| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gavin P Reynolds, Shona L Kir. Metabolic side effects of antipsychotic drug treatment--pharmacological mechanisms. Pharmacology & therapeutics. vol 125. issue 1. 2010-03-01. PMID:19931306. |
elevated leptin secretion in the absence of a decrease in food intake indicates drug-induced leptin insensitivity in the hypothalamus. |
2010-03-01 |
2023-08-12 |
Not clear |
| Ana Paula Arruda, Marciane Milanski, Talita Romanatto, Carina Solon, Andressa Coope, Luciane C Alberici, William T Festuccia, Sandro M Hirabara, Eduardo Ropelle, Rui Curi, José B Carvalheira, Aníbal E Vercesi, Licio A Vellos. Hypothalamic actions of tumor necrosis factor alpha provide the thermogenic core for the wastage syndrome in cachexia. Endocrinology. vol 151. issue 2. 2010-02-26. PMID:19996183. |
however, by acting directly in the hypothalamus, tnfalpha can activate thermogenesis and modulate food intake. |
2010-02-26 |
2023-08-12 |
rat |
| Aaron J Grossberg, Jarrad M Scarlett, XinXia Zhu, Darren D Bowe, Ayesha K Batra, Theodore P Braun, Daniel L Mark. Arcuate nucleus proopiomelanocortin neurons mediate the acute anorectic actions of leukemia inhibitory factor via gp130. Endocrinology. vol 151. issue 2. 2010-02-26. PMID:20016025. |
we demonstrate that lif acutely inhibits food intake by directly activating pro-opiomelanocortin (pomc) neurons in the arcuate nucleus of the hypothalamus. |
2010-02-26 |
2023-08-12 |
mouse |
| Ryusuke Yoshida, Tadahiro Ohkuri, Masafumi Jyotaki, Toshiaki Yasuo, Nao Horio, Keiko Yasumatsu, Keisuke Sanematsu, Noriatsu Shigemura, Tsuneyuki Yamamoto, Robert F Margolskee, Yuzo Ninomiy. Endocannabinoids selectively enhance sweet taste. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 2. 2010-02-26. PMID:20080779. |
endocannabinoids such as anandamide [n-arachidonoylethanolamine (aea)] and 2-arachidonoyl glycerol (2-ag) are known orexigenic mediators that act via cb(1) receptors in hypothalamus and limbic forebrain to induce appetite and stimulate food intake. |
2010-02-26 |
2023-08-12 |
mouse |
| C García-Luna, M I Amaya, E Alvarez-Salas, P de Gortar. Prepro-orexin and feeding-related peptide receptor expression in dehydration-induced anorexia. Regulatory peptides. vol 159. issue 1-3. 2010-02-23. PMID:19800927. |
stress by dehydration induces an anorexic behavior in rats, loss of weight and reduced food intake when compared to ad libitum fed animals, however these alterations are accompanied by hpt axis changes such as increased serum thyrotropin levels and enhanced expression of thyrotropin-releasing hormone (trh) in the paraventricular nucleus of the hypothalamus, which is considered as anorexigenic peptide. |
2010-02-23 |
2023-08-12 |
rat |
| Keisuke Maruyama, Kohei Wada, Kotaro Ishiguro, Sei-Ichi Shimakura, Tatsuya Wakasugi, Minoru Uchiyama, Seiji Shioda, Kouhei Matsud. Neuromedin U-induced anorexigenic action is mediated by the corticotropin-releasing hormone receptor-signaling pathway in goldfish. Peptides. vol 30. issue 12. 2010-02-17. PMID:19699772. |
we first investigated the effect of intracerebroventricular (icv) administration of nmu-21 at 100 pmol/g body weight (bw), which is enough to suppress food intake, on expression levels of mrna for crh and proopiomelanocortin (pomc) in the hypothalamus. |
2010-02-17 |
2023-08-12 |
Not clear |
| B A Henry, D Blache, F R Dunshea, I J Clark. Altered "set-point" of the hypothalamus determines effects of cortisol on food intake, adiposity, and metabolic substrates in sheep. Domestic animal endocrinology. vol 38. issue 1. 2010-01-28. PMID:19733031. |
altered "set-point" of the hypothalamus determines effects of cortisol on food intake, adiposity, and metabolic substrates in sheep. |
2010-01-28 |
2023-08-12 |
Not clear |
| Philippe Ciofi, Maurice Garret, Olivier Lapirot, Pierrette Lafon, Anne Loyens, Vincent Prévot, Jon E Levin. Brain-endocrine interactions: a microvascular route in the mediobasal hypothalamus. Endocrinology. vol 150. issue 12. 2010-01-19. PMID:19837874. |
blood-borne hormones acting in the mediobasal hypothalamus, like those controlling food intake, require relatively direct access to target chemosensory neurons of the arcuate nucleus (arc). |
2010-01-19 |
2023-08-12 |
rat |
| Karolina P Skibicka, Harvey J Gril. Hypothalamic and hindbrain melanocortin receptors contribute to the feeding, thermogenic, and cardiovascular action of melanocortins. Endocrinology. vol 150. issue 12. 2010-01-19. PMID:19854868. |
the literature indicates that reexpression of mc4r in the paraventricular nucleus (pvh) affects the feeding but not the energetic phenotype of the mc4r knockout, suggesting that divergent mc4r populations mediate energy expenditure (hindbrain) and fi (hypothalamus) effects of stimulation. |
2010-01-19 |
2023-08-12 |
rat |
| Benedek Erdos, Christopher S Broxson, Idan Cudykier, Bilgen Basgut, Melissa Whidden, Tessa Landa, Philip J Scarpace, Nihal Tüme. Effect of high-fat diet feeding on hypothalamic redox signaling and central blood pressure regulation. Hypertension research : official journal of the Japanese Society of Hypertension. vol 32. issue 11. 2010-01-12. PMID:19713964. |
protein levels of angiotensin ii type 1 receptor (at(1)) and nox2, p67(phox) and p47(phox) subunits of nadph oxidase, as well as nadph oxidase activity increased significantly in the hypothalamus with hf feeding, whereas levels of antioxidant enzymes and nitric oxide synthases remained unchanged. |
2010-01-12 |
2023-08-12 |
rat |
| Benedek Erdos, Christopher S Broxson, Idan Cudykier, Bilgen Basgut, Melissa Whidden, Tessa Landa, Philip J Scarpace, Nihal Tüme. Effect of high-fat diet feeding on hypothalamic redox signaling and central blood pressure regulation. Hypertension research : official journal of the Japanese Society of Hypertension. vol 32. issue 11. 2010-01-12. PMID:19713964. |
this study shows that feeding obesity-prone sprague-dawley rats with a hf diet results in elevated bp and hr and delayed cardiovascular post-stress recovery, and that these changes are paralleled by increases in the expression and activity of nadph oxidase in the hypothalamus without a compensatory increase in the antioxidant enzyme levels, possibly leading to superoxide-mediated sympathoexcitation and hypertension. |
2010-01-12 |
2023-08-12 |
rat |
| Sushil Kumar, Jyoti Parkash, Hardeep Kataria, Gurcharan Kau. Interactive effect of excitotoxic injury and dietary restriction on neurogenesis and neurotrophic factors in adult male rat brain. Neuroscience research. vol 65. issue 4. 2010-01-08. PMID:19732799. |
in the present study, we examined the effect of dr (alternate day feeding regimen) on neurogenesis, expression of immature neuronal marker polysialic acid neural cell adhesion molecule (psa-ncam) and neurotrophic factors from different brain regions such as subventricular zone (svz), subgranular zone (sgz) of hippocampus, median eminence arcuate (me-arc) region of hypothalamus, and piriform cortex (pir) of adult male rats and further challenged ad libitum fed (al) and dr rats with pilocarpine to induce excitotoxic injury. |
2010-01-08 |
2023-08-12 |
rat |
| Brent E Wisse, Michael W Schwart. Does hypothalamic inflammation cause obesity? Cell metabolism. vol 10. issue 4. 2010-01-06. PMID:19808014. |
in this issue, brüning and colleagues (kleinridders et al., 2009) add to growing evidence that this response occurs in the hypothalamus, as well as in peripheral tissues, which helps to explain how high-fat feeding induces a gradual increase in defended body weight. |
2010-01-06 |
2023-08-12 |
Not clear |
| Amalia Fedeli, Simone Braconi, Daina Economidou, Nazzareno Cannella, Marsida Kallupi, Remo Guerrini, Girolamo Calò, Carlo Cifani, Maurizio Massi, Roberto Ciccociopp. The paraventricular nucleus of the hypothalamus is a neuroanatomical substrate for the inhibition of palatable food intake by neuropeptide S. The European journal of neuroscience. vol 30. issue 8. 2010-01-05. PMID:19821837. |
the paraventricular nucleus of the hypothalamus is a neuroanatomical substrate for the inhibition of palatable food intake by neuropeptide s. neuropeptide s (nps) is a recently discovered neurotransmitter that binds to its cognate g-protein coupled receptor, npsr. |
2010-01-05 |
2023-08-12 |
rat |
| Amalia Fedeli, Simone Braconi, Daina Economidou, Nazzareno Cannella, Marsida Kallupi, Remo Guerrini, Girolamo Calò, Carlo Cifani, Maurizio Massi, Roberto Ciccociopp. The paraventricular nucleus of the hypothalamus is a neuroanatomical substrate for the inhibition of palatable food intake by neuropeptide S. The European journal of neuroscience. vol 30. issue 8. 2010-01-05. PMID:19821837. |
brain site-specific microinjection experiments revealed that nps markedly inhibits palatable food intake if administered into the paraventricular nucleus of the hypothalamus (pvn). |
2010-01-05 |
2023-08-12 |
rat |
| Amalia Fedeli, Simone Braconi, Daina Economidou, Nazzareno Cannella, Marsida Kallupi, Remo Guerrini, Girolamo Calò, Carlo Cifani, Maurizio Massi, Roberto Ciccociopp. The paraventricular nucleus of the hypothalamus is a neuroanatomical substrate for the inhibition of palatable food intake by neuropeptide S. The European journal of neuroscience. vol 30. issue 8. 2010-01-05. PMID:19821837. |
a similar but smaller and shorter lasting reduction of feeding was observed following intra-lateral hypothalamus administration, whereas no effect was observed following injection into the central amygdala. |
2010-01-05 |
2023-08-12 |
rat |
| Seung Baek Han, Byung-il Choi, Dongmin Lee, Sun-Ho Kee, Hyeon Soo Kim, Woong Sun, Hyun Ki. Regulation of AHI1 expression in adult rat brain: Implication in hypothalamic feeding control. Biochemical and biophysical research communications. vol 390. issue 3. 2009-12-29. PMID:19819228. |
furthermore, we demonstrated that food deprivation caused induction of ahi1 in the hypothalamus and subsequent re-feeding down-regulated ahi1 expression, suggesting the involvement of ahi1 in feeding control. |
2009-12-29 |
2023-08-12 |
rat |
| Takeo Sakoguchi, Masahisa Horiuchi, Akihiro Asakawa, Miharu Ushikai, Goichiro Yoshida, Mineko Fujimiya, Ikuo Kato, Masamitsu Nakazato, Toru Takeuchi, Takeyori Saheki, Akio Inu. Failure of the feeding response to fasting in carnitine-deficient juvenile visceral steatosis (JVS) mice: involvement of defective acyl-ghrelin secretion and enhanced corticotropin-releasing factor signaling in the hypothalamus. Biochimica et biophysica acta. vol 1792. issue 11. 2009-12-23. PMID:19744557. |
failure of the feeding response to fasting in carnitine-deficient juvenile visceral steatosis (jvs) mice: involvement of defective acyl-ghrelin secretion and enhanced corticotropin-releasing factor signaling in the hypothalamus. |
2009-12-23 |
2023-08-12 |
mouse |
| Takeo Sakoguchi, Masahisa Horiuchi, Akihiro Asakawa, Miharu Ushikai, Goichiro Yoshida, Mineko Fujimiya, Ikuo Kato, Masamitsu Nakazato, Toru Takeuchi, Takeyori Saheki, Akio Inu. Failure of the feeding response to fasting in carnitine-deficient juvenile visceral steatosis (JVS) mice: involvement of defective acyl-ghrelin secretion and enhanced corticotropin-releasing factor signaling in the hypothalamus. Biochimica et biophysica acta. vol 1792. issue 11. 2009-12-23. PMID:19744557. |
the defective feeding response to fasting in carnitine-deficient jvs mice is due to the defective acyl-ghrelin and enhanced crf signaling in the hypothalamus through fatty acid metabolism abnormalities. |
2009-12-23 |
2023-08-12 |
mouse |
| Takuya Chiba, Daisuke Inoue, Aya Mizuno, Toshimitsu Komatsu, Satoshi Fujita, Haruaki Kubota, Maria Luisa Tagliaro, Seongjoon Park, Lucas Siqueira Trindade, Takahiro Hayashida, Hiroko Hayashi, Haruyoshi Yamaza, Yoshikazu Higami, Isao Shimokaw. Identification and characterization of an insulin receptor substrate 4-interacting protein in rat brain: implications for longevity. Neurobiology of aging. vol 30. issue 3. 2009-12-07. PMID:17720279. |
the hypothalamus is organized as a collection of distinct, autonomously active nuclei that regulate discrete functions, such as feeding activity and metabolism. |
2009-12-07 |
2023-08-12 |
mouse |