| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kevin M Keary, Zheng L. Protocol for preparing mouse hippocampal slices for ex vivo recordings of the temporoammonic pathway. STAR protocols. vol 6. issue 2. 2025-03-15. PMID:40088452. |
the temporoammonic pathway (tap), the direct input from the entorhinal cortex to the hippocampus, is an important model structure for investigating synaptic plasticity. |
2025-03-15 |
2025-03-18 |
mouse |
| Lilit Darbinyan, Karen Simonyan, Lilia Hambardzumyan, Larisa Manukyan, Kristine Karapetyan, Margarita Danielya. Impact of L-thyroxine on hippocampal activity, morphology, and behavioral performance in thyroidectomized rats. Metabolic brain disease. vol 40. issue 3. 2025-03-10. PMID:40063269. |
results revealed significant changes in hippocampal electrophysiological responses in the l-thyroxine-treated group, including enhanced synaptic plasticity, increased excitatory activity, and more frequent, synchronized neuronal firing in the ca1 and ca3 regions. |
2025-03-10 |
2025-03-13 |
rat |
| Tanja Fuchsberger, Imogen Stockwell, Matty Woods, Zuzanna Brzosko, Ingo H Greger, Ole Paulse. Dopamine increases protein synthesis in hippocampal neurons enabling dopamine-dependent LTP. eLife. vol 13. 2025-03-10. PMID:40063079. |
the reward and novelty-related neuromodulator dopamine plays an important role in hippocampal long-term memory, which is thought to involve protein-synthesis-dependent synaptic plasticity. |
2025-03-10 |
2025-03-12 |
mouse |
| Si-Yu Huang, Zhi-Jun Yang, Jin Cheng, Hang-Yu Li, Si Chen, Zi-Hui Huang, Jie-Dong Chen, Ruo-Gu Xiong, Meng-Tao Yang, Chen Wang, Meng-Chu Li, Shuang Song, Wen-Ge Huang, Dong-Liang Wang, Hua-Bin Li, Qiu-Ye La. Choline alleviates cognitive impairment in sleep-deprived young mice via reducing neuroinflammation and altering phospholipidomic profile. Redox biology. vol 81. 2025-03-08. PMID:40056720. |
choline also reduces inflammation and oxidative stress biomarkers, and mitigates microglial activation in the hippocampus, which preserves synaptic plasticity. |
2025-03-08 |
2025-03-11 |
mouse |
| Jill C Flannery, Parker S Tirrell, Nina E Baumgartner, Jill M Danie. Neuroestrogens, the hippocampus, and female cognitive aging. Hormones and behavior. vol 170. 2025-03-04. PMID:40036999. |
these brain-derived neuroestrogens act in the hippocampus to regulate dendritic spine dynamics and synaptic plasticity as well as hippocampus-dependent memory. |
2025-03-04 |
2025-03-07 |
Not clear |
| Wei Zhou, Pengqi Li, Wen Meng, Stephanie Hong Zheng, Shixiong Zhang, Shasha Yi, Minghui Gao, Zhengrong Li. Selective sub-nucleus ultrasound stimulation induces synaptic potentiation in the mouse hippocampus. IEEE transactions on ultrasonics, ferroelectrics, and frequency control. vol PP. 2025-03-03. PMID:40031237. |
in this study, we developed a miniature, high target-specificity ultrasound neuro-stimulation chip to selectively stimulate sub-nucleus and investigate the synaptic plasticity induced by ultrasound stimulation in mouse hippocampal slices. |
2025-03-03 |
2025-03-06 |
mouse |
| Linlin Zhang, Yanzhong Liu, Xin Wang, Hao Wu, Jiahui Xie, Yiping Li. Treadmill exercise ameliorates hippocampal synaptic injury and recognition memory deficits by TREM2 in AD rat model. Brain research bulletin. 2025-02-27. PMID:40015348. |
here, we aim to explore whether physical exercise pretreatment alters aβ-induced recognition memory impairment in structural synaptic plasticity within the hippocampus in ad rats. |
2025-02-27 |
2025-03-02 |
rat |
| Lihong Su, Jinchao Hou, Boxuan Wang, Yuqi Li, Xiaodong Huo, Tao Wang, Yuankang Zou, Gang Zhen. Mitofilin-mtDNA Axis Mediates Chronic Lead Exposure-Induced Synaptic Plasticity Impairment of Hippocampal and Cognitive Deficits. Biomolecules. vol 15. issue 2. 2025-02-26. PMID:40001575. |
mitofilin-mtdna axis mediates chronic lead exposure-induced synaptic plasticity impairment of hippocampal and cognitive deficits. |
2025-02-26 |
2025-02-28 |
mouse |
| Lihong Su, Jinchao Hou, Boxuan Wang, Yuqi Li, Xiaodong Huo, Tao Wang, Yuankang Zou, Gang Zhen. Mitofilin-mtDNA Axis Mediates Chronic Lead Exposure-Induced Synaptic Plasticity Impairment of Hippocampal and Cognitive Deficits. Biomolecules. vol 15. issue 2. 2025-02-26. PMID:40001575. |
to elucidate the role and mechanism of the mitofilin-mtdna axis in hippocampal synaptic plasticity and learning and memory impairment induced by lead exposure, in this study, both in vivo and in vitro models were subjected to chronic lead exposure. |
2025-02-26 |
2025-02-28 |
mouse |
| Christopher L Robison, Victoria Madore, Nicole Cova, Mona Karbalivand, Sherine F Elsawa, Sergios Charntiko. Differential Gene Expression in the Prefrontal Cortex and Hippocampus Following Long-Access Methamphetamine Self-Administration in Male Rats. International journal of molecular sciences. vol 26. issue 4. 2025-02-26. PMID:40003870. |
we identified 41 degs in the pfc and 32 in the hippocampus, many involved in synaptic plasticity, immune response, and energy metabolism. |
2025-02-26 |
2025-02-28 |
rat |
| Weijia Zhi, Jiale Tang, Mingzhao Zhang, Yong Zou, Simo Qiao, Lizhen Ma, Ji Dong, Binwei Yao, Xuelong Zhao, Zhenqi Yang, Zhongwu Lin, Xiangjun Hu, Lifeng Wan. Mechanistic insights into microwave radiation induced cognitive impairments: The role of m Ecotoxicology and environmental safety. vol 292. 2025-02-25. PMID:39999628. |
based on previous studies, we hypothesize that microwave-induced cognitive impairments and vulnerability in the hippocampal dentate gyrus (dg) region are due to abnormal synaptic plasticity regulated by both newborn and mature neurons derived from neural stem cells (nscs). |
2025-02-25 |
2025-02-28 |
human |
| Souhail Djebari, Raquel Jiménez-Herrera, Guillermo Iborra-Lázaro, Lydia Jiménez-Díaz, Juan D Navarro-Lópe. Social and contextual memory impairments induced by Amyloid-β oligomers are rescued by Sigma-1 receptor activation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 184. 2025-02-25. PMID:39999645. |
they also interact with various proteins and signaling pathways, playing a key role in regulating synaptic plasticity in brain areas such as the hippocampus, thereby influencing learning and memory processes. |
2025-02-25 |
2025-02-28 |
Not clear |
| Can Tang, Jie Gao, Sen Li, Hui Cheng, Yu-Yuan Peng, Yang Ding, Huan Yang, Xin-Mei Ma, Hai-Yan Wang, Zai-Yun Long, Xiu-Min Lu, Yong-Tang Wan. Chlorogenic acid improves SPS-induced PTSD-like behaviors in rats by regulating the crosstalk between Nrf2 and NF-κB signaling pathway. Free radical biology & medicine. 2025-02-25. PMID:39999932. |
the followed vivo experiments indicated that cga could alleviate single prolonged stress (sps)-induced ptsd-like behaviors, and improve hippocampal pathological damage, apoptosis and synaptic plasticity through antioxidant and anti-inflammatory effects by regulating nrf2 and nf-κb pathways. |
2025-02-25 |
2025-02-28 |
rat |
| Can Tang, Jie Gao, Sen Li, Hui Cheng, Yu-Yuan Peng, Yang Ding, Huan Yang, Xin-Mei Ma, Hai-Yan Wang, Zai-Yun Long, Xiu-Min Lu, Yong-Tang Wan. Chlorogenic acid improves SPS-induced PTSD-like behaviors in rats by regulating the crosstalk between Nrf2 and NF-κB signaling pathway. Free radical biology & medicine. 2025-02-25. PMID:39999932. |
thus, cga may inhibit hippocampal neuronal apoptosis, reduce neuroinflammatory and oxdiative stress response, and enhance hippocampal synaptic plasticity through regulating the crosstalk between nrf2 and nf-κb signaling pathway, thereby improving sps-induced ptsd-like behaviors. |
2025-02-25 |
2025-02-28 |
rat |
| Christina Strauch, Juliane Böge, Olena Shchyglo, Valentyna Dubovyk, Denise Manahan-Vaugha. The Suprapyramidal and Infrapyramidal Blades of the Dentate Gyrus Exhibit Different GluN Subunit Content and Dissimilar Frequency-Dependent Synaptic Plasticity In Vivo. Hippocampus. vol 35. issue 2. 2025-02-25. PMID:39994965. |
different electrophysiological stimulation patterns of the pp can generate hippocampal synaptic plasticity. |
2025-02-25 |
2025-02-27 |
rat |
| Gioia Marino, Federica Campanelli, Giuseppina Natale, Maria De Carluccio, Federica Servillo, Veronica Ghiglieri, Paolo Calabres. Synaptic Interactions Between Serotonergic and Dopaminergic Systems in Parkinson's Disease. Current neuropharmacology. 2025-02-24. PMID:39988779. |
since both serotonergic and dopaminergic afferents densely innervate many parts of the central nervous system, intact crosstalk between serotonin (5-ht) and dopamine (da) transmission is essential for regulating synaptic plasticity in the striatum (str), prefrontal cortex (pfc), and hippocampus (hpc).. |
2025-02-24 |
2025-02-26 |
Not clear |
| Leilei Shi, Mingmei Wang, Ruixuan Yu, Yuyu An, Xin Wang, Yuhan Zhang, Yongheng Shi, Chaojun Han, Jiping Li. Sigma-1 receptor agonist PRE-084 increases BDNF by activating the ERK/CREB pathway to rescue learning and memory impairment caused by type II diabetes. Behavioural brain research. 2025-02-22. PMID:39986614. |
given the fundamental role of intact hippocampal synaptic plasticity in maintaining cognitive function, we investigated the correlation between sig-1r and brain-derived neurotrophic factor (bdnf), a well-established neurotrophic factor. |
2025-02-22 |
2025-02-25 |
rat |
| Shuang Lin, Chuan-Jie Wang, Peng-Kun Yang, Bing Li, Yi Wu, Ke-Wei Y. Enriched environment improves memory function by promoting synaptic remodeling in vascular dementia rats. Brain research bulletin. 2025-02-20. PMID:39978738. |
the potential of enriched environment (ee) to ameliorate cognitive impairments by enhancing hippocampal synaptic plasticity, neurogenesis, and white matter remodeling has garnered considerable interest. |
2025-02-20 |
2025-02-23 |
rat |
| Yukitoshi Izumi, Kazuko A O'Dell, Steven Mennerick, Charles F Zorumsk. Effects of acute pro-inflammatory stimulation and 25-hydroxycholesterol on hippocampal plasticity and learning involve NLRP3 inflammasome and cellular stress responses. Scientific reports. vol 15. issue 1. 2025-02-20. PMID:39979396. |
we previously found that acute effects of pro-inflammatory stimulation with lipopolysaccharide (lps) on hippocampal long-term potentiation (ltp), a form of synaptic plasticity involved in learning and memory, requires synthesis of the oxysterol, 25-hydroxycholesterol (25hc) and exogenous 25hc mimics effects of lps. |
2025-02-20 |
2025-02-23 |
rat |
| Yukitoshi Izumi, Kazuko A O'Dell, Steven Mennerick, Charles F Zorumsk. Effects of acute pro-inflammatory stimulation and 25-hydroxycholesterol on hippocampal plasticity and learning involve NLRP3 inflammasome and cellular stress responses. Scientific reports. vol 15. issue 1. 2025-02-20. PMID:39979396. |
here we use rat hippocampal slices and in vivo behavioral studies to provide evidence that acute modulation of synaptic plasticity by both lps and 25hc requires activation of the nlrp3 inflammasome, caspase-1 and interleukin-1 receptor. |
2025-02-20 |
2025-02-23 |
rat |