| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Javier Calleja-Conde, Rosalía Fernández-Calle, José M Zapico, Ana Ramos, Beatriz de Pascual-Teresa, Kora-Mareen Bühler, Victor Echeverry-Alzate, Elena Giné, Fernando Rodríguez de Fonseca, Jose Antonio López-Moreno, Gonzalo Herradó. Inhibition of Receptor Protein Tyrosine Phosphatase β/ζ Reduces Alcohol Intake in Rats. Alcoholism, clinical and experimental research. vol 44. issue 5. 2021-11-04. PMID:32154588. |
pleiotrophin (ptn) and midkine (mk) are cytokines that are up-regulated in the prefrontal cortex (pfc) after alcohol administration and have been shown to reduce alcohol intake and reward. |
2021-11-04 |
2023-08-13 |
mouse |
| M A Bertocci, H W Chase, S Graur, R Stiffler, E K Edmiston, B A Coffman, B D Greenberg, M L Phillip. The impact of targeted cathodal transcranial direct current stimulation on reward circuitry and affect in Bipolar Disorder. Molecular psychiatry. vol 26. issue 8. 2021-11-02. PMID:31664174. |
one potential region is the left ventrolateral prefrontal cortex (vlpfc), which shows abnormally elevated activity during reward expectancy in individuals with bipolar disorder. |
2021-11-02 |
2023-08-13 |
human |
| Shijing Wang, Francesco Leri, Sakina J Rizv. Anhedonia as a central factor in depression: Neural mechanisms revealed from preclinical to clinical evidence. Progress in neuro-psychopharmacology & biological psychiatry. vol 110. 2021-11-01. PMID:33631251. |
substantial preclinical and clinical research has explored the neural basis of reward deficits in the context of depression, and has implicated mesocorticolimbic reward circuitry comprising the nucleus accumbens, ventral pallidum, ventral tegmental area, amygdala, hippocampus, anterior cingulate, insula, orbitofrontal cortex, and other prefrontal cortex regions. |
2021-11-01 |
2023-08-13 |
Not clear |
| Tiago Bortolini, Bruno Melo, Rodrigo Basilio, Ronald Fischer, Roland Zahn, Ricardo de Oliveira-Souza, Brian Knutson, Jorge Mol. Striatal and septo-hypothalamic responses to anticipation and outcome of affiliative rewards. NeuroImage. vol 243. 2021-10-29. PMID:34407439. |
on the one hand, anticipation of both affiliative and nonaffiliative rewards increased activity in the nacc, anterior insula, and supplementary motor cortex, but activity in the amygdala and the ventromedial prefrontal cortex (vmpfc) increased in response to reward outcomes. |
2021-10-29 |
2023-08-13 |
human |
| Michael J Lucido, Mandy Bekhbat, David R Goldsmith, Michael T Treadway, Ebrahim Haroon, Jennifer C Felger, Andrew H Mille. Aiding and Abetting Anhedonia: Impact of Inflammation on the Brain and Pharmacological Implications. Pharmacological reviews. vol 73. issue 3. 2021-10-28. PMID:34285088. |
neuroimaging data indicate that these inflammation-induced neurotransmitter effects manifest as decreased activation of ventral striatum and decreased functional connectivity in reward circuitry involving ventral striatum and ventromedial prefrontal cortex. |
2021-10-28 |
2023-08-13 |
Not clear |
| Hira E Shah, Nitin Bhawnani, Aarthi Ethirajulu, Almothana Alkasabera, Chike B Onyali, Comfort Anim-Koranteng, Jihan A Mostaf. Iron Deficiency-Induced Changes in the Hippocampus, Corpus Striatum, and Monoamines Levels That Lead to Anxiety, Depression, Sleep Disorders, and Psychotic Disorders. Cureus. vol 13. issue 9. 2021-10-26. PMID:34692346. |
the mechanisms of how iron deficiency affects behavior include affecting the hippocampus, the corpus striatum, and certain neurotransmitters. the hippocampus is a brain region that is essential for memory, learning, and other purposes. the hippocampus is very sensitive to lack of iron during early development. the corpus striatum dispatches dopamine-rich projects to the prefrontal cortex, and it is involved in controlling executive activities such as planning, inhibitory control, sustained attention, working memory, regulation of emotion, memory storage and retrieval, motivation, and reward. |
2021-10-26 |
2023-08-13 |
Not clear |
| Matthew N Tran, Kristen R Maynard, Abby Spangler, Louise A Huuki, Kelsey D Montgomery, Vijay Sadashivaiah, Madhavi Tippani, Brianna K Barry, Dana B Hancock, Stephanie C Hicks, Joel E Kleinman, Thomas M Hyde, Leonardo Collado-Torres, Andrew E Jaffe, Keri Martinowic. Single-nucleus transcriptome analysis reveals cell-type-specific molecular signatures across reward circuitry in the human brain. Neuron. vol 109. issue 19. 2021-10-25. PMID:34582785. |
we therefore created a single-nucleus rna-sequencing resource of 70,615 high-quality nuclei to generate a molecular taxonomy of cell types across five human brain regions that serve as key nodes of the human brain reward circuitry: nucleus accumbens, amygdala, subgenual anterior cingulate cortex, hippocampus, and dorsolateral prefrontal cortex. |
2021-10-25 |
2023-08-13 |
human |
| Jeremy E Solly, Roxanne W Hook, Jon E Grant, Samuele Cortese, Samuel R Chamberlai. Structural gray matter differences in Problematic Usage of the Internet: a systematic review and meta-analysis. Molecular psychiatry. 2021-10-22. PMID:34642454. |
in conclusion, voxel-based morphometric studies indicate replicable gray matter reductions in the dorsolateral prefrontal cortex and anterior cingulate cortex in pui, regions implicated in reward processing and top-down inhibitory control. |
2021-10-22 |
2023-08-13 |
Not clear |
| Y Sar. Potential therapeutic role of glutamate transporter 1 for the treatment of alcohol dependence. OA alcohol. vol 1. issue 1. 2021-10-21. PMID:24409344. |
alcohol-seeking behaviour is promoted by increased glutamate transmission in key regions of the mesocorticolimbic reward circuit, including the nucleus accumbens and prefrontal cortex. |
2021-10-21 |
2023-08-12 |
human |
| Roger I Grant, Elizabeth M Doncheck, Kelsey M Vollmer, Kion T Winston, Elizaveta V Romanova, Preston N Siegler, Heather Holman, Christopher W Bowen, James M Oti. Specialized coding patterns among dorsomedial prefrontal neuronal ensembles predict conditioned reward seeking. eLife. vol 10. 2021-10-20. PMID:34184635. |
non-overlapping cell populations within dorsomedial prefrontal cortex (dmpfc), defined by gene expression or projection target, control dissociable aspects of reward seeking through unique activity patterns. |
2021-10-20 |
2023-08-13 |
mouse |
| Bing-Yan Zeng, Bing-Syuan Zeng, Yen-Wen Chen, Chao-Ming Hung, Cheuk-Kwan Sun, Yu-Shian Cheng, Brendon Stubbs, Andre F Carvalho, Andre R Brunoni, Kuan-Pin Su, Yu-Kang Tu, Yi-Cheng Wu, Tien-Yu Chen, Pao-Yen Lin, Chih-Sung Liang, Chih-Wei Hsu, Ping-Tao Tseng, Cheng-Ta L. Efficacy and acceptability of noninvasive brain stimulation interventions for weight reduction in obesity: a pilot network meta-analysis. International journal of obesity (2005). vol 45. issue 8. 2021-10-19. PMID:33972697. |
obesity has recently been recognized as a neurocognitive disorder involving circuits associated with the reward system and the dorsolateral prefrontal cortex (dlpfc). |
2021-10-19 |
2023-08-13 |
human |
| Shole Jamali, Shahram Zarrabian, Abbas Haghparas. Similar role of mPFC orexin-1 receptors in the acquisition and expression of morphine- and food-induced conditioned place preference in male rats. Neuropharmacology. vol 198. 2021-10-14. PMID:34450116. |
different brain areas are involved in natural and drug reward processing including the mesolimbic pathway, amygdala, nucleus accumbens (nac), and prefrontal cortex. |
2021-10-14 |
2023-08-13 |
rat |
| Jessica Bomyea, Soo-Hee Choi, Alison Sweet, Murray Stein, Martin Paulus, Charles Taylo. Neural Changes in Reward Processing Following Approach Avoidance Training for Depression. Social cognitive and affective neuroscience. 2021-10-13. PMID:34643736. |
following training, connectivity patterns across reward regions were observed in the full sample and connectivity between the medial pfc and caudate was associated with anticipatory positive affect before the social interaction; preliminary evidence of differential connectivity patterns between the two groups also emerged. |
2021-10-13 |
2023-08-13 |
human |
| David S Jacobs, Bita Moghadda. Medial prefrontal cortex encoding of stress and anxiety. International review of neurobiology. vol 158. 2021-10-11. PMID:33785149. |
we conclude by proposing that pfc neurons selectively influence action encoding during conditions where actions toward obtaining a reward or avoiding harm are executed under a fog of fear and anxiety. |
2021-10-11 |
2023-08-13 |
human |
| Sylvain Iceta, Mahsa Dadar, Justine Daoust, Anais Scovronec, Vicky Leblanc, Melissa Pelletier, Laurent Biertho, André Tchernof, Catherine Bégin, Andreanne Michau. Association between Visceral Adiposity Index, Binge Eating Behavior, and Grey Matter Density in Caudal Anterior Cingulate Cortex in Severe Obesity. Brain sciences. vol 11. issue 9. 2021-10-01. PMID:34573180. |
in 20 men and 59 women with severe obesity, grey matter density was measured by voxel-based morphometry for six regions of interest associated with reward, emotion, or self-regulation: insula, orbitofrontal cortex, caudal and rostral anterior cingulate cortex (acc), ventromedial prefrontal cortex (vmpfc), and dorsolateral prefrontal cortex (dlpfc). |
2021-10-01 |
2023-08-13 |
Not clear |
| Elisa Ciaramelli, Flavia De Luca, Donna Kwan, Jenkin Mok, Francesca Bianconi, Violetta Knyagnytska, Carl Craver, Leonard Green, Joel Myerson, R Shayna Rosenbau. The role of ventromedial prefrontal cortex in reward valuation and future thinking during intertemporal choice. eLife. vol 10. 2021-09-23. PMID:34342577. |
the role of ventromedial prefrontal cortex in reward valuation and future thinking during intertemporal choice. |
2021-09-23 |
2023-08-13 |
human |
| C Figueroa, H Yang, J DiSpirito, J R Bourgeois, G Kalyanasundaram, I Doshi, S D Bilbo, A M Kope. Morphine exposure alters Fos expression in a sex-, age-, and brain region-specific manner during adolescence. Developmental psychobiology. vol 63. issue 6. 2021-08-31. PMID:34423851. |
by quantifying fos positive cells, a proxy for neural activity, at different stages during adolescence (pre-, early, mid-, and late adolescence) and in multiple reward regions (prefrontal cortex, nucleus accumbens, caudate/putamen), we determined that the neural response to acute morphine is highly dependent on adolescent age, sex, and brain region. |
2021-08-31 |
2023-08-13 |
human |
| David Roura-Martínez, Paula Díaz-Bejarano, Marcos Ucha, Raquel R Paiva, Emilio Ambrosio, Alejandro Higuera-Mata. Comparative analysis of the modulation of perineuronal nets in the prefrontal cortex of rats during protracted withdrawal from cocaine, heroin and sucrose self-administration. Neuropharmacology. vol 180. 2021-08-27. PMID:32888961. |
our results show that two different drugs of abuse (but not a natural reward) with specific pharmacological and physiological actions, differentially modulate pnns in specific areas of the rodent prefrontal cortex with potential implications for the incubation of seeking phenomenon. |
2021-08-27 |
2023-08-13 |
rat |
| Ewa Niedzielska-Andres, Lucyna Pomierny-Chamioło, Michał Andres, Maria Walczak, Lori A Knackstedt, Małgorzata Filip, Edmund Przegalińsk. Cocaine use disorder: A look at metabotropic glutamate receptors and glutamate transporters. Pharmacology & therapeutics. vol 221. 2021-08-26. PMID:33359590. |
the present review summarizes the changes in glutamate levels in the reward system (the prefrontal cortex, nucleus accumbens, dorsal striatum, hippocampus, and ventral tegmental area) observed in preclinical studies at different stages of cocaine exposure and withdrawal as well as after reinstatement of cocaine-seeking behavior. |
2021-08-26 |
2023-08-13 |
Not clear |
| Hamed Salmanzadeh, S Mohammad Ahmadi-Soleimani, Narges Pachenari, Maryam Azadi, Robert F Halliwell, Tiziana Rubino, Hossein Aziz. Adolescent drug exposure: A review of evidence for the development of persistent changes in brain function. Brain research bulletin. vol 156. 2021-08-20. PMID:31926303. |
these agents can affect development of the prefrontal cortex and mesolimbic dopamine pathways and modify the reward systems, socio-emotional processing and cognition. |
2021-08-20 |
2023-08-13 |
Not clear |