| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gaga Kochlamazashvili, Oleg Senkov, Sergei Grebenyuk, Catrina Robinson, Mei-Fang Xiao, Katharina Stummeyer, Rita Gerardy-Schahn, Andreas K Engel, Larry Feig, Alexey Semyanov, Vishnu Suppiramaniam, Melitta Schachner, Alexander Dityate. Neural cell adhesion molecule-associated polysialic acid regulates synaptic plasticity and learning by restraining the signaling through GluN2B-containing NMDA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 11. 2010-05-18. PMID:20237287. |
abnormalities in psa and ncam expression are associated with schizophrenia in humans and cause deficits in hippocampal synaptic plasticity and contextual fear conditioning in mice. |
2010-05-18 |
2023-08-12 |
mouse |
| Loren J Martin, Agnieszka A Zurek, John F MacDonald, John C Roder, Michael F Jackson, Beverley A Orse. Alpha5GABAA receptor activity sets the threshold for long-term potentiation and constrains hippocampus-dependent memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 15. 2010-05-14. PMID:20392949. |
we studied the regulation of synaptic plasticity by alpha5 subunit-containing gaba(a)rs (alpha5gaba(a)rs), which generate a tonic inhibitory conductance in ca1 pyramidal neurons using electrophysiological recordings of field and whole-cell potentials in hippocampal slices from both wild-type and null mutant mice for the alpha5 subunit of the gaba(a)r (gabra5(-/-) mice). |
2010-05-14 |
2023-08-12 |
mouse |
| Michel L Samson, Kosuke Kajitani, George S Robertso. Nitric-oxide synthase mediates the ability of darbepoetin alfa to attenuate pre-existing spatial working memory deficits in rats subjected to transient global ischemia. The Journal of pharmacology and experimental therapeutics. vol 333. issue 2. 2010-05-10. PMID:20167842. |
erythropoietin has been reported to improve the behavioral performance of healthy mice in tests thought to depend on synaptic plasticity in the ca1 region of the hippocampus. |
2010-05-10 |
2023-08-12 |
mouse |
| Alexandra Auffret, Vanessa Gautheron, Mark P Mattson, Jean Mariani, Catherine Rovir. Progressive age-related impairment of the late long-term potentiation in Alzheimer's disease presenilin-1 mutant knock-in mice. Journal of Alzheimer's disease : JAD. vol 19. issue 3. 2010-05-05. PMID:20157256. |
while increasing evidence points to impaired synaptic plasticity as an early event in ad, ps1 mutant mice exhibit a paradoxical increase in hippocampal long-term potentiation (ltp). |
2010-05-05 |
2023-08-12 |
mouse |
| Detlef Balschun, Diederik Moechars, Zsuzsanna Callaerts-Vegh, Ben Vermaercke, Nathalie Van Acker, Luc Andries, Rudi D'Hoog. Vesicular glutamate transporter VGLUT1 has a role in hippocampal long-term potentiation and spatial reversal learning. Cerebral cortex (New York, N.Y. : 1991). vol 20. issue 3. 2010-05-04. PMID:19574394. |
we generated and characterized vglut1 knockout mice in order to examine the functional contribution of this transporter to hippocampal synaptic plasticity and hippocampus-dependent spatial learning. |
2010-05-04 |
2023-08-12 |
mouse |
| Detlef Balschun, Diederik Moechars, Zsuzsanna Callaerts-Vegh, Ben Vermaercke, Nathalie Van Acker, Luc Andries, Rudi D'Hoog. Vesicular glutamate transporter VGLUT1 has a role in hippocampal long-term potentiation and spatial reversal learning. Cerebral cortex (New York, N.Y. : 1991). vol 20. issue 3. 2010-05-04. PMID:19574394. |
our data suggest a functional role of vglut1 in forms of hippocampal synaptic plasticity that are required to adapt and modify acquired spatial maps to external stimuli and changes. |
2010-05-04 |
2023-08-12 |
mouse |
| Daisuke Ibi, Atsumi Nitta, Kumiko Ishige, Xiaobo Cen, Tomohiro Ohtakara, Toshitaka Nabeshima, Yoshihisa It. Piccolo knockdown-induced impairments of spatial learning and long-term potentiation in the hippocampal CA1 region. Neurochemistry international. vol 56. issue 1. 2010-05-04. PMID:19766155. |
taken together, these results indicate that piccolo plays a pivotal role in synaptic plasticity in area ca1 and in hippocampus-dependent learning in mice, and that the extracellular levels of glutamate in the hippocampus under stimulated conditions are controlled by piccolo. |
2010-05-04 |
2023-08-12 |
mouse |
| Ping Jun Zhu, David M Lovinge. Developmental alteration of endocannabinoid retrograde signaling in the hippocampus. Journal of neurophysiology. vol 103. issue 2. 2010-05-03. PMID:20007500. |
the differential dsi magnitude at different stages of maturation could alter synaptic plasticity and learning and memory during hippocampal development. |
2010-05-03 |
2023-08-12 |
rat |
| Takami Tomiyama, Shogo Matsuyama, Hiroyuki Iso, Tomohiro Umeda, Hiroshi Takuma, Kiyouhisa Ohnishi, Kenichi Ishibashi, Rie Teraoka, Naomi Sakama, Takenari Yamashita, Kazuchika Nishitsuji, Kazuhiro Ito, Hiroyuki Shimada, Mary P Lambert, William L Klein, Hiroshi Mor. A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 14. 2010-04-26. PMID:20371804. |
hippocampal synaptic plasticity and memory were impaired at 8 months, at which time the presynaptic marker synaptophysin began to decrease. |
2010-04-26 |
2023-08-12 |
mouse |
| Gang Lu, Qi-Xin Zhou, Shuo Kang, Qing-Lin Li, Liang-Cai Zhao, Jia-Dong Chen, Jian-Feng Sun, Jun Cao, Yu-Jun Wang, Jie Chen, Xiao-Yan Chen, Da-Fang Zhong, Zhi-Qiang Chi, Lin Xu, Jing-Gen Li. Chronic morphine treatment impaired hippocampal long-term potentiation and spatial memory via accumulation of extracellular adenosine acting on adenosine A1 receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 14. 2010-04-26. PMID:20371826. |
given the well known effects of adenosine, an important neuromodulator, on hippocampal neuronal excitability and synaptic plasticity, we investigated the potential effect of changes in adenosine concentrations on chronic morphine treatment-induced impairment of hippocampal ca1 ltp and spatial memory. |
2010-04-26 |
2023-08-12 |
mouse |
| Suhel Parvez, Binu Ramachandran, Julietta U Fre. Functional differences between and across different regions of the apical branch of hippocampal CA1 dendrites with respect to long-term depression induction and synaptic cross-tagging. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 14. 2010-04-26. PMID:20371832. |
the hippocampus is an ideal system to study synaptic plasticity in the context of learning and memory. |
2010-04-26 |
2023-08-12 |
Not clear |
| Jian Feng, Yu Zhou, Susan L Campbell, Thuc Le, En Li, J David Sweatt, Alcino J Silva, Guoping Fa. Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nature neuroscience. vol 13. issue 4. 2010-04-22. PMID:20228804. |
although we found no neuronal loss, hippocampal neurons in dko mice were smaller than in the wild type; furthermore, dko neurons showed deregulated expression of genes, including the class i mhc genes and stat1, that are known to contribute to synaptic plasticity. |
2010-04-22 |
2023-08-12 |
mouse |
| Jonathan L Brigman, Tara Wright, Giuseppe Talani, Shweta Prasad-Mulcare, Seiichiro Jinde, Gail K Seabold, Poonam Mathur, Margaret I Davis, Roland Bock, Richard M Gustin, Roger J Colbran, Veronica A Alvarez, Kazu Nakazawa, Eric Delpire, David M Lovinger, Andrew Holme. Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 13. 2010-04-22. PMID:20357110. |
these data further demonstrate the importance of glun2b for synaptic plasticity in the adult hippocampus and suggest a particularly critical role in ltd, at least the form studied here. |
2010-04-22 |
2023-08-12 |
mouse |
| Emily B Einstein, Carlyn A Patterson, Beverly J Hon, Kathleen A Regan, Jyoti Reddi, David E Melnikoff, Marcus J Mateer, Stefan Schulz, Brian N Johnson, Melanie K Tallen. Somatostatin signaling in neuronal cilia is critical for object recognition memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 12. 2010-04-20. PMID:20335466. |
to examine mechanisms of sst(3), we tested synaptic plasticity in ca1 hippocampus. |
2010-04-20 |
2023-08-12 |
mouse |
| Anne-Marie Miller, Alessia Piazza, Darren S D Martin, Michelle Walsh, Arkady Mandel, Anthony E Bolton, Marina A Lync. The deficit in long-term potentiation induced by chronic administration of amyloid-beta is attenuated by treatment of rats with a novel phospholipid-based drug formulation, VP025. Experimental gerontology. vol 44. issue 4. 2010-04-16. PMID:19121379. |
one of the consequences of increased abeta in the brain, either as a result of overexpression of the precursor amyloid precursor protein in transgenic mice, or injection into the brain is a decrease in one form of synaptic plasticity, long-term potentiation (ltp) in the hippocampus. |
2010-04-16 |
2023-08-12 |
mouse |
| Gaël Malleret, Juan M Alarcon, Guillaume Martel, Shuichi Takizawa, Svetlana Vronskaya, Deqi Yin, Irene Z Chen, Eric R Kandel, Gleb P Shumyatsk. Bidirectional regulation of hippocampal long-term synaptic plasticity and its influence on opposing forms of memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 10. 2010-04-09. PMID:20220016. |
bidirectional regulation of hippocampal long-term synaptic plasticity and its influence on opposing forms of memory. |
2010-04-09 |
2023-08-12 |
mouse |
| Kyle A Vick, Michael Guidi, Robert W Stackma. In vivo pharmacological manipulation of small conductance Ca(2+)-activated K(+) channels influences motor behavior, object memory and fear conditioning. Neuropharmacology. vol 58. issue 3. 2010-04-07. PMID:19944112. |
the activation of dendritic sk channels limits the induction of synaptic plasticity that may underlie hippocampal and amygdala dependent memory. |
2010-04-07 |
2023-08-12 |
mouse |
| Jeanette Hellgren Kotaleski, Kim T Blackwel. Modelling the molecular mechanisms of synaptic plasticity using systems biology approaches. Nature reviews. Neuroscience. vol 11. issue 4. 2010-04-07. PMID:20300102. |
computer modelling has been used to investigate the information processing that is performed by the signalling pathways involved in synaptic plasticity in principal neurons of the hippocampus, striatum and cerebellum. |
2010-04-07 |
2023-08-12 |
Not clear |
| Hey-Kyoung Lee, Kogo Takamiya, Kaiwen He, Lihua Song, Richard L Hugani. Specific roles of AMPA receptor subunit GluR1 (GluA1) phosphorylation sites in regulating synaptic plasticity in the CA1 region of hippocampus. Journal of neurophysiology. vol 103. issue 1. 2010-03-30. PMID:19906877. |
specific roles of ampa receptor subunit glur1 (glua1) phosphorylation sites in regulating synaptic plasticity in the ca1 region of hippocampus. |
2010-03-30 |
2023-08-12 |
mouse |
| Gisela Grecksch, Heinz Rüthrich, Volker Höllt, Axel Becke. Transient prenatal vitamin D deficiency is associated with changes of synaptic plasticity in the dentate gyrus in adult rats. Psychoneuroendocrinology. vol 34 Suppl 1. 2010-03-26. PMID:19647946. |
it can be suggested, that changes in brain development induced by prenatal vitamin d deficiency lead to specific functional alterations in hippocampal synaptic plasticity. |
2010-03-26 |
2023-08-12 |
rat |