| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fatima Ezzahra Laghchioua, Carlos F M da Silva, Diana C G A Pinto, José A S Cavaleiro, Ricardo F Mendes, Filipe A Almeida Paz, Maria A F Faustino, El Mostapha Rakib, M Graça P M S Neves, Florbela Pereira, Nuno M M Mour. Design of Promising Thiazoloindazole-Based Acetylcholinesterase Inhibitors Guided by Molecular Docking and Experimental Insights. ACS chemical neuroscience. 2024-07-22. PMID:39037949. |
since acetylcholinesterase (ache) is a critical enzyme in the nervous system, responsible for breaking down the neurotransmitter acetylcholine, its inhibition holds a significant interest in the treatment of various neurological disorders. |
2024-07-22 |
2024-07-25 |
Not clear |
| Shikha Asthana, Shivam Kumar Pandey, Avtar Singh Gautam, Rakesh Kumar Sing. MK2 inhibitor PF-3644022 shows protective effect in mouse microglial N9 cell line induced with cigarette smoke extract. Chemical biology & drug design. vol 104. issue 1. 2024-07-16. PMID:39013758. |
therefore, we have used an mk2 inhibitor, pf-3644022 to study modulation of cs-extract induced oxidative and inflammatory signaling in a mouse microglial cell line, furthermore, we also evaluated the enzymatic activity of acetylcholinesterase (ache) on a direct exposure of enzyme with cs. |
2024-07-16 |
2024-07-19 |
mouse |
| Sofía Pastene-Burgos, Evelyn Muñoz-Nuñez, Soledad Quiroz-Carreño, Edgar Pastene-Navarrete, Luis Espinoza Catalan, Luis Bustamante, Julio Alarcón-Eno. Ceanothanes Derivatives as Peripheric Anionic Site and Catalytic Active Site Inhibitors of Acetylcholinesterase: Insights for Future Drug Design. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:39000410. |
acetylcholinesterase (ache) plays a key role in the regulation of the cholinergic system and particularly in the formation of amyloid plaques; therefore, the inhibition of ache has become one of the most promising strategies for the treatment of ad, particularly concerning ache inhibitors that interact with the peripheral anionic site (pas). |
2024-07-13 |
2024-07-15 |
Not clear |
| Giovana R Oliveira, Matheus Gallas-Lopes, Rafael Chitolina, Leonardo M Bastos, Stefani M Portela, Thailana Stahlhofer-Buss, Darlan Gusso, Rosane Gomez, Angela T S Wyse, Ana P Herrmann, Angelo Piat. Evaluation of behavioral and neurochemical changes induced by carbofuran in zebrafish (Danio rerio). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2024-06-26. PMID:38925284. |
research has revealed that this pesticide acts as an inhibitor of acetylcholinesterase (ache), inducing an accumulation of acetylcholine in the brain. |
2024-06-26 |
2024-06-29 |
zebrafish |
| Behjat Pouramiri, Maryam Abbasi, Elahe Hadadianpou. Design, Green Synthesis and in silico Studies of New Substituted Naphtho[1,2-e][1,3]Oxazines as Potential Acetylcholinesterase Inhibitors. Chemistry & biodiversity. 2024-06-26. PMID:38923807. |
acetylcholinesterase (ache) inhibitors as the primary pharmacotherapy for numerous neurodegenerative conditions, leveraging their capacity to modulate acetylcholine levels crucial for cognitive function. |
2024-06-26 |
2024-06-29 |
Not clear |
| Ranju Bansal, Ranjit Singh, Tuhin Shubra Dutta, Zahid Ahmad Dar, Ankit Bajpa. Indanone: a promising scaffold for new drug discovery against neurodegenerative disorders. Drug discovery today. 2024-06-20. PMID:38901670. |
further, indanone derivatives are capable of modulating the activities of both monoamine oxidases (mao-a and -b) and acetylcholinesterase (ache), and thus could be useful in various neurodegenerative diseases. |
2024-06-20 |
2024-06-23 |
Not clear |
| Liyuan Guo, Zelei Chang, Jianbo Tong, Peng Gao, Yakun Zhang, Yuan Liu, Yulu Yang, Chunying Wan. Design of vilazodone-donepezil chimeric derivatives as acetylcholinesterase inhibitors by QSAR, molecular docking and molecular dynamics simulations. Physical chemistry chemical physics : PCCP. 2024-06-19. PMID:38896464. |
acetylcholinesterase (ache) can increase acetylcholine concentrations and improve cognitive function in patients, and is a potential target to develop small molecule inhibitors for the treatment of alzheimer's disease (ad). |
2024-06-19 |
2024-06-21 |
Not clear |
| Allison Carles, Matthias Hoffmann, Matthias Scheiner, Lucie Crouzier, Christelle Bertrand-Gaday, Arnaud Chatonnet, Michael Decker, Tangui Mauric. The selective butyrylcholinesterase inhibitor UW-MD-95 shows symptomatic and neuroprotective effects in a pharmacological mouse model of Alzheimer's disease. CNS neuroscience & therapeutics. vol 30. issue 6. 2024-06-18. PMID:38887858. |
clinically available drugs mainly target acetylcholinesterase (ache) and indirectly sustain cholinergic neuronal tonus. |
2024-06-18 |
2024-06-21 |
mouse |
| Mohamed Hamed, Christopher J Martyniuk, Hamdy A M Soliman, Alaa G M Osman, Rashad E M Sai. Neurotoxic and Cardiotoxic Effects of Pyrogallol on catfish (Clarias gariepinus). Environmental toxicology and pharmacology. 2024-06-10. PMID:38857774. |
enzyme activities such as acetylcholinesterase (ache), monoamine oxidase (mao), aldehyde oxidase (ao), and nitric oxide (no) were measured in serum and brain, along with histopathological examinations in the brain and heart. |
2024-06-10 |
2024-06-14 |
Not clear |
| Yashika Sarangle, Kiran Bamel, Ram Singh Purt. Role of acetylcholine and acetylcholinesterase in improving abiotic stress resistance/tolerance. Communicative & integrative biology. vol 17. issue 1. 2024-06-03. PMID:38827581. |
acetylcholine hydrolyzing enzyme acetylcholinesterase (ache) belongs to the gdsl lipase/acylhydrolase protein family and has been found in several plant species. |
2024-06-03 |
2024-06-05 |
Not clear |
| Salimat O Sofela, Abdulwasiu Ibrahim, Uchechukwu C Ogbodo, Damilola S Bodun, Daniel O Nwankwo, Mojirade Mafimisebi, Buhari Abdulrasheed, Toheeb Balogun, Isaac Opeyem. Computational identification of potential acetylcholinesterase (AChE) and monoamine oxidase-B inhibitors from In silico pharmacology. vol 12. issue 1. 2024-06-03. PMID:38828442. |
computational identification of potential acetylcholinesterase (ache) and monoamine oxidase-b inhibitors from alzheimer's disease (ad) is the most prevalent neurodegenerative disease that affects people aged 60 years and above. |
2024-06-03 |
2024-06-05 |
Not clear |
| Ashraf Albrakat. The potential neuroprotective of luteolin against acetamiprid-induced neurotoxicity in the rat cerebral cortex. Frontiers in veterinary science. vol 11. 2024-06-01. PMID:38818490. |
luteolin also demonstrated a neuroprotective role via the modulation of acetylcholinesterase (ache) activity in the cerebral cortex tissue. |
2024-06-01 |
2024-06-02 |
rat |
| Haiyan Hao, Ailong Sh. Study on Anti-fatigue Effects and Mechanisms of Polysaccharide from Paris polyphylla. Doklady. Biochemistry and biophysics. vol 516. issue 1. 2024-05-25. PMID:38722403. |
the effects of pppm-1 on the contents of blood lactate, serum urea nitrogen, hepatic glycogen, muscle glycogen in the exercise fatigue model of mice, and acetylcholine (ach) content and acetylcholinesterase (ache) activity at the junction of the frog sciatic nerve-gastrocnemius under normal physiological, and na |
2024-05-25 |
2024-05-27 |
mouse |
| Li Zhang, Xue Li, Qiang Yuan, Sujie Sun, Fasheng Liu, Xinjun Liao, Huiqiang Lu, Jianjun Chen, Zigang Ca. Isavuconazole Induces Neurodevelopment Defects and Motor Behaviour Impairment in Zebrafish Larvae. Molecular neurobiology. 2024-05-24. PMID:38787492. |
at the same time, exposure of zebrafish embryos to isavuconazole downregulated acetylcholinesterase (ache) and adenosine triphosphate (atpase) activities but upregulated oxidative stress, thereby disrupting neural development and gene expression of neurotransmitter pathways. |
2024-05-24 |
2024-05-27 |
zebrafish |
| Elif Korkusuz, Yusuf Sert, Seher Arslan, Hava Aydın, İsmail Yıldırım, Yeliz Demir, İlhami Gülçin, İrfan Koc. Synthesis and biological studies of pyrimidine derivatives targeting metabolic enzymes. Archiv der Pharmazie. 2024-05-21. PMID:38772694. |
novel synthesized pyrimidine derivatives were investigated against carbonic anhydrase isoenzymes i and ii (hca i and ii), acetylcholinesterase (ache), butyrylcholinesterase (bche), α-glycosidase, and aldose reductase (ar) enzymes associated with some common diseases such as epilepsy, glaucoma, alzheimer's disease, diabetes, and neuropathy. |
2024-05-21 |
2024-05-27 |
Not clear |
| Cibelle de Melo Bastos Cavalcante, Kellysson Bruno Oliveira, Fernanda Maria Araújo de Souza, Milenna Maria Jatobá Hasten Reiter, Bianca Rodrigues Melo da Silva, Keylla Lavínia da Silva Oliveira, Marcos Vinicius Dos Santos Sales, Amanda Larissa Dias Pacheco, Edite Santos Siqueira, Maisa de Araújo Costa, José Gomes Dos Santos Neto, Rayssa Gabriely Duarte Torres, Ana Catarina R Leite, Igor Santana de Melo, Sônia Salgueiro Machado, Marcelo Duzzioni, Daniel Leite Góes Gitaí, Olagide Wagner de Castr. Crack cocaine inhalation increases seizure susceptibility by reducing acetylcholinesterase activity. Epilepsy & behavior : E&B. vol 156. 2024-05-18. PMID:38761450. |
here we evaluate the acetylcholinesterase (ache) and reactive oxygen species (ros) activity, behavioral profile, and the threshold for epileptic seizures in rats that received intrahippocampal pilocarpine (h-pilo) followed by exposure to crack cocaine (h-pilo + crack). |
2024-05-18 |
2024-05-27 |
rat |
| Pankaj Kadyan, Lovedeep Sing. Unraveling the mechanistic interplay of mediators orchestrating the neuroprotective potential of harmine. Pharmacological reports : PR. 2024-05-17. PMID:38758470. |
elevated levels of acetylcholinesterase (ache) and butyrylcholinesterase (bche), alongside decreased expression of brain-derived neurotrophic factor (bdnf) and glutamate transporter subtype 1 (glt-1), constitute significant factors contributing to the pathogenesis of ndds. |
2024-05-17 |
2024-05-27 |
Not clear |
| b' Re\\xc5\\x9fit \\xc3\\x87akmak, Ey\\xc3\\xbcp Ba\\xc5\\x9faran, Kader Sahin, Murat \\xc5\\x9eent\\xc3\\xbcrk, Serdar Durda\\xc4\\x9f\\xc4\\xb. Synthesis of Novel Hydrazide-Hydrazone Compounds and ACS omega. vol 9. issue 18. 2024-05-13. PMID:38737075.' |
synthesis of novel hydrazide-hydrazone compounds and the abnormal levels of the human carbonic anhydrase isoenzymes i and ii (hca i and ii) and cholinesterase enzymes, namely, acetylcholinesterase (ache) and butyrylcholinesterase (bche), are linked with various disorders including alzheimer's disease. |
2024-05-13 |
2024-05-27 |
human |
| Hind Al Khashali, Ravel Ray, Ban Darweesh, Caroline Wozniak, Ben Haddad, Stuti Goel, Issah Seidu, Jeneen Khalil, Brooke Lopo, Nayrooz Murshed, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evan. Amyloid Beta Leads to Decreased Acetylcholine Levels and Non-Small Cell Lung Cancer Cell Survival via a Mechanism That Involves p38 Mitogen-Activated Protein Kinase and Protein Kinase C in a p53-Dependent and -Independent Manner. International journal of molecular sciences. vol 25. issue 9. 2024-05-11. PMID:38732252. |
we previously reported that the levels of amyloid beta (aβ), at the center of alzheimer's disease pathophysiology, are regulated by acetylcholinesterase (ache) in non-small cell lung cancer (nsclc). |
2024-05-11 |
2024-05-27 |
Not clear |
| Yuxin Zhang, Xiaoqing Pei, Lingyang Jing, Qingyu Zhang, Hongfeng Zha. Lead induced cerebellar toxicology of developmental Japanese quail (Coturnix japonica) via oxidative stress-based Nrf2/Keap1 pathway inhibition and glutathione-mediated apoptosis signaling activation. Environmental pollution (Barking, Essex : 1987). vol 352. 2024-05-10. PMID:38718965. |
moreover, cerebellar neurotransmission was disturbed by pb with increasing acetylcholine (ach) and decreasing acetylcholinesterase (ache), dopamine (da), γ-aminobutyric acid (gaba) and na |
2024-05-10 |
2024-05-27 |
Not clear |