| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J F Disterhoft, M Kronforst-Collins, M M Oh, J M Power, A R Preston, C Weis. Cholinergic facilitation of trace eyeblink conditioning in aging rabbits. Life sciences. vol 64. issue 6-7. 1999-03-25. PMID:10069521. |
the hippocampus is importantly involved in learning and memory, and is severely impacted by aging. |
1999-03-25 |
2023-08-12 |
Not clear |
| J L Guillou, J Micheau, R Jaffar. The opposite effects of cysteamine on the acquisition of two different tasks in mice are associated with bidirectional testing-induced changes in hippocampal adenylyl cyclase activity. Behavioral neuroscience. vol 112. issue 4. 1999-03-09. PMID:9733196. |
the hypothesis of a role for hippocampal somatostatin (ss-14) in learning and memory processes was further examined by means of 2 selective learning tasks that were previously shown to be either impaired (spatial discrimination task) or facilitated (barpressing task) by hippocampal lesions. |
1999-03-09 |
2023-08-12 |
mouse |
| J T Isaac, A Lüthi, M J Palmer, W W Anderson, T A Benke, G L Collingridg. An investigation of the expression mechanism of LTP of AMPA receptor-mediated synaptic transmission at hippocampal CA1 synapses using failures analysis and dendritic recordings. Neuropharmacology. vol 37. issue 10-11. 1999-03-04. PMID:9849675. |
there is considerable controversy surrounding the mechanism of expression of long-term potentiation of ampa receptor-mediated synaptic transmission in the ca1 region of the hippocampus, a process thought to be important for learning and memory in the mammalian cns. |
1999-03-04 |
2023-08-12 |
Not clear |
| H Zhang, X Zhao, L Son. [Effects of lead on the release of glutamate neurotransmitter in rat hippocampal slices]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. vol 31. issue 5. 1999-02-26. PMID:9812607. |
effects of lead on the release of glutamate neurotransmitter were observed in rat hippocampal slices in vitro to study its neurobiological mechanism of lead-induced impairment in learning and memory function. |
1999-02-26 |
2023-08-12 |
rat |
| M Y Chiang, D Misner, G Kempermann, T Schikorski, V Giguère, H M Sucov, F H Gage, C F Stevens, R M Evan. An essential role for retinoid receptors RARbeta and RXRgamma in long-term potentiation and depression. Neuron. vol 21. issue 6. 1999-01-26. PMID:9883728. |
hippocampal long-term potentiation (ltp) and long-term depression (ltd) are the most widely studied forms of synaptic plasticity thought to underlie spatial learning and memory. |
1999-01-26 |
2023-08-12 |
mouse |
| H Zhang, S Li, X Zha. [Activation of glutamate uptake in rat hippocampal synaptosome by lead]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. vol 31. issue 1. 1999-01-07. PMID:9812630. |
in order to investigate the mechanism of effects of lead on learning and memory, an experiment of glutamate uptake in the hippocampal synaptosome of rats was carried out. |
1999-01-07 |
2023-08-12 |
rat |
| V Lessman. Neurotrophin-dependent modulation of glutamatergic synaptic transmission in the mammalian CNS. General pharmacology. vol 31. issue 5. 1998-12-23. PMID:9809461. |
in addition, long-term potentiation (a potential cellular correlate for learning and memory formation in mammals) in the rodent hippocampus depends on endogenous supply of neurons with bdnf. |
1998-12-23 |
2023-08-12 |
Not clear |
| G V Wallenstein, H Eichenbaum, M E Hasselm. The hippocampus as an associator of discontiguous events. Trends in neurosciences. vol 21. issue 8. 1998-11-16. PMID:9720595. |
the hippocampus has long been thought to be an important cortical region for associative learning and memory. |
1998-11-16 |
2023-08-12 |
Not clear |
| M J Marino, S T Rouse, A I Levey, L T Potter, P J Con. Activation of the genetically defined m1 muscarinic receptor potentiates N-methyl-D-aspartate (NMDA) receptor currents in hippocampal pyramidal cells. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 19. 1998-10-26. PMID:9736760. |
evidence suggests that cholinergic input to the hippocampus plays an important role in learning and memory and that degeneration of cholinergic terminals in the hippocampus may contribute to the memory loss associated with alzheimer's disease. |
1998-10-26 |
2023-08-12 |
Not clear |
| G Leanza, A Martìnez-Serrano, A Björklun. Amelioration of spatial navigation and short-term memory deficits by grafts of foetal basal forebrain tissue placed into the hippocampus and cortex of rats with selective cholinergic lesions. The European journal of neuroscience. vol 10. issue 7. 1998-10-22. PMID:9749764. |
impairments in learning and memory, induced by surgical or excitotoxic lesions of the septo-hippocampal or basalo-cortical pathways, can be ameliorated by grafts of cholinergic-rich foetal basal forebrain tissue into the hippocampus and/or neocortex. |
1998-10-22 |
2023-08-12 |
rat |
| C I Cha, M R Uhm, D H Shin, Y H Chung, S H Bai. Immunocytochemical study on the distribution of NOS-immunoreactive neurons in the cerebral cortex of aged rats. Neuroreport. vol 9. issue 10. 1998-10-14. PMID:9694194. |
nitric oxide (no) involvement has been demonstrated in mechanisms of synaptic plasticity, particularly in hippocampal long-term potentiation, a mechanism that underlies certain forms of learning and memory. |
1998-10-14 |
2023-08-12 |
rat |
| K A Radcliffe, J A Dan. Nicotinic stimulation produces multiple forms of increased glutamatergic synaptic transmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 18. 1998-10-02. PMID:9736631. |
the hippocampus is a center for learning and memory that receives abundant cholinergic innervation and has a high density of nicotinic acetylcholine receptors (nachrs) (wada et al., 1989; woolf, 1991). |
1998-10-02 |
2023-08-12 |
Not clear |
| M J Thomas, A M Watabe, T D Moody, M Makhinson, T J O'Del. Postsynaptic complex spike bursting enables the induction of LTP by theta frequency synaptic stimulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 18. 1998-10-02. PMID:9736635. |
long-term potentiation (ltp), a persistent enhancement of synaptic transmission that may be involved in some forms of learning and memory, is induced at excitatory synapses in the ca1 region of the hippocampus by coincident presynaptic and postsynaptic activity. |
1998-10-02 |
2023-08-12 |
Not clear |
| K Onodera, J Kojima, M Wach. Ipidacrine (NIK-247), a novel antidementia, rapidly enters the brain and improves scopolamine-induced amnesia in rats during the Morris water maze task. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 18. issue 2. 1998-09-18. PMID:9656230. |
moreover, higher drug levels were observed mainly in the cortex and hippocampus, which both play important roles in learning and memory. |
1998-09-18 |
2023-08-12 |
rat |
| G Winocur, S Gagno. Glucose treatment attenuates spatial learning and memory deficits of aged rats on tests of hippocampal function. Neurobiology of aging. vol 19. issue 3. 1998-09-16. PMID:9661998. |
glucose treatment attenuates spatial learning and memory deficits of aged rats on tests of hippocampal function. |
1998-09-16 |
2023-08-12 |
rat |
| G Winocur, S Gagno. Glucose treatment attenuates spatial learning and memory deficits of aged rats on tests of hippocampal function. Neurobiology of aging. vol 19. issue 3. 1998-09-16. PMID:9661998. |
groups of old and young rats were administered three tests of spatial learning and memory that are known to be sensitive to hippocampal dysfunction: the radial arm maze (ram), spatial non-matching-to-sample (snmts), and a spatial vs. local cue-preference task. |
1998-09-16 |
2023-08-12 |
rat |
| M A Kronforst-Collins, J F Disterhof. Lesions of the caudal area of rabbit medial prefrontal cortex impair trace eyeblink conditioning. Neurobiology of learning and memory. vol 69. issue 2. 1998-09-14. PMID:9619994. |
the subprimate prefrontal cortex is intimately interconnected with the hippocampus, which is also recognized for its role in learning and memory. |
1998-09-14 |
2023-08-12 |
human |
| S Strack, R J Colbra. Autophosphorylation-dependent targeting of calcium/ calmodulin-dependent protein kinase II by the NR2B subunit of the N-methyl- D-aspartate receptor. The Journal of biological chemistry. vol 273. issue 33. 1998-09-14. PMID:9694809. |
activation and thr286 autophosphorylation of calcium/calmodulindependent kinase ii (camkii) following ca2+ influx via n-methyl-d-aspartate (nmda)-type glutamate receptors is essential for hippocampal long term potentiation (ltp), a widely investigated cellular model of learning and memory. |
1998-09-14 |
2023-08-12 |
Not clear |
| T Manabe, Y Noda, T Mamiya, H Katagiri, T Houtani, M Nishi, T Noda, T Takahashi, T Sugimoto, T Nabeshima, H Takeshim. Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors. Nature. vol 394. issue 6693. 1998-08-24. PMID:9707118. |
histological analysis revealed the expression of both the nociceptin precursor and the nociceptin receptor in the hippocampus, thought to take part in aspects of learning and memory. |
1998-08-24 |
2023-08-12 |
mouse |
| K R Magnusso. The aging of the NMDA receptor complex. Frontiers in bioscience : a journal and virtual library. vol 3. 1998-08-13. PMID:9576682. |
n-methyl-d-aspartate (nmda) receptors are present at high density in the cerebral cortex and hippocampus and play an important role in learning and memory. |
1998-08-13 |
2023-08-12 |
Not clear |