| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michel Félétou, Jean-Pierre Galizzi, Nigel R Leven. NPY receptors as drug targets for the central regulation of body weight. CNS & neurological disorders drug targets. vol 5. issue 3. 2006-08-18. PMID:16787228. |
npy levels in the hypothalamus are temporally correlated with food intake and are markedly elevated in response to energy depletion. |
2006-08-18 |
2023-08-12 |
mouse |
| Duo Li, Harrison S Weisinger, Richard S Weisinger, Michael Mathai, James A Armitage, Algis J Vingrys, Andrew J Sinclai. Omega 6 to omega 3 fatty acid imbalance early in life leads to persistent reductions in DHA levels in glycerophospholipids in rat hypothalamus even after long-term omega 3 fatty acid repletion. Prostaglandins, leukotrienes, and essential fatty acids. vol 74. issue 6. 2006-08-14. PMID:16716580. |
the present study investigated whether changes in brain (i.e., hypothalamus) glycerophospholipid fatty acid profiles induced by a diet rich in omega 6 fatty acids and very low in alpha-linolenic acid (ala) during pregnancy and the perinatal period could be reversed by subsequent feeding of a diet containing ala. |
2006-08-14 |
2023-08-12 |
rat |
| D Osei-Hyiaman, J Harvey-White, S Bátkai, G Kuno. The role of the endocannabinoid system in the control of energy homeostasis. International journal of obesity (2005). vol 30 Suppl 1. 2006-08-08. PMID:16570103. |
studies in our laboratory, using leptin-deficient obese rodents and cb1 cannabinoid receptor (cb1)-deficient mice, have indicated that endocannabinoids acting via cb1 are involved in the hunger-induced increase in food intake and are negatively regulated by leptin in brain areas involved in appetite control, including the hypothalamus, limbic forebrain and amygdala. |
2006-08-08 |
2023-08-12 |
mouse |
| Shu Lin, Dana Boey, Nicola Lee, Christoph Schwarzer, Amanda Sainsbury, Herbert Herzo. Distribution of prodynorphin mRNA and its interaction with the NPY system in the mouse brain. Neuropeptides. vol 40. issue 2. 2006-08-04. PMID:16439015. |
in the arcuate nucleus of the hypothalamus (arc), double-labelling in situ hybridisation revealed that prodynorphin expressing neurons also contained npy mrna, with a co-localisation rate of approximately 88% in the lateral part of the arc, and 79% in the dorsal part of the arc, respectively, suggesting potential overlapping functions of these two neurotransmitters in feeding type behaviour. |
2006-08-04 |
2023-08-12 |
mouse |
| T Komori, Y Morikawa, K Nanjo, E Senb. Induction of brain-derived neurotrophic factor by leptin in the ventromedial hypothalamus. Neuroscience. vol 139. issue 3. 2006-08-03. PMID:16564638. |
leptin, an adipocyte-derived hormone, reduces food intake by regulating orexigenic and anorexigenic factors in the hypothalamus. |
2006-08-03 |
2023-08-12 |
mouse |
| Sami Dridi, Cedric Ververken, F Bradley Hillgartner, Lutgarde Arckens, Arckens Lutgarde, Estel Van der Gucht, Lieselotte Cnops, Eddy Decuypere, Johan Buys. FAS inhibitor cerulenin reduces food intake and melanocortin receptor gene expression without modulating the other (an)orexigenic neuropeptides in chickens. American journal of physiology. Regulatory, integrative and comparative physiology. vol 291. issue 1. 2006-07-26. PMID:16455759. |
cerulenin, a natural fatty acid synthase (fas) inhibitor, and its synthetic analog c75 are hypothesized to alter the metabolism of neurons in the hypothalamus that regulate ingestive behavior to cause a profound decrease of food intake and an increase in metabolic rate, leading to body weight loss. |
2006-07-26 |
2023-08-12 |
Not clear |
| Nicolas Chartrel, Federica Bruzzone, Jérôme Leprince, Hélène Tollemer, Youssef Anouar, Jean-Claude Do-Régo, Isabelle Ségalas-Milazzo, Laure Guilhaudis, Pascal Cosette, Thierry Jouenne, Guy Simonnet, Mauro Vallarino, Jean-Claude Beauvillain, Jean Costentin, Hubert Vaudr. Structure and functions of the novel hypothalamic RFamide neuropeptides R-RFa and 26RFa in vertebrates. Peptides. vol 27. issue 5. 2006-07-20. PMID:16517014. |
as for several other rfamide peptides, 26rfa-containing neurons are present in the hypothalamus, notably in two nuclei involved in the control of feeding behavior. |
2006-07-20 |
2023-08-12 |
Not clear |
| Tadahiro Kitamura, Yun Feng, Yukari Ido Kitamura, Streamson C Chua, Allison W Xu, Gregory S Barsh, Luciano Rossetti, Domenico Accil. Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nature medicine. vol 12. issue 5. 2006-07-18. PMID:16604086. |
leptin controls food intake by regulating the transcription of key neuropeptides in the hypothalamus. |
2006-07-18 |
2023-08-12 |
Not clear |
| Guoqing Sheng, Guo-qing Chang, John Y Lin, Zhao-Xue Yu, Zhi-Hui Fang, Juan Rong, Stuart A Lipton, Shi-Hua Li, Gang Tong, Sarah F Leibowitz, Xiao-Jiang L. Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior. Nature medicine. vol 12. issue 5. 2006-07-18. PMID:16604089. |
the hypothalamus responds to circulating leptin and insulin in the control of food intake and body weight. |
2006-07-18 |
2023-08-12 |
mouse |
| Guoqing Sheng, Guo-qing Chang, John Y Lin, Zhao-Xue Yu, Zhi-Hui Fang, Juan Rong, Stuart A Lipton, Shi-Hua Li, Gang Tong, Sarah F Leibowitz, Xiao-Jiang L. Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior. Nature medicine. vol 12. issue 5. 2006-07-18. PMID:16604089. |
a number of neurotransmitters in the hypothalamus, including gamma-aminobutyric acid (gaba), also have key roles in feeding. |
2006-07-18 |
2023-08-12 |
mouse |
| Chun Yang, David Gagnon, Pascal Vachon, André Tremblay, Emile Levy, Bernard Massie, Jacques L Michau. Adenoviral-mediated modulation of Sim1 expression in the paraventricular nucleus affects food intake. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 26. 2006-07-18. PMID:16807340. |
sim1 is expressed in several areas of the brain, including the developing and postnatal paraventricular nucleus (pvn), a region of the hypothalamus that controls food intake. |
2006-07-18 |
2023-08-12 |
mouse |
| Miguel López, Christopher J Lelliott, Sulay Tovar, Wendy Kimber, Rosalía Gallego, Sam Virtue, Margaret Blount, Maria J Vázquez, Nick Finer, Trevor J Powles, Stephen O'Rahilly, Asish K Saha, Carlos Diéguez, Antonio J Vidal-Pui. Tamoxifen-induced anorexia is associated with fatty acid synthase inhibition in the ventromedial nucleus of the hypothalamus and accumulation of malonyl-CoA. Diabetes. vol 55. issue 5. 2006-06-26. PMID:16644689. |
fatty acid metabolism in the hypothalamus has recently been shown to regulate feeding. |
2006-06-26 |
2023-08-12 |
Not clear |
| Lourdes Mounien, Patrice Bizet, Isabelle Boutelet, Hubert Vaudry, Sylvie Jégo. Expression of melanocortin MC3 and MC4 receptor mRNAs by neuropeptide Y neurons in the rat arcuate nucleus. Neuroendocrinology. vol 82. issue 3-4. 2006-06-23. PMID:16508337. |
neuropeptide y (npy) and alpha-melanocyte-stimulating hormone (alpha-msh), two neuropeptides that are synthesized in neurons of the arcuate nucleus of the hypothalamus, exert opposite actions on food intake and body weight. |
2006-06-23 |
2023-08-12 |
rat |
| Sun Kwang Kim, Giseog Lee, Marie Shin, Jae-Bok Han, Hak Jin Moon, Jung Hyuk Park, Kye Jin Kim, Joohun Ha, Dong Suk Park, Byung-Il Mi. The association of serum leptin with the reduction of food intake and body weight during electroacupuncture in rats. Pharmacology, biochemistry, and behavior. vol 83. issue 1. 2006-06-19. PMID:16497365. |
previous studies indicate that acupuncture or electroacupuncture (ea) treatment reduces body weight and food intake in rats by increasing the level of anoretic peptides and decreasing that of orexigenic peptides in the hypothalamus. |
2006-06-19 |
2023-08-12 |
rat |
| Sun Kwang Kim, Giseog Lee, Marie Shin, Jae-Bok Han, Hak Jin Moon, Jung Hyuk Park, Kye Jin Kim, Joohun Ha, Dong Suk Park, Byung-Il Mi. The association of serum leptin with the reduction of food intake and body weight during electroacupuncture in rats. Pharmacology, biochemistry, and behavior. vol 83. issue 1. 2006-06-19. PMID:16497365. |
considering a well-established role of leptin as a major regulator for feeding behavior in the hypothalamus, we hypothesized that ea might exert its effect via increasing serum leptin levels. |
2006-06-19 |
2023-08-12 |
rat |
| G Sun, Z Tian, Y Yao, H Li, T Higuch. Central and/or peripheral immunoreactivity of orexin-A in pregnant rats and women. Journal of molecular endocrinology. vol 36. issue 1. 2006-06-13. PMID:16461933. |
significantly decreased the number (p< 0.01) and mean staining intensity (p< 0.01) of orexin-a-ir neurons in the hypothalamus, food intake (p< 0.01) and body weight gain (p< 0.001) compared with vehicle injection in normal rats. |
2006-06-13 |
2023-08-12 |
rat |
| Antonello E Rigamonti, Sara M Bonomo, Diego Scanniffio, Silvano G Cella, Eugenio E Mülle. Orexigenic effects of a growth hormone secretagogue and nitric oxide in aged rats and dogs: correlation with the hypothalamic expression of some neuropeptidergic/receptorial effectors mediating food intake. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 61. issue 4. 2006-06-08. PMID:16611696. |
there is scarce information on these topics in elderly persons; therefore, the aims of the present study were: (i) to evaluate the orexigenic effects of a growth hormone secretagogue, administered to young and old rats and dogs, alone or in combination with molsidomine, a donor of nitric oxide and (ii) to evaluate by reverse transcription-polymerase chain reaction in the whole hypothalamus of young and old rats messenger rna levels of a wide number of anabolic and catabolic peptides, receptors, and enzymes involved in the control of feeding behavior, relating the detected titers, whenever possible, to the feeding responses to growth hormone secretagogue. |
2006-06-08 |
2023-08-12 |
rat |
| Antonello E Rigamonti, Sara M Bonomo, Diego Scanniffio, Silvano G Cella, Eugenio E Mülle. Orexigenic effects of a growth hormone secretagogue and nitric oxide in aged rats and dogs: correlation with the hypothalamic expression of some neuropeptidergic/receptorial effectors mediating food intake. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 61. issue 4. 2006-06-08. PMID:16611696. |
in all, the results obtained strengthen the proposition that, in the hypothalamus of old rats, anti-anorexigenic compensatory mechanisms are operative, aimed at maintaining a "normal" feeding pattern. |
2006-06-08 |
2023-08-12 |
rat |
| M Michael Cohe. Role of leptin in regulating appetite, neuroendocrine function, and bone remodeling. American journal of medical genetics. Part A. vol 140. issue 5. 2006-05-30. PMID:16463275. |
leptin, in regulating food intake and body weight, acts, in part, by inhibiting the synthesis of neuropeptide y and its release from the hypothalamus. |
2006-05-30 |
2023-08-12 |
Not clear |
| Yih-Shou Hsieh, Shun-Fa Yang, Hui-Ling Chiou, Dong-Yih Ku. Activations of c-fos/c-jun signaling are involved in the modulation of hypothalamic superoxide dismutase (SOD) and neuropeptide Y (NPY) gene expression in amphetamine-mediated appetite suppression. Toxicology and applied pharmacology. vol 212. issue 2. 2006-05-25. PMID:16084549. |
results showed that amph treatment decreased food intake, which was correlated with changes of npy mrna level, but increased c-fos, c-jun and superoxide dismutase (sod) mrna levels in hypothalamus. |
2006-05-25 |
2023-08-12 |
rat |