| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Alexandra Gallo, St\\xc3\\xa9phanie Lapointe, Emmanuel Stip, St\\xc3\\xa9phane Potvin, Pierre-Paul Rompr\\xc3\\xa. Quetiapine blocks cocaine-induced enhancement of brain stimulation reward. Behavioural brain research. vol 208. issue 1. 2010-05-03. PMID:19941909.' |
this clinical effect of quetiapine is hypothesized to be due to its low affinity for dopamine receptors and its weak attenuation of central reward functions. |
2010-05-03 |
2023-08-12 |
rat |
| b' Alexandra Gallo, St\\xc3\\xa9phanie Lapointe, Emmanuel Stip, St\\xc3\\xa9phane Potvin, Pierre-Paul Rompr\\xc3\\xa. Quetiapine blocks cocaine-induced enhancement of brain stimulation reward. Behavioural brain research. vol 208. issue 1. 2010-05-03. PMID:19941909.' |
the magnitude of the reward attenuation induced by quetiapine is consistent with its low affinity for dopamine receptors. |
2010-05-03 |
2023-08-12 |
rat |
| b' Alexandra Gallo, St\\xc3\\xa9phanie Lapointe, Emmanuel Stip, St\\xc3\\xa9phane Potvin, Pierre-Paul Rompr\\xc3\\xa. Quetiapine blocks cocaine-induced enhancement of brain stimulation reward. Behavioural brain research. vol 208. issue 1. 2010-05-03. PMID:19941909.' |
its actions on dopamine and non-dopamine neurotransmission are likely to account for its effectiveness at blocking the enhancement of reward by cocaine. |
2010-05-03 |
2023-08-12 |
rat |
| Garret R Anderson, Yan Cao, Steve Davidson, Hai V Truong, Marco Pravetoni, Mark J Thomas, Kevin Wickman, Glenn J Giesler, Kirill A Martemyano. R7BP complexes with RGS9-2 and RGS7 in the striatum differentially control motor learning and locomotor responses to cocaine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 4. 2010-04-28. PMID:20043004. |
in the striatum, signaling through g protein-coupled dopamine receptors mediates motor and reward behavior, and underlies the effects of addictive drugs. |
2010-04-28 |
2023-08-12 |
mouse |
| B C Jones, S Ben-Hamida, A Pereira de Vasconcelos, C Kelche, C Lazarus, R Jackisch, J C Casse. Effects of ethanol and ecstasy on conditioned place preference in the rat. Journal of psychopharmacology (Oxford, England). vol 24. issue 2. 2010-04-26. PMID:19282425. |
more recently, we demonstrated in striatal slices that mdma produced preferential release of serotonin, but when combined with etoh, the preferential release shifted to dopamine, raising the possibility that administration of etoh may increase the reward effect of mdma. |
2010-04-26 |
2023-08-12 |
rat |
| Stéphane Doly, Jesus Bertran-Gonzalez, Jacques Callebert, Alexandra Bruneau, Sophie Marie Banas, Arnauld Belmer, Katia Boutourlinsky, Denis Hervé, Jean-Marie Launay, Luc Maroteau. Role of serotonin via 5-HT2B receptors in the reinforcing effects of MDMA in mice. PloS one. vol 4. issue 11. 2010-04-26. PMID:19956756. |
the amphetamine derivative 3,4-methylenedioxymethamphetamine (mdma, ecstasy) reverses dopamine and serotonin transporters to produce efflux of dopamine and serotonin, respectively, in regions of the brain that have been implicated in reward. |
2010-04-26 |
2023-08-12 |
mouse |
| Joshua W Buckholtz, Michael T Treadway, Ronald L Cowan, Neil D Woodward, Stephen D Benning, Rui Li, M Sib Ansari, Ronald M Baldwin, Ashley N Schwartzman, Evan S Shelby, Clarence E Smith, David Cole, Robert M Kessler, David H Zal. Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits. Nature neuroscience. vol 13. issue 4. 2010-04-22. PMID:20228805. |
mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits. |
2010-04-22 |
2023-08-12 |
Not clear |
| Joshua W Buckholtz, Michael T Treadway, Ronald L Cowan, Neil D Woodward, Stephen D Benning, Rui Li, M Sib Ansari, Ronald M Baldwin, Ashley N Schwartzman, Evan S Shelby, Clarence E Smith, David Cole, Robert M Kessler, David H Zal. Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits. Nature neuroscience. vol 13. issue 4. 2010-04-22. PMID:20228805. |
using [(18)f]fallypride positron emission tomography and blood oxygen level-dependent functional magnetic resonance imaging, we found that impulsive-antisocial psychopathic traits selectively predicted nucleus accumbens dopamine release and reward anticipation-related neural activity in response to pharmacological and monetary reinforcers, respectively. |
2010-04-22 |
2023-08-12 |
Not clear |
| Wei-Min Qu, Xin-Hong Xu, Ming-Ming Yan, Yi-Qun Wang, Yoshihiro Urade, Zhi-Li Huan. Essential role of dopamine D2 receptor in the maintenance of wakefulness, but not in homeostatic regulation of sleep, in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 12. 2010-04-20. PMID:20335474. |
dopamine (da) and its d(2) receptor (r) are involved in cognition, reward processing, and drug addiction. |
2010-04-20 |
2023-08-12 |
mouse |
| Richard P Ebstein, Salomon Israel, Soo Hong Chew, Songfa Zhong, Ariel Knaf. Genetics of human social behavior. Neuron. vol 65. issue 6. 2010-04-12. PMID:20346758. |
other polymorphic genes constituting the "usual suspects"--i.e., those encoding for dopamine reward pathways, serotonergic emotional regulation, or sex hormones--further enable elaborate social behaviors. |
2010-04-12 |
2023-08-12 |
human |
| Falk W Lohoff, Paul J Bloch, Rachel Hodge, Aleksandra H Nall, Thomas N Ferraro, Kyle M Kampman, Charles A Dackis, Charles P O'Brien, Helen M Pettinati, David W Osli. Association analysis between polymorphisms in the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes with cocaine dependence. Neuroscience letters. vol 473. issue 2. 2010-04-08. PMID:20170711. |
since dopamine neurotransmission has been shown to be involved in drug reward, related genes are plausible candidates for susceptibility to cd. |
2010-04-08 |
2023-08-12 |
Not clear |
| Xingu He, Lin Xiao, Nan Su. Effects of SCH23390 and spiperone administered into medial striatum and intermediate medial mesopallium on rewarding effects of morphine in day-old chicks. European journal of pharmacology. vol 627. issue 1-3. 2010-04-05. PMID:19878668. |
these data suggest that the medial striatum and the intermediate medial mesopallium in birds are differentially involved in the rewarding effects of morphine, and similarly to mammals, the dopamine d(1) system may play an important role in the development of opiate reward. |
2010-04-05 |
2023-08-12 |
Not clear |
| Sam A Deadwyle. Electrophysiological correlates of abused drugs: relation to natural rewards. Annals of the New York Academy of Sciences. vol 1187. 2010-04-02. PMID:20201851. |
investigations aimed at determining the underlying basis for substance abuse have resulted in breakthroughs related to drug actions on normal neural processes; for example, the singular role of dopamine as the basis for drug addiction has been revised to include effects that, with other transmitter systems, produce changes in target neuronal firing that are different from those previously assumed, including "reward value" at the neuronal and systems levels and changes in the significance of pursued stimuli as a function of motivational state, context, effort, salience, and cognitive demand. |
2010-04-02 |
2023-08-12 |
Not clear |
| Pushplata Prasad, Atul Ambekar, Meera Vaswan. Dopamine D2 receptor polymorphisms and susceptibility to alcohol dependence in Indian males: a preliminary study. BMC medical genetics. vol 11. 2010-03-30. PMID:20146828. |
dopamine is an important neurotransmitter involved in reward mechanism in the brain and thereby influences development and relapse of alcohol dependence. |
2010-03-30 |
2023-08-12 |
human |
| Helga Höifödt Lidö, Rosita Stomberg, Anne Fagerberg, Mia Ericson, Bo Söderpal. The glycine reuptake inhibitor org 25935 interacts with basal and ethanol-induced dopamine release in rat nucleus accumbens. Alcoholism, clinical and experimental research. vol 33. issue 7. 2010-03-26. PMID:19389199. |
the mesolimbic dopamine (da) projection from the ventral tegmental area to nucleus accumbens (nac), a central part of the reward system, is activated by ethanol (etoh) and other drugs of abuse. |
2010-03-26 |
2023-08-12 |
rat |
| S J Wanchoo, M J Lee, A C Swann, N Dafn. Bilateral six-hydroxydopamine administration to PFC prevents the expression of behavioral sensitization to methylphenidate. Brain research. vol 1312. 2010-03-25. PMID:19932692. |
neuropsychological analyses indicate that adhd patients are impaired on tasks of behavioral inhibition, reward reversal, and working memory, which are functions of the prefrontal cortex (pfc) and are modulated by the mesocortical dopamine (da) system. |
2010-03-25 |
2023-08-12 |
rat |
| Kelly R Tan, Matthew Brown, Gwenaël Labouèbe, Cédric Yvon, Cyril Creton, Jean-Marc Fritschy, Uwe Rudolph, Christian Lüsche. Neural bases for addictive properties of benzodiazepines. Nature. vol 463. issue 7282. 2010-03-23. PMID:20148031. |
addictive drugs increase the levels of dopamine and also trigger long-lasting synaptic adaptations in the mesolimbic reward system that ultimately may induce the pathological behaviour. |
2010-03-23 |
2023-08-12 |
Not clear |
| Luke Clar. Decision-making during gambling: an integration of cognitive and psychobiological approaches. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 365. issue 1538. 2010-03-22. PMID:20026469. |
the psychobiological approach has examined case-control differences between groups of pathological gamblers and healthy controls, and has identified dysregulation of brain areas linked to reward and emotion, including the ventromedial prefrontal cortex (vmpfc) and striatum, as well as alterations in dopamine neurotransmission. |
2010-03-22 |
2023-08-12 |
human |
| K Wu, M Politis, P Piccin. Parkinson disease and impulse control disorders: a review of clinical features, pathophysiology and management. Postgraduate medical journal. vol 85. issue 1009. 2010-03-12. PMID:19892894. |
the pathophysiology of underlying mechanisms is not fully understood, but recent evidence suggests that dopaminergic drugs, particularly dopamine agonists, coupled with changes in reward pathways involving the ventral striatal and related circuitry, may play a role. |
2010-03-12 |
2023-08-12 |
Not clear |
| K D Carr, L S Chau, S Cabeza de Vaca, K Gustafson, M Stouffer, D S Tukey, S Restituito, E B Zif. AMPA receptor subunit GluR1 downstream of D-1 dopamine receptor stimulation in nucleus accumbens shell mediates increased drug reward magnitude in food-restricted rats. Neuroscience. vol 165. issue 4. 2010-03-12. PMID:19931598. |
previous findings suggest that neuroadaptations downstream of d-1 dopamine (da) receptor stimulation in nucleus accumbens (nac) are involved in the enhancement of drug reward by chronic food restriction (fr). |
2010-03-12 |
2023-08-12 |
rat |