| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong Xu, Yang Zhou, Yongxia Liu, Jian Ping, Qiyang Shou, Fangming Chen, Ru Ru. Metformin improves hepatic IRS2/PI3K/Akt signaling in insulin-resistant rats of NASH and cirrhosis. The Journal of endocrinology. vol 229. issue 2. 2017-06-08. PMID:26941037. |
limited studies have evaluated the effect of metformin on hepatic insulin signaling pathway in vivo in this study, an insulin-resistant rat model of nonalcoholic steatohepatitis and cirrhosis was developed by high-fat and high-sucrose diet feeding in combination with subcutaneous injection of carbon tetrachloride. |
2017-06-08 |
2023-08-13 |
rat |
| Jean-Pascal De Band. Leucine and Mammalian Target of Rapamycin-Dependent Activation of Muscle Protein Synthesis in Aging. The Journal of nutrition. vol 146. issue 12. 2017-06-06. PMID:27934653. |
whatever its origin, this anabolic resistance to feeding can be mitigated by quantitative and qualitative manipulation of protein supply, such as leucine supplementation; however, there remains the question of possible adverse effects of long-term, high-dose leucine supplementation in terms of insulin resistance and tumorigenesis. |
2017-06-06 |
2023-08-13 |
Not clear |
| Michael J Williams, Lyle Wiemerslage, Priya Gohel, Sania Kheder, Lakshmi V Kothegala, Helgi B Schiöt. Dibutyl Phthalate Exposure Disrupts Evolutionarily Conserved Insulin and Glucagon-Like Signaling in Drosophila Males. Endocrinology. vol 157. issue 6. 2017-06-05. PMID:27100621. |
furthermore, although acute dbp exposure in adult flies is able to affect insulin levels, only chronic feeding influences akh expression. |
2017-06-05 |
2023-08-13 |
drosophila_melanogaster |
| Xia Lei, Susana Rodriguez, Pia S Petersen, Marcus M Seldin, Caitlyn E Bowman, Michael J Wolfgang, G William Won. Loss of CTRP5 improves insulin action and hepatic steatosis. American journal of physiology. Endocrinology and metabolism. vol 310. issue 11. 2017-06-05. PMID:27143553. |
loss of ctrp5 also improved the capacity of chow-fed aged mice to respond to subsequent high-fat feeding, as evidenced by decreased insulin resistance. |
2017-06-05 |
2023-08-13 |
mouse |
| Marc J Tol, Roelof Ottenhoff, Marco van Eijk, Noam Zelcer, Jan Aten, Sander M Houten, Dirk Geerts, Cindy van Roomen, Marlou C Bierlaagh, Saskia Scheij, Marten A Hoeksema, Johannes M Aerts, Jonathan S Bogan, Gerald W Dorn, Carmen A Argmann, Arthur J Verhoeve. A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity. Diabetes. vol 65. issue 9. 2017-06-05. PMID:27325287. |
finally, bnip3(-/-) mice trade reduced adiposity for increased liver steatosis and develop aggravated systemic insulin resistance in response to high-fat feeding. |
2017-06-05 |
2023-08-13 |
mouse |
| Chloé Chrétien, Claire Fenech, Fabienne Liénard, Sylvie Grall, Charlène Chevalier, Sylvie Chaudy, Xavier Brenachot, Raymond Berges, Katie Louche, Romana Stark, Emmanuelle Nédélec, Amélie Laderrière, Zane B Andrews, Alexandre Benani, Veit Flockerzi, Jean Gascuel, Jana Hartmann, Cédric Moro, Lutz Birnbaumer, Corinne Leloup, Luc Pénicaud, Xavier Fioramont. Transient Receptor Potential Canonical 3 (TRPC3) Channels Are Required for Hypothalamic Glucose Detection and Energy Homeostasis. Diabetes. vol 66. issue 2. 2017-06-05. PMID:27899482. |
hypothalamic glucose detection was studied in vivo by measuring food intake and insulin secretion in response to increased brain glucose level. |
2017-06-05 |
2023-08-13 |
mouse |
| Chloé Chrétien, Claire Fenech, Fabienne Liénard, Sylvie Grall, Charlène Chevalier, Sylvie Chaudy, Xavier Brenachot, Raymond Berges, Katie Louche, Romana Stark, Emmanuelle Nédélec, Amélie Laderrière, Zane B Andrews, Alexandre Benani, Veit Flockerzi, Jean Gascuel, Jana Hartmann, Cédric Moro, Lutz Birnbaumer, Corinne Leloup, Luc Pénicaud, Xavier Fioramont. Transient Receptor Potential Canonical 3 (TRPC3) Channels Are Required for Hypothalamic Glucose Detection and Energy Homeostasis. Diabetes. vol 66. issue 2. 2017-06-05. PMID:27899482. |
together, the results demonstrate that trpc3 channels are required for the response to glucose of mbh ge neurons and the central effect of glucose on insulin secretion and food intake. |
2017-06-05 |
2023-08-13 |
mouse |
| E Mahjoubi, H Amanlou, M Hossein Yazdi, N Aghaziarati, G R Noori, C I Vahl, B J Bradford, L H Baumgar. A supplement containing multiple types of gluconeogenic substrates alters intake but not productivity of heat-stressed Afshari lambs. Journal of animal science. vol 94. issue 6. 2017-06-02. PMID:27285926. |
in contrast to the glucose responses, circulating insulin was influenced only by thermal treatment; hs lambs had increased insulin concentration ( < 0.01) before feeding and decreased concentration ( < 0.05) after feeding compared with pftn lambs. |
2017-06-02 |
2023-08-13 |
Not clear |
| Bart B L Groen, Astrid M H Horstman, Henrike M Hamer, Michiel de Haan, Janneau van Kranenburg, Jörgen Bierau, Martijn Poeze, Will K W H Wodzig, Blake B Rasmussen, Luc J C van Loo. Increasing Insulin Availability Does Not Augment Postprandial Muscle Protein Synthesis Rates in Healthy Young and Older Men. The Journal of clinical endocrinology and metabolism. vol 101. issue 11. 2017-06-02. PMID:27745529. |
it has been suggested that the postprandial increase in circulating insulin modulates the muscle protein synthetic response to feeding. |
2017-06-02 |
2023-08-13 |
Not clear |
| Thomas Scherer, Claudia Lindtner, James O'Hare, Martina Hackl, Elizabeth Zielinski, Angelika Freudenthaler, Sabina Baumgartner-Parzer, Klaus Tödter, Joerg Heeren, Martin Krššák, Ludger Scheja, Clemens Fürnsinn, Christoph Buettne. Insulin Regulates Hepatic Triglyceride Secretion and Lipid Content via Signaling in the Brain. Diabetes. vol 65. issue 6. 2017-06-01. PMID:26861781. |
chronic infusion of insulin into the cns via osmotic minipumps reduced the hepatic lipid content as assessed by noninvasive (1)h-mrs and lipid profiling independent of changes in hepatic de novo lipogenesis and food intake. |
2017-06-01 |
2023-08-13 |
mouse |
| Kyota Aoyagi, Mica Ohara-Imaizumi, Makoto Itakura, Seiji Torii, Yoshihiro Akimoto, Chiyono Nishiwaki, Yoko Nakamichi, Takuma Kishimoto, Hayato Kawakami, Akihiro Harada, Masami Takahashi, Shinya Nagamats. VAMP7 Regulates Autophagy to Maintain Mitochondrial Homeostasis and to Control Insulin Secretion in Pancreatic β-Cells. Diabetes. vol 65. issue 6. 2017-06-01. PMID:26953164. |
feeding a high-fat diet to vamp7(flox/y);cre mice exacerbated mitochondrial dysfunction, further decreased atp production and insulin secretion, and consequently induced glucose intolerance. |
2017-06-01 |
2023-08-13 |
mouse |
| Yang Sun, Yili Yang, Zhen Qin, Jinya Cai, Xiuming Guo, Yun Tang, Jingjing Wan, Ding-Feng Su, Xia Li. The Acute-Phase Protein Orosomucoid Regulates Food Intake and Energy Homeostasis via Leptin Receptor Signaling Pathway. Diabetes. vol 65. issue 6. 2017-06-01. PMID:27207522. |
intravenous or intraperitoneal administration of exogenous orm decreased food intake in c57bl/6, hfd, and leptin-deficient ob/ob mice, which was absent in db/db mice and was significantly reduced in mice with arcuate nucleus (arc) lepr knockdown, whereas enforced expression of orm1 in arc significantly decreased food intake, body weight, and serum insulin level. |
2017-06-01 |
2023-08-13 |
mouse |
| Katsutaka Oishi, Yuki Yasumoto, Sayaka Higo-Yamamoto, Saori Yamamoto, Naoki Ohkur. Feeding cycle-dependent circulating insulin fluctuation is not a dominant Zeitgeber for mouse peripheral clocks except in the liver: Differences between endogenous and exogenous insulin effects. Biochemical and biophysical research communications. vol 483. issue 1. 2017-06-01. PMID:28042033. |
feeding cycle-dependent circulating insulin fluctuation is not a dominant zeitgeber for mouse peripheral clocks except in the liver: differences between endogenous and exogenous insulin effects. |
2017-06-01 |
2023-08-13 |
mouse |
| Katsutaka Oishi, Yuki Yasumoto, Sayaka Higo-Yamamoto, Saori Yamamoto, Naoki Ohkur. Feeding cycle-dependent circulating insulin fluctuation is not a dominant Zeitgeber for mouse peripheral clocks except in the liver: Differences between endogenous and exogenous insulin effects. Biochemical and biophysical research communications. vol 483. issue 1. 2017-06-01. PMID:28042033. |
we therefore investigated the temporal expression profiles of clock genes in the peripheral tissues of mice fed for 8 h during either the daytime (df) or the nighttime (nf) for one week to determine the involvement of feeding cycle-dependent endogenous insulin rhythms in the circadian regulation of peripheral clocks. |
2017-06-01 |
2023-08-13 |
mouse |
| Katsutaka Oishi, Yuki Yasumoto, Sayaka Higo-Yamamoto, Saori Yamamoto, Naoki Ohkur. Feeding cycle-dependent circulating insulin fluctuation is not a dominant Zeitgeber for mouse peripheral clocks except in the liver: Differences between endogenous and exogenous insulin effects. Biochemical and biophysical research communications. vol 483. issue 1. 2017-06-01. PMID:28042033. |
these findings suggest that feeding cycles and feeding cycle-dependent endogenous insulin fluctuations are not dominant entrainment signals for peripheral clocks other than the liver, although exogenous insulin might reset peripheral oscillators in mammals. |
2017-06-01 |
2023-08-13 |
mouse |
| Hao Yang, Jiang W Wu, Shu P Wang, Ilenia Severi, Loris Sartini, Norma Frizzell, Saverio Cinti, Gongshe Yang, Grant A Mitchel. Adipose-Specific Deficiency of Fumarate Hydratase in Mice Protects Against Obesity, Hepatic Steatosis, and Insulin Resistance. Diabetes. vol 65. issue 11. 2017-05-31. PMID:27554470. |
afhko mice are strongly protected against obesity, insulin resistance, and fatty liver despite aging and high-fat feeding. |
2017-05-31 |
2023-08-13 |
mouse |
| T Y Chen, P Stott, S O'Leary, R Z Athorn, E G Bouwman, P Langendij. Effects of pre-weaning dietary substitutions on plasma insulin and glucose profiles in primiparous sows. Journal of animal physiology and animal nutrition. vol 97. issue 5. 2017-05-25. PMID:22747788. |
at 3 days before weaning, serial blood samples were collected for a total of 228 min around feeding to establish pre- and postprandial plasma glucose and insulin concentrations. |
2017-05-25 |
2023-08-12 |
Not clear |
| Vanessa Abella, Morena Scotece, Javier Conde, Jesús Pino, Miguel Angel Gonzalez-Gay, Juan J Gómez-Reino, Antonio Mera, Francisca Lago, Rodolfo Gómez, Oreste Gualill. Leptin in the interplay of inflammation, metabolism and immune system disorders. Nature reviews. Rheumatology. vol 13. issue 2. 2017-05-25. PMID:28053336. |
once secreted into the circulation, leptin reaches the central and peripheral nervous systems and acts by binding and activating the long form of leptin receptor (lepr), regulating appetite and food intake, bone mass, basal metabolism, reproductive function and insulin secretion, among other processes. |
2017-05-25 |
2023-08-13 |
Not clear |
| Hiroshi Tsuneki, Kanta Kon, Hisakatsu Ito, Mitsuaki Yamazaki, Satoyuki Takahara, Naoki Toyooka, Yoko Ishii, Masakiyo Sasahara, Tsutomu Wada, Masashi Yanagisawa, Takeshi Sakurai, Toshiyasu Sasaok. Timed Inhibition of Orexin System by Suvorexant Improved Sleep and Glucose Metabolism in Type 2 Diabetic db/db Mice. Endocrinology. vol 157. issue 11. 2017-05-19. PMID:27631554. |
the daily resting-phase administration of suvorexant for 2-4 weeks improved impaired glucose tolerance in db/db mice without affecting body weight gain, food intake, systemic insulin sensitivity, or serum insulin, and glucagon levels. |
2017-05-19 |
2023-08-13 |
mouse |
| J A R MacPherson, H Berends, L N Leal, J P Cant, J Martín-Tereso, M A Steel. Effect of plane of milk replacer intake and age on glucose and insulin kinetics and abomasal emptying in female Holstein Friesian dairy calves fed twice daily. Journal of dairy science. vol 99. issue 10. 2017-05-17. PMID:27522426. |
the findings from this study suggest that feeding dairy calves an elevated plane of nutrition in 2 meals of milk replacer per day does not decrease insulin sensitivity. |
2017-05-17 |
2023-08-13 |
Not clear |