All Relations between acetylcholinesterase and bche

Publication Sentence Publish Date Extraction Date Species
Varish Ahmad, Ibrahim Alotibi, Anwar A Alghamdi, Aftab Ahmad, Qazi Mohammad Sajid Jamal, Supriya Srivastav. Computational Approaches to Evaluate the Acetylcholinesterase Binding Interaction with Taxifolin for the Management of Alzheimer's Disease. Molecules (Basel, Switzerland). vol 29. issue 3. 2024-02-10. PMID:38338420. acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that break down and reduce the level of the neurotransmitter acetylcholine (ach). 2024-02-10 2024-02-12 Not clear
b' Suzana \\xc5\\xbdunec, Donna Vadlja, Alma Rami\\xc4\\x87, Antonio Zandona, Nikola Marakovi\\xc4\\x87, Iva Brekalo, Ines Primo\\xc5\\xbei\\xc4\\x8d, Maja Katalini\\xc4\\x8. Profiling Novel Quinuclidine-Based Derivatives as Potential Anticholinesterase Drugs: Enzyme Inhibition and Effects on Cell Viability. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203326.' the enzymes acetylcholinesterase, ache, and butyrylcholinesterase, bche, responsible for hydrolyzing ach, can fine-tune the cholinergic system's activity and are, therefore, excellent pharmacological targets to address a range of medical conditions. 2024-01-11 2024-01-13 Not clear
Géssica Oliveira Mendes, Moysés Fagundes de Araújo Neto, Deyse Brito Barbosa, Mayra Ramos do Bomfim, Lorena Silva Matos Andrade, Paulo Batista de Carvalho, Tiago Alves de Oliveira, Daniel Luciano Falkoski, Eduardo Habib Bechelane Maia, Marcelo Siqueira Valle, Laila Cristina Moreira Damázio, Alisson Marques da Silva, Alex Gutterres Taranto, Franco Henrique Andrade Leit. Identification of Potential Multitarget Compounds against Alzheimer's Disease through Pharmacophore-Based Virtual Screening. Pharmaceuticals (Basel, Switzerland). vol 16. issue 12. 2023-12-23. PMID:38139772. this study aims to present new multipurpose compounds capable of simultaneously inhibiting acetylcholinesterase (ache), butyrylcholinesterase (bche)-responsible for recycling acetylcholine in the synaptic cleft-and beta-secretase 1 (bace-1)-responsible for the generation of amyloid-β plaques. 2023-12-23 2023-12-25 Not clear
Saira Naseem, Samra Khan, Safdar Hussain, Muhammad Usman Mirza, Muhammad Ashraf, Zahid Shafiq, John F Tran. Synthesis, biological evaluation, and molecular docking study of xanthene-linked thiosemicarbazones as cholinesterase inhibitors. Journal of biomolecular structure & dynamics. 2023-11-10. PMID:37948312. this study delineates the design and synthesis of a series of xanthene-based thiosemicarbazones that show low μm inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche), crucial enzymes associated with, among others, alzheimer's disease (ad) pathology. 2023-11-10 2023-11-20 Not clear
Maha Aljabri, Khadiga Alharbi, Mona Alonaz. Saudi journal of biological sciences. vol 30. issue 10. 2023-10-09. PMID:37811479. a significant approach to mitigate cognitive dysfunction involves the inhibition of cholinesterases, namely acetylcholinesterase (ache) and butyrylcholinesterase (bche). 2023-10-09 2023-10-15 Not clear
Javier Avendaño-Godoy, Arnoldo Miranda, Sigrid Mennickent, Carolina Gómez-Gaet. Intramuscularly Administered PLGA Microparticles for Sustained Release of Rivastigmine: In Vitro, In Vivo and Histological Evaluation. Journal of pharmaceutical sciences. 2023-08-26. PMID:37595752. rivastigmine is an acetylcholinesterase (ache) and butyrylcholinesterase (bche) inhibitor drug approved by the us food and drug administration (fda) for the treatment of mild to moderate dementia of alzheimer's type. 2023-08-26 2023-09-07 rat
Dane Sands, Andrew Davis, Scott Banfield, Ian R Pottie, Sultan Darves. Solvents and detergents compatible with enzyme kinetic studies of cholinesterases. Chemico-biological interactions. 2023-08-14. PMID:37579937. acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that serve a wide range of physiological functions including the hydrolysis of the neurotransmitter acetylcholine and several other xenobiotics. 2023-08-14 2023-09-07 Not clear
Ana Matošević, Dejan M Opsenica, Marta Spasić, Nikola Maraković, Antonio Zandona, Suzana Žunec, Marija Bartolić, Zrinka Kovarik, Anita Bosa. Evaluation of 4-aminoquinoline derivatives with an n-octylamino spacer as potential multi-targeting ligands for the treatment of Alzheimer's disease. Chemico-biological interactions. 2023-07-05. PMID:37406982. the most successful therapeutic strategy in the treatment of alzheimer's disease (ad) is directed toward increasing levels of the neurotransmitter acetylcholine (ach) by inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche), the enzymes responsible for its hydrolysis. 2023-07-05 2023-08-14 human
Jonathan Godinez, Catherine Y Lee, Jason P Schwan. Synthesis and Evaluation of Fmoc-Amino Esters and Amides Bearing a Substrate Like Quaternary Ammonium Group as Selective Butyrylcholinesterase Inhibitors. Bioorganic & medicinal chemistry letters. 2023-06-26. PMID:37364726. for the two major cholinesterases, butyrylcholinesterase (bche) and acetylcholinesterase (ache), increased bche activity observed in individuals with ad has been suggested to deplete acetylcholine levels. 2023-06-26 2023-08-14 Not clear
Muslum Gok, Cigdem Cicek, Ebru Bodu. Butyrylcholinesterase in lipid metabolism: A new outlook. Journal of neurochemistry. 2023-05-02. PMID:37129444. cholinesterase enzymes acetylcholinesterase (ache) and butyrylcholinesterase (bche) are traditionally associated with the termination of acetylcholine mediated neural signaling. 2023-05-02 2023-08-14 Not clear
Hina Rehman, Waqar Ali, Mohammad Ali, Nadir Zaman Khan, Muhammad Aasim, Ayaz Ali Khan, Tariq Khan, Muhammad Ali, Ashaq Ali, Muhammad Ayaz, Muzamil Shah, Syed Salman Hashm. Delpinium uncinatum mediated green synthesis of AgNPs and its antioxidant, enzyme inhibitory, cytotoxic and antimicrobial potentials. PloS one. vol 18. issue 4. 2023-04-04. PMID:37014921. the agnps exhibited efficient antioxidant activities and considerable enzyme inhibition potential against alpha amylase, acetylcholinesterase (ache) and butyrylcholinesterase (bche) enzymes. 2023-04-04 2023-08-14 human
Tuan Xu, Shuaizhang Li, Andrew J Li, Jinghua Zhao, Srilatha Sakamuru, Wenwei Huang, Menghang Xia, Ruili Huan. Identification of Potent and Selective Acetylcholinesterase/Butyrylcholinesterase Inhibitors by Virtual Screening. Journal of chemical information and modeling. 2023-04-03. PMID:37011147. acetylcholinesterase (ache) and butyrylcholinesterase (bche) play important roles in human neurodegenerative disorders such as alzheimer's disease. 2023-04-03 2023-08-14 human
Ignazio Schino, Mariangela Cantore, Modesto de Candia, Cosimo D Altomare, Catarina Maria, João Barros, Vasco Cachatra, Patrícia Calado, Karina Shimizu, Adilson A Freitas, Maria C Oliveira, Maria J Ferreira, José N C Lopes, Nicola A Colabufo, Amélia P Raute. Exploring Mannosylpurines as Copper Chelators and Cholinesterase Inhibitors with Potential for Alzheimer's Disease. Pharmaceuticals (Basel, Switzerland). vol 16. issue 1. 2023-01-21. PMID:36678552. alzheimer's disease (ad) is characterized by a progressive cholinergic neurotransmission imbalance, with a decrease of acetylcholinesterase (ache) activity followed by a significant increase of butyrylcholinesterase (bche) in the later ad stages. 2023-01-21 2023-08-14 Not clear
Ashraf K El-Damasy, Jong Eun Park, Hyun Ji Kim, Jinhyuk Lee, Eun-Kyoung Bang, Hoon Kim, Gyochang Keu. Identification of New Pharmaceuticals (Basel, Switzerland). vol 16. issue 1. 2023-01-21. PMID:36678580. identification of new monoamine oxidase-b (mao-b), acetylcholinesterase (ache), and butyrylcholinesterase (bche) have been considered target enzymes of depression and neurodegenerative diseases, including alzheimer's disease (ad). 2023-01-21 2023-08-14 Not clear
Melvin Selim Atay, Suat Sari, Ebru Bodu. Molecular and Computational Analysis Identify Statins as Selective Inhibitors of Human Butyrylcholinesterase. The protein journal. 2023-01-17. PMID:36648628. cholinesterase enzyme family consists of acetylcholinesterase (ache, 3.1.1.7), the major enzyme responsible for hydrolysis of acetylcholine at cholinergic synapses, and butyrylcholinesterase (bche, 3.1.1.8) a detoxification enzyme of plasma. 2023-01-17 2023-08-14 human
Asma Gholami, Dariush Minai-Tehrani, Leif A Eriksso. In silico and in vitro studies confirm Ondansetron as a novel acetylcholinesterase and butyrylcholinesterase inhibitor. Scientific reports. vol 13. issue 1. 2023-01-12. PMID:36635365. studies show that a lack of acetylcholine and butyrylcholine due to the overexpression of enzymes acetylcholinesterase (ache) and butyrylcholinesterase (bche) may lead to reduced communication between neuron cells. 2023-01-12 2023-08-14 Not clear
Esra Palabıyık, Ayşe Nurseli Sulumer, Handan Uguz, Bahri Avcı, Seda Askın, Hakan Askın, Yeliz Demi. Assessment of hypolipidemic and anti-inflammatory properties of Walnut (Juglans regia) Seed Coat Extract and Modulates Some Metabolic Enzymes Activity In Triton WR-1339-Induced Hyperlipidemia In Rat Kidney, Liver and Heart. Journal of molecular recognition : JMR. 2022-12-20. PMID:36537558. hence, the purpose of this study was to investigate the possible amendatory impact of ethanol extract walnut (juglans regia) seed coat (e-wsc) on some metabolic enzymes (glutathione reductase (gr), paraoxonase-1 (pon1), aldose reductase (ar), sorbitol dehydrogenase (sdh), acetylcholinesterase (ache), glutathione s-transferase (gst) and butyrylcholinesterase (bche)) activity in the liver, kidney and heart of rats with triton wr-1339-induced hyperlipidemia. 2022-12-20 2023-08-14 rat
Itam Ako Hogan, Yu-Cheng Kuo, Asmau N Abubakar, Bashir Lawal, Abdulhakeem R Agboola, Halimat Yusuf Lukman, Sunday Amos Onikanni, Femi Olawale, Adewale Oluwaseun Fadaka, Yunusa O Ibrahim, Shukurat B Babalola, Gaber El-Saber Batiha, Sarah M Albogami, Mohammed Alorabi, Michel De Waard, Hsu-Shan Huan. Attenuation of hyperglycemia-associated dyslipidemic, oxidative, cognitive, and inflammatory crises via modulation of neuronal ChEs/NF-κB/COX-2/NOx, and hepatorenal functional deficits by the Tridax procumbens extract. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 158. 2022-12-16. PMID:36525818. the tpme also improved the antioxidant status as evidenced by increased superoxide dismutase (sod), catalase (cat), glutathione (gsh), and decreased malondialdehyde (mda); and decreased levels of cholinesterases (acetylcholinesterase (ache) and butyrylcholinesterase (bche)), and proinflammatory mediators including nuclear factor (nf)-κb, cyclooxygenase (cox)- 2, and nitrogen oxide (nox) in the brain of rats with stz-induced diabetes compared to rats with stz-induced diabetes that received distilled water. 2022-12-16 2023-08-14 rat
Saritha S L Silva, Luciane V Tureck, Leonardo C Souza, João V M Hortega, Ana Luiza Piumbini, Mayza D Teixeira, Lupe Furtado-Alle Writing-Reviewing, Maria A B F Vital, Ricardo L R Souz. Animal model of Alzheimer's disease induced by streptozotocin: new insights about cholinergic pathway. Brain research. 2022-11-27. PMID:36436686. disorders of the cholinergic system are well known to be involved in the pathogenesis of ad, characterized by increased acetylcholinesterase (ache) and butyrylcholinesterase (bche) and decreased acetyltransferase (chat) enzymatic activities. 2022-11-27 2023-08-14 human
Ana Matošević, Anamarija Knežević, Antonio Zandona, Nikola Maraković, Zrinka Kovarik, Anita Bosa. Design, Synthesis and Biological Evaluation of Biscarbamates as Potential Selective Butyrylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease. Pharmaceuticals (Basel, Switzerland). vol 15. issue 10. 2022-10-27. PMID:36297332. as butyrylcholinesterase (bche) plays a role in the progression of symptoms and pathophysiology of alzheimer's disease (ad), selective inhibition of bche over acetylcholinesterase (ache) can represent a promising pathway in treating ad. 2022-10-27 2023-08-14 Not clear