| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lin-Hui Ma, Jie Wan, Jing Yan, Ning Wang, Yan-Ping Liu, Hai-Bi Wang, Cheng-Hua Zhou, Yu-Qing W. Hippocampal SIRT1-Mediated Synaptic Plasticity and Glutamatergic Neuronal Excitability Are Involved in Prolonged Cognitive Dysfunction of Neonatal Rats Exposed to Propofol. Molecular neurobiology. 2022-01-16. PMID:35034265. |
hippocampal sirt1-mediated synaptic plasticity and glutamatergic neuronal excitability are involved in prolonged cognitive dysfunction of neonatal rats exposed to propofol. |
2022-01-16 |
2023-08-13 |
rat |
| Sampath Kumar, Sanjay S Kuma. A Model for Predicting Cation Selectivity and Permeability in AMPA and NMDA Receptors Based on Receptor Subunit Composition. Frontiers in synaptic neuroscience. vol 13. 2021-12-16. PMID:34912205. |
glutamatergic ampa (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) and nmda (n-methyl-d-aspartate) receptors are implicated in diverse functions ranging from synaptic plasticity to cell death. |
2021-12-16 |
2023-08-13 |
Not clear |
| Jacob C Nordma. Anger management: Mechanisms of glutamate receptor-mediated synaptic plasticity underlying animal aggression. The international journal of biochemistry & cell biology. vol 142. 2021-12-10. PMID:34823006. |
this review will assess the importance of glutamate receptors and glutamatergic pathways in aggression, focusing on the role of glutamate receptor-mediated synaptic plasticity in experience-dependent long-lasting aggression. |
2021-12-10 |
2023-08-13 |
Not clear |
| Malgorzata Borczyk, Kasia Radwanska, K Peter Gies. The importance of ultrastructural analysis of memory. Brain research bulletin. vol 173. 2021-12-09. PMID:33984429. |
here, we systematically compare how long-term potentiation of synaptic transmission (ltp) (a primary form of synaptic plasticity and cellular model of memory) and behavioral training affect hippocampal glutamatergic synapses at the ultrastructural level enabled by electron microscopy. |
2021-12-09 |
2023-08-13 |
mouse |
| Glenn Dallérac, Xia Li, Pierre Lecouflet, Nadège Morisot, Silvia Sacchi, Rachel Asselot, Thu Ha Pham, Brigitte Potier, David J G Watson, Staffan Schmidt, Grégoire Levasseur, Pascal Fossat, Andrey Besedin, Jean-Michel Rivet, Joseph T Coyle, Ginetta Collo, Loredano Pollegioni, Jan Kehr, Micaela Galante, Kevin C Fone, Alain M Gardier, Thomas Freret, Angelo Contarino, Mark J Millan, Jean-Pierre Mothe. Dopaminergic neuromodulation of prefrontal cortex activity requires the NMDA receptor coagonist d-serine. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 23. 2021-12-04. PMID:34083436. |
here, using electrophysiological recordings, we show that d-serine is required for the fine-tuning of glutamatergic neurotransmission, neuronal excitability, and synaptic plasticity in the pfc through the actions of dopamine at d |
2021-12-04 |
2023-08-13 |
Not clear |
| Cheng-Yi Yang, Yu-Chieh Hung, Kuan-Hsiang Cheng, Pin Ling, Kuei-Sen Hs. Loss of CC2D1A in Glutamatergic Neurons Results in Autistic-Like Features in Mice. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 18. issue 3. 2021-12-04. PMID:34132974. |
we recently reported that conditional deletion of cc2d1a in glutamatergic neurons of the postnatal mouse forebrain leads to impaired hippocampal synaptic plasticity and cognitive function. |
2021-12-04 |
2023-08-13 |
mouse |
| Jonathan D Lautz, Kaleb B Tsegay, Zhiyi Zhu, Edward P Gniffke, John P Welsh, Stephen E P Smit. Synaptic protein interaction networks encode experience by assuming stimulus-specific and brain-region-specific states. Cell reports. vol 37. issue 9. 2021-12-01. PMID:34852231. |
a core network of widely expressed proteins within the glutamatergic post-synapse mediates activity-dependent synaptic plasticity throughout the brain, but the specific proteomic composition of synapses differs between brain regions. |
2021-12-01 |
2023-08-13 |
Not clear |
| Maksim Storozhuk, Andrii Cherninskyi, Oleksandr Maximyuk, Dmytro Isaev, Oleg Krishta. Acid-Sensing Ion Channels: Focus on Physiological and Some Pathological Roles in the Brain. Current neuropharmacology. vol 19. issue 9. 2021-11-25. PMID:33550975. |
here we review and discuss evidence regarding the roles of asics: (i) as postsynaptic receptors activated by protons coreleased with glutamate at glutamatergic synapses; (ii) as modulators of synaptic transmission at glutamatergic synapses and gabaergic synapses; (iii) in synaptic plasticity, memory and learning; (iv) in some pathologies such as epilepsy, mood disorders and alzheimer's disease. |
2021-11-25 |
2023-08-13 |
Not clear |
| Diana Fernández-Suárez, Favio A Krapacher, Katarzyna Pietrajtis, Annika Andersson, Lilian Kisiswa, Alvaro Carrier-Ruiz, Marco A Diana, Carlos F Ibáñe. Adult medial habenula neurons require GDNF receptor GFRα1 for synaptic stability and function. PLoS biology. vol 19. issue 11. 2021-11-20. PMID:34748545. |
these results uncover an unexpected function for gfrα1 in the maintenance and function of adult glutamatergic synapses and reveal a potential new mechanism for regulating synaptic plasticity in the septohabenulointerpeduncular pathway and attuning of anxiety and fear behaviors. |
2021-11-20 |
2023-08-13 |
mouse |
| Véronique Brault, Thu Lan Nguyen, Javier Flores-Gutiérrez, Giovanni Iacono, Marie-Christine Birling, Valérie Lalanne, Hamid Meziane, Antigoni Manousopoulou, Guillaume Pavlovic, Loïc Lindner, Mohammed Selloum, Tania Sorg, Eugene Yu, Spiros D Garbis, Yann Héraul. Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome. PLoS genetics. vol 17. issue 9. 2021-11-19. PMID:34587162. |
molecular analyses pointed at a deregulation of transcriptional activity through immediate early genes and a role of dyrk1a at the glutamatergic post-synapse by deregulating and interacting with key post-synaptic proteins implicated in mechanism leading to long-term enhanced synaptic plasticity. |
2021-11-19 |
2023-08-13 |
mouse |
| Ya-Ting Wang, Xiao-Le Wang, Si-Tong Feng, Nai-Hong Chen, Zhen-Zhen Wang, Yi Zhan. Novel rapid-acting glutamatergic modulators: Targeting the synaptic plasticity in depression. Pharmacological research. vol 171. 2021-11-09. PMID:34242798. |
novel rapid-acting glutamatergic modulators: targeting the synaptic plasticity in depression. |
2021-11-09 |
2023-08-13 |
Not clear |
| Yaojun Ju, Kin Yip Ta. Pathological mechanisms and therapeutic strategies for Alzheimer's disease. Neural regeneration research. vol 17. issue 3. 2021-11-02. PMID:34380884. |
the deficiencies in various sorts of neurotransmissions are responsible for the multifarious neurodegenerative symptoms in alzheimer's disease, for example, the cholinergic and glutamatergic deficits for cognitive decline, the excitatory and inhibitory neurotransmission dyshomeostasis for synaptic plasticity deficits and epileptiform symptoms, and the monoamine neurotransmission for neuropsychiatric symptoms. |
2021-11-02 |
2023-08-13 |
Not clear |
| Louise Martens, Luisa Herrmann, Lejla Colic, Meng Li, Anni Richter, Gusalija Behnisch, Oliver Stork, Constanze Seidenbecher, Björn H Schott, Martin Walte. Met carriers of the BDNF Val66Met polymorphism show reduced Glx/NAA in the pregenual ACC in two independent cohorts. Scientific reports. vol 11. issue 1. 2021-10-25. PMID:33762638. |
the met allele of the val66met snp of the bdnf gene (rs6265) is associated with impaired activity-dependent release of brain-derived neurotrophic factor (bdnf), resulting in reduced synaptic plasticity, impaired glutamatergic neurotransmission, and morphological changes. |
2021-10-25 |
2023-08-13 |
Not clear |
| Soma Godó, Klaudia Barabás, Ferenc Lengyel, Dávid Ernszt, Tamás Kovács, Miklós Kecskés, Csaba Varga, Tibor Z Jánosi, Géza Makkai, Gergely Kovács, Barbara Orsolits, Takahiro Fujiwara, Akihiro Kusumi, István M Ábrahá. Single-Molecule Imaging Reveals Rapid Estradiol Action on the Surface Movement of AMPA Receptors in Live Neurons. Frontiers in cell and developmental biology. vol 9. 2021-10-12. PMID:34631701. |
gonadal steroid 17β-estradiol (e2) exerts rapid, non-genomic effects on neurons and strictly regulates learning and memory through altering glutamatergic neurotransmission and synaptic plasticity. |
2021-10-12 |
2023-08-13 |
Not clear |
| Júnia L de Deus, Mateus R Amorim, Aline B Ribeiro, Procópio C G Barcellos-Filho, César C Ceballos, Luiz Guilherme S Branco, Alexandra O S Cunha, Ricardo M Leã. Loss of Brain-Derived Neurotrophic Factor Mediates Inhibition of Hippocampal Long-Term Potentiation by High-Intensity Sound. Cellular and molecular neurobiology. vol 41. issue 4. 2021-10-06. PMID:32445041. |
although sound stimulation did not affect glutamatergic or gabaergic neurotransmission in ca1, it did depress the level of brain-derived neurotrophic factor (bdnf), which is involved in promoting hippocampal synaptic plasticity. |
2021-10-06 |
2023-08-13 |
rat |
| Abdallah Ahnaou, Kobe Heleven, Ria Biermans, Nikolay V Manyakov, Wilhelmus H Drinkenbur. NMDARs Containing NR2B Subunit Do Not Contribute to the LTP Form of Hippocampal Plasticity: In Vivo Pharmacological Evidence in Rats. International journal of molecular sciences. vol 22. issue 16. 2021-09-15. PMID:34445376. |
the best known and most studied form of activity-dependent synaptic plasticity remains long-term potentiation (ltp), which is controlled by glutamatergic n-methyl-d-aspartate) receptors (nmdar) and considered to be a mechanism crucial for cellular learning and memory. |
2021-09-15 |
2023-08-13 |
rat |
| Gabriela Rodríguez-Manzo, Estefanía González-Morales, René Garduño-Gutiérre. Endocannabinoids Released in the Ventral Tegmental Area During Copulation to Satiety Modulate Changes in Glutamate Receptors Associated With Synaptic Plasticity Processes. Frontiers in synaptic neuroscience. vol 13. 2021-09-07. PMID:34483875. |
glutamatergic inputs to the vta express cb1rs and contribute to da neuron burst firing and synaptic plasticity. |
2021-09-07 |
2023-08-13 |
rat |
| Gabriela Rodríguez-Manzo, Estefanía González-Morales, René Garduño-Gutiérre. Endocannabinoids Released in the Ventral Tegmental Area During Copulation to Satiety Modulate Changes in Glutamate Receptors Associated With Synaptic Plasticity Processes. Frontiers in synaptic neuroscience. vol 13. 2021-09-07. PMID:34483875. |
we hypothesized that ecbs, released during copulation to satiety, would activate vta cb1rs and modulate synaptic plasticity processes involving glutamatergic transmission. |
2021-09-07 |
2023-08-13 |
rat |
| Camilla Bellone, Michael Loureiro, Christian Lüsche. Drug-Evoked Synaptic Plasticity of Excitatory Transmission in the Ventral Tegmental Area. Cold Spring Harbor perspectives in medicine. vol 11. issue 4. 2021-08-25. PMID:32341062. |
here, we discuss cocaine-evoked synaptic plasticity of glutamatergic transmission onto dopamine (da) neurons of the ventral tegmental area (vta) as one of the earliest traces after a first injection of cocaine. |
2021-08-25 |
2023-08-13 |
Not clear |
| Parvin Babae. NMDA and AMPA receptors dysregulation in Alzheimer's disease. European journal of pharmacology. vol 908. 2021-08-20. PMID:34265291. |
this negative correlation highlights glutamatergic neurotransmission via n-methyl-d-aspartate (nmda) and α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors and (ampa) receptors as a critical mediator of synaptic plasticity. |
2021-08-20 |
2023-08-13 |
Not clear |