| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T L Petit, J C LeBoutillier, W J Brook. Altered sensitivity to NMDA following developmental lead exposure in rats. Physiology & behavior. vol 52. issue 4. 1992-11-23. PMID:1409940. |
the excitatory amino acid, nmda, is found in high concentrations in the hippocampus and has been implicated in learning and memory functions and seizure activity. |
1992-11-23 |
2023-08-11 |
rat |
| G L Collingridge, A D Randall, C H Davies, S Alfor. The synaptic activation of NMDA receptors and Ca2+ signalling in neurons. Ciba Foundation symposium. vol 164. 1992-11-19. PMID:1327677. |
long-term potentiation (ltp) in the hippocampus is a model system for understanding the synaptic basis of learning and memory. |
1992-11-19 |
2023-08-11 |
rat |
| T Falkenberg, A K Mohammed, B Henriksson, H Persson, B Winblad, N Lindefor. Increased expression of brain-derived neurotrophic factor mRNA in rat hippocampus is associated with improved spatial memory and enriched environment. Neuroscience letters. vol 138. issue 1. 1992-10-26. PMID:1407655. |
enriched environment has been shown to enhance learning and memory and to induce morphological changes in the hippocampus. |
1992-10-26 |
2023-08-11 |
rat |
| T Falkenberg, A K Mohammed, B Henriksson, H Persson, B Winblad, N Lindefor. Increased expression of brain-derived neurotrophic factor mRNA in rat hippocampus is associated with improved spatial memory and enriched environment. Neuroscience letters. vol 138. issue 1. 1992-10-26. PMID:1407655. |
this was not seen when rats subjected to impoverished housing were tested suggesting that environmental history of the animal is of importance to induce expression of brain-derived neurotrophic factor in the hippocampus that may promote neuronal changes related to learning and memory. |
1992-10-26 |
2023-08-11 |
rat |
| J A Gorter, J P de Brui. Chronic neonatal MK-801 treatment results in an impairment of spatial learning in the adult rat. Brain research. vol 580. issue 1-2. 1992-09-23. PMID:1504791. |
since many studies have shown that nmda receptors play a crucial role in learning and memory, and since one of the hippocampal functions is spatial learning, we have examined whether this changed response of hippocampal neurons is associated with changes in its normal function. |
1992-09-23 |
2023-08-11 |
rat |
| R B Messing, V Devauges, S J Sar. Limbic forebrain toxin trimethyltin reduces behavioral suppression by clonidine. Pharmacology, biochemistry, and behavior. vol 42. issue 2. 1992-08-17. PMID:1631185. |
trimethyltin (tmt) at moderate doses selectively damages hippocampus and related olfactory cortex and produces learning and memory impairments. |
1992-08-17 |
2023-08-11 |
human |
| H Maegawa, N Katsube, T Okegawa, H Aishita, A Kawasak. Arginine-vasopressin fragment 4-9 stimulates the acetylcholine release in hippocampus of freely-moving rats. Life sciences. vol 51. issue 4. 1992-08-07. PMID:1625520. |
we examined the effects of arginine-vasopressin (avp) c-terminal fragment 4-9, which facilitates learning and memory, on the extracellular acetylcholine (ach) release in hippocampus of freely-moving rats using the microdialysis technique. |
1992-08-07 |
2023-08-11 |
rat |
| D F Emerich, B A Black, J P Kesslak, C W Cotman, T J Wals. Transplantation of fetal cholinergic neurons into the hippocampus attenuates the cognitive and neurochemical deficits induced by AF64A. Brain research bulletin. vol 28. issue 2. 1992-07-07. PMID:1596741. |
bilateral injections of af64a (3 nmol) into the lateral ventricles produced significant learning and memory impairments together with decreases in hippocampal high-affinity choline uptake (hachu). |
1992-07-07 |
2023-08-11 |
rat |
| S M Dudek, M F Bea. Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 10. 1992-06-16. PMID:1350090. |
we propose that this mechanism is important for the modifications of hippocampal response properties that underlie some forms of learning and memory. |
1992-06-16 |
2023-08-11 |
rat |
| A C Scalle. Neurotoxicology of cannabis and THC: a review of chronic exposure studies in animals. Pharmacology, biochemistry, and behavior. vol 40. issue 3. 1992-05-14. PMID:1666926. |
several laboratories have reported that chronic exposure to delta-9-tetrahydrocannabinol (thc) or marijuana extracts persistently altered the structure and function of the rat hippocampus, a paleocortical brain region involved with learning and memory processes in both rats and humans. |
1992-05-14 |
2023-08-11 |
human |
| E Klann, S J Chen, J D Sweat. Increased phosphorylation of a 17-kDa protein kinase C substrate (P17) in long-term potentiation. Journal of neurochemistry. vol 58. issue 4. 1992-04-17. PMID:1548487. |
hippocampal long-term potentiation (ltp) is a persistent increase in the efficacy of synaptic transmission, which is widely thought to be a cellular mechanism that could contribute to learning and memory. |
1992-04-17 |
2023-08-11 |
rat |
| R Paylor, J W Rudy, J M Wehne. Acute phorbol ester treatment improves spatial learning performance in rats. Behavioural brain research. vol 45. issue 2. 1992-03-27. PMID:1789927. |
recent findings have lead researchers to speculate that hippocampal protein kinase c (pkc) in rodents is involved in spatial learning and memory. |
1992-03-27 |
2023-08-11 |
human |
| A C Sharma, S K Kulkarni, U Naya. Effect of NMDA-receptor ligands on neocortical and hippocampal EEG activity of rat brain. Indian journal of experimental biology. vol 29. issue 8. 1992-02-26. PMID:1837539. |
neocortex and hippocampus play important role in motor activity, neuronal plasticity and learning and memory mechanisms. |
1992-02-26 |
2023-08-11 |
rat |
| M M'Harzi, L E Jarrard, F Willig, A Palacios, J Delacou. Selective fimbria and thalamic lesions differentially impair forms of working memory in rats. Behavioral and neural biology. vol 56. issue 3. 1992-02-06. PMID:1759943. |
these data may contribute two main points to animal models of hippocampal and thalamic amnesia: (1) different forms of working memory in rats might have different neural bases and (2) the fr may be involved in learning and memory processes. |
1992-02-06 |
2023-08-11 |
rat |
| M Jones-Gotma. Localization of lesions by neuropsychological testing. Epilepsia. vol 32 Suppl 5. 1992-01-10. PMID:1743170. |
different aspects of learning and memory are tested, and measures sensitive to hippocampal function should be included. |
1992-01-10 |
2023-08-11 |
Not clear |
| E Gould, C S Woolley, B S McEwe. The hippocampal formation: morphological changes induced by thyroid, gonadal and adrenal hormones. Psychoneuroendocrinology. vol 16. issue 1-3. 1992-01-09. PMID:1961845. |
manipulations of thyroid, gonadal and adrenal hormones have been shown to influence hippocampal physiology as well as learning and memory. |
1992-01-09 |
2023-08-11 |
rat |
| W Fischer, O G Nilsson, A Björklun. In vivo acetylcholine release as measured by microdialysis is unaltered in the hippocampus of cognitively impaired aged rats with degenerative changes in the basal forebrain. Brain research. vol 556. issue 1. 1991-12-03. PMID:1933353. |
the results indicate that hippocampal ach release is maintained in aged rats that exhibit severe spatial learning and memory impairments and that the septo-hippocampal cholinergic system retains its capacity to increase its ach release in response to both k(+)-induced depolarization and behavioral activation in the aged rat. |
1991-12-03 |
2023-08-11 |
rat |
| R L Port, J A Sample, K S Seybol. Partial hippocampal pyramidal cell loss alters behavior in rats: implications for an animal model of schizophrenia. Brain research bulletin. vol 26. issue 6. 1991-12-02. PMID:1933418. |
while hippocampal dysfunction is associated with impaired learning and memory, schizophrenics have been observed to acquire simple conditioned reflexes at rates superior to controls. |
1991-12-02 |
2023-08-11 |
rat |
| R F Thompso. Are memory traces localized or distributed? Neuropsychologia. vol 29. issue 6. 1991-11-29. PMID:1944862. |
although it plays a key role in certain aspects of classical conditioning, the hippocampus is not necessary for learning and memory of the basic conditioned responses. |
1991-11-29 |
2023-08-11 |
Not clear |
| T J O'Dell, E R Kandel, S G Gran. Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. Nature. vol 353. issue 6344. 1991-11-07. PMID:1656271. |
because of the high amount of protein tyrosine kinases in hippocampus and cerebellum, two regions implicated in learning and memory, we examined the possible additional requirement of tyrosine kinase activity in ltp. |
1991-11-07 |
2023-08-11 |
Not clear |