| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haiyan Hao, Ailong Sh. Study on Anti-fatigue Effects and Mechanisms of Polysaccharide from Paris polyphylla. Doklady. Biochemistry and biophysics. vol 516. issue 1. 2024-05-25. PMID:38722403. |
the effects of pppm-1 on the contents of blood lactate, serum urea nitrogen, hepatic glycogen, muscle glycogen in the exercise fatigue model of mice, and acetylcholine (ach) content and acetylcholinesterase (ache) activity at the junction of the frog sciatic nerve-gastrocnemius under normal physiological, and na |
2024-05-25 |
2024-05-27 |
mouse |
| Li Zhang, Xue Li, Qiang Yuan, Sujie Sun, Fasheng Liu, Xinjun Liao, Huiqiang Lu, Jianjun Chen, Zigang Ca. Isavuconazole Induces Neurodevelopment Defects and Motor Behaviour Impairment in Zebrafish Larvae. Molecular neurobiology. 2024-05-24. PMID:38787492. |
at the same time, exposure of zebrafish embryos to isavuconazole downregulated acetylcholinesterase (ache) and adenosine triphosphate (atpase) activities but upregulated oxidative stress, thereby disrupting neural development and gene expression of neurotransmitter pathways. |
2024-05-24 |
2024-05-27 |
zebrafish |
| Elif Korkusuz, Yusuf Sert, Seher Arslan, Hava Aydın, İsmail Yıldırım, Yeliz Demir, İlhami Gülçin, İrfan Koc. Synthesis and biological studies of pyrimidine derivatives targeting metabolic enzymes. Archiv der Pharmazie. 2024-05-21. PMID:38772694. |
novel synthesized pyrimidine derivatives were investigated against carbonic anhydrase isoenzymes i and ii (hca i and ii), acetylcholinesterase (ache), butyrylcholinesterase (bche), α-glycosidase, and aldose reductase (ar) enzymes associated with some common diseases such as epilepsy, glaucoma, alzheimer's disease, diabetes, and neuropathy. |
2024-05-21 |
2024-05-27 |
Not clear |
| Cibelle de Melo Bastos Cavalcante, Kellysson Bruno Oliveira, Fernanda Maria Araújo de Souza, Milenna Maria Jatobá Hasten Reiter, Bianca Rodrigues Melo da Silva, Keylla Lavínia da Silva Oliveira, Marcos Vinicius Dos Santos Sales, Amanda Larissa Dias Pacheco, Edite Santos Siqueira, Maisa de Araújo Costa, José Gomes Dos Santos Neto, Rayssa Gabriely Duarte Torres, Ana Catarina R Leite, Igor Santana de Melo, Sônia Salgueiro Machado, Marcelo Duzzioni, Daniel Leite Góes Gitaí, Olagide Wagner de Castr. Crack cocaine inhalation increases seizure susceptibility by reducing acetylcholinesterase activity. Epilepsy & behavior : E&B. vol 156. 2024-05-18. PMID:38761450. |
here we evaluate the acetylcholinesterase (ache) and reactive oxygen species (ros) activity, behavioral profile, and the threshold for epileptic seizures in rats that received intrahippocampal pilocarpine (h-pilo) followed by exposure to crack cocaine (h-pilo + crack). |
2024-05-18 |
2024-05-27 |
rat |
| Pankaj Kadyan, Lovedeep Sing. Unraveling the mechanistic interplay of mediators orchestrating the neuroprotective potential of harmine. Pharmacological reports : PR. 2024-05-17. PMID:38758470. |
elevated levels of acetylcholinesterase (ache) and butyrylcholinesterase (bche), alongside decreased expression of brain-derived neurotrophic factor (bdnf) and glutamate transporter subtype 1 (glt-1), constitute significant factors contributing to the pathogenesis of ndds. |
2024-05-17 |
2024-05-27 |
Not clear |
| b' Re\\xc5\\x9fit \\xc3\\x87akmak, Ey\\xc3\\xbcp Ba\\xc5\\x9faran, Kader Sahin, Murat \\xc5\\x9eent\\xc3\\xbcrk, Serdar Durda\\xc4\\x9f\\xc4\\xb. Synthesis of Novel Hydrazide-Hydrazone Compounds and ACS omega. vol 9. issue 18. 2024-05-13. PMID:38737075.' |
synthesis of novel hydrazide-hydrazone compounds and the abnormal levels of the human carbonic anhydrase isoenzymes i and ii (hca i and ii) and cholinesterase enzymes, namely, acetylcholinesterase (ache) and butyrylcholinesterase (bche), are linked with various disorders including alzheimer's disease. |
2024-05-13 |
2024-05-27 |
human |
| Hind Al Khashali, Ravel Ray, Ban Darweesh, Caroline Wozniak, Ben Haddad, Stuti Goel, Issah Seidu, Jeneen Khalil, Brooke Lopo, Nayrooz Murshed, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evan. Amyloid Beta Leads to Decreased Acetylcholine Levels and Non-Small Cell Lung Cancer Cell Survival via a Mechanism That Involves p38 Mitogen-Activated Protein Kinase and Protein Kinase C in a p53-Dependent and -Independent Manner. International journal of molecular sciences. vol 25. issue 9. 2024-05-11. PMID:38732252. |
we previously reported that the levels of amyloid beta (aβ), at the center of alzheimer's disease pathophysiology, are regulated by acetylcholinesterase (ache) in non-small cell lung cancer (nsclc). |
2024-05-11 |
2024-05-27 |
Not clear |
| Yuxin Zhang, Xiaoqing Pei, Lingyang Jing, Qingyu Zhang, Hongfeng Zha. Lead induced cerebellar toxicology of developmental Japanese quail (Coturnix japonica) via oxidative stress-based Nrf2/Keap1 pathway inhibition and glutathione-mediated apoptosis signaling activation. Environmental pollution (Barking, Essex : 1987). vol 352. 2024-05-10. PMID:38718965. |
moreover, cerebellar neurotransmission was disturbed by pb with increasing acetylcholine (ach) and decreasing acetylcholinesterase (ache), dopamine (da), γ-aminobutyric acid (gaba) and na |
2024-05-10 |
2024-05-27 |
Not clear |
| Morteza Sadeghi, Seyedehmasoumeh Seyedebrahimi, Mustafa Ghanadian, Mehran Miroliae. Identification of cholinesterases inhibitors from flavonoids derivatives for possible treatment of Alzheimer's disease: Current research in structural biology. vol 7. 2024-05-06. PMID:38707547. |
identification of cholinesterases inhibitors from flavonoids derivatives for possible treatment of alzheimer's disease: nowadays, one of the methods to prevent the progress of alzheimer's disease (ad) is to prescribe compounds that inhibit the acetylcholinesterase (ache) and butyrylcholinesterase (bche) enzymes. |
2024-05-06 |
2024-05-08 |
Not clear |
| Dayan Liu, Tao Song, Kang Na, Shudong Wan. PED: a novel predictor-encoder-decoder model for Alzheimer drug molecular generation. Frontiers in artificial intelligence. vol 7. 2024-05-01. PMID:38690194. |
acetylcholinesterase (ache) is an efficient hydrolase that catalyzes the hydrolysis of acetylcholine (ach), which regulates the concentration of ach at synapses and then terminates ach-mediated neurotransmission. |
2024-05-01 |
2024-05-03 |
Not clear |
| Qiyun Wu, Yingjie Xia, Maggie Suisui Guo, Tsz Yu Au, Gary K W Yuen, Ivan Kong, Zhengqi Wang, Yingyi Lin, Tina T X Dong, Karl W K Tsi. Acetylcholinesterase is regulated by exposure of ultraviolet B in skin keratinocytes: A potential inducer of cholinergic urticaria. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 9. 2024-05-01. PMID:38690717. |
this skin problem is hypothesized to be attributed to a reduced expression of acetylcholinesterase (ache), an enzyme responsible for hydrolyzing acetylcholine (ach). |
2024-05-01 |
2024-05-03 |
Not clear |
| Laila Mowafy, Manal Abdul-Hamid, Nadia Moustafa, Saleh Al-Quraishy, Abdel-Azeem S Abdel-Baki, Mohamed Y Zaky, Abdul-Mawgoud A Asran, Heba Abdel-Tawa. Repurposing the drug, amprolium as a novel molluscicide against the land snail (Eobania vermiculata). Pesticide biochemistry and physiology. vol 201. 2024-04-30. PMID:38685220. |
when snails treated with ½ lc₅₀ of amp, the levels of alkaline phosphatase (alp), total lipids (tl), urea, creatinine, malondialdehyde (mda), catalase (cat), and nitric oxide (no) were significantly increased, whereas the levels of acetylcholinesterase (ache), total protein (tp), and glutathione (gsh) decreased. |
2024-04-30 |
2024-05-03 |
cat |
| Kerem Teralı, Dilek Ozbeyli, Duygu Yiğit-Hanoğlu, Kemal Hüsnü Can Başer, Göksel Şener, Asli Ayka. A comprehensive assessment of the cholinergic-supporting and cognitive-enhancing effects of Rosa damascena Mill. (Damask rose) essential oil on scopolamine-induced amnestic rats. Brain and behavior. vol 14. issue 5. 2024-04-30. PMID:38688895. |
here, we aimed at investigating the effects of rosa damascena essential oil (rdeo) on learning and memory functions in a rat model of amnesia induced by scopolamine, as well as on changes in acetylcholinesterase (ache) activity, m |
2024-04-30 |
2024-05-03 |
rat |
| Ming Liu, Ping Deng, Guangyu Li, Haoling Liu, Junli Zuo, Wenwen Cui, Huixian Zhang, Xin Chen, Jingjing Yao, Xitian Peng, Lijun Peng, Jiao Liu, Wenting Zheng, Wei Yan, Ning Lua. Neurotoxicity of Combined Exposure to the Heavy Metals (Pb and As) in Zebrafish ( Toxics. vol 12. issue 4. 2024-04-26. PMID:38668505. |
to elucidate the underlying mechanisms, we examined changes in acetylcholinesterase (ache) activity, neurotransmitter (dopamine, 5-hydroxytryptamine) levels, hpi axis-related hormone (cortisol and epinephrine) contents and neurodevelopment-related gene expression in zebrafish brain. |
2024-04-26 |
2024-04-28 |
zebrafish |
| G A Reid, S Darves. Interaction of Exogenous Acetylcholinesterase and Butyrylcholinesterase with Amyloid-β Plaques in Human Brain Tissue. Chemico-biological interactions. 2024-04-22. PMID:38648920. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are associated with amyloid-β (aβ) plaques and exhibit altered biochemical properties in human alzheimer's disease (ad), as well as in the transgenic 5xfad mouse model of ad amyloidosis. |
2024-04-22 |
2024-04-26 |
mouse |
| Juan David Villeda-González, José Luis Gómez-Olivares, Luis Arturo Baiza-Gutma. New paradigms in the study of the cholinergic system and metabolic diseases: Acetyl-and-butyrylcholinesterase. Journal of cellular physiology. 2024-04-12. PMID:38605655. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that belong to the neuromuscular cholinergic system, their main function is to hydrolyze the neurotransmitter acetylcholine (ach), through their hydrolysis these enzymes regulate the neuronal and neuromuscular cholinergic system. |
2024-04-12 |
2024-04-14 |
Not clear |
| Maciej Zadrozny, Patrycja Drapich, Anna Gasiorowska-Bien, Wiktor Niewiadomski, Charles R Harrington, Claude M Wischik, Gernot Riedel, Grazyna Niewiadomsk. Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model. Cells. vol 13. issue 7. 2024-04-12. PMID:38607082. |
immunohistochemical staining and quantification of choline acetyltransferase (chat), tyrosine kinase a (trka)-positive neurons and relative optical intensity (roi) for vesicular acetylcholine transporter (vacht), and acetylcholinesterase (ache) reactivity confirmed reversal of the diminished cholinergic phenotype of interneurons (nucleus accumbens, striatum) and projection neurons (medial septum, nucleus basalis magnocellularis) by hmtm, to a greater extent than by rivastigmine alone in l1 mice. |
2024-04-12 |
2024-04-14 |
mouse |
| Surbhi Jaiswal, Brijeshwar Singh, Isha Dhingra, Abhijeet Joshi, Prashant Kodgir. Bioremediation and Bioscavenging for elimination of Organophosphorus threats: An approach using enzymatic advancements. Environmental research. 2024-04-10. PMID:38599448. |
these compounds inhibit the action of the acetylcholinesterase enzyme (ache) by phosphorylation, which prevents the breakdown of acetylcholine (ach) neurotransmitters into choline and acetate. |
2024-04-10 |
2024-04-13 |
human |
| Ali Asadipour, Yaghoub Pourshojaei, Moein Mansouri, Elham Mahdavizadeh, Cambyz Irajie, Javad Mottaghipisheh, Ehsan Faghih-Mirzaei, Mohammad Mahdavi, Aida Iraj. Amino-7,8-dihydro-4H-chromenone derivatives as potential inhibitors of acetylcholinesterase and butyrylcholinesterase for Alzheimer's disease management; in vitro and in silico study. BMC chemistry. vol 18. issue 1. 2024-04-10. PMID:38600537. |
in this article, we present the design and synthesis of amino-7,8-dihydro-4h-chromenone derivatives as possible inhibitors of acetylcholinesterase (ache) and butyrylcholinesterase (bche) for the management of alzheimer's disease (ad). |
2024-04-10 |
2024-04-13 |
Not clear |
| Jae Yeon Park, Seong Doo Kang, Yun Gon Son, Ju Yeon Kim, Gihwan Lee, Kwang Dong Kim, Sang Won Lee, Jeong Yoon Ki. Eucalyptus globulus leaf-isolated isorhapontin serves as a natural insecticide via acetylcholinesterase inhibition. Pesticide biochemistry and physiology. vol 200. 2024-04-08. PMID:38582576. |
acetylcholinesterase (ache) inhibitors cause insect death by preventing the hydrolysis of the neurotransmitter acetylcholine, which overstimulates the nervous system. |
2024-04-08 |
2024-04-10 |
Not clear |