| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lei Wu, Yan Sun, Zhangjie Wu, Ruiyi Liu, Ying Yin, Nga-Lee Wong, Wenzheng Ju, Hailou Zhan. A rich component of Fructus Aurantii, meranzin hydrate, exerts antidepressant effects via suppressing caspase4 to regulate glial cell and neuronal functions in the hippocampus. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 182. 2024-12-15. PMID:39675136. |
furthermore, mh could increase long-term potential (ltp) in the hippocampal dentate gyrus (dg) and activation of hippocampal caspase4 blocked mh's enhancement on neuronal activities and synaptic plasticity in the hippocampal dg. |
2024-12-15 |
2024-12-21 |
mouse |
| Lei Wu, Yan Sun, Zhangjie Wu, Ruiyi Liu, Ying Yin, Nga-Lee Wong, Wenzheng Ju, Hailou Zhan. A rich component of Fructus Aurantii, meranzin hydrate, exerts antidepressant effects via suppressing caspase4 to regulate glial cell and neuronal functions in the hippocampus. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 182. 2024-12-15. PMID:39675136. |
to sum up, the antidepressant effects of a rich component mh in fructus aurantii suppressed the activation of caspase4 by maintaining glial cells function to promote neuronal activities and synaptic plasticity in the hippocampus. |
2024-12-15 |
2024-12-21 |
mouse |
| Junjie Li, Xiaojuan Mi, Zhilun Yang, Ziqi Feng, Yong Han, Ting Wang, Haowen Lv, Yanbo Liu, Kang Wu, Juan Li. Minocycline ameliorates cognitive impairment in rats with trigeminal neuralgia by regulating microglial polarization. International immunopharmacology. vol 145. 2024-12-13. PMID:39672028. |
our results suggested that minocycline treatment attenuated cognitive deficits by alleviating hippocampal neuronal damage and enhancing synaptic plasticity in tn rats. |
2024-12-13 |
2024-12-21 |
rat |
| Tim Blis. Pursuing Synaptic Plasticity From Cortex to LTP in the Hippocampus. Hippocampus. vol 35. issue 1. 2024-12-13. PMID:39670336. |
pursuing synaptic plasticity from cortex to ltp in the hippocampus. |
2024-12-13 |
2024-12-21 |
rabbit |
| Xiaoqian He, Ziying Lai, Xueyan Wang, Jingjing Li, Guangbing Duan, Junwen Wang, Zhao Qin, Shuchang Xu, Ying Huan. Role of 5-hydroxytryptamine type 3 receptors in aerobic exercise-induced improvement of memory and hippocampal synaptic plasticity. Neural regeneration research. 2024-12-12. PMID:39665807. |
role of 5-hydroxytryptamine type 3 receptors in aerobic exercise-induced improvement of memory and hippocampal synaptic plasticity. |
2024-12-12 |
2024-12-14 |
mouse |
| Qing Wu, Xiao-Yu Jia, Shi-Hua Zhang, Yun-Zhe Wu, Long-Sheng Xu, Jun-Gang Han, Wei Yu, Qing-He Zho. Metformin activates the PI3K/AKT/BDNF axis to attenuate postoperative cognitive dysfunction. Neuropharmacology. 2024-12-11. PMID:39662703. |
additionally, metformin attenuated the impairment of synaptic plasticity induced by pocd and restored levels of synaptic proteins and dendritic density in the hippocampus. |
2024-12-11 |
2024-12-14 |
mouse |
| Jingzhi Wang, Zhongyu Huang, Yiwen Li, Qian Li, Xi Li, Li Che. Electroacupuncture improves cognitive function in high-fat diet/streptozocin-induced type 2 diabetic mice by inhibiting autophagy-related ferroptosis. Experimental animals. 2024-12-08. PMID:39647901. |
electroacupuncture treatment exhibited ameliorative outcomes on spatial learning, memory function, hippocampal insulin resistance, neuronal damage, and synaptic plasticity in t2dm mice. |
2024-12-08 |
2024-12-11 |
mouse |
| Bing-Ying Wang, Bo Wang, Bo Cao, Ling-Ling Gu, Jiayu Chen, Hua He, Zheng Zhao, Fujun Chen, Zhiru Wan. Associative Learning-Induced Synaptic Potentiation at the Two Major Hippocampal CA1 Inputs for Cued Memory Acquisition. Neuroscience bulletin. 2024-11-28. PMID:39604622. |
here, in a single session of reward-based trace conditioning, we examine learning-induced synaptic plasticity in the dorsal ca1 hippocampus (dca1). |
2024-11-28 |
2024-11-30 |
Not clear |
| Francesca Natale, Matteo Spinelli, Marco Rinaudo, Walter Gulisano, Ida Nifo Sarrapochiello, Giuseppe Aceto, Daniela Puzzo, Salvatore Fusco, Claudio Grass. Inhibition of zDHHC7-driven protein S-palmitoylation prevents cognitive deficits in an experimental model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 49. 2024-11-26. PMID:39589870. |
chronic intranasal administration of the s-palmitoylation inhibitor 2-bromopalmitate counteracted synaptic plasticity and cognitive deficits, reduced the aβ deposition in the hippocampus and extended the lifespan of both male and female 3×tg-ad mice. |
2024-11-26 |
2024-11-29 |
mouse |
| Lingmin Chen, Jiao Jiao, Fan Lei, Bin Zhou, Hong Li, Ping Liao, Xin Li, Yi Kang, Jin Liu, Ruotian Jian. Ezrin-mediated astrocyte-synapse signaling regulates cognitive function via astrocyte morphological changes in fine processes in male mice. Brain, behavior, and immunity. 2024-11-23. PMID:39580057. |
down-regulation of ezrin in hippocampal astrocytes led to disrupted astrocyte-synapse interactions and impaired synaptic functions, including synaptic transmission and synaptic plasticity, which could be rescued by exogenous administration of d-serine. |
2024-11-23 |
2024-11-26 |
mouse |
| Qi-Chao Gao, Ge-Liang Liu, Qi Wang, Sheng-Xiao Zhang, Zhi-Lin Ji, Zhao-Jun Wang, Mei-Na Wu, Qi Yu, Pei-Feng H. A promising drug repurposing approach for Alzheimer's treatment: Givinostat improves cognitive behavior and pathological features in APP/PS1 mice. Redox biology. vol 78. 2024-11-22. PMID:39577323. |
our research found that givinostat improved cognitive behavior and brain pathology in models and enhanced hippocampal synaptic plasticity. |
2024-11-22 |
2024-11-25 |
mouse |
| Valentina Castelli, Gianluca Lavanco, Giuseppe Tringali, Cesare D'Amico, Salvatore Feo, Martina Di Bartolomeo, Claudio D'Addario, Martin Kuchar, Anna Brancato, Carla Cannizzar. Prenatal THC exposure drives sex-specific alterations in spatial memory and hippocampal excitatory/inhibitory balance in adolescent rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 181. 2024-11-21. PMID:39571245. |
the adolescent progeny of both sexes was tested for: spatial memory retrieval and flexibility in the barnes maze; mrna expression of relevant players of hippocampal synaptic plasticity; density of cholecystokinin-positive basket cells (cck+bcs) - a major subtype of hippocampal inhibitory interneurons; mrna expression of the excitatory and inhibitory synaptic proteins neuroligins (nlgns), as a proxy of synaptic efficiency. |
2024-11-21 |
2024-11-24 |
rat |
| Wudu Lado, Ahrom Ham, Hongyu Li, Hong Zhang, Audrey Yuen Chang, Sergio Pablo Sardi, Roy N Alcalay, Ottavio Arancio, Serge Przedborsky, Guomei Tan. Synaptic and cognitive impairment associated with L444P heterozygous glucocerebrosidase mutation. Brain : a journal of neurology. 2024-11-19. PMID:39562000. |
the mutation disrupts hippocampal synaptic plasticity and basal synaptic transmission by reducing the density of hippocampal ca3-ca1 synapses, a mechanism that is dissociated from αsyn-mediated presynaptic neurotransmitter release. |
2024-11-19 |
2024-11-23 |
mouse |
| Osman Sinen, Ayşegül Gemici Sinen, Narin Deri. Central treatment of neuropeptide-S attenuates cognitive dysfunction and hippocampal synaptic plasticity impairment by increasing CaMKII/GluR1 in hemiparkinsonian rats. Neuroscience. 2024-11-15. PMID:39547334. |
central treatment of neuropeptide-s attenuates cognitive dysfunction and hippocampal synaptic plasticity impairment by increasing camkii/glur1 in hemiparkinsonian rats. |
2024-11-15 |
2024-11-18 |
rat |
| Osman Sinen, Ayşegül Gemici Sinen, Narin Deri. Central treatment of neuropeptide-S attenuates cognitive dysfunction and hippocampal synaptic plasticity impairment by increasing CaMKII/GluR1 in hemiparkinsonian rats. Neuroscience. 2024-11-15. PMID:39547334. |
long-term potentiation (ltp) recordings were conducted to assess hippocampal synaptic plasticity. |
2024-11-15 |
2024-11-18 |
rat |
| Isaac Vingan, Shwetha Phatarpekar, Victoria Sook Keng Tung, Alejandro Iván Hernández, Oleg V Evgrafov, Juan Marcos Alarco. Spatially resolved transcriptomic signatures of hippocampal subregions and Frontiers in molecular neuroscience. vol 17. 2024-11-15. PMID:39544521. |
we found that recall induced differentially expressed genes (degs) in the ca1 and ca3 hippocampal subregions were enriched with genes involved in synaptic transmission and synaptic plasticity, while degs in the dentate gyrus (dg) were enriched with genes involved in energy balance and ribosomal function. |
2024-11-15 |
2024-11-17 |
Not clear |
| Kui Wang, Haidong Wei, Liufei Yang, Shuyue Zhang, Yiqin Cheng, Chen Li, Pengyu Jia, Yuanyuan Zhang, Yan Zhang, Pei Fan, Ning Wang, Haixia Lu, Xinlin Chen, Yong Liu, Pengbo Zhan. Pretreatment with tetramethylpyrazine alleviated the impairment of learning and memory induced by sevoflurane exposure in neonatal rats. Neuroscience. 2024-11-14. PMID:39542344. |
long-term potentiation (ltp) was recorded to evaluate synaptic plasticity electrophysiologically in the hippocampal slices. |
2024-11-14 |
2024-11-17 |
rat |
| Kui Wang, Haidong Wei, Liufei Yang, Shuyue Zhang, Yiqin Cheng, Chen Li, Pengyu Jia, Yuanyuan Zhang, Yan Zhang, Pei Fan, Ning Wang, Haixia Lu, Xinlin Chen, Yong Liu, Pengbo Zhan. Pretreatment with tetramethylpyrazine alleviated the impairment of learning and memory induced by sevoflurane exposure in neonatal rats. Neuroscience. 2024-11-14. PMID:39542344. |
these findings indicated that pretreatment with tetramethylpyrazine alleviated the impairment of learning and memory induced by sevoflurane through improvement of hippocampal synaptic plasticity in neonatal rats. |
2024-11-14 |
2024-11-17 |
rat |
| Jorge Parodi, Rodrigo G Mira, Marco Fuenzalida, Waldo Cerpa, Felipe G Serrano, Cheril Tapia-Rojas, Ataulfo Martinez-Torres, Nibaldo C Inestros. Wnt-5a Signaling Mediates Metaplasticity at Hippocampal CA3-CA1 Synapses in Mice. Cellular and molecular neurobiology. vol 44. issue 1. 2024-11-13. PMID:39535658. |
both effects are related to the metaplastic switch of hippocampal ca3-ca1 synaptic transmission, a complex mechanism underlying the regulation of the threshold required to induce synaptic plasticity and of synaptic efficacy. |
2024-11-13 |
2024-11-17 |
mouse |
| Qin Lyu, Liu-Qing Shi, Hai-Yang Chen, Mei Lu, Xi-Cai Liang, Xian-De Ma, Xin Zhou, Lu Re. Electroacupuncture combined with NSCs-Exo alters the response of hippocampal neurons in a chronic unpredictable mild stress paradigm in ovx rats. Life sciences. vol 359. 2024-11-13. PMID:39528081. |
this was evidenced by reductions in hippocampal synaptic plasticity proteins psd95, syn, and gap43, as well as decreased expression of energy metabolism pathway proteins ampk, nrf1, pgc1α, and tfam. |
2024-11-13 |
2024-11-17 |
rat |