| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kenneth Blum, Amanda L C Chen, Marlene Oscar-Berman, Thomas J H Chen, Joel Lubar, Nancy White, Judith Lubar, Abdalla Bowirrat, Eric Braverman, John Schoolfield, Roger L Waite, Bernard W Downs, Margaret Madigan, David E Comings, Caroline Davis, Mallory M Kerner, Jennifer Knopf, Tomas Palomo, John J Giordano, Siobhan A Morse, Frank Fornari, Debmalya Barh, John Femino, John A Baile. Generational association studies of dopaminergic genes in reward deficiency syndrome (RDS) subjects: selecting appropriate phenotypes for reward dependence behaviors. International journal of environmental research and public health. vol 8. issue 12. 2012-06-19. PMID:22408582. |
generational association studies of dopaminergic genes in reward deficiency syndrome (rds) subjects: selecting appropriate phenotypes for reward dependence behaviors. |
2012-06-19 |
2023-08-12 |
human |
| Kenneth Blum, Amanda L C Chen, Marlene Oscar-Berman, Thomas J H Chen, Joel Lubar, Nancy White, Judith Lubar, Abdalla Bowirrat, Eric Braverman, John Schoolfield, Roger L Waite, Bernard W Downs, Margaret Madigan, David E Comings, Caroline Davis, Mallory M Kerner, Jennifer Knopf, Tomas Palomo, John J Giordano, Siobhan A Morse, Frank Fornari, Debmalya Barh, John Femino, John A Baile. Generational association studies of dopaminergic genes in reward deficiency syndrome (RDS) subjects: selecting appropriate phenotypes for reward dependence behaviors. International journal of environmental research and public health. vol 8. issue 12. 2012-06-19. PMID:22408582. |
abnormal behaviors involving dopaminergic gene polymorphisms often reflect an insufficiency of usual feelings of satisfaction, or reward deficiency syndrome (rds). |
2012-06-19 |
2023-08-12 |
human |
| Kenneth Blum, Amanda L C Chen, Marlene Oscar-Berman, Thomas J H Chen, Joel Lubar, Nancy White, Judith Lubar, Abdalla Bowirrat, Eric Braverman, John Schoolfield, Roger L Waite, Bernard W Downs, Margaret Madigan, David E Comings, Caroline Davis, Mallory M Kerner, Jennifer Knopf, Tomas Palomo, John J Giordano, Siobhan A Morse, Frank Fornari, Debmalya Barh, John Femino, John A Baile. Generational association studies of dopaminergic genes in reward deficiency syndrome (RDS) subjects: selecting appropriate phenotypes for reward dependence behaviors. International journal of environmental research and public health. vol 8. issue 12. 2012-06-19. PMID:22408582. |
rds results from a dysfunction in the "brain reward cascade," a complex interaction among neurotransmitters (primarily dopaminergic and opioidergic). |
2012-06-19 |
2023-08-12 |
human |
| Kenneth Blum, Eliot Gardner, Marlene Oscar-Berman, Mark Gol. "Liking" and "wanting" linked to Reward Deficiency Syndrome (RDS): hypothesizing differential responsivity in brain reward circuitry. Current pharmaceutical design. vol 18. issue 1. 2012-05-31. PMID:22236117. |
addictive drugs have in common that they are voluntarily selfadministered, they enhance (directly or indirectly) dopaminergic synaptic function in the nucleus accumbens (nac), and they stimulate the functioning of brain reward circuitry (producing the "high" that drug users seek). |
2012-05-31 |
2023-08-12 |
Not clear |
| Bhagirathi Dash, Minoti Bhakta, Yongchang Chang, Ronald J Luka. Modulation of recombinant, α2*, α3* or α4*-nicotinic acetylcholine receptor (nAChR) function by nAChR β3 subunits. Journal of neurochemistry. vol 121. issue 3. 2012-05-24. PMID:22309577. |
the nicotinic acetylcholine receptor (nachr) β3 subunit is thought to serve an accessory role in nachr subtypes expressed in dopaminergic regions implicated in drug dependence and reward. |
2012-05-24 |
2023-08-12 |
xenopus_laevis |
| Karolina P Skibicka, Caroline Hansson, Emil Egecioglu, Suzanne L Dickso. Role of ghrelin in food reward: impact of ghrelin on sucrose self-administration and mesolimbic dopamine and acetylcholine receptor gene expression. Addiction biology. vol 17. issue 1. 2012-05-14. PMID:21309956. |
recently, however, it has emerged as a potent modulator of the mesolimbic dopaminergic reward pathway, suggesting a role for ghrelin in food reward. |
2012-05-14 |
2023-08-12 |
Not clear |
| Zachary Y Weinberg, Marjorie L Nicholson, Paul J Curri. 6-Hydroxydopamine lesions of the ventral tegmental area suppress ghrelin's ability to elicit food-reinforced behavior. Neuroscience letters. vol 499. issue 2. 2012-05-14. PMID:21640160. |
our findings demonstrate that ghrelin induces food-reinforced behavior in the mesotelencephalic reward pathway and that this effect is dependent on intact dopaminergic signaling. |
2012-05-14 |
2023-08-12 |
rat |
| Liwang Liu, Rubing Zhao-Shea, J Michael McIntosh, Paul D Gardner, Andrew R Tappe. Nicotine persistently activates ventral tegmental area dopaminergic neurons via nicotinic acetylcholine receptors containing α4 and α6 subunits. Molecular pharmacology. vol 81. issue 4. 2012-05-07. PMID:22222765. |
nicotine is reinforcing because it activates dopaminergic (daergic) neurons within the ventral tegmental area (vta) of the brain's mesocorticolimbic reward circuitry. |
2012-05-07 |
2023-08-12 |
mouse |
| Sudarat Nimitvilai, Devinder S Arora, Mark S Brodi. Reversal of dopamine inhibition of dopaminergic neurons of the ventral tegmental area is mediated by protein kinase C. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 2. 2012-04-17. PMID:21976045. |
reversal of dopamine inhibition of dopaminergic neurons of the ventral tegmental area is mediated by protein kinase c. adaptation of putative dopaminergic (pda) neurons in the ventral tegmental area (vta) to drugs of abuse may alter information processing related to reward and reinforcement and is an important factor in the development of addiction. |
2012-04-17 |
2023-08-12 |
rat |
| Jeremiah Y Cohen, Sebastian Haesler, Linh Vong, Bradford B Lowell, Naoshige Uchid. Neuron-type-specific signals for reward and punishment in the ventral tegmental area. Nature. vol 482. issue 7383. 2012-03-15. PMID:22258508. |
these results show that vta gabaergic neurons signal expected reward, a key variable for dopaminergic neurons to calculate reward prediction error. |
2012-03-15 |
2023-08-12 |
mouse |
| Birgit Abler, Georg Grön, Antonie Hartmann, Coraline Metzger, Martin Walte. Modulation of frontostriatal interaction aligns with reduced primary reward processing under serotonergic drugs. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 4. 2012-03-12. PMID:22279217. |
our results corroborate and extend previous insights on interregional crosstalk from secondary to primary rewards and demonstrate parallels between active inhibitory control of and serotonergic effects on the dopaminergic reward system's activity. |
2012-03-12 |
2023-08-12 |
human |
| Bogusława Pietrzak, Agnieszka Dunaj, Karolina Piątkowsk. [The role of the cannabinoid system in the pathogenesis and treatment of alcohol dependence]. Postepy higieny i medycyny doswiadczalnej (Online). vol 65. 2012-03-01. PMID:21934185. |
the results show an interplay between the endocannabinoid and dopaminergic signaling in activation of the limbic reward system. |
2012-03-01 |
2023-08-12 |
Not clear |
| Elizabeth Rickenbacher, Douglas N Greve, Sheeva Azma, Josef Pfeuffer, Ksenija Marinkovi. Effects of alcohol intoxication and gender on cerebral perfusion: an arterial spin labeling study. Alcohol (Fayetteville, N.Y.). vol 45. issue 8. 2012-02-28. PMID:21621371. |
alcohol-induced perfusion increase correlated positively with impulsivity/antisocial tendencies, consistent with dopaminergic mediation of reward, and its effects on cortical perfusion. |
2012-02-28 |
2023-08-12 |
Not clear |
| Y Pan, L Chau, S Liu, M V Avshalumov, M E Rice, K D Car. A food restriction protocol that increases drug reward decreases tropomyosin receptor kinase B in the ventral tegmental area, with no effect on brain-derived neurotrophic factor or tropomyosin receptor kinase B protein levels in dopaminergic forebrain regions. Neuroscience. vol 197. 2012-02-27. PMID:21945647. |
a food restriction protocol that increases drug reward decreases tropomyosin receptor kinase b in the ventral tegmental area, with no effect on brain-derived neurotrophic factor or tropomyosin receptor kinase b protein levels in dopaminergic forebrain regions. |
2012-02-27 |
2023-08-12 |
human |
| Jan Kassubek, Birgit Abler, Elmar H Pinkhard. Neural reward processing under dopamine agonists: imaging. Journal of the neurological sciences. vol 310. issue 1-2. 2012-02-16. PMID:21762926. |
functional changes in a network involving striatal-thalamic loops, key structures of the reward system, together with limbic areas (such as the amygdala) and the ventral tegmental area could be related to pharmacological alterations of reward processing by dopaminergic medication. |
2012-02-16 |
2023-08-12 |
Not clear |
| Jan Kassubek, Birgit Abler, Elmar H Pinkhard. Neural reward processing under dopamine agonists: imaging. Journal of the neurological sciences. vol 310. issue 1-2. 2012-02-16. PMID:21762926. |
a synopsis is given on the applications of functional neuroimaging to investigate reward processing and the influence of dopaminergic medication. |
2012-02-16 |
2023-08-12 |
Not clear |
| L Strathear. Maternal neglect: oxytocin, dopamine and the neurobiology of attachment. Journal of neuroendocrinology. vol 23. issue 11. 2012-02-10. PMID:21951160. |
oxytocin may activate the dopaminergic reward pathways in response to social cues. |
2012-02-10 |
2023-08-12 |
human |
| Lynette C Daws, Malcolm J Avison, Sabrina D Robertson, Kevin D Niswender, Aurelio Galli, Christine Saunder. Insulin signaling and addiction. Neuropharmacology. vol 61. issue 7. 2012-01-27. PMID:21420985. |
given that many abused drugs target the da system, the elucidation of how dopaminergic, as well as other brain reward systems, are regulated by insulin will create opportunities to develop therapies for drug and potentially food addiction. |
2012-01-27 |
2023-08-12 |
monkey |
| W N Marsde. Stressor-induced NMDAR dysfunction as a unifying hypothesis for the aetiology, pathogenesis and comorbidity of clinical depression. Medical hypotheses. vol 77. issue 4. 2011-12-29. PMID:21741771. |
amygdala); and regional disruption of cortico-limbic circuits and dopaminergic reward pathways (e.g. |
2011-12-29 |
2023-08-12 |
Not clear |
| R M Krebs, D Heipertz, H Schuetze, E Duze. Novelty increases the mesolimbic functional connectivity of the substantia nigra/ventral tegmental area (SN/VTA) during reward anticipation: Evidence from high-resolution fMRI. NeuroImage. vol 58. issue 2. 2011-12-21. PMID:21723396. |
reward and novelty are potent learning signals that critically rely on dopaminergic midbrain responses. |
2011-12-21 |
2023-08-12 |
human |