| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Delaney L Davis, Daniel B Metzger, Philip H Vann, Jessica M Wong, Ritu A Shetty, Michael J Forster, Nathalie Sumie. Effects of chronic methamphetamine exposure on rewarding behavior and neurodegeneration markers in adult mice. Psychopharmacology. 2023-05-01. PMID:37127834. |
the midbrain and striatum, regions involved in reward circuit, were assessed for markers associated with neurotoxicity, dopaminergic function, neuroinflammation and epigenetic changes after behavioral testing.previous exposure to chronic meth did not have significant short-term effects on cpp response but led to a decreased cpp response in 10-month-old females. |
2023-05-01 |
2023-08-14 |
mouse |
| Julong Wei, Tova Y Lambert, Aditi Valada, Nikhil Patel, Kellie Walker, Jayna Lenders, Carl J Schmidt, Marina Iskhakova, Adnan Alazizi, Henriette Mair-Meijers, Deborah C Mash, Francesca Luca, Roger Pique-Regi, Michael J Bannon, Schahram Akbaria. Single Nucleus Transcriptomics Reveals Pervasive Glial Activation in Opioid Overdose Cases. bioRxiv : the preprint server for biology. 2023-03-22. PMID:36945611. |
dynamic interactions of neurons and glia in the ventral midbrain (vm) mediate reward and addiction behavior. |
2023-03-22 |
2023-08-14 |
human |
| Elahe Amohashemi, Hojjatallah Alaei, Parham Reis. Effects of GABA Research in pharmaceutical sciences. vol 18. issue 1. 2023-02-27. PMID:36846735. |
effects of gaba the lateral habenula (lhb), a key area in the regulation of the reward system, exerts a major influence on midbrain neurons. |
2023-02-27 |
2023-08-14 |
Not clear |
| Carina Soares-Cunha, Jasper A Heinsbroe. Ventral pallidal regulation of motivated behaviors and reinforcement. Frontiers in neural circuits. vol 17. 2023-02-23. PMID:36817646. |
vp neurons respond temporally faster and show more advanced reward coding and prediction error processing than neurons in the upstream nucleus accumbens, and regulate the activity of the ventral mesencephalon dopamine system. |
2023-02-23 |
2023-08-14 |
Not clear |
| Daniel F Hill, Robert W Hickman, Alaa Al-Mohammad, Arkadiusz Stasiak, Wolfram Schult. Dopamine signals encode internally determined subjective value regardless of externally indicated reward attributes. bioRxiv : the preprint server for biology. 2023-01-30. PMID:36711724. |
responses of midbrain dopamine neurons followed the trial-by-trial variation of bids despite constant, explicitly predicted reward amounts; correspondingly, the dopamine responses were similar when the animal placed similar bids for different reward amounts. |
2023-01-30 |
2023-08-14 |
human |
| Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Shouta Serizawa, Fumiko Kihara-Negishi, Koichi J Homma, Shinji Yamaguch. Dopaminergic nuclei in the chick midbrain express serotonin receptor subfamily genes. Frontiers in physiology. vol 13. 2022-11-25. PMID:36425295. |
another important neural modulatory system exists in the midbrain, the dopaminergic system, which is associated to reward processing and motivation control. |
2022-11-25 |
2023-08-14 |
chicken |
| Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Shouta Serizawa, Fumiko Kihara-Negishi, Koichi J Homma, Shinji Yamaguch. Dopaminergic nuclei in the chick midbrain express serotonin receptor subfamily genes. Frontiers in physiology. vol 13. 2022-11-25. PMID:36425295. |
among them, groups a8-a10 associated with reward processing and motivation control are located in the midbrain and projected to the forebrain. |
2022-11-25 |
2023-08-14 |
chicken |
| Akitoshi Ogawa, Takahiro Osada, Masaki Tanaka, Akimitsu Suda, Koji Nakajima, Satoshi Oka, Koji Kamagata, Shigeki Aoki, Yasushi Oshima, Sakae Tanaka, Nobutaka Hattori, Seiki Konish. Hypothalamic interaction with reward-related regions during subjective evaluation of foods. NeuroImage. 2022-11-11. PMID:36368500. |
the reward system implemented in the midbrain, ventral striatum, orbitofrontal cortex, and ventromedial prefrontal cortex evaluates and compares various types of rewards given to the organisms. |
2022-11-11 |
2023-08-14 |
human |
| Qiao-Qiong Liu, Yu-Xiao Cheng, Qi Jing, Ke-Ming Zhang, Lu-Feng Ding, Xiao-Wei Fan, Chun-Hui Jia, Fang Xu, Guo-Qiang Bi, Pak-Ming La. Preferential subcortical collateral projections of pedunculopontine nucleus-targeting cortical pyramidal neurons revealed by brain-wide single fiber tracing. Molecular brain. vol 15. issue 1. 2022-10-30. PMID:36309684. |
the pedunculopontine nucleus (ppn) is a heterogeneous midbrain structure involved in various brain functions, such as motor control, learning, reward, and sleep. |
2022-10-30 |
2023-08-14 |
mouse |
| Karolina Farrell, Armin Lak, Aman B Salee. Midbrain dopamine neurons signal phasic and ramping reward prediction error during goal-directed navigation. Cell reports. vol 41. issue 2. 2022-10-12. PMID:36223748. |
midbrain dopamine neurons are involved in reward value learning and have been linked to reward location learning. |
2022-10-12 |
2023-08-14 |
mouse |
| Vasilios Pallikaras, Peter Shizga. Dopamine and Beyond: Implications of Psychophysical Studies of Intracranial Self-Stimulation for the Treatment of Depression. Brain sciences. vol 12. issue 8. 2022-08-26. PMID:36009115. |
we chart the evolution of the new model from its predecessors, which held that midbrain dopamine neurons constituted an obligatory stage of the final common path for reward seeking. |
2022-08-26 |
2023-08-14 |
Not clear |
| Fabian M P Kaiser, Sarah Gruenbacher, Maria Roa Oyaga, Enzo Nio, Markus Jaritz, Qiong Sun, Wietske van der Zwaag, Emanuel Kreidl, Lydia M Zopf, Virgil A S H Dalm, Johan Pel, Carolin Gaiser, Rick van der Vliet, Lucas Wahl, André Rietman, Louisa Hill, Ines Leca, Gertjan Driessen, Charlie Laffeber, Alice Brooks, Peter D Katsikis, Joyce H G Lebbink, Kikuë Tachibana, Mirjam van der Burg, Chris I De Zeeuw, Aleksandra Badura, Meinrad Busslinge. Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder. The Journal of experimental medicine. vol 219. issue 9. 2022-08-10. PMID:35947077. |
pax5 deficiency also caused profound hypoplasia of the substantia nigra and ventral tegmental area due to loss of gabaergic neurons, thus affecting two midbrain hubs, controlling motor function and reward processing, respectively. |
2022-08-10 |
2023-08-14 |
mouse |
| Sage S Frehner, Kip T Dooley, Michelle C Palumbo, Aaron L Smith, Mark M Goodman, Karen L Bales, Sara M Freema. Effect of sex and autism spectrum disorder on oxytocin receptor binding and mRNA expression in the dopaminergic pars compacta of the human substantia nigra. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 377. issue 1858. 2022-07-20. PMID:35858098. |
previous studies from our laboratory found a dense population of oxtr in the human substantia nigra (sn), a basal ganglia structure in the midbrain that is important in both movement and reward pathways. |
2022-07-20 |
2023-08-14 |
human |
| Mengjiao Chen, Fangqing Liu, Longying Wen, Xia H. Nonlinear relationship between CAN current and Cognitive neurodynamics. vol 16. issue 3. 2022-05-23. PMID:35603052. |
nonlinear relationship between can current and bursting of midbrain dopamine (da) neurons is believed to represent an important reward signal that instructs and reinforces goal-directed behaviors. |
2022-05-23 |
2023-08-13 |
Not clear |
| Vasilios Pallikaras, Peter Shizga. The Convergence Model of Brain Reward Circuitry: Implications for Relief of Treatment-Resistant Depression by Deep-Brain Stimulation of the Medial Forebrain Bundle. Frontiers in behavioral neuroscience. vol 16. 2022-04-18. PMID:35431828. |
a recent study in which rats worked for optogenetic stimulation of midbrain dopamine neurons challenges the series-circuit hypothesis and provides a new model of intracranial self-stimulation in which the myelinated non-dopaminergic neurons and the midbrain dopamine projections access the behavioral final common path for reward seeking via separate, converging routes. |
2022-04-18 |
2023-08-13 |
rat |
| b' Joseane Morari, Roberta Haddad-T\\xc3\\xb3volli, Pedro Augusto Silva Nogueira, Caio Jord\\xc3\\xa3o Teixeira, Rafael Mar\\xc3\\xb3stica, Nat\\xc3\\xa1lia Tobar, Celso Dario Ramos, Licio Augusto Velloso, Vanessa Cristina Dias Bobbo, Gabriel Forato Anh\\xc3\\xa. Body mass variability in age-matched outbred male Swiss mice is associated to differential control of food intake by ghrelin. Molecular and cellular endocrinology. 2022-04-12. PMID:35413387.' |
in conclusion, our data show that differences in the expression of genes related to the reward system in the midbrain as well as in ghrelin concentrations in serum correlate with spontaneous variability in body mass and food intake seen in age-matched male swiss mice. |
2022-04-12 |
2023-08-13 |
mouse |
| Lvshuang Chen, Hanyu Wu, Yongxiang Li, Xiajie Feng, Shuqing Zhu, Kailai Xie, Xin Wu, Zhonghua Sun, Gang Shu, Songbo Wang, Ping Gao, Xiaotong Zhu, Canjun Zhu, Qingyan Jiang, Lina Wan. Corticotropin-releasing factor receptor type 2 in the midbrain critically contributes to the hedonic feeding behavior of mice under heat stress. Biochemical and biophysical research communications. vol 602. 2022-03-07. PMID:35255437. |
however, the relationship between heat stress and midbrain reward regulation has not been reported. |
2022-03-07 |
2023-08-13 |
mouse |
| Melissa L Caras, Max F K Happel, Bharath Chandrasekaran, Pablo Ripollés, Sarah M Keesom, Laura M Hurley, Luke Remage-Healey, Lori L Holt, Beverly A Wrigh. Non-sensory Influences on Auditory Learning and Plasticity. Journal of the Association for Research in Otolaryngology : JARO. 2022-03-02. PMID:35235100. |
we begin by presenting evidence that reward signals from the dopaminergic midbrain act on cortico-subcortical networks to shape sound-evoked responses of auditory cortical neurons, facilitate auditory category learning, and modulate the long-term storage of new words and their meanings. |
2022-03-02 |
2023-08-13 |
human |
| Michiaki Suzuki, Ken-Ichi Inoue, Hiroshi Nakagawa, Hiroaki Ishida, Kenta Kobayashi, Tadashi Isa, Masahiko Takada, Yukio Nishimur. A multisynaptic pathway from the ventral midbrain toward spinal motoneurons in monkeys. The Journal of physiology. 2022-02-05. PMID:35122444. |
motivation to obtain reward is thought to boost motor performance, and the activity in the ventral midbrain is important to the motivational process. |
2022-02-05 |
2023-08-13 |
monkey |
| Zhi-Bing You, Eliot L Gardner, Ewa Galaj, Allamar R Moore, Tristram Buck, Chloe J Jordan, Bree A Humburg, Guo-Hua Bi, Zheng-Xiong Xi, Lorenzo Leggi. Involvement of the ghrelin system in the maintenance of oxycodone self-administration: converging evidence from endocrine, pharmacologic and transgenic approaches. Molecular psychiatry. 2022-01-22. PMID:35064236. |
here, we investigated the reciprocal interactions between the endogenous ghrelin system and oxycodone self-administration behaviors in rats and the role of the ghrelin system in brain stimulation reward (bsr) driven by optogenetic stimulation of midbrain reward circuits in mice. |
2022-01-22 |
2023-08-13 |
mouse |