| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giovanni Marsicano, Pauline Lafenêtr. Roles of the endocannabinoid system in learning and memory. Current topics in behavioral neurosciences. vol 1. 2011-01-04. PMID:21104385. |
the endocannabinoid system (ecs) plays a central role in the regulation of learning and memory processes. |
2011-01-04 |
2023-08-12 |
Not clear |
| Giovanni Marsicano, Pauline Lafenêtr. Roles of the endocannabinoid system in learning and memory. Current topics in behavioral neurosciences. vol 1. 2011-01-04. PMID:21104385. |
in this chapter, we review the data in the literature showing the direct involvement of the physiological activation of cannabinoid receptors in the modulation of different forms of learning and memory. |
2011-01-04 |
2023-08-12 |
Not clear |
| Huibing Tan, Nicole M Lauzon, Stephanie F Bishop, Melanie A Bechard, Steven R Laviolett. Integrated cannabinoid CB1 receptor transmission within the amygdala-prefrontal cortical pathway modulates neuronal plasticity and emotional memory encoding. Cerebral cortex (New York, N.Y. : 1991). vol 20. issue 6. 2010-10-29. PMID:19880592. |
the cannabinoid cb1 receptor system is functionally involved in the processing and encoding of emotionally salient sensory information, learning and memory. |
2010-10-29 |
2023-08-12 |
rat |
| Nora Laaris, Cameron H Good, Carl R Lupic. Delta9-tetrahydrocannabinol is a full agonist at CB1 receptors on GABA neuron axon terminals in the hippocampus. Neuropharmacology. vol 59. issue 1-2. 2010-10-20. PMID:20417220. |
marijuana impairs learning and memory through actions of its psychoactive constituent, delta-9-tetrahydrocannabinol (delta(9)-thc), in the hippocampus, through activation of cannabinoid cb1 receptors (cb1r). |
2010-10-20 |
2023-08-12 |
mouse |
| Lianne Robinson, Anushka V Goonawardena, Roger Pertwee, Robert E Hampson, Bettina Platt, Gernot Riede. WIN55,212-2 induced deficits in spatial learning are mediated by cholinergic hypofunction. Behavioural brain research. vol 208. issue 2. 2010-05-25. PMID:20079375. |
cannabinoids acting on cb(1) receptors induce learning and memory impairments. |
2010-05-25 |
2023-08-12 |
rat |
| Lianne Robinson, Anushka V Goonawardena, Roger Pertwee, Robert E Hampson, Bettina Platt, Gernot Riede. WIN55,212-2 induced deficits in spatial learning are mediated by cholinergic hypofunction. Behavioural brain research. vol 208. issue 2. 2010-05-25. PMID:20079375. |
however, the identification of novel non-cb(1) receptors which are insensitive to the psychoactive ingredient of marijuana, delta(9)-tetrahydrocannabinol (delta(9)-thc) but sensitive to synthetic cannabinoids such as win55,212-2 (win-2) or endocannabinoids like anandamide lead us to question whether win-2 induced learning and memory deficits are indeed mediated by cb(1) receptor activation. |
2010-05-25 |
2023-08-12 |
rat |
| Yoko Nawata, Takato Hiranita, Tsuneyuki Yamamot. A cannabinoid CB(1) receptor antagonist ameliorates impairment of recognition memory on withdrawal from MDMA (Ecstasy). Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 2. 2010-03-01. PMID:19829291. |
on the other hand, cannabinoid cb(1) receptors have been implicated in learning/memory, and are highly expressed in the hippocampus, a region of the brain believed to have an important function in certain forms of learning and memory. |
2010-03-01 |
2023-08-12 |
mouse |
| A Higuera-Matas, F Botreau, M Miguéns, N Del Olmo, E Borcel, L Pérez-Alvarez, C García-Lecumberri, E Ambrosi. Chronic periadolescent cannabinoid treatment enhances adult hippocampal PSA-NCAM expression in male Wistar rats but only has marginal effects on anxiety, learning and memory. Pharmacology, biochemistry, and behavior. vol 93. issue 4. 2009-11-27. PMID:19576923. |
chronic periadolescent cannabinoid treatment enhances adult hippocampal psa-ncam expression in male wistar rats but only has marginal effects on anxiety, learning and memory. |
2009-11-27 |
2023-08-12 |
rat |
| A Higuera-Matas, F Botreau, M Miguéns, N Del Olmo, E Borcel, L Pérez-Alvarez, C García-Lecumberri, E Ambrosi. Chronic periadolescent cannabinoid treatment enhances adult hippocampal PSA-NCAM expression in male Wistar rats but only has marginal effects on anxiety, learning and memory. Pharmacology, biochemistry, and behavior. vol 93. issue 4. 2009-11-27. PMID:19576923. |
here, we measured anxiety in the elevated plus maze (epm) in adult wistar rats treated at periadolescence (p28-p38) with the cannabinoid agonist cp 55,940 (cp) (0.4 mg/kg; 2 ml/kg i.p., 1 daily injection), and we also defined their recognition memory in the novel object paradigm and spatial learning and memory in the water maze. |
2009-11-27 |
2023-08-12 |
rat |
| A Higuera-Matas, F Botreau, M Miguéns, N Del Olmo, E Borcel, L Pérez-Alvarez, C García-Lecumberri, E Ambrosi. Chronic periadolescent cannabinoid treatment enhances adult hippocampal PSA-NCAM expression in male Wistar rats but only has marginal effects on anxiety, learning and memory. Pharmacology, biochemistry, and behavior. vol 93. issue 4. 2009-11-27. PMID:19576923. |
based on our data, minimal long-term effects on anxiety, learning and memory appear to result from cannabinoid exposure during the periadolescent period. |
2009-11-27 |
2023-08-12 |
rat |
| Lu-lu Yu, Xue-yi Wang, Mei Zhao, Yu Liu, Yan-qin Li, Fang-qiong Li, Xiaoyi Wang, Yan-xue Xue, Lin L. Effects of cannabinoid CB1 receptor antagonist rimonabant in consolidation and reconsolidation of methamphetamine reward memory in mice. Psychopharmacology. vol 204. issue 2. 2009-08-05. PMID:19148622. |
previous studies have shown that cannabinoid cb1 receptors play an important role in specific aspects of learning and memory, yet there has been no systematic study focusing on the involvement of cannabinoid cb1 receptors in methamphetamine-related reward memory. |
2009-08-05 |
2023-08-12 |
mouse |
| Masako Isokaw. Time-dependent induction of CREB phosphorylation in the hippocampus by the endogenous cannabinoid. Neuroscience letters. vol 457. issue 1. 2009-07-22. PMID:19429161. |
the ability of hippocampal neurons to integrate a time-dependent effect on the endogenous cannabinoid signaling may be a key function of plasticity as related to the induction and maintenance of maladaptive learning and memory that underlies both cue-induced cravings as well as relapses in drug-seeking. |
2009-07-22 |
2023-08-12 |
Not clear |
| Toshiko Suenaga, Masami Kaku, Yukio Ichitan. Effects of intrahippocampal cannabinoid receptor agonist and antagonist on radial maze and T-maze delayed alternation performance in rats. Pharmacology, biochemistry, and behavior. vol 91. issue 1. 2008-11-06. PMID:18639576. |
brain cannabinoid receptors are abundantly distributed in the hippocampus, however their detailed role in learning and memory remains unclear. |
2008-11-06 |
2023-08-12 |
rat |
| Gunnar Thiemann, Ben C Fletcher, Catherine Ledent, Areles Molleman, Rüdiger U Hasenöhr. The genetic versus pharmacological invalidation of the cannabinoid CB(1) receptor results in differential effects on 'non-associative' memory and forebrain monoamine concentrations in mice. Neurobiology of learning and memory. vol 88. issue 4. 2008-01-08. PMID:17884611. |
the endocannabinoid cb(1) receptor has been implicated in the inhibitory control of learning and memory. |
2008-01-08 |
2023-08-12 |
mouse |
| Floride Niyuhire, Stephen A Varvel, Billy R Martin, Aron H Lichtma. Exposure to marijuana smoke impairs memory retrieval in mice. The Journal of pharmacology and experimental therapeutics. vol 322. issue 3. 2007-10-19. PMID:17586723. |
although delta(9)-thc and other cannabinoids disrupt performance in a wide range of animal models of learning and memory, few studies have investigated the effects of smoked marijuana in these paradigms. |
2007-10-19 |
2023-08-12 |
mouse |
| Alexander F Hoffman, Murat Oz, Ruiqin Yang, Aron H Lichtman, Carl R Lupic. Opposing actions of chronic Delta9-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiation. Learning & memory (Cold Spring Harbor, N.Y.). vol 14. issue 1-2. 2007-07-03. PMID:17202425. |
although cannabinoids acutely reduce glutamate release and block hippocampal long-term potentiation (ltp), a potential substrate for learning and memory, the consequences of prolonged exposure to delta(9)-thc for hippocampal function are poorly understood. |
2007-07-03 |
2023-08-12 |
rat |
| Yuki Hashimotodani, Takako Ohno-Shosaku, Masanobu Kan. Endocannabinoids and synaptic function in the CNS. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 13. issue 2. 2007-05-25. PMID:17404373. |
retrograde endocannabinoid signaling is crucial for certain forms of short-term and long-term synaptic plasticity at excitatory or inhibitory synapses in many brain regions, and thereby contributes to various aspects of brain function including learning and memory. |
2007-05-25 |
2023-08-12 |
mouse |
| Jeremy D Arenos, Richard E Musty, David J Bucc. Blockade of cannabinoid CB1 receptors alters contextual learning and memory. European journal of pharmacology. vol 539. issue 3. 2006-07-27. PMID:16716290. |
blockade of cannabinoid cb1 receptors alters contextual learning and memory. |
2006-07-27 |
2023-08-12 |
Not clear |
| Jeremy D Arenos, Richard E Musty, David J Bucc. Blockade of cannabinoid CB1 receptors alters contextual learning and memory. European journal of pharmacology. vol 539. issue 3. 2006-07-27. PMID:16716290. |
the endocannabinoid system appears to have an important role in specific aspects of learning and memory, yet there has been no systematic study of the role of cannabinoid receptors in contextual fear conditioning. |
2006-07-27 |
2023-08-12 |
Not clear |
| Steven R Laviolette, Anthony A Grac. Cannabinoids Potentiate Emotional Learning Plasticity in Neurons of the Medial Prefrontal Cortex through Basolateral Amygdala Inputs. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 24. 2006-07-11. PMID:16775133. |
we report that systemic activation or blockade of cannabinoid cb1 receptors modulates emotional associative learning and memory formation in a subpopulation of neurons in the mammalian medial prefrontal cortex (mpfc) that receives functional input from the basolateral amygdala (bla). |
2006-07-11 |
2023-08-12 |
rat |