| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sinan Saral, Tolga Mercantepe, Atilla Topçu, Ali Koray Kaya, Aykut Öztür. Dexmedetomidine Improves Learning Functions in Male Rats Modeling Cognitive Impairment by Modulating the BDNF/TrkB/CREB Signaling Pathway. Life (Basel, Switzerland). vol 14. issue 12. 2025-01-14. PMID:39768379. |
the brain-derived neurotrophic factor (bdnf), acetylcholine (ach) and acetylcholinesterase (ache) levels were determined by elisa. |
2025-01-14 |
2025-01-16 |
rat |
| Yu Sun, Guanghua Lu, Peng Zhang, Jiaqi Zhang, Yeting Yu, Fulin Li, Jian Li. Effects of colloids with different compositions on benzophenone-3 biotoxicity in zebrafish embryos. Environmental pollution (Barking, Essex : 1987). vol 367. 2025-01-12. PMID:39798796. |
the bcm and organic colloids regulated the acetylcholinesterase (ache) activity and/or 5-hydroxytryptamine (5-ht) contents by affecting the neuroactive ligand receptor interaction pathway in zebrafish larvae, significantly increasing their swimming speed in co-exposure groups under the light condition. |
2025-01-12 |
2025-01-16 |
zebrafish |
| Natalia Cichon, Weronika Grabowska, Leslaw Gorniak, Maksymilian Stela, Piotr Harmata, Michal Ceremuga, Michal Bija. Mechanistic and Therapeutic Insights into Flavonoid-Based Inhibition of Acetylcholinesterase: Implications for Neurodegenerative Diseases. Nutrients. vol 17. issue 1. 2025-01-11. PMID:39796512. |
this review focuses on the inhibitory effects of flavonoids on acetylcholinesterase (ache) and their potential as therapeutic agents for cognitive dysfunction. |
2025-01-11 |
2025-01-14 |
Not clear |
| Hanane Naeimi, Maryam Taheri, Hossein Ghafouri, Asadollah Mohammad. Investigation of Thiazolidine-2,4-Dione Derivatives as Acetylcholinesterase Inhibitors: Synthesis, In Vitro Biological Activities and In Silico Studies. ChemistryOpen. 2025-01-11. PMID:39797425. |
the inhibition of acetylcholinesterase (ache), an enzyme responsible for the inactivation and decrease in acetylcholine in the cholinergic pathway, has been considered an attractive target for small-molecule drug discovery in alzheimer's disease (ad) therapy. |
2025-01-11 |
2025-01-14 |
Not clear |
| Tejas Ahuja, Farmiza Begum, Gautam Kumar, Smita Shenoy, Nitesh Kumar, Rekha R Sheno. Exploring the protective role of metformin and dehydrozingerone in sodium fluoride-induced neurotoxicity: evidence from prenatal rat models. 3 Biotech. vol 15. issue 2. 2025-01-11. PMID:39790448. |
behavioural studies like novel object recognition test (nort), open field & actophotometer test and biochemical estimations like acetylcholinesterase (ache), glutathione (gsh), malondialdehyde (mda) were conducted on animals followed by histopathological image analysis. |
2025-01-11 |
2025-01-13 |
rat |
| Samireh Nemati, Mohammad Amin Edalatmanesh, Mohsen Forouzanfa. The effect of Naringin on cognitive function, oxidative stress, cholinergic activity, CREB/BDNF signaling and hippocampal cell damage in offspring rats with utero-placental insufficiency-induced intrauterine growth restriction. Brain research. vol 1849. 2025-01-10. PMID:39761747. |
subsequently, hippocampal acetylcholinesterase (ache) activity, catalase (cat), superoxide dismutase (sod), total antioxidant capacity (tac), malondialdehyde (mda), hippocampal transcript level of cyclic amp response element-binding protein (creb) and brain derived neurotrophic factor (bdnf) and apoptotic neuron density in the hippocampus were evaluated. |
2025-01-10 |
2025-01-13 |
rat |
| Ysaías J Alvarado, Lenin González-Paz, José L Paz, Marcos A Loroño-González, Julio Santiago Contreras, Carla Lossada, Alejandro Vivas, Yovani Marrero-Ponce, Felix Martinez-Rios, Patricia Rodriguez-Lugo, Yanpiero Balladores, Joan Vera-Villalobo. Biological Implications of the Intrinsic Deformability of Human Acetylcholinesterase Induced by Diverse Compounds: A Computational Study. Biology. vol 13. issue 12. 2025-01-08. PMID:39765732. |
the enzyme acetylcholinesterase (ache) plays a crucial role in the termination of nerve impulses by hydrolyzing the neurotransmitter acetylcholine (ach). |
2025-01-08 |
2025-01-13 |
human |
| David Griffiths, Jami Hanif, Jacob McCammon, Luke McMaster, Cameron Gemmel. Accidental Organophosphate Poisoning in a Patient Due to a Bed Bug Pesticide in the United Kingdom: A Case Report. Cureus. vol 16. issue 12. 2025-01-06. PMID:39759751. |
as irreversible inhibitors of the enzyme acetylcholinesterase (ache), they reduce anti-cholinesterase activity and therefore increase acetylcholine (ach) levels at the neuromuscular junction (nmj). |
2025-01-06 |
2025-01-08 |
Not clear |
| Ting Zeng, Chengwei Zhang, Lili Sun, Haiyan X. Water-Soluble Ginseng Oligosaccharides Prevent Scopolamine-Induced Cholinergic Dysfunction and Inflammatory Cytokine Overexpression. Cell biochemistry and biophysics. 2025-01-03. PMID:39751741. |
the effect of wgos on the cholinergic system was evaluated by measuring acetylcholine (ach) neurotransmitter concentration and acetylcholinesterase (ache) activity in the hippocampus. |
2025-01-03 |
2025-01-05 |
mouse |
| Brenda Rufino da Silva, Joyce Maria Ferreira Alexandre Lima, Marcela Bermudez Echeverry, Carlos Alberto-Silv. Haloperidol-Induced Catalepsy and Its Correlations with Acetylcholinesterase Activity in Different Brain Structures of Mice. Neurology international. vol 16. issue 6. 2024-12-27. PMID:39728751. |
hal blocks the function of presynaptic d2 receptors on cholinergic interneurons, leading to the release of acetylcholine (ach), which is hydrolyzed by the enzyme acetylcholinesterase (ache). |
2024-12-27 |
2024-12-29 |
mouse |
| Adel Salari, Mehrdad Roghani, Mohsen Khalil. HMG-CoA reductase inhibitor simvastatin ameliorates trimethyltin neurotoxicity and cognitive impairment through reversal of Alzheimer's-associated markers. Metabolic brain disease. vol 40. issue 1. 2024-12-20. PMID:39704877. |
in addition, hippocampal inflammatory, oxidative, and apoptotic factors were attenuated besides reduction of acetylcholinesterase (ache) activity and alzheimer's pathology factors including presenilin-1 and hyperphorphorylated tau (p-tau) upon simvastatin. |
2024-12-20 |
2024-12-22 |
rat |
| Izza Irum, Fariha Khan, Muhammad Sufyan, Syeda Hafiza Benish Ali, Sidra Rehma. Developing multifaceted drug synergistic therapeutic strategy against neurological disorders. Computers in biology and medicine. vol 185. 2024-12-18. PMID:39693689. |
acetylcholinesterase (ache) inhibitors as symptomatic drugs are potent therapeutic regimen for neurodegenerative diseases. |
2024-12-18 |
2024-12-21 |
Not clear |
| Mohammed Sakib Musa, Md Tahsinul Islam, Wasif Billah, Md Siam Hossain, Md Shirajuce Shalakin Rahat, Imren Bayil, Yeasmin Akter Munni, Sumon Gangul. Structure-based virtual screening of Trachyspermum ammi metabolites targeting acetylcholinesterase for Alzheimer's disease treatment. PloS one. vol 19. issue 12. 2024-12-17. PMID:39689077. |
the cholinergic hypothesis posits that the degradation of acetylcholine by acetylcholinesterase (ache) contributes to ad development. |
2024-12-17 |
2024-12-21 |
human |
| Stavroula Kostoudi, Nikolaos Iatridis, Dimitra Hadjipavlou-Litina, Eleni Pontiki, Georgios Pampalaki. Chemical, In Cellulo, and In Silico Characterization of the Aminocholine Analogs of VG. International journal of molecular sciences. vol 25. issue 23. 2024-12-17. PMID:39684368. |
v-type nerve agents are exceedingly toxic chemical warfare agents that irreversibly inhibit acetylcholinesterase (ache), leading to acetylcholine accumulation in synapses and the disruption of neurotransmission. |
2024-12-17 |
2024-12-21 |
Not clear |
| Maryam Aliabadi, Farhad Valizadegan, Bagher Seyedalipour, Sahar Yaqubi, Ehsan Nazif. A promising therapeutic potential of International journal of environmental health research. 2024-12-16. PMID:39676694. |
biochemical tests showed ethanol suppressed catalase (cat), superoxide dismutase (sod), and acetylcholinesterase (ache) activities within the hippocampus and cortex. |
2024-12-16 |
2024-12-21 |
rat |
| Xumin Lin, Baojun Yang, Xiaowei Yuan, Zewen Li. Overexpression of ace2 compensating for the acetylcholinesterase activity loss from ace1 mutations accelerated the development of eggs and early nymphs in Nilaparvata lugens. International journal of biological macromolecules. 2024-12-08. PMID:39647749. |
acetylcholinesterase (ache) guarantees the acetylcholine signal in insect central nervous system, and is the target of organophosphorus and carbamate insecticides, towards which resistance was often reported due to ache mutations. |
2024-12-08 |
2024-12-11 |
Not clear |
| Elif Türkdönmez Ak, Büşra Okuyucu, Burcu Hatipoğlu, Gökhan Arsla. The effect of acetylcholinesterase inhibitor rivastigmine in pentylenetetrazole-induced kindling model of epilepsy in rats. Naunyn-Schmiedeberg's archives of pharmacology. 2024-12-06. PMID:39643806. |
this study aimed to investigate the role of acetylcholinesterase (ache) and butyrylcholinesterase (buche) inhibitor rivastigmine (riva) in the pentylenetetrazole (ptz)- induced kindling model of epilepsy. |
2024-12-06 |
2024-12-10 |
rat |
| Malik Saadullah, Amna Sehar, Zunera Chauhdary, Rida Siddique, Hafsa Tariq, Muhammad Asif, Shazia Anwer Bukhari, Aisha Seth. Anti-neuroinflammatory and neuroprotective potential of Cissus tuberosa ethanol extract in Parkinson's disease model through the modulation of neuroinflammatory markers. PloS one. vol 19. issue 12. 2024-12-06. PMID:39642134. |
neurotransmitter levels were significantly improved in a dose-dependent manner (p<0.001), while acetylcholinesterase (ache) levels were significantly reduced (p<0.001). |
2024-12-06 |
2024-12-09 |
rat |
| Kalpana Rawat, Disha Tewari, Amisha Bisht, Subhash Chandra, Yewulsew Kebede Tiruneh, Hesham M Hassan, Ahmed Al-Emam, Emad Rashad Sindi, Al-Anood M Al-Die. Identification of AChE targeted therapeutic compounds for Alzheimer's disease: an in-silico study with DFT integration. Scientific reports. vol 14. issue 1. 2024-12-05. PMID:39638823. |
acetylcholinesterase (ache), which hydrolyzes acetylcholine, is a key drug target for treating ad. |
2024-12-05 |
2024-12-08 |
Not clear |
| Fresthel Monica M Climacosa, Veeda Michelle M Anlacan, Francis James A Gordovez, John Carlo B Reyes, Ian Kim B Tabios, Rafael Vincent M Manalo, Joana Marie Ceripulo Cruz, Joannes Luke B Asis, Rozel B Razal, Mark Joseph M Abaca, Aira B Dacasin, Ayra Patrice N Espiritu, Nicole Clarence Louise L Gapaz, Melody Hope L Lee Y. BMJ open. vol 14. issue 11. 2024-11-28. PMID:39608999. |
pharmacological agents approved for dementia include acetylcholinesterase enzyme (ache) inhibitors like rivastigmine, donepezil and galantamine and the n-methyl-d-aspartate (nmda) receptor antagonist memantine, prescribed as monotherapy or in combination with each other, depending on the severity of disease. |
2024-11-28 |
2024-12-01 |
Not clear |