All Relations between acetylcholinesterase and ache

Publication Sentence Publish Date Extraction Date Species
Morteza Sadeghi, Seyedehmasoumeh Seyedebrahimi, Mustafa Ghanadian, Mehran Miroliae. Identification of cholinesterases inhibitors from flavonoids derivatives for possible treatment of Alzheimer's disease: Current research in structural biology. vol 7. 2024-05-06. PMID:38707547. identification of cholinesterases inhibitors from flavonoids derivatives for possible treatment of alzheimer's disease: nowadays, one of the methods to prevent the progress of alzheimer's disease (ad) is to prescribe compounds that inhibit the acetylcholinesterase (ache) and butyrylcholinesterase (bche) enzymes. 2024-05-06 2024-05-08 Not clear
Dayan Liu, Tao Song, Kang Na, Shudong Wan. PED: a novel predictor-encoder-decoder model for Alzheimer drug molecular generation. Frontiers in artificial intelligence. vol 7. 2024-05-01. PMID:38690194. acetylcholinesterase (ache) is an efficient hydrolase that catalyzes the hydrolysis of acetylcholine (ach), which regulates the concentration of ach at synapses and then terminates ach-mediated neurotransmission. 2024-05-01 2024-05-03 Not clear
Qiyun Wu, Yingjie Xia, Maggie Suisui Guo, Tsz Yu Au, Gary K W Yuen, Ivan Kong, Zhengqi Wang, Yingyi Lin, Tina T X Dong, Karl W K Tsi. Acetylcholinesterase is regulated by exposure of ultraviolet B in skin keratinocytes: A potential inducer of cholinergic urticaria. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 9. 2024-05-01. PMID:38690717. this skin problem is hypothesized to be attributed to a reduced expression of acetylcholinesterase (ache), an enzyme responsible for hydrolyzing acetylcholine (ach). 2024-05-01 2024-05-03 Not clear
Laila Mowafy, Manal Abdul-Hamid, Nadia Moustafa, Saleh Al-Quraishy, Abdel-Azeem S Abdel-Baki, Mohamed Y Zaky, Abdul-Mawgoud A Asran, Heba Abdel-Tawa. Repurposing the drug, amprolium as a novel molluscicide against the land snail (Eobania vermiculata). Pesticide biochemistry and physiology. vol 201. 2024-04-30. PMID:38685220. when snails treated with ½ lc₅₀ of amp, the levels of alkaline phosphatase (alp), total lipids (tl), urea, creatinine, malondialdehyde (mda), catalase (cat), and nitric oxide (no) were significantly increased, whereas the levels of acetylcholinesterase (ache), total protein (tp), and glutathione (gsh) decreased. 2024-04-30 2024-05-03 cat
Kerem Teralı, Dilek Ozbeyli, Duygu Yiğit-Hanoğlu, Kemal Hüsnü Can Başer, Göksel Şener, Asli Ayka. A comprehensive assessment of the cholinergic-supporting and cognitive-enhancing effects of Rosa damascena Mill. (Damask rose) essential oil on scopolamine-induced amnestic rats. Brain and behavior. vol 14. issue 5. 2024-04-30. PMID:38688895. here, we aimed at investigating the effects of rosa damascena essential oil (rdeo) on learning and memory functions in a rat model of amnesia induced by scopolamine, as well as on changes in acetylcholinesterase (ache) activity, m 2024-04-30 2024-05-03 rat
Ming Liu, Ping Deng, Guangyu Li, Haoling Liu, Junli Zuo, Wenwen Cui, Huixian Zhang, Xin Chen, Jingjing Yao, Xitian Peng, Lijun Peng, Jiao Liu, Wenting Zheng, Wei Yan, Ning Lua. Neurotoxicity of Combined Exposure to the Heavy Metals (Pb and As) in Zebrafish ( Toxics. vol 12. issue 4. 2024-04-26. PMID:38668505. to elucidate the underlying mechanisms, we examined changes in acetylcholinesterase (ache) activity, neurotransmitter (dopamine, 5-hydroxytryptamine) levels, hpi axis-related hormone (cortisol and epinephrine) contents and neurodevelopment-related gene expression in zebrafish brain. 2024-04-26 2024-04-28 zebrafish
G A Reid, S Darves. Interaction of Exogenous Acetylcholinesterase and Butyrylcholinesterase with Amyloid-β Plaques in Human Brain Tissue. Chemico-biological interactions. 2024-04-22. PMID:38648920. acetylcholinesterase (ache) and butyrylcholinesterase (bche) are associated with amyloid-β (aβ) plaques and exhibit altered biochemical properties in human alzheimer's disease (ad), as well as in the transgenic 5xfad mouse model of ad amyloidosis. 2024-04-22 2024-04-26 mouse
Juan David Villeda-González, José Luis Gómez-Olivares, Luis Arturo Baiza-Gutma. New paradigms in the study of the cholinergic system and metabolic diseases: Acetyl-and-butyrylcholinesterase. Journal of cellular physiology. 2024-04-12. PMID:38605655. acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that belong to the neuromuscular cholinergic system, their main function is to hydrolyze the neurotransmitter acetylcholine (ach), through their hydrolysis these enzymes regulate the neuronal and neuromuscular cholinergic system. 2024-04-12 2024-04-14 Not clear
Maciej Zadrozny, Patrycja Drapich, Anna Gasiorowska-Bien, Wiktor Niewiadomski, Charles R Harrington, Claude M Wischik, Gernot Riedel, Grazyna Niewiadomsk. Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model. Cells. vol 13. issue 7. 2024-04-12. PMID:38607082. immunohistochemical staining and quantification of choline acetyltransferase (chat), tyrosine kinase a (trka)-positive neurons and relative optical intensity (roi) for vesicular acetylcholine transporter (vacht), and acetylcholinesterase (ache) reactivity confirmed reversal of the diminished cholinergic phenotype of interneurons (nucleus accumbens, striatum) and projection neurons (medial septum, nucleus basalis magnocellularis) by hmtm, to a greater extent than by rivastigmine alone in l1 mice. 2024-04-12 2024-04-14 mouse
Surbhi Jaiswal, Brijeshwar Singh, Isha Dhingra, Abhijeet Joshi, Prashant Kodgir. Bioremediation and Bioscavenging for elimination of Organophosphorus threats: An approach using enzymatic advancements. Environmental research. 2024-04-10. PMID:38599448. these compounds inhibit the action of the acetylcholinesterase enzyme (ache) by phosphorylation, which prevents the breakdown of acetylcholine (ach) neurotransmitters into choline and acetate. 2024-04-10 2024-04-13 human
Ali Asadipour, Yaghoub Pourshojaei, Moein Mansouri, Elham Mahdavizadeh, Cambyz Irajie, Javad Mottaghipisheh, Ehsan Faghih-Mirzaei, Mohammad Mahdavi, Aida Iraj. Amino-7,8-dihydro-4H-chromenone derivatives as potential inhibitors of acetylcholinesterase and butyrylcholinesterase for Alzheimer's disease management; in vitro and in silico study. BMC chemistry. vol 18. issue 1. 2024-04-10. PMID:38600537. in this article, we present the design and synthesis of amino-7,8-dihydro-4h-chromenone derivatives as possible inhibitors of acetylcholinesterase (ache) and butyrylcholinesterase (bche) for the management of alzheimer's disease (ad). 2024-04-10 2024-04-13 Not clear
Jae Yeon Park, Seong Doo Kang, Yun Gon Son, Ju Yeon Kim, Gihwan Lee, Kwang Dong Kim, Sang Won Lee, Jeong Yoon Ki. Eucalyptus globulus leaf-isolated isorhapontin serves as a natural insecticide via acetylcholinesterase inhibition. Pesticide biochemistry and physiology. vol 200. 2024-04-08. PMID:38582576. acetylcholinesterase (ache) inhibitors cause insect death by preventing the hydrolysis of the neurotransmitter acetylcholine, which overstimulates the nervous system. 2024-04-08 2024-04-10 Not clear
Hussein M Ali, Basma Abdel-Aty, Walaa El-Sayed, Faiza M Mariy, Gamal M Hegazy, Rehab A Mohamed, Hala M Zoghl. Imidacloprid effects on acetylcholinesterase and nicotinic acetylcholine receptor in Apis mellifera. Experimental and molecular modeling approaches. Chemosphere. vol 356. 2024-04-06. PMID:38579952. therefore, the effects of imidacloprid (imi), the most used neonicotinoid, on the two main bioreceptors, acetylcholinesterase (ache) and nicotinic acetylcholine receptor alpha subunit (nachrα1) of honeybees were examined to identify their roles in honeybee toxicity and possible binding sites which assist in selecting and designing neonicotinoids. 2024-04-06 2024-04-10 Not clear
Sathish Thandivel, Poovarasan Rajan, Tamizharasan Gunasekar, Abisek Arjunan, Sulekha Khute, Srinivasa Rao Kareti, Subash Paranthama. Heliyon. vol 10. issue 7. 2024-04-01. PMID:38560123. acetylcholinesterase (ache) is a promising target for symptomatic improvement in ad due to its consistent and early cholinergic deficit. 2024-04-01 2024-04-04 Not clear
William K Clay, Anne K Buck, Yiran He, Dalyanne N Hernández Sánchez, Nathan A Ward, Jeremy M Lear, Kenny Q Nguyen, Benjamin H Clark, Ryan J Sapia, Remy F Lalisse, Aishwarya Sriraman, C Linn Cadieux, Craig A McElroy, Christopher S Callam, Christopher M Hada. Treatment of Organophosphorus Poisoning with 6-Alkoxypyridin-3-ol Quinone Methide Precursors: Resurrection of Methylphosphonate-Aged Acetylcholinesterase. Chemical research in toxicology. 2024-04-01. PMID:38556765. organophosphorus (op) nerve agents inhibit acetylcholinesterase (ache), creating a cholinergic crisis in which death can occur. 2024-04-01 2024-04-03 Not clear
Hind Yassmine Chennai, Salah Belaidi, Lotfi Bourougaa, Mebarka Ouassaf, Leena Sinha, Abdelouahid Samadi, Samir Chtit. Identification of Potent Acetylcholinesterase Inhibitors as New Candidates for Alzheimer Disease via Virtual Screening, Molecular Docking, Dynamic Simulation, and Molecular Mechanics-Poisson-Boltzmann Surface Area Calculations. Molecules (Basel, Switzerland). vol 29. issue 6. 2024-03-28. PMID:38542869. huperzine a (hup) plays a crucial role in alzheimer's therapy by enhancing cognitive function through increased cholinergic activity as a reversible acetylcholinesterase (ache) inhibitor. 2024-03-28 2024-03-30 Not clear
Sabrina Lekmine, Ouided Benslama, Hichem Tahraoui, Mohammad Shamsul Ola, Aicha Laouani, Kenza Kadi, Antonio Ignacio Martín-García, Ahmad Al. Anti-Cholinergic Effects of the Phenolic Extract from the Pharmaceuticals (Basel, Switzerland). vol 17. issue 3. 2024-03-28. PMID:38543134. cholinesterase enzymes, namely, acetylcholinesterase (ache) and butyrylcholinesterase (bche), hold pivotal significance in alzheimer's disease (ad) treatment. 2024-03-28 2024-03-30 Not clear
Dora Kolić, Vesna Pehar, Zrinka Kovari. Environmental exposure to glyphosate does not inhibit human acetylcholinesterase and butyrylcholinesterase. Arhiv za higijenu rada i toksikologiju. vol 75. issue 1. 2024-03-28. PMID:38548375. chemically, glyphosate belongs to a large family of organophosphorus pesticides, which exert a neurotoxic effect by inhibiting acetylcholinesterase (ache) and butyrylcholinesterase (bche), enzymes of the cholinergic system essential for maintaining neurotransmission. 2024-03-28 2024-03-31 human
Mustafa Kemal Ozalp, Patricia A Vignaux, Ana C Puhl, Thomas R Lane, Fabio Urbina, Sean Ekin. Sequential Contrastive and Deep Learning Models to Identify Selective Butyrylcholinesterase Inhibitors. Journal of chemical information and modeling. 2024-03-27. PMID:38532612. butyrylcholinesterase (bche) is a target of interest in late-stage alzheimer's disease (ad) where selective bche inhibitors (bis) may offer symptomatic treatment without the harsh side effects of acetylcholinesterase (ache) inhibitors. 2024-03-27 2024-03-29 Not clear
Varsha Mugundhan, Abirami Arthanari, Parameswari R Parthasarath. Protective Effect of Ferulic Acid on Acetylcholinesterase and Amyloid Beta Peptide Plaque Formation in Alzheimer's Disease: An In Vitro Study. Cureus. vol 16. issue 2. 2024-03-15. PMID:38487137. aim this study aims to comprehensively evaluate the effects of ferulic acid (fa) on acetylcholinesterase (ache) enzyme activity and amyloid beta (aβ) peptide plaque formation in an in vitro model of alzheimer's disease (ad). 2024-03-15 2024-03-17 Not clear