| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dong-Hee Kim, Bo-Ryoung Choi, Yong-Jae Jeon, Yoon-Sun Jang, Jung-Soo Ha. Engagement of lateral habenula in the extinction of the appetitive conditioned responses. Behavioural brain research. vol 415. 2021-11-04. PMID:34389424. |
midbrain dopamine neurons are activated by presenting a reward or predictable reward cue, whereas the cue signaling the absence of reward activates the lateral habenula (lhb) neurons. |
2021-11-04 |
2023-08-13 |
rat |
| Andrea N Belovich, Jenny I Aguilar, Samuel J Mabry, Mary H Cheng, Daniele Zanella, Peter J Hamilton, Daniel J Stanislowski, Aparna Shekar, James D Foster, Ivet Bahar, Heinrich J G Matthies, Aurelio Gall. A network of phosphatidylinositol (4,5)-bisphosphate (PIP Molecular psychiatry. vol 26. issue 8. 2021-11-02. PMID:31796894. |
numerous human pet-fmri studies establish a link between midbrain dopamine (da) release, da transporter (dat) availability, and reward responses. |
2021-11-02 |
2023-08-13 |
human |
| Shijing Wang, Francesco Leri, Sakina J Rizv. Anhedonia as a central factor in depression: Neural mechanisms revealed from preclinical to clinical evidence. Progress in neuro-psychopharmacology & biological psychiatry. vol 110. 2021-11-01. PMID:33631251. |
dopamine modulates several reward facets including anticipation, motivation, effort, and learning. |
2021-11-01 |
2023-08-13 |
Not clear |
| Sebastijan Veselic, Gerhard Jocham, Christian Gausterer, Bernhard Wagner, Miriam Ernhoefer-Reßler, Rupert Lanzenberger, Christoph Eisenegger, Claus Lamm, Annabel Losecaat Vermee. A causal role of estradiol in human reinforcement learning. Hormones and behavior. vol 134. 2021-11-01. PMID:34273676. |
the sex hormone estradiol is hypothesized to play a key role in human cognition, and reward processing specifically, via increased dopamine d1-receptor signalling. |
2021-11-01 |
2023-08-13 |
human |
| Kenneth Blum, Abdalla Bowirrat, Marjorie C Gondre Lewis, Thomas A Simpatico, Mauro Ceccanti, Bruce Steinberg, Edward J Modestino, Panayotis K Thanos, David Baron, Thomas McLaughlin, Raymond Brewer, Rajendra D Badgaiyan, Jessica Valdez Ponce, Lisa Lott, Mark S Gol. Exploration of Epigenetic State Hyperdopaminergia (Surfeit) and Genetic Trait Hypodopaminergia (Deficit) During Adolescent Brain Development. Current psychopharmacology. vol 10. 2021-10-30. PMID:34707969. |
some reveal an underlying hyperdopaminergia that seems to set our youth up for risky behaviors by inducing high quanta pre-synaptic dopamine release at reward site neurons. |
2021-10-30 |
2023-08-13 |
human |
| Kenneth Blum, Rajendra D Badgaiya. Translational and Molecular Cytoarchitectural Genetic Guided Therapy to Induce Dopamine Homeostatic Neuro-signaling in Reward Deficiency and Associated Drug and Behavioral Addiction Seeking: A 60 Year Sojourn the Future is Now. EC psychology and psychiatry. vol 10. issue 8. 2021-10-30. PMID:34708222. |
translational and molecular cytoarchitectural genetic guided therapy to induce dopamine homeostatic neuro-signaling in reward deficiency and associated drug and behavioral addiction seeking: a 60 year sojourn the future is now. |
2021-10-30 |
2023-08-13 |
Not clear |
| Chang You, Bertha J Vandegrift, Mark S Brodi. KCNK13 potassium channels in the ventral tegmental area of rats are important for excitation of ventral tegmental area neurons by ethanol. Alcoholism, clinical and experimental research. vol 45. issue 7. 2021-10-29. PMID:33960499. |
alcohol excites neurons of the ventral tegmental area (vta) and the release of dopamine from these neurons is a key event in ethanol (etoh)-induced reward and reinforcement. |
2021-10-29 |
2023-08-13 |
mouse |
| Felix P Mayer, Hideki Iwamoto, Maureen K Hahn, Gregory J Grumbar, Adele Stewart, Yulong Li, Randy D Blakel. There's no place like home? Return to the home cage triggers dopamine release in the mouse nucleus accumbens. Neurochemistry international. vol 142. 2021-10-27. PMID:33161093. |
various stimuli have been employed as reinforcers in preclinical rodent models to elucidate the underpinnings of reward at a molecular and circuit level, with the release of dopamine (da) in the nucleus accumbens (nac) as a well-replicated, physiological correlate. |
2021-10-27 |
2023-08-13 |
mouse |
| Andrea K Shields, Mauricio Suarez, Ken T Wakabayashi, Caroline E Bas. Activation of VTA GABA neurons disrupts reward seeking by altering temporal processing. Behavioural brain research. vol 410. 2021-10-22. PMID:33836166. |
the role of ventral tegmental area (vta) dopamine in reward, cue processing, and interval timing is well characterized. |
2021-10-22 |
2023-08-13 |
rat |
| Yunbok Kim, Sojeong Kwon, Raghav Rajan, Chihiro Mori, Satoshi Kojim. Intrinsic motivation for singing in songbirds is enhanced by temporary singing suppression and regulated by dopamine. Scientific reports. vol 11. issue 1. 2021-10-22. PMID:34645903. |
moreover, by examining latencies to the first song following singing suppression as a measure of singing motivation independent of singing-associated reward, we demonstrate that intrinsic singing motivation is critically regulated by dopamine through d2 receptors. |
2021-10-22 |
2023-08-13 |
Not clear |
| Jason J Paris, Kate J Reilley, Jay P McLaughli. Kappa Opioid Receptor-Mediated Disruption of Novel Object Recognition: Relevance for Psychostimulant Treatment. Journal of addiction research & therapy. vol S4. 2021-10-21. PMID:22900234. |
kappa opioid receptor (kor) agonists are potentially valuable as therapeutics for the treatment of psychostimulant reward as they suppress dopamine signaling in reward circuitry to repress drug seeking behavior. |
2021-10-21 |
2023-08-12 |
mouse |
| K Blum, M Oscar-Berman, J Giordano, Bw Downs, T Simpatico, D Han, John Femin. Neurogenetic Impairments of Brain Reward Circuitry Links to Reward Deficiency Syndrome (RDS): Potential Nutrigenomic Induced Dopaminergic Activation. Journal of genetic syndromes & gene therapy. vol 3. issue 4. 2021-10-21. PMID:23264886. |
additionally, it briefly describes the concept of natural dopamine d2 receptor agonist therapy coupled with genetic testing of a panel of reward genes, the genetic addiction risk score (gars). |
2021-10-21 |
2023-08-12 |
Not clear |
| Kenneth Blum, Marlene Oscar-Berman, Elizabeth Stuller, David Miller, John Giordano, Siobhan Morse, Lee McCormick, William B Downs, Roger L Waite, Debmalya Barh, Dennis Neal, Eric R Braverman, Raquel Lohmann, Joan Borsten, Mary Hauser, David Han, Yijun Liu, Manya Helman, Thomas Simpatic. Neurogenetics and Nutrigenomics of Neuro-Nutrient Therapy for Reward Deficiency Syndrome (RDS): Clinical Ramifications as a Function of Molecular Neurobiological Mechanisms. Journal of addiction research & therapy. vol 3. issue 5. 2021-10-21. PMID:23926462. |
neurogenetic research in both animal and humans revealed that there is a well-defined cascade in the reward site of the brain that leads to normal dopamine release. |
2021-10-21 |
2023-08-12 |
Not clear |
| Kenneth Blum, Marlene Oscar-Berman, Elizabeth Stuller, David Miller, John Giordano, Siobhan Morse, Lee McCormick, William B Downs, Roger L Waite, Debmalya Barh, Dennis Neal, Eric R Braverman, Raquel Lohmann, Joan Borsten, Mary Hauser, David Han, Yijun Liu, Manya Helman, Thomas Simpatic. Neurogenetics and Nutrigenomics of Neuro-Nutrient Therapy for Reward Deficiency Syndrome (RDS): Clinical Ramifications as a Function of Molecular Neurobiological Mechanisms. Journal of addiction research & therapy. vol 3. issue 5. 2021-10-21. PMID:23926462. |
any impairment due to either genetics or environmental influences on this cascade will result in a reduced amount of dopamine release in the brain reward site. |
2021-10-21 |
2023-08-12 |
Not clear |
| Mikhail U Inyushin, Francisco Arencibia-Albite, Angel de la Cruz, Rafael Vázquez-Torres, Katiria Colon, Priscila Sanabria, Carlos A Jiménez-River. New method to visualize neurons with DAT in slices of rat VTA using fluorescent substrate for DAT, ASP+ Journal of neuroscience and neuroengineering. vol 2. issue 2. 2021-10-21. PMID:24052926. |
new method to visualize neurons with dat in slices of rat vta using fluorescent substrate for dat, asp+ the ventral tegmental area (vta), and in particular dopamine (da) neurons in this region of midbrain, has been shown to play an important role in motivation (goal-directed behavior), reward, and drug addiction. |
2021-10-21 |
2023-08-12 |
rat |
| Rajendra D Badgaiya. A Novel Perspective on Dopaminergic Processing of Human Addiction. Journal of alcoholism and drug dependence. vol 1. issue 1. 2021-10-21. PMID:24350303. |
these findings indicate that dysregulated dopamine neurotransmission alters the brain processing of not only the reward system but also that of the memory of association between an addictive substance and reward. |
2021-10-21 |
2023-08-12 |
human |
| John J Woodward, Jacob Beckle. Effects of the abused inhalant toluene on the mesolimbic dopamine system. Journal of drug and alcohol research. vol 3. 2021-10-21. PMID:25360326. |
together, these data provide the first evidence linking the voluntary inhalation of solvents to changes in reward -sensitive dopamine neurons. |
2021-10-21 |
2023-08-13 |
rat |
| F Joseph McClerno. Neuroimaging of Nicotine Dependence: Key Findings and Application to the Study of Smoking-Mental Illness Comorbidity. Journal of dual diagnosis. vol 5. issue 2. 2021-10-20. PMID:19756221. |
research on the effects of smoking a cigarette confirms that smoking leads to the release of dopamine in brain reward areas and to nicotinic receptor binding. |
2021-10-20 |
2023-08-12 |
Not clear |
| George F Koo. Hedonic Homeostatic Dysregulation as a Driver of Drug-Seeking Behavior. Drug discovery today. Disease models. vol 5. issue 4. 2021-10-20. PMID:20054425. |
specific neurochemical elements in these structures include not only decreases in reward neurotransmission, such as decreases in dopamine and opioid peptide function in the ventral striatum, but also recruitment of brain stress systems, such as corticotropin-releasing factor (crf), in the extended amygdala. |
2021-10-20 |
2023-08-12 |
Not clear |
| Kent C Berridge, J Wayne Aldridg. DECISION UTILITY, THE BRAIN, AND PURSUIT OF HEDONIC GOALS. Social cognition. vol 26. issue 5. 2021-10-20. PMID:20198128. |
the answer involves brain mesolimbic dopamine mechanisms that amplify the incentive salience of reward cues, selectively elevating decision utility to trigger "wanting" for the goal. |
2021-10-20 |
2023-08-12 |
Not clear |