| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O Ghirardi, S Milano, M T Ramacci, L Angelucc. Effect of acetyl-l-carnitine chronic treatment on discrimination models in aged rats. Physiology & behavior. vol 44. issue 6. 1989-07-12. PMID:3249750. |
because impaired learning and memory are related to alterations in hippocampal function, these data indicate that alc is capable of antagonizing the natural age-dependent deterioration process in the hippocampal structure. |
1989-07-12 |
2023-08-11 |
rat |
| S N Davies, R A Lester, K G Reymann, G L Collingridg. Temporally distinct pre- and post-synaptic mechanisms maintain long-term potentiation. Nature. vol 338. issue 6215. 1989-05-05. PMID:2564640. |
long-term potentiation (ltp) in the hippocampus is widely studied as the mechanisms involved in its induction and maintenance are believed to underlie fundamental properties of learning and memory in vertebrates. |
1989-05-05 |
2023-08-11 |
Not clear |
| N A Muma, P P Rowel. Effects of chronic choline and lecithin on mouse hippocampal dendritic spine density. Experimental aging research. vol 14. issue 2-3. 1989-05-04. PMID:3234454. |
the results indicate that dietary supplementation may have different effects in different brain areas and that the relative increase in learning and memory function in aged animals given a choline or lecithin enriched diet is not due to an increase in hippocampal dendritic spine density. |
1989-05-04 |
2023-08-11 |
mouse |
| N Popov, S Schulzeck, D Nüss, A U Vopel, C Jendrny, H Struy, H Matthie. Alterations in calmodulin content of rat brain areas after chronic application of haloperidol and amphetamine. Biomedica biochimica acta. vol 47. issue 4-5. 1989-04-25. PMID:3240294. |
the hippocampus, the region poor in dopamine while playing an essential role in learning and memory formation processes, revealed similar patterns after both modes of treatment. |
1989-04-25 |
2023-08-11 |
rat |
| P W Landfiel. Hippocampal neurobiological mechanisms of age-related memory dysfunction. Neurobiology of aging. vol 9. issue 5-6. 1989-02-16. PMID:3062468. |
studies are reviewed which indicate that hippocampal frequency potentiation (the growth of neural responses during repetitive synaptic stimulation) is impaired in aged rats, and that this impairment may be important in learning and memory deficits found in these aged animals. |
1989-02-16 |
2023-08-11 |
human |
| J T Greenamyre, W F Maragos, R L Albin, J B Penney, A B Youn. Glutamate transmission and toxicity in Alzheimer's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 12. issue 4. 1988-09-21. PMID:2900537. |
glutamate is the major excitatory transmitter of the cerebral cortex and hippocampus and it appears to have an important role in learning and memory. |
1988-09-21 |
2023-08-11 |
Not clear |
| L S Bikbulatova, N V Orlova, S B Deviato. [Participation of the genetic apparatus of the hippocampal and neocortical cells in the mechanisms of action of desglycine-arginine vasopressin on learning and memory processes in rats]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 37. issue 6. 1988-05-27. PMID:2452528. |
[participation of the genetic apparatus of the hippocampal and neocortical cells in the mechanisms of action of desglycine-arginine vasopressin on learning and memory processes in rats]. |
1988-05-27 |
2023-08-11 |
rat |
| A V Nowicky, T J Teyler, R M Vardari. The modulation of long-term potentiation by delta-9-tetrahydrocannabinol in the rat hippocampus, in vitro. Brain research bulletin. vol 19. issue 6. 1988-04-15. PMID:2830949. |
in context with previous reports of the disruptive action of marihuana intoxication on learning and memory, these results suggest that one possible action of thc may be in modulating hippocampal electrophysiology and its role in short-term memory processes. |
1988-04-15 |
2023-08-11 |
rat |
| K Pang, G M Ros. Differential effects of norepinephrine on hippocampal complex-spike and theta-neurons. Brain research. vol 425. issue 1. 1988-02-26. PMID:2892569. |
since the hippocampus receives a noradrenergic projection from the locus coeruleus, knowledge of norepinephrine's actions in the hippocampus may help determine its role in learning and memory. |
1988-02-26 |
2023-08-11 |
Not clear |
| M W Decke. The effects of aging on hippocampal and cortical projections of the forebrain cholinergic system. Brain research. vol 434. issue 4. 1988-02-17. PMID:3319050. |
it has been proposed that disruption of cholinergic input to the hippocampus and cortex contributes to the learning and memory deficits associated with aging. |
1988-02-17 |
2023-08-11 |
Not clear |
| M W Decke. The effects of aging on hippocampal and cortical projections of the forebrain cholinergic system. Brain research. vol 434. issue 4. 1988-02-17. PMID:3319050. |
thus, investigation of these changes in the dynamic properties of cholinergic input to the hippocampus and cortex during aging may provide clarification of the relationship between cholinergic dysfunction and age-related decline in learning and memory and may also provide a more reasonable rationale for treatment approaches. |
1988-02-17 |
2023-08-11 |
Not clear |
| S B Sparber, C A Cohen, R B Messin. Reversal of a trimethyltin-induced learning deficit by desglycinamide-8-arginine vasopressin. Life sciences. vol 42. issue 2. 1988-02-17. PMID:3336276. |
selectivity seems to depend upon the dose, but the hippocampus and related entorhinal cortical structures, of importance for learning and memory, are most often described as target sites. |
1988-02-17 |
2023-08-11 |
human |
| W D Blaker, S D Goodwi. Biochemical and behavioral effects of intrahippocampal AF64A in rats. Pharmacology, biochemistry, and behavior. vol 28. issue 2. 1988-01-13. PMID:3685051. |
we conclude that even relatively minor, localized, cholinergic deficits confined to the hippocampus can produce significant learning and memory impairments in situations where intermediate or long term memory formation is required. |
1988-01-13 |
2023-08-11 |
rat |
| P J Riekkinen, V Laulumaa, J Sirviö, H Soininen, E L Helkal. Recent progress in the research of Alzheimer's disease. Medical biology. vol 65. issue 2-3. 1987-11-19. PMID:3309490. |
the hippocampus and entorhinal cortex seem to play an important role in learning and memory. |
1987-11-19 |
2023-08-11 |
Not clear |
| R Pohorecki, E F Domin. Synaptic pharmacology of the hippocampus. Reviews in clinical & basic pharmacology. vol 6. issue 3. 1987-11-19. PMID:3310131. |
in view of the important role of the hippocampus in learning and memory and other brain functions, it is essential that the detailed synaptic mechanisms of the hippocampus be thoroughly understood. |
1987-11-19 |
2023-08-11 |
Not clear |
| O G Nilsson, M L Shapiro, F H Gage, D S Olton, A Björklun. Spatial learning and memory following fimbria-fornix transection and grafting of fetal septal neurons to the hippocampus. Experimental brain research. vol 67. issue 1. 1987-10-21. PMID:3622677. |
spatial learning and memory following fimbria-fornix transection and grafting of fetal septal neurons to the hippocampus. |
1987-10-21 |
2023-08-11 |
rat |
| T J Teyler, S B Fountai. Neuronal plasticity in the mammalian brain: relevance to behavioral learning and memory. Child development. vol 58. issue 3. 1987-08-28. PMID:3038482. |
several current theories of learning and memory with respect to hippocampal and other brain circuit involvement are considered. |
1987-08-28 |
2023-08-11 |
Not clear |
| R C Walovitch, D K Ingram, E L Spangler, E D Londo. Co-dergocrine, cerebral glucose utilization and maze performance in middle-aged rats. Pharmacology, biochemistry, and behavior. vol 26. issue 1. 1987-05-11. PMID:3562504. |
both doses stimulated lcgu in the locus ceruleus and median raphe nucleus and in subcortical structures associated with learning and memory (hippocampus and subiculum). |
1987-05-11 |
2023-08-11 |
rat |
| M Jones-Gotma. Right hippocampal excision impairs learning and recall of a list of abstract designs. Neuropsychologia. vol 24. issue 5. 1987-01-06. PMID:3785653. |
patients with a right temporal lobectomy that included a large hippocampal excision showed deficient learning and memory, and, on the serial-position analysis, they recalled essentially none of the first items of the list. |
1987-01-06 |
2023-08-11 |
human |
| C E Herron, R A Lester, E J Coan, G L Collingridg. Frequency-dependent involvement of NMDA receptors in the hippocampus: a novel synaptic mechanism. Nature. vol 322. issue 6076. 1986-09-17. PMID:2874493. |
nmda receptors have, however, been shown to be involved in long-term potentiation (ltp) in the hippocampus, a form of synaptic plasticity which may be involved in learning and memory. |
1986-09-17 |
2023-08-11 |
Not clear |