| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M J McNulty, M Casanova-Schmitz, H D Hec. Metabolism of dimethylamine in the nasal mucosa of the Fischer 344 rat. Drug metabolism and disposition: the biological fate of chemicals. vol 11. issue 5. 1983-12-21. PMID:6138226. |
microsomes were prepared from liver, and from respiratory and olfactory nasal mucosa. |
1983-12-21 |
2023-08-12 |
rat |
| M J McNulty, M Casanova-Schmitz, H D Hec. Metabolism of dimethylamine in the nasal mucosa of the Fischer 344 rat. Drug metabolism and disposition: the biological fate of chemicals. vol 11. issue 5. 1983-12-21. PMID:6138226. |
the results demonstrate that the respiratory and olfactory nasal mucosa have the capability to metabolize dma to ch2o, and indicate that such metabolism occurs in vivo. |
1983-12-21 |
2023-08-12 |
rat |
| M J McNulty, H D Hec. Disposition and pharmacokinetics of inhaled dimethylamine in the Fischer 344 rat. Drug metabolism and disposition: the biological fate of chemicals. vol 11. issue 5. 1983-12-21. PMID:6138225. |
analysis of tissue radioactivity immediately after exposure to [14c]dma showed that the respiratory nasal mucosa contained the highest concentration of 14c, followed by the olfactory nasal mucosa; concentrations of 14c in liver, lung, kidney, brain, and testes were approximately 2 orders of magnitude less than in the nasal mucosal tissues. |
1983-12-21 |
2023-08-12 |
rat |
| X Z Jiang, L A Buckley, K T Morga. Pathology of toxic responses to the RD50 concentration of chlorine gas in the nasal passages of rats and mice. Toxicology and applied pharmacology. vol 71. issue 2. 1983-12-17. PMID:6636187. |
therefore, chlorine-induced severe lesions in specific locations in both the olfactory and respiratory epithelia of the nasal passages with more widespread loss of respiratory and olfactory cilia. |
1983-12-17 |
2023-08-12 |
mouse |
| M M Mozell, D E Hornung, D A Leopold, S L Youngento. Initial mechanisms basic to olfactory perception. American journal of otolaryngology. vol 4. issue 4. 1983-11-23. PMID:6312828. |
thus, in humans any naturally occurring or surgically induced alteration in the nasal airflow which appreciably alters these variables may affect olfactory perception. |
1983-11-23 |
2023-08-12 |
Not clear |
| J W Witkin, A J Silverma. Luteinizing hormone-releasing hormone (LHRH) in rat olfactory systems. The Journal of comparative neurology. vol 218. issue 4. 1983-11-23. PMID:6352748. |
the luteinizing hormone-releasing hormone (lhrh) systems of rat olfactory bulbs and nasal areas were studied in neonatal and adult rats. |
1983-11-23 |
2023-08-12 |
rat |
| J W Witkin, A J Silverma. Luteinizing hormone-releasing hormone (LHRH) in rat olfactory systems. The Journal of comparative neurology. vol 218. issue 4. 1983-11-23. PMID:6352748. |
animals were perfused with zamboni's fixative and olfactory bulbs with nasal olfactory areas intact were removed, postfixed, and decalcified. |
1983-11-23 |
2023-08-12 |
rat |
| H Tjälve, A Castongua. The in vivo tissue disposition and in vitro target-tissue metabolism of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in Syrian golden hamsters. Carcinogenesis. vol 4. issue 10. 1983-11-23. PMID:6616754. |
microautoradiography of the nasal olfactory mucosa showed the highest labeling over bowman's glands in the lamina propria mucosae. |
1983-11-23 |
2023-08-12 |
Not clear |
| M J McNulty, J C Chang, C S Barrow, M Casanova-Schmitz, H D Hec. Sulfhydryl oxidation in rat nasal mucosal tissues after chlorine inhalation. Toxicology letters. vol 17. issue 3-4. 1983-11-23. PMID:6623516. |
male f-344 rats were exposed to target concentrations of 2.5, 5, or 10 ppm cl2 for various amounts of time, after which respiratory and olfactory nasal mucosal tissues were analyzed for changes in total sulfhydryl (tsh) content. |
1983-11-23 |
2023-08-12 |
rat |
| S N Ghorbanian, J L Paradise, R L Dot. Odor perception in children in relation to nasal obstruction. Pediatrics. vol 72. issue 4. 1983-10-28. PMID:6889064. |
to determine whether nasal obstruction in children results in impaired nasal function, olfactory sensitivity was assessed in 65 children with various degrees of nasal obstruction and in 13 children without nasal obstruction. |
1983-10-28 |
2023-08-12 |
human |
| S N Ghorbanian, J L Paradise, R L Dot. Odor perception in children in relation to nasal obstruction. Pediatrics. vol 72. issue 4. 1983-10-28. PMID:6889064. |
overall, olfactory detection thresholds were directly related to clinical ratings of degree of nasal obstruction. |
1983-10-28 |
2023-08-12 |
human |
| S N Ghorbanian, J L Paradise, R L Dot. Odor perception in children in relation to nasal obstruction. Pediatrics. vol 72. issue 4. 1983-10-28. PMID:6889064. |
of the subjects with nasal obstruction attributable to adenoid hypertrophy, 28 received adenoidectomy; when retested 2 to 28 months later, 20 of the 28 subjects showed generally commensurate reductions in nasal obstruction ratings and olfactory detection thresholds. |
1983-10-28 |
2023-08-12 |
human |
| S N Ghorbanian, J L Paradise, R L Dot. Odor perception in children in relation to nasal obstruction. Pediatrics. vol 72. issue 4. 1983-10-28. PMID:6889064. |
in a comparison subgroup of 16 subjects retested after intervals of 5 to 13 months without having received intervening adenoidectomy, both the nasal obstruction ratings and the olfactory detection thresholds remained relatively unchanged. |
1983-10-28 |
2023-08-12 |
human |
| S N Ghorbanian, J L Paradise, R L Dot. Odor perception in children in relation to nasal obstruction. Pediatrics. vol 72. issue 4. 1983-10-28. PMID:6889064. |
olfactory function, although hitherto accorded little pediatric attention, deserves consideration both in weighing the importance of nasal obstruction in children and in deciding about therapeutic intervention. |
1983-10-28 |
2023-08-12 |
human |
| M W Bradbury, R J Westro. Factors influencing exit of substances from cerebrospinal fluid into deep cervical lymph of the rabbit. The Journal of physiology. vol 339. 1983-10-08. PMID:6411905. |
and deep cervical lymph is via prolongations of subarachnoid space around the olfactory nerves, leading into the interstitial spaces of the nasal submucosa. |
1983-10-08 |
2023-08-12 |
rabbit |
| E B Brittebo, A Castonguay, K Furuya, S S Hech. Metabolism of tobacco-specific nitrosamines by cultured rat nasal mucosa. Cancer research. vol 43. issue 9. 1983-09-23. PMID:6871868. |
microautoradiographic studies of explants showed that binding of radioactivity occurred preferentially in the respiratory and olfactory epithelia and in the subepithelial glands of the nasal mucosa. |
1983-09-23 |
2023-08-12 |
rat |
| J R Srigley, V S Dayal, R T Gregor, R Love, A W van Nostran. Hyponatremia secondary to olfactory neuroblastoma. Archives of otolaryngology (Chicago, Ill. : 1960). vol 109. issue 8. 1983-08-26. PMID:6870650. |
a patient with a four-year history of unexplained hyponatremia was seen with recurrent nasal discharge and was found to have a typical olfactory neuroblastoma. |
1983-08-26 |
2023-08-12 |
Not clear |
| H M Reznik-Schülle. Pathogenesis of tumors induced with N-nitrosomethylpiperazine in the olfactory region of the rat nasal cavity. Journal of the National Cancer Institute. vol 71. issue 1. 1983-08-11. PMID:6191067. |
pathogenesis of tumors induced with n-nitrosomethylpiperazine in the olfactory region of the rat nasal cavity. |
1983-08-11 |
2023-08-12 |
rat |
| H M Reznik-Schülle. Pathogenesis of tumors induced with N-nitrosomethylpiperazine in the olfactory region of the rat nasal cavity. Journal of the National Cancer Institute. vol 71. issue 1. 1983-08-11. PMID:6191067. |
tumors in the olfactory region of the nasal cavity of the f344 rat were induced by chronic treatment with n-nitrosomethylpiperazine. |
1983-08-11 |
2023-08-12 |
rat |
| S B Jobst, B M Ljung, F N Gilkey, D L Rosentha. Cytologic diagnosis of olfactory neuroblastoma. Report of a case with multiple diagnostic parameters. Acta cytologica. vol 27. issue 3. 1983-08-11. PMID:6575548. |
the patient was a 40-year-old male who had a 13-year history of "adenocarcinoma" of the nasal cavity until the correct diagnosis of olfactory neuroblastoma was made cytologically from pleural fluid shortly before his death. |
1983-08-11 |
2023-08-12 |
Not clear |