| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Gómez Beldarrain, J Grafman, A Pascual-Leone, J C Garcia-Monc. Procedural learning is impaired in patients with prefrontal lesions. Neurology. vol 52. issue 9. 1999-07-15. PMID:10371534. |
to 1) determine the effect of prefrontal cortex lesions on procedural learning (pl), measured by a serial reaction-time task (srtt); 2) confirm whether visuomotor pl is lateralized to one hemisphere; and 3) clarify the relation between visuomotor sequence learning and verbal sequence learning, working memory, and executive functions. |
1999-07-15 |
2023-08-12 |
Not clear |
| J M Fuste. Synopsis of function and dysfunction of the frontal lobe. Acta psychiatrica Scandinavica. Supplementum. vol 395. 1999-06-28. PMID:10225333. |
the prefrontal cortex serves temporal organization by coordinating three cognitive operations that are essential for the formation of 'gestalts' in the time domain: (i) preparatory set; (ii) working memory; and (iii) inhibitory control of interference. |
1999-06-28 |
2023-08-12 |
human |
| R Levy, P S Goldman-Raki. Association of storage and processing functions in the dorsolateral prefrontal cortex of the nonhuman primate. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 12. 1999-06-28. PMID:10366648. |
the prominent role of the prefrontal cortex (pfc) in working memory (wm) is widely acknowledged both in nonhuman primates and in humans. |
1999-06-28 |
2023-08-12 |
monkey |
| R Levy, P S Goldman-Raki. Association of storage and processing functions in the dorsolateral prefrontal cortex of the nonhuman primate. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 12. 1999-06-28. PMID:10366648. |
however, less agreement exists on the issue of functional segregation within different subregions of the pfc with regard to the domains of spatial and nonspatial processing or involvement in simpler versus more complex aspects of wm, e.g., maintenance versus processing function. |
1999-06-28 |
2023-08-12 |
monkey |
| R Levy, P S Goldman-Raki. Association of storage and processing functions in the dorsolateral prefrontal cortex of the nonhuman primate. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 12. 1999-06-28. PMID:10366648. |
these results support a functional segregation within the dorsolateral prefrontal cortex for wm: the dorsolateral prefrontal cortex (area 46/8a) is selectively involved in spatial wm, whereas the dorsomedial convexity (area 9/8b) is not critically engaged in either spatial or nonspatial working memory. |
1999-06-28 |
2023-08-12 |
monkey |
| B Rypma, M D'Esposit. The roles of prefrontal brain regions in components of working memory: effects of memory load and individual differences. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 11. 1999-06-24. PMID:10339627. |
using an event-related functional mri design, we explored the relative roles of dorsal and ventral prefrontal cortex (pfc) regions during specific components (encoding, delay, response) of a working memory task under different memory-load conditions. |
1999-06-24 |
2023-08-12 |
human |
| B Rypma, M D'Esposit. The roles of prefrontal brain regions in components of working memory: effects of memory load and individual differences. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 11. 1999-06-24. PMID:10339627. |
this study supports the idea that dorsal and ventral pfc play different roles in component processes of working memory. |
1999-06-24 |
2023-08-12 |
human |
| R Romo, C D Brody, A Hernández, L Lemu. Neuronal correlates of parametric working memory in the prefrontal cortex. Nature. vol 399. issue 6735. 1999-06-24. PMID:10365959. |
neuronal correlates of parametric working memory in the prefrontal cortex. |
1999-06-24 |
2023-08-12 |
monkey |
| G Esposito, B S Kirkby, J D Van Horn, T M Ellmore, K F Berma. Context-dependent, neural system-specific neurophysiological concomitants of ageing: mapping PET correlates during cognitive activation. Brain : a journal of neurology. vol 122 ( Pt 5). 1999-06-15. PMID:10355679. |
absolute regional cerebral blood flow (rcbf) was measured in 41 healthy volunteers, evenly distributed across an age range of 18-80 years, during two task paradigms: (i) the wisconsin card sorting test (wcst), which depends heavily on working memory and is particularly sensitive to dysfunction of the dorsolateral prefrontal cortex (dlpfc); and (ii) raven's progressive matrices (rpm), which may also have a working memory component, but depends more on visuo-spatial processing and is most sensitive to dysfunction of postrolandic regions. |
1999-06-15 |
2023-08-12 |
human |
| M Diana, M Melis, G L Gess. Increase in meso-prefrontal dopaminergic activity after stimulation of CB1 receptors by cannabinoids. The European journal of neuroscience. vol 10. issue 9. 1999-06-07. PMID:9758152. |
considering that supranormal stimulation of d1 dopamine receptors in the prefrontal cortex has been shown to impair working memory, the present results suggest that the negative effects of cannabinoids on cognitive processes might be related to the activation of dopaminergic transmission in the prefrontal cortex. |
1999-06-07 |
2023-08-12 |
Not clear |
| M D'Esposito, G K Aguirre, E Zarahn, D Ballard, R K Shin, J Leas. Functional MRI studies of spatial and nonspatial working memory. Brain research. Cognitive brain research. vol 7. issue 1. 1999-05-21. PMID:9714705. |
this analysis did not find evidence for a dorsal/ventral subdivision of prefrontal cortex depending on the type of material held in working memory, but a hemispheric organization was suggested (i.e., left-nonspatial; right-spatial). |
1999-05-21 |
2023-08-12 |
human |
| M D'Esposito, G K Aguirre, E Zarahn, D Ballard, R K Shin, J Leas. Functional MRI studies of spatial and nonspatial working memory. Brain research. Cognitive brain research. vol 7. issue 1. 1999-05-21. PMID:9714705. |
neurobiol., 4 (1994) 207-211], a reconsideration of the previous imaging literature data suggested that a dorsal/ventral subdivision of prefrontal cortex may depend upon the type of processing performed upon the information held in working memory. |
1999-05-21 |
2023-08-12 |
human |
| J A Mangels, R B Ivry, N Shimiz. Dissociable contributions of the prefrontal and neocerebellar cortex to time perception. Brain research. Cognitive brain research. vol 7. issue 1. 1999-05-21. PMID:9714713. |
these findings support the hypothesis that neocerebellar regions subserve a central timing mechanism, whereas the prefrontal cortex subserves supportive functions associated with the acquisition, maintenance, monitoring and organization of temporal representations in working memory. |
1999-05-21 |
2023-08-12 |
Not clear |
| S G Rao, G V Williams, P S Goldman-Raki. Isodirectional tuning of adjacent interneurons and pyramidal cells during working memory: evidence for microcolumnar organization in PFC. Journal of neurophysiology. vol 81. issue 4. 1999-05-13. PMID:10200225. |
isodirectional tuning of adjacent interneurons and pyramidal cells during working memory: evidence for microcolumnar organization in pfc. |
1999-05-13 |
2023-08-12 |
Not clear |
| S G Rao, G V Williams, P S Goldman-Raki. Isodirectional tuning of adjacent interneurons and pyramidal cells during working memory: evidence for microcolumnar organization in PFC. Journal of neurophysiology. vol 81. issue 4. 1999-05-13. PMID:10200225. |
studies on the cellular mechanisms of working memory demonstrated that neurons in dorsolateral prefrontal cortex (dpfc) exhibit directionally tuned activity during an oculomotor delayed response. |
1999-05-13 |
2023-08-12 |
Not clear |
| A M Owen, N J Herrod, D K Menon, J C Clark, S P Downey, T A Carpenter, P S Minhas, F E Turkheimer, E J Williams, T W Robbins, B J Sahakian, M Petrides, J D Pickar. Redefining the functional organization of working memory processes within human lateral prefrontal cortex. The European journal of neuroscience. vol 11. issue 2. 1999-04-21. PMID:10051756. |
redefining the functional organization of working memory processes within human lateral prefrontal cortex. |
1999-04-21 |
2023-08-12 |
human |
| D Durstewitz, M Kelc, O Güntürkü. A neurocomputational theory of the dopaminergic modulation of working memory functions. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 7. 1999-04-13. PMID:10087092. |
the dopaminergic modulation of neural activity in the prefrontal cortex (pfc) is essential for working memory. |
1999-04-13 |
2023-08-12 |
Not clear |
| D Durstewitz, M Kelc, O Güntürkü. A neurocomputational theory of the dopaminergic modulation of working memory functions. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 7. 1999-04-13. PMID:10087092. |
delay-activity in the pfc in working memory tasks persists even if interfering stimuli intervene between the presentation of the sample and the target stimulus. |
1999-04-13 |
2023-08-12 |
Not clear |
| D Durstewitz, M Kelc, O Güntürkü. A neurocomputational theory of the dopaminergic modulation of working memory functions. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 7. 1999-04-13. PMID:10087092. |
here, the hypothesis is put forward that the functional role of dopamine in working memory processing is to stabilize active neural representations in the pfc network and thereby to protect goal-related delay-activity against interfering stimuli. |
1999-04-13 |
2023-08-12 |
Not clear |
| J I Friedman, H Temporini, K L Davi. Pharmacologic strategies for augmenting cognitive performance in schizophrenia. Biological psychiatry. vol 45. issue 1. 1999-04-01. PMID:9894570. |
dopamine activity at d1 receptors mediates many cognitive processes subserved by the prefrontal cortex (pfc), particularly working memory. |
1999-04-01 |
2023-08-12 |
human |