| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana Beatriz Dos Santos, Jaciana Souza Dos Anjos, Giany Gabriely Padão Dos Santos, Maria Vitória Takemura Mariano, Luana Paganotto Leandro, Marcelo Farina, Jeferson Luis Franco, Karen Kich Gomes, Thais Posse. Developmental iron exposure induces locomotor alterations in Drosophila: Exploring potential association with oxidative stress. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2024-02-19. PMID:38373512. |
although chronic fe exposure did not alter acetylcholinesterase (ache) activity, flies exhibited reduced locomotion, increased grooming, and antisocial behavior from 5 mm of fe. |
2024-02-19 |
2024-02-22 |
drosophila_melanogaster |
| Inn Lee, Tuzz-Ying Song, Chien-Lin Chen, Jiann-Jou Yang, Nae-Cherng Yan. Parapyruvate Induces Neurodegeneration in C57BL/6JNarl Mice via Inhibition of the α-Ketoglutarate Dehydrogenase Complex. ACS omega. vol 9. issue 5. 2024-02-13. PMID:38343944. |
the results demonstrated that parapyruvate significantly impaired the learning and memory ability, decreased the kgdhc activity, and promoted the oxidative stress and acetylcholinesterase (ache) activity in mice in a dose-dependent manner. |
2024-02-13 |
2024-02-15 |
mouse |
| Varish Ahmad, Ibrahim Alotibi, Anwar A Alghamdi, Aftab Ahmad, Qazi Mohammad Sajid Jamal, Supriya Srivastav. Computational Approaches to Evaluate the Acetylcholinesterase Binding Interaction with Taxifolin for the Management of Alzheimer's Disease. Molecules (Basel, Switzerland). vol 29. issue 3. 2024-02-10. PMID:38338420. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that break down and reduce the level of the neurotransmitter acetylcholine (ach). |
2024-02-10 |
2024-02-12 |
Not clear |
| F Javier Luque, Diego Muñoz-Torrer. Acetylcholinesterase: A Versatile Template to Coin Potent Modulators of Multiple Therapeutic Targets. Accounts of chemical research. 2024-02-09. PMID:38333993. |
conspectusthe enzyme acetylcholinesterase (ache) hydrolyzes the neurotransmitter acetylcholine (ach) at cholinergic synapses of the peripheral and central nervous system. |
2024-02-09 |
2024-02-11 |
human |
| Yi-Long Lu, Jing Su, Jian-Wei Li, Wen-Rong X. A molecular container providing supramolecular protection against acetylcholine hydrolysis. Organic & biomolecular chemistry. 2024-02-07. PMID:38323382. |
alzheimer's disease (ad) is characterized by cognitive decline, often attributed to the deficiency of acetylcholine, which can undergo hydrolysis by acetylcholinesterase (ache) within the biological milieu. |
2024-02-07 |
2024-02-09 |
Not clear |
| Keisuke Obara, Haruka Mori, Suzune Ihara, Kento Yoshioka, Yoshio Tanak. Inhibitory Actions of Antidepressants, Hypnotics, and Anxiolytics on Recombinant Human Acetylcholinesterase Activity. Biological & pharmaceutical bulletin. vol 47. issue 1. 2024-02-06. PMID:38296462. |
if these drugs also inhibit acetylcholinesterase (ache) activity, they may contribute to the suppression of ad progression by increasing brain acetylcholine concentrations. |
2024-02-06 |
2024-02-09 |
human |
| Navneet Dhaliwal, Jatinder Dhaliwal, Kanwaljit Chopr. 7, 8-dihydroxyflavone Ameliorates Cholinergic Dysfunction, Inflammation, Oxidative Stress, and Apoptosis in a Rat Model of Vascular Dementia. Neurochemical research. 2024-02-01. PMID:38300457. |
inflammatory (tnf-α, il-1β, and nf-kβ), oxidative stress, and apoptotic (bax, bcl-2, caspase-3) markers, along with the activity of choline acetylcholinesterase (ache) was assessed. |
2024-02-01 |
2024-02-03 |
rat |
| Dhairiya Agarwal, Sumit Kumar, Ramesh Ambatwar, Neeru Bhanwala, Lokesh Chandrakar, Gopal Khati. Lead Identification Through In Silico Studies: Targeting Acetylcholinesterase Enzyme Against Alzheimer's Disease. Central nervous system agents in medicinal chemistry. 2024-01-30. PMID:38288823. |
in this work, we aimed to acquire the best potential small molecule for alzheimer's disease (ad) treatment using different models in biovia discovery studio to identify new potential inhibitors of acetylcholinesterase (ache) via in silico studies. |
2024-01-30 |
2024-02-01 |
Not clear |
| Lei Xing, Pinyi Ma, Fangfang Che. A novel turn-on near-infrared fluorescent probe for highly sensitive in vitro and in vivo detection of acetylcholinesterase activity. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. vol 310. 2024-01-30. PMID:38290281. |
acetylcholinesterase (ache) is a key enzyme in the cholinergic pathway of the nervous systems, with its aberrant expression linked to various diseases. |
2024-01-30 |
2024-02-02 |
mouse |
| Fereshteh Farajdokht, Saeed Sadigh-Eteghad, Seyedmahdi Vatandoust, Leila Hosseini, Soroush Morsali, Hamidreza Feizi, Pedram Ghaderi Shadbad, Javad Mahmoud. Sericin Improves Memory Impairment Via Activation of the PKA-CREB-BDNF Signaling Pathway and Suppression of Oxidative Stress in Ovariectomized Mice. Neurochemical research. 2024-01-30. PMID:38291264. |
in the current study, the impact of chronic sericin treatment (200 mg/kg/day for 6 weeks, gavage) on memory process, oxidative stress markers, synaptic neurotransmission, and acetylcholinesterase (ache) activity in the hippocampus (hip) of ovariectomized (ovx) mice was examined and compared to the effects of 17β-estradiol (es; 20 µg/kg, s.c.). |
2024-01-30 |
2024-02-02 |
mouse |
| Oluwatobiloba F Da-Silva, Adedoyin R Adelowo, Adesina A Babalola, Cynthia N Ikeji, Olatunde Owoeye, Joao B T Rocha, Isaac A Adedara, Ebenezer O Faromb. Diphenyl Diselenide Through Reduction of Inflammation, Oxidative Injury and Caspase-3 Activation Abates Doxorubicin-Induced Neurotoxicity in Rats. Neurochemical research. 2024-01-24. PMID:38267690. |
moreover, with exception of cerebral glutathione (gsh) level, superoxide dismutase (sod) and glutathione peroxidase (gpx) activities, biochemical data demonstrated reversal of doxorubicin-mediated decline in cerebral and cerebellar antioxidant status indices and the increase in acetylcholinesterase (ache) activity by both doses of dpds. |
2024-01-24 |
2024-01-27 |
rat |
| A N Khabibrakhmanov, I V Zueva, K A Petrov, E I Bogdanov, M A Mukhamedyaro. [Plasma and salivary acetylcholinesterase activity in amyotrophic lateral sclerosis]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 124. issue 1. 2024-01-23. PMID:38261295. |
assessment of plasma and salivary acetylcholinesterase (ache) activity in patients with amyotrophic lateral sclerosis (als) and in an animal model of the disease. |
2024-01-23 |
2024-01-25 |
Not clear |
| Ahlam H Mahmoud, Doaa M Elhefnawei, Mohamed A El-Desouky, Mai O Kadr. Reciprocal crosslink among MeCP2/BDNF /CREB signaling pinpointed in autism spectrum disorder. Toxicology reports. vol 12. 2024-01-17. PMID:38229920. |
the neurotransmitters gamma amino-butyric acid (gaba), acetylcholine (ach), and acetylcholinesterase (ache) in addition to, the gene expressions of brain-derived neurotrophic factor (bdnf), camp response element-binding protein (creb), and methyl-cpg-binding protein 2 (mecp2) and the dna damage comet analysis at different time intervals of the study, were assessed. |
2024-01-17 |
2024-01-19 |
rat |
| Ashwaq H Bataw. The International journal of neuroscience. vol 134. issue 1. 2024-01-16. PMID:35634646. |
alzheimer's disease (ad) appears as a result of an increase in the accumulation of amyloid beta peptide (aβ) and a decrease in neurotransmitters (acetylcholine) within the brain cells which may be due to increase in acetylcholinesterase (ache) activity and change in expression of apolipoprotein e4 (apoe4) and clusterin (clu) genes. |
2024-01-16 |
2024-01-19 |
Not clear |
| Dongyan Chen, Li Wang, Jie Wei, Tianhui Jiao, Qingmin Chen, Munetaka Oyama, Quansheng Chen, Xi Chen, Xiaomei Che. Metal-organic framework-based multienzyme cascade bioreactor for sensitive detection of methyl parathion. Food chemistry. vol 442. 2024-01-14. PMID:38219569. |
the simultaneous encapsulation of acetylcholinesterase (ache) and choline oxidase (cho) in a zeolitic imidazole ester backbone (zif-8) effectively improved the stability and cascade catalytic efficiency of the enzymes. |
2024-01-14 |
2024-01-17 |
Not clear |
| Nworie Okoro, Doris Olachi Alilonu, Eze Chinazom Martina, Azubuike Peter Ebokaiw. Aflatoxin B1-induced redox imbalance in the hippocampus and cerebral cortex of male Wistar rats is accompanied by altered cholinergic, indoleaminergic, and purinergic pathways: Abatement by dietary rutin. Toxicon : official journal of the International Society on Toxinology. 2024-01-11. PMID:38211804. |
abatement of afb1-induced decreases in acetylcholinesterase (ache) activity, and increased antioxidant status, by rutin was accompanied by a marked reduction in oxidative stress markers and increased hydrolysis of the purinergic molecules in the cerebral cortex and hippocampus of rats. |
2024-01-11 |
2024-01-14 |
rat |
| b' Suzana \\xc5\\xbdunec, Donna Vadlja, Alma Rami\\xc4\\x87, Antonio Zandona, Nikola Marakovi\\xc4\\x87, Iva Brekalo, Ines Primo\\xc5\\xbei\\xc4\\x8d, Maja Katalini\\xc4\\x8. Profiling Novel Quinuclidine-Based Derivatives as Potential Anticholinesterase Drugs: Enzyme Inhibition and Effects on Cell Viability. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203326.' |
the enzymes acetylcholinesterase, ache, and butyrylcholinesterase, bche, responsible for hydrolyzing ach, can fine-tune the cholinergic system's activity and are, therefore, excellent pharmacological targets to address a range of medical conditions. |
2024-01-11 |
2024-01-13 |
Not clear |
| Kunal Bhattacharya, Atanu Bhattacharjee, Manodeep Chakrabort. Assessing the potential of Journal of biomolecular structure & dynamics. 2024-01-11. PMID:38205777. |
assessing the potential of acetylcholinesterase (ache) inhibitors play a crucial role in the treatment of alzheimer's disease. |
2024-01-11 |
2024-01-13 |
Not clear |
| Mikael Ham Sembiring, Okta Nursanti, Tesia Aisyah Rahmani. Molecular docking and toxicity studies of nerve agents against acetylcholinesterase (AChE). Journal of receptor and signal transduction research. 2024-01-08. PMID:38189350. |
acetylcholinesterase (ache) is a cholinergic enzyme that plays an essential role in the autonomic nervous system. |
2024-01-08 |
2024-01-10 |
Not clear |
| Ya-Nan Zhang, Xin-Lu Chen, Ling-Yu Guo, Pei-Ran Jiang, Hui Lu, Kai Pan, Lei Guo, Yu-Ting Hu, Ai-Min Ba. Downregulation of peripheral luteinizing hormone rescues ovariectomy-associated cognitive deficits in APP/PS1 mice. Neurobiology of aging. vol 135. 2024-01-07. PMID:38185053. |
we and others found that the transcription factor early growth response-1 (egr1) regulates cholinergic function including the expression of acetylcholinesterase (ache) and plays a significant role in cognitive decline of ad. |
2024-01-07 |
2024-01-10 |
mouse |