| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M-P Cossette, K Conover, P Shizga. The neural substrates for the rewarding and dopamine-releasing effects of medial forebrain bundle stimulation have partially discrepant frequency responses. Behavioural brain research. vol 297. 2016-09-20. PMID:26477378. |
this study assessed the hypothesis that midbrain dopamine neurons are in series with the directly stimulated substrate for self-stimulation of the mfb and either perform spatio-temporal integration of synaptic input from directly activated mfb fibers or relay the results of such integration to efferent stages of the reward circuitry. |
2016-09-20 |
2023-08-13 |
human |
| b' Giovanni Hernandez, Marie-Pierre Cossette, Peter Shizgal, Pierre-Paul Rompr\\xc3\\xa. Ventral Midbrain NMDA Receptor Blockade: From Enhanced Reward and Dopamine Inactivation. Frontiers in behavioral neuroscience. vol 10. 2016-09-12. PMID:27616984.' |
ventral midbrain nmda receptor blockade: from enhanced reward and dopamine inactivation. |
2016-09-12 |
2023-08-13 |
rat |
| b' Giovanni Hernandez, Marie-Pierre Cossette, Peter Shizgal, Pierre-Paul Rompr\\xc3\\xa. Ventral Midbrain NMDA Receptor Blockade: From Enhanced Reward and Dopamine Inactivation. Frontiers in behavioral neuroscience. vol 10. 2016-09-12. PMID:27616984.' |
glutamate stimulates ventral midbrain (vm) n-methyl-d-aspartate receptors (nmdar) to initiate dopamine (da) burst firing activity, a mode of discharge associated with enhanced da release and reward. |
2016-09-12 |
2023-08-13 |
rat |
| Tim D Auman. Environment- and activity-dependent dopamine neurotransmitter plasticity in the adult substantia nigra. Journal of chemical neuroanatomy. vol 73. 2016-09-06. PMID:26718607. |
although further research is required to establish snc (and vta) da neurotransmitter plasticity, and to determine whether it alters brain function and behavior, it is an exciting prospect because: (1) it may play important roles in movement, motor learning, reward, motivation, memory and cognition; and (2) imbalances in midbrain da cause symptoms associated with several prominent brain and behavioral disorders such as schizophrenia, addiction, obsessive-compulsive disorder, depression, parkinson's disease and attention-deficit and hyperactivity disorder. |
2016-09-06 |
2023-08-13 |
mouse |
| Sarah X Luo, Eric J Huan. Dopaminergic Neurons and Brain Reward Pathways: From Neurogenesis to Circuit Assembly. The American journal of pathology. vol 186. issue 3. 2016-08-09. PMID:26724386. |
midbrain dopaminergic (da) neurons in the substantia nigra pars compacta and ventral tegmental area regulate extrapyramidal movement and important cognitive functions, including motivation, reward associations, and habit learning. |
2016-08-09 |
2023-08-13 |
Not clear |
| Brandon J Henderson, Teagan R Wall, Beverley M Henley, Charlene H Kim, Weston A Nichols, Ruin Moaddel, Cheng Xiao, Henry A Leste. Menthol Alone Upregulates Midbrain nAChRs, Alters nAChR Subtype Stoichiometry, Alters Dopamine Neuron Firing Frequency, and Prevents Nicotine Reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 10. 2016-07-19. PMID:26961950. |
menthol alone upregulates midbrain nachrs, alters nachr subtype stoichiometry, alters dopamine neuron firing frequency, and prevents nicotine reward. |
2016-07-19 |
2023-08-13 |
mouse |
| Sarah A Eisenstein, Allison N Bischoff, Danuta M Gredysa, Jo Ann V Antenor-Dorsey, Jonathan M Koller, Amal Al-Lozi, Marta Y Pepino, Samuel Klein, Joel S Perlmutter, Stephen M Moerlein, Kevin J Black, Tamara Hershe. Emotional Eating Phenotype is Associated with Central Dopamine D2 Receptor Binding Independent of Body Mass Index. Scientific reports. vol 5. 2016-06-20. PMID:26066863. |
across normal-weight and obese participants, self-reported emotional eating and non-food reward behavior positively correlated with striatal (p<0.05) and midbrain (p<0.05) d2r binding, respectively. |
2016-06-20 |
2023-08-13 |
human |
| Jonathan Murray Lovell, Judith Mylius, Henning Scheich, Michael Brosc. Stimulation of the Dopaminergic Midbrain as a Behavioral Reward in Instrumentally Conditioned Monkeys. Brain stimulation. vol 8. issue 5. 2016-06-09. PMID:26070295. |
stimulation of the dopaminergic midbrain as a behavioral reward in instrumentally conditioned monkeys. |
2016-06-09 |
2023-08-13 |
monkey |
| Benjamin T Saunders, Jocelyn M Richard, Patricia H Jana. Contemporary approaches to neural circuit manipulation and mapping: focus on reward and addiction. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 370. issue 1677. 2016-05-31. PMID:26240425. |
here we discuss contemporary approaches for understanding reward and addiction, with a focus on midbrain dopamine and cortico-striato-pallidal circuits. |
2016-05-31 |
2023-08-13 |
Not clear |
| Paul F Kramer, John T William. Cocaine Decreases Metabotropic Glutamate Receptor mGluR1 Currents in Dopamine Neurons by Activating mGluR5. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 10. 2016-05-09. PMID:25829143. |
midbrain dopamine neurons are important mediators of reward and movement and are sensitive to cocaine-induced plasticity. |
2016-05-09 |
2023-08-13 |
Not clear |
| Cody A Siciliano, Mark J Ferris, Sara R Jone. Cocaine self-administration disrupts mesolimbic dopamine circuit function and attenuates dopaminergic responsiveness to cocaine. The European journal of neuroscience. vol 42. issue 4. 2016-05-06. PMID:26037018. |
dopaminergic projections from the ventral midbrain to the nucleus accumbens (nac) have long been implicated in encoding associations between reward availability and environmental stimuli. |
2016-05-06 |
2023-08-13 |
rat |
| Agnieszka Chocyk, Iwona Majcher-Maślanka, Aleksandra Przyborowska, Marzena Maćkowiak, Krzysztof Wędzon. Early-life stress increases the survival of midbrain neurons during postnatal development and enhances reward-related and anxiolytic-like behaviors in a sex-dependent fashion. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 44. 2016-04-18. PMID:25980793. |
these results suggest that els induces distinct dysregulation in the midbrain circuitry of males, which may lead to sex-specific psychopathology of the reward system. |
2016-04-18 |
2023-08-13 |
rat |
| Puja K Parekh, Angela R Ozburn, Colleen A McClun. Circadian clock genes: effects on dopamine, reward and addiction. Alcohol (Fayetteville, N.Y.). vol 49. issue 4. 2016-02-23. PMID:25641765. |
in this review, we will discuss how circadian genes can regulate midbrain dopaminergic activity and subsequently, drug intake and reward. |
2016-02-23 |
2023-08-13 |
Not clear |
| Kristoffer Carl Aberg, Kimberly C Doell, Sophie Schwart. Hemispheric Asymmetries in Striatal Reward Responses Relate to Approach-Avoidance Learning and Encoding of Positive-Negative Prediction Errors in Dopaminergic Midbrain Regions. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 43. 2016-02-02. PMID:26511241. |
hemispheric asymmetries in striatal reward responses relate to approach-avoidance learning and encoding of positive-negative prediction errors in dopaminergic midbrain regions. |
2016-02-02 |
2023-08-13 |
human |
| Kristoffer Carl Aberg, Kimberly C Doell, Sophie Schwart. Hemispheric Asymmetries in Striatal Reward Responses Relate to Approach-Avoidance Learning and Encoding of Positive-Negative Prediction Errors in Dopaminergic Midbrain Regions. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 43. 2016-02-02. PMID:26511241. |
moreover, using a computational modeling approach, we demonstrate that better encoding of positive (vs negative) pes in dopaminergic midbrain regions is associated with better approach (vs avoidance) learning, specifically in participants with larger reward responses in the left (vs right) ventral striatum. |
2016-02-02 |
2023-08-13 |
human |
| Joshua M Carlson, Dan Foti, Eddie Harmon-Jones, Greg H Proudfi. Midbrain volume predicts fMRI and ERP measures of reward reactivity. Brain structure & function. vol 220. issue 3. 2016-01-27. PMID:24549705. |
midbrain volume predicts fmri and erp measures of reward reactivity. |
2016-01-27 |
2023-08-12 |
Not clear |
| Joshua M Carlson, Dan Foti, Eddie Harmon-Jones, Greg H Proudfi. Midbrain volume predicts fMRI and ERP measures of reward reactivity. Brain structure & function. vol 220. issue 3. 2016-01-27. PMID:24549705. |
although there is a long history of research implicating the midbrain dopamine system in reward processing, there has been little research into the possibility that structural variability in the midbrain may be linked to functional variability in reward reactivity. |
2016-01-27 |
2023-08-12 |
Not clear |
| Joshua M Carlson, Dan Foti, Eddie Harmon-Jones, Greg H Proudfi. Midbrain volume predicts fMRI and ERP measures of reward reactivity. Brain structure & function. vol 220. issue 3. 2016-01-27. PMID:24549705. |
the results suggest that as midbrain volumes increase, fmri reward reactivity in the ventral striatum and medial prefrontal cortex also increases. |
2016-01-27 |
2023-08-12 |
Not clear |
| Joshua M Carlson, Dan Foti, Eddie Harmon-Jones, Greg H Proudfi. Midbrain volume predicts fMRI and ERP measures of reward reactivity. Brain structure & function. vol 220. issue 3. 2016-01-27. PMID:24549705. |
thus, structural variability in the midbrain relates to variability in fmri and erp measures of functional reward reactivity, which may play a critical role in reward-related psychopathologies and the treatment of these disorders. |
2016-01-27 |
2023-08-12 |
Not clear |
| Agnes Norbury, Masud Husai. Sensation-seeking: Dopaminergic modulation and risk for psychopathology. Behavioural brain research. vol 288. 2016-01-27. PMID:25907745. |
both high tonic dopamine levels and hyper-reactive midbrain dopaminergic responses to signals of forthcoming reward are evident in higher sensations-seekers. |
2016-01-27 |
2023-08-13 |
human |