| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu-Tien Hsu, Jie Li, Dick Wu, Thomas C Südhof, Lu Che. Synaptic retinoic acid receptor signaling mediates mTOR-dependent metaplasticity that controls hippocampal learning. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 14. 2019-05-16. PMID:30782829. |
here, we show in mice that the experience of an enriched environment (ee) engaged homeostatic synaptic plasticity in hippocampal circuits, thereby reducing excitatory synaptic transmission. |
2019-05-16 |
2023-08-13 |
mouse |
| Gayane Grigoryan, Niklas Lonnemann, Martin Kort. Immune Challenge Alters Reactivity of Hippocampal Noradrenergic System in Prenatally Stressed Aged Mice. Neural plasticity. vol 2019. 2019-05-13. PMID:30804990. |
a ps-induced proinflammatory status of the organism may result in an impairment of both hippocampal synaptic plasticity and hippocampus-dependent memory formation in adults. |
2019-05-13 |
2023-08-13 |
mouse |
| Zikai Zhou, An Liu, Shuting Xia, Celeste Leung, Junxia Qi, Yanghong Meng, Wei Xie, Pojeong Park, Graham L Collingridge, Zhengping Ji. The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning. Nature neuroscience. vol 21. issue 1. 2019-05-09. PMID:29230056. |
the c-terminal tails of endogenous glua1 and glua2 differentially contribute to hippocampal synaptic plasticity and learning. |
2019-05-09 |
2023-08-13 |
mouse |
| Xi Xiao, Xueliang Shang, Baohui Zhai, Hui Zhang, Tao Zhan. Nicotine alleviates chronic stress-induced anxiety and depressive-like behavior and hippocampal neuropathology via regulating autophagy signaling. Neurochemistry international. vol 114. 2019-05-08. PMID:29339018. |
recently, we reported that chronic nicotine significantly improved chronic stress-induced impairments of cognition and the hippocampal synaptic plasticity in mice, however, the underlying mechanism still needs to be explored. |
2019-05-08 |
2023-08-13 |
mouse |
| Gemma McGregor, Jenni Harve. Leptin Regulation of Synaptic Function at Hippocampal TA-CA1 and SC-CA1 Synapses: Implications for Health and Disease. Neurochemical research. vol 44. issue 3. 2019-05-07. PMID:28819795. |
indeed, numerous studies show that leptin facilitates the cellular events that underlie hippocampal learning and memory including activity-dependent synaptic plasticity and glutamate receptor trafficking, indicating that leptin may be a potential cognitive enhancer. |
2019-05-07 |
2023-08-13 |
Not clear |
| Patrick Dutar, Brigitte Potie. Susceptibility to Aβo and TBOA of LTD and Extrasynaptic NMDAR-Dependent Tonic Current in the Aged Rat Hippocampus. Neurochemical research. vol 44. issue 3. 2019-05-07. PMID:30426348. |
in this study, we asked for the effects of aβo on long-term depression (ltd), a form of synaptic plasticity dependent on extrasynaptic nmdar activation, and on a tonic current (tc) resulting from the activation of extrasynaptic nmdar by ambient glutamate in hippocampal slices from young (3-6-month-old) and aged (24-28-month-old) sprague-dawley rats. |
2019-05-07 |
2023-08-13 |
rat |
| Nichola Marie Brydges, Anna Moon, Lowenna Rule, Holly Watkin, Kerrie L Thomas, Jeremy Hal. Sex specific effects of pre-pubertal stress on hippocampal neurogenesis and behaviour. Translational psychiatry. vol 8. issue 1. 2019-05-06. PMID:30531788. |
stress in utero can lead to impaired hippocampal synaptic plasticity, and stress in the first 2-3 weeks of life reduces ahn in animal models. |
2019-05-06 |
2023-08-13 |
human |
| Tirill Medin, Vidar Jensen, Øyvind Skare, Jon Storm-Mathisen, Øyvind Hvalby, Linda Hildegard Bergerse. Altered α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor function and expression in hippocampus in a rat model of attention-deficit/hyperactivity disorder (ADHD). Behavioural brain research. vol 360. 2019-05-02. PMID:30552946. |
their modulation plays key roles in synaptic plasticity, which underlies hippocampal learning and memory. |
2019-05-02 |
2023-08-13 |
rat |
| Jikai Zhao, Chen Bian, Mengying Liu, Yangang Zhao, Tao Sun, Fangzhou Xing, Jiqiang Zhan. Orchiectomy and letrozole differentially regulate synaptic plasticity and spatial memory in a manner that is mediated by SRC-1 in the hippocampus of male mice. The Journal of steroid biochemistry and molecular biology. vol 178. 2019-05-01. PMID:29452160. |
orchiectomy and letrozole differentially regulate synaptic plasticity and spatial memory in a manner that is mediated by src-1 in the hippocampus of male mice. |
2019-05-01 |
2023-08-13 |
mouse |
| Jikai Zhao, Chen Bian, Mengying Liu, Yangang Zhao, Tao Sun, Fangzhou Xing, Jiqiang Zhan. Orchiectomy and letrozole differentially regulate synaptic plasticity and spatial memory in a manner that is mediated by SRC-1 in the hippocampus of male mice. The Journal of steroid biochemistry and molecular biology. vol 178. 2019-05-01. PMID:29452160. |
hippocampal synaptic plasticity is the basis of spatial memory and cognition and is strongly regulated by both testicular androgens (testosterone, t) and hippocampal estrogens (17β-estradiol, e2) converted from t by aromatase, which is inhibited by letrozole (let), but the contribution of each pathway to spatial memory and the associated mechanisms are unclear. |
2019-05-01 |
2023-08-13 |
mouse |
| Jikai Zhao, Chen Bian, Mengying Liu, Yangang Zhao, Tao Sun, Fangzhou Xing, Jiqiang Zhan. Orchiectomy and letrozole differentially regulate synaptic plasticity and spatial memory in a manner that is mediated by SRC-1 in the hippocampus of male mice. The Journal of steroid biochemistry and molecular biology. vol 178. 2019-05-01. PMID:29452160. |
in this study, we first used orchiectomy (orx) and let injection to investigate the effects of t and hippocampal e2 on spatial memory and hippocampal synaptic plasticity. |
2019-05-01 |
2023-08-13 |
mouse |
| Hei-Jen Huang, Shu-Ling Chen, Hsin-Yu Huang, Ying-Chieh Sun, Guan-Chiun Lee, Guey-Jen Lee-Chen, Hsiu Mei Hsieh-Li, Ming-Tsan S. Chronic low dose of AM404 ameliorates the cognitive impairment and pathological features in hyperglycemic 3xTg-AD mice. Psychopharmacology. vol 236. issue 2. 2019-04-25. PMID:30426182. |
our previous biochemical assay identified am404 as a gsk3β inhibitor at high dose (ic50 = 5.353 μm); however, other study suggests that am404 impaired synaptic plasticity of hippocampus at high dose (10 mg/kg; i.p.). |
2019-04-25 |
2023-08-13 |
mouse |
| Toshiko Ishikawa, Motoki Okano, Akiko Minami, Hiroko Tsunekawa, Hiroshi Satoyoshi, Yuka Tsukamoto, Kazue Takahata, Shizuko Muraok. Selegiline ameliorates depression-like behaviors in rodents and modulates hippocampal dopaminergic transmission and synaptic plasticity. Behavioural brain research. vol 359. 2019-04-23. PMID:30359642. |
selegiline ameliorates depression-like behaviors in rodents and modulates hippocampal dopaminergic transmission and synaptic plasticity. |
2019-04-23 |
2023-08-13 |
mouse |
| Toshiko Ishikawa, Motoki Okano, Akiko Minami, Hiroko Tsunekawa, Hiroshi Satoyoshi, Yuka Tsukamoto, Kazue Takahata, Shizuko Muraok. Selegiline ameliorates depression-like behaviors in rodents and modulates hippocampal dopaminergic transmission and synaptic plasticity. Behavioural brain research. vol 359. 2019-04-23. PMID:30359642. |
these results suggest that the antidepressant-like effects of selegiline are attributable to enhancement of dopaminergic transmission and prevention of the impairment of synaptic plasticity in the hippocampus. |
2019-04-23 |
2023-08-13 |
mouse |
| Vassilios Papaleonidopoulos, Stylianos Kouvaros, Costas Papatheodoropoulo. Effects of endogenous and exogenous D1/D5 dopamine receptor activation on LTP in ventral and dorsal CA1 hippocampal synapses. Synapse (New York, N.Y.). vol 72. issue 8. 2019-04-22. PMID:29537707. |
hippocampus is importantly involved in dopamine-dependent behaviors and dopamine is a significant modulator of synaptic plasticity in the hippocampus. |
2019-04-22 |
2023-08-13 |
Not clear |
| Vassilios Papaleonidopoulos, Stylianos Kouvaros, Costas Papatheodoropoulo. Effects of endogenous and exogenous D1/D5 dopamine receptor activation on LTP in ventral and dorsal CA1 hippocampal synapses. Synapse (New York, N.Y.). vol 72. issue 8. 2019-04-22. PMID:29537707. |
moreover, the dopaminergic innervation appears to be disproportionally segregated along the hippocampal longitudinal (dorsoventral) axis with unknown consequences for synaptic plasticity. |
2019-04-22 |
2023-08-13 |
Not clear |
| Ralph J Koek, Tinh N Luon. Theranostic pharmacology in PTSD: Neurobiology and timing. Progress in neuro-psychopharmacology & biological psychiatry. vol 90. 2019-04-22. PMID:30529001. |
a theranostic approach however, also requires consideration of timing, pre, peri or post trauma in conjunction with underlying dynamic processes affecting synaptic plasticity, the hpa axis, hippocampal activation, pfc-amygdala circuitry and fear memory. |
2019-04-22 |
2023-08-13 |
Not clear |
| Srdjan M Joksimovic, Yukitoshi Izumi, Sonja Lj Joksimovic, Vesna Tesic, Kathiresan Krishnan, Betelehem Asnake, Vesna Jevtovic-Todorovic, Douglas F Covey, Charles F Zorumski, Slobodan M Todorovi. Novel neurosteroid hypnotic blocks T-type calcium channel-dependent rebound burst firing and suppresses long-term potentiation in the rat subiculum. British journal of anaesthesia. vol 122. issue 5. 2019-04-22. PMID:30916017. |
hypnotics and general anaesthetics impair memory by altering hippocampal synaptic plasticity. |
2019-04-22 |
2023-08-13 |
rat |
| Srdjan M Joksimovic, Yukitoshi Izumi, Sonja Lj Joksimovic, Vesna Tesic, Kathiresan Krishnan, Betelehem Asnake, Vesna Jevtovic-Todorovic, Douglas F Covey, Charles F Zorumski, Slobodan M Todorovi. Novel neurosteroid hypnotic blocks T-type calcium channel-dependent rebound burst firing and suppresses long-term potentiation in the rat subiculum. British journal of anaesthesia. vol 122. issue 5. 2019-04-22. PMID:30916017. |
here, we investigated the effects of 3β-oh on neuronal excitability in the subiculum, the major output structure of the hippocampal formation, and synaptic plasticity at two key hippocampal synapses in juvenile rats. |
2019-04-22 |
2023-08-13 |
rat |
| Wei Cheng, Fan Han, Yuxiu Sh. Neonatal isolation modulates glucocorticoid-receptor function and synaptic plasticity of hippocampal and amygdala neurons in a rat model of single prolonged stress. Journal of affective disorders. vol 246. 2019-04-17. PMID:30611912. |
neonatal isolation modulates glucocorticoid-receptor function and synaptic plasticity of hippocampal and amygdala neurons in a rat model of single prolonged stress. |
2019-04-17 |
2023-08-13 |
rat |