| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sandrine Schuhler, Francis J P Eblin. Role of melanocortin in the long-term regulation of energy balance: lessons from a seasonal model. Peptides. vol 27. issue 2. 2006-05-25. PMID:16269204. |
icv administration of a mc3/4-r agonist (mtii) potently suppresses food intake in hamsters in both the obese and lean state, indicating the potential for melanocortin systems to regulate energy metabolism in the hypothalamus of the siberian hamster. |
2006-05-25 |
2023-08-12 |
Not clear |
| Koji Toshinai, Hideki Yamaguchi, Yuxiang Sun, Roy G Smith, Akihiro Yamanaka, Takeshi Sakurai, Yukari Date, Muhtashan S Mondal, Takuya Shimbara, Takashi Kawagoe, Noboru Murakami, Mikiya Miyazato, Kenji Kangawa, Masamitsu Nakazat. Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor. Endocrinology. vol 147. issue 5. 2006-05-23. PMID:16484324. |
ghrelin enhances feeding via the neuronal pathways of neuropeptide y and orexin, which act as orexigenic peptides in the hypothalamus. |
2006-05-23 |
2023-08-12 |
mouse |
| Guey-Mei Jow, Tsung-Tsair Yang, Chun-Lan Che. Leptin and cholesterol levels are low in major depressive disorder, but high in schizophrenia. Journal of affective disorders. vol 90. issue 1. 2006-05-09. PMID:16324751. |
leptin is an adipocyte hormone, as the product of the ob gene, regulating food intake and energy balance providing the hypothalamus with information on the amount of body fat. |
2006-05-09 |
2023-08-12 |
human |
| Bulent O Yildiz, Ibrahim C Haznedarogl. Rethinking leptin and insulin action: therapeutic opportunities for diabetes. The international journal of biochemistry & cell biology. vol 38. issue 5-6. 2006-05-08. PMID:16236542. |
leptin is an adipocyte-derived hormone that primarily acts in the hypothalamus and plays a key role in the regulation of food intake, body weight, energy expenditure and neuroendocrine function. |
2006-05-08 |
2023-08-12 |
Not clear |
| J T Smith, B V Acohido, D K Clifton, R A Steine. KiSS-1 neurones are direct targets for leptin in the ob/ob mouse. Journal of neuroendocrinology. vol 18. issue 4. 2006-05-04. PMID:16503925. |
leptin is an adipocyte-derived hormone that acts on the hypothalamus to influence feeding, metabolism and reproduction, but the cellular and molecular targets for the action of leptin in the brain have yet to be fully elucidated. |
2006-05-04 |
2023-08-12 |
mouse |
| Akihiko Wada, Hiroki Yokoo, Toshihiko Yanagita, Hideyuki Kobayash. New twist on neuronal insulin receptor signaling in health, disease, and therapeutics. Journal of pharmacological sciences. vol 99. issue 2. 2006-05-03. PMID:16210778. |
in the hypothalamus, insulin regulates food intake, body weight, peripheral fat deposition, hepatic gluconeogenesis, reproductive endocrine axis, and compensatory secretion of counter-regulatory hormones to hypoglycemia. |
2006-05-03 |
2023-08-12 |
Not clear |
| M D Lane, Z Hu, S-H Cha, Y Dai, M Wolfgang, A Sidhay. Role of malonyl-CoA in the hypothalamic control of food intake and energy expenditure. Biochemical Society transactions. vol 33. issue Pt 5. 2006-05-02. PMID:16246046. |
changes in the level of malonyl-coa in the hypothalamus alter the expression/secretion of key hypothalamic orexigenic and anorexigenic neuropeptides that regulate the feeding behaviour and energy expenditure. |
2006-05-02 |
2023-08-12 |
mouse |
| M D Lane, Z Hu, S-H Cha, Y Dai, M Wolfgang, A Sidhay. Role of malonyl-CoA in the hypothalamic control of food intake and energy expenditure. Biochemical Society transactions. vol 33. issue Pt 5. 2006-05-02. PMID:16246046. |
thus malonyl-coa appears to link the energy-responsive fatty acid synthesis in the hypothalamus to feeding behaviour and peripheral energy expenditure. |
2006-05-02 |
2023-08-12 |
mouse |
| Bernard Beck, Rouba Kozak, Kim M Moar, Julian G Merce. Hypothalamic orexigenic peptides are overexpressed in young Long-Evans rats after early life exposure to fat-rich diets. Biochemical and biophysical research communications. vol 342. issue 2. 2006-04-28. PMID:16487482. |
to establish the influence of the macronutrient type on feeding regulatory mechanisms and more particularly on stimulatory pathways (galanin and orexins), we fed female rats on either a high-carbohydrate (hc), a high-fat (hf), or a well-balanced control diet during gestation and lactation, and measured peptide expression in the hypothalamus and important hormones (leptin, insulin) in their pups at weaning. |
2006-04-28 |
2023-08-12 |
rat |
| Seung Hun Cha, Zhiyuan Hu, Shigeru Chohnan, M Daniel Lan. Inhibition of hypothalamic fatty acid synthase triggers rapid activation of fatty acid oxidation in skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 41. 2006-04-20. PMID:16203972. |
the central administration of c75, a potent inhibitor of the fatty acid synthase (fas), increases malonyl-coa concentration in the hypothalamus and suppresses food intake while activating fatty acid oxidation in skeletal muscle. |
2006-04-20 |
2023-08-12 |
Not clear |
| Ratnakar Mukherjee, Daniel Villarreal, Garry P Reams, Ronald H Freeman, Inna Tchoukina, Robert M Spea. Leptin as a common link to obesity and hypertension. Drugs of today (Barcelona, Spain : 1998). vol 41. issue 10. 2006-04-10. PMID:16389411. |
one of the major functions of this hormone is the control of energy balance by binding to receptors in the hypothalamus, leading to reduction in food intake, elevation in temperature and energy expenditure. |
2006-04-10 |
2023-08-12 |
Not clear |
| Uberto Pagotto, Giovanni Marsicano, Daniela Cota, Beat Lutz, Renato Pasqual. The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Endocrine reviews. vol 27. issue 1. 2006-03-16. PMID:16306385. |
in the hypothalamus, cb1 receptor and endocannabinoids are integrated components of the networks controlling appetite and food intake. |
2006-03-16 |
2023-08-12 |
Not clear |
| Monika Proszkowiec-Weglarz, Mark P Richards, Ramesh Ramachandran, John P McMurtr. Characterization of the AMP-activated protein kinase pathway in chickens. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. vol 143. issue 1. 2006-03-07. PMID:16343965. |
immunocytochemical analysis of the chicken hypothalamus showed that activated ampk was present in hypothalamic nuclei involved in regulation of food intake and energy balance. |
2006-03-07 |
2023-08-12 |
chicken |
| Natalija Stasiūniene, Antanas Praskeviciu. [Peptides regulating food intake and body weight]. Medicina (Kaunas, Lithuania). vol 41. issue 12. 2006-03-02. PMID:16401955. |
regulation of food intake and body weight depends on direct and feedback signals from adipose tissue, alimentary canal and pancreas to the hypothalamus nuclei, where hunger and satiety centers are. |
2006-03-02 |
2023-08-12 |
Not clear |
| A C Heijboer, P J Voshol, E Donga, C G van Eden, L M Havekes, J A Romijn, H Pijl, E P M Corssmi. High fat diet induced hepatic insulin resistance is not related to changes in hypothalamic mRNA expression of NPY, AgRP, POMC and CART in mice. Peptides. vol 26. issue 12. 2006-02-28. PMID:15979206. |
the purpose of the present study was to investigate the effects of 2 weeks high fat feeding in wildtype mice on (1) insulin sensitivity and triglyceride accumulation in liver and muscle in relation to (2) mrna expression levels of neuropeptide y (npy), agouti-related protein (agrp), pro-opiomelanocortin (pomc), and cocaine- and amphetamine-regulated transcript (cart) in the hypothalamus. |
2006-02-28 |
2023-08-12 |
mouse |
| A C Heijboer, P J Voshol, E Donga, C G van Eden, L M Havekes, J A Romijn, H Pijl, E P M Corssmi. High fat diet induced hepatic insulin resistance is not related to changes in hypothalamic mRNA expression of NPY, AgRP, POMC and CART in mice. Peptides. vol 26. issue 12. 2006-02-28. PMID:15979206. |
this study shows that 2 weeks of high fat feeding in mice does not affect mrna expression levels of npy, agrp, pomc or cart, in the whole hypothalamus, despite induction of hepatic, but not peripheral, insulin resistance. |
2006-02-28 |
2023-08-12 |
mouse |
| F Batool, D J Halee. Increased precursor availability did not increase food intake and 5-HT turnover rate in the hypothalamus of diazepam injected rats. Pakistan journal of pharmaceutical sciences. vol 12. issue 1. 2006-02-27. PMID:16414823. |
increased precursor availability did not increase food intake and 5-ht turnover rate in the hypothalamus of diazepam injected rats. |
2006-02-27 |
2023-08-12 |
rat |
| O Ruetsch, A Viala, H Bardou, P Martin, M N Vachero. [Psychotropic drugs induced weight gain: a review of the literature concerning epidemiological data, mechanisms and management]. L'Encephale. vol 31. issue 4 Pt 1. 2006-02-24. PMID:16389718. |
according to current concepts, appetite and feeding are regulated by a complex of neurotransmitters, neuromodulators, cytokines and hormones interacting with the hypothalamus, including the leptin and the tumor necrosis factor system. |
2006-02-24 |
2023-08-12 |
Not clear |
| S F Leibowitz, G Shor-Posner, G Brennan, J T Alexande. Meal pattern analysis of macronutrient intake after PVN norepinephrine and peripheral clonidine administration. Obesity research. vol 1. issue 1. 2006-02-06. PMID:16353348. |
norepinephrine (ne) injected into the paraventricular nucleus (pvn) of the hypothalamus of rats is a potent stimulant of food intake, more specifically ingestion of the carbohydrate nutrient. |
2006-02-06 |
2023-08-12 |
rat |
| Zhiyuan Hu, Yun Dai, Marc Prentki, Shigeru Chohnan, M Daniel Lan. A role for hypothalamic malonyl-CoA in the control of food intake. The Journal of biological chemistry. vol 280. issue 48. 2006-02-03. PMID:16219771. |
when delivered by bilateral stereotaxic injection into the ventral hypothalamus (encompassing the arcuate nucleus) of mice, ad-cmcd increases food intake and body weight. |
2006-02-03 |
2023-08-12 |
mouse |