2,4-Triazole Bearing Azinane Analogues. ACS omega. vol 7. issue 36. 2022-09-19. PMID:36119993. |
considering the importance of acetylcholine esterase (ache, bche) and α-glucosidase in the treatment of alzheimer's disease and diabetes mellitus, the synthesis of novel azinane triazole-based derivatives as effective acetylcholinesterase (ache), α-glucosidase, urease, lipoxygenase (lox), and butyrylcholinesterase (bche) inhibitors is described. |
2022-09-19 |
2023-08-14 |
Not clear |
| Philipp Spatz, Thomas Zimmermann, Sophie Steinmüller, Julian Hofmann, Tangui Maurice, Michael Decke. Novel benzimidazole-based pseudo-irreversible butyrylcholinesterase inhibitors with neuroprotective activity in an Alzheimer's disease mouse model. RSC medicinal chemistry. vol 13. issue 8. 2022-09-12. PMID:36092149. |
as levels of acetylcholinesterase (ache) decrease while levels of butyrylcholinesterase (bche) increase in later stages of alzheimer's disease (ad), bche stands out as a promising target for treatment of ad. |
2022-09-12 |
2023-08-14 |
mouse |
| H F Seabra, A C Campello, E F G Chagas, L P A Martins, R B Suzuki, M O Ruiz, E A Donadi, W Baleot. The role of cholinesterases in chagas disease. Parasitology international. 2022-08-27. PMID:36029960. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) hydrolyze acetylcholine (ach) in neural synaptic clefts and are primarily found in erythrocytes and blood plasma, respectively. |
2022-08-27 |
2023-08-14 |
Not clear |
| Irene Gouvinhas, Juliana Garcia, Daniel Granato, Ana Barro. Seed Phytochemical Profiling of Three Olive Cultivars, Antioxidant Capacity, Enzymatic Inhibition, and Effects on Human Neuroblastoma Cells (SH-SY5Y). Molecules (Basel, Switzerland). vol 27. issue 16. 2022-08-26. PMID:36014295. |
in addition, it also appraised their potential antineurodegenerative properties on the basis of their ability to inhibit enzymes associated with neurodegenerative diseases: acetylcholinesterase (ache), butyrylcholinesterase (bche), and tyrosinase (tyr). |
2022-08-26 |
2023-08-14 |
human |