| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D D Pierroz, C Catzeflis, A C Aebi, J E Rivier, M L Auber. Chronic administration of neuropeptide Y into the lateral ventricle inhibits both the pituitary-testicular axis and growth hormone and insulin-like growth factor I secretion in intact adult male rats. Endocrinology. vol 137. issue 1. 1996-02-05. PMID:8536627. |
chronic icv infusion of npy produced the expected dose-related increases in food intake from 33.0 +/- 0.9 (basal) to 53.4 +/- 3.3 g/day (18 micrograms npy/day) and body weight gain (5.7 +/- 0.7 to 10.5 +/- 1.2 d/day). |
1996-02-05 |
2023-08-12 |
rat |
| R D O'Shea, A L Gundlac. NPY mRNA and peptide immunoreactivity in the arcuate nucleus are increased by osmotic stimuli: correlation with dehydration anorexia. Peptides. vol 16. issue 6. 1996-02-01. PMID:8532596. |
together these findings suggest that npy neuron activity in the arc may be regulated by decreases in food intake rather than changes in body weight per se or increased osmolarity and support other data implicating npy in the central regulation of energy homeostasis. |
1996-02-01 |
2023-08-12 |
rat |
| D C Jewett, J Cleary, A S Levine, D W Schaal, T Thompso. Effects of neuropeptide Y, insulin, 2-deoxyglucose, and food deprivation on food-motivated behavior. Psychopharmacology. vol 120. issue 3. 1996-01-19. PMID:8524973. |
although insulin (3-8 u/kg) and 2-deoxyglucose (150-250 mg/kg) also increased food intake, neither increased break points to levels produced by npy or food deprivation. |
1996-01-19 |
2023-08-12 |
Not clear |
| D G Baskin, B J Norwood, M W Schwartz, D J Koerke. Estradiol inhibits the increase of hypothalamic neuropeptide Y messenger ribonucleic acid expression induced by weight loss in ovariectomized rats. Endocrinology. vol 136. issue 12. 1995-12-28. PMID:7588307. |
therefore, when e2 is administered to ovx rats, reduced npy mrna expression in the hypothalamus is unlikely to be a primary cause of weight loss, although it may contribute to the maintenance of reduced food intake and body weight. |
1995-12-28 |
2023-08-12 |
rat |
| A Sahu, M G Dube, C P Phelps, C A Sninsky, P S Kalra, S P Kalr. Insulin and insulin-like growth factor II suppress neuropeptide Y release from the nerve terminals in the paraventricular nucleus: a putative hypothalamic site for energy homeostasis. Endocrinology. vol 136. issue 12. 1995-12-28. PMID:7588328. |
to establish the site of interaction between the hypothalamus and the pancreas, we examined the effects of insulin on npy release in vivo and in vitro from hypothalamic sites known to be involved in feeding behavior. |
1995-12-28 |
2023-08-12 |
rat |
| D A Kirby, S C Koerber, J M May, C Hagaman, M J Cullen, M A Pelleymounter, J E Rivie. Y1 and Y2 receptor selective neuropeptide Y analogues: evidence for a Y1 receptor subclass. Journal of medicinal chemistry. vol 38. issue 22. 1995-12-26. PMID:7473586. |
neuropeptide y (npy), a 36-residue polypeptide produced abundantly in both nervous and peripheral tissues, appears to play a significant role in the regulation of diverse biological processes, including feeding behavior and cardiovascular and psychotropic functions. |
1995-12-26 |
2023-08-12 |
human |
| P J Currie, D V Coscin. Dissociated feeding and hypothermic effects of neuropeptide Y in the paraventricular and perifornical hypothalamus. Peptides. vol 16. issue 4. 1995-11-30. PMID:7479290. |
the present study investigated the effects of neuropeptide y (npy) on food intake and body temperature (tbo) in free-feeding unrestrained rats following injection into the medial hypothalamic paraventricular nucleus (pvn) or the lateral perifornical hypothalamus (pfh). |
1995-11-30 |
2023-08-12 |
rat |
| P J Currie, D V Coscin. Dissociated feeding and hypothermic effects of neuropeptide Y in the paraventricular and perifornical hypothalamus. Peptides. vol 16. issue 4. 1995-11-30. PMID:7479290. |
npy (78-235 pmol) or saline was infused unilaterally into the pvn or pfh in a volume of 0.4 microliter and simultaneous measures of food intake and tbo were taken every 30 min for 3 h. results indicated that npy evoked changes in eating behavior and tbo that were dependent upon the site of hypothalamic injection. |
1995-11-30 |
2023-08-12 |
rat |
| P J Currie, D V Coscin. Dissociated feeding and hypothermic effects of neuropeptide Y in the paraventricular and perifornical hypothalamus. Peptides. vol 16. issue 4. 1995-11-30. PMID:7479290. |
although pvn and pfh administration of npy both increased food intake dose dependently within 30 min of treatment, pfh npy-injected rats (n = 9) showed a stronger behavioral response compared to rats (n = 9) receiving npy injections into the pvn. |
1995-11-30 |
2023-08-12 |
rat |
| P J Currie, D V Coscin. Dissociated feeding and hypothermic effects of neuropeptide Y in the paraventricular and perifornical hypothalamus. Peptides. vol 16. issue 4. 1995-11-30. PMID:7479290. |
these findings are consistent with evidence that npy in the pvn and pfh may have distinct functions and suggest that although pfh npy acts to stimulate a robust and relatively specific ingestive response, pvn npy may participate in the complex integrative mechanisms responsible for the simultaneous regulation of feeding, thermoregulatory, and metabolic processes. |
1995-11-30 |
2023-08-12 |
rat |
| C M Brown, D V Coscin. Ineffectiveness of hypothalamic serotonin to block neuropeptide Y-induced feeding. Pharmacology, biochemistry, and behavior. vol 51. issue 4. 1995-10-19. PMID:7675837. |
a variety of recent research has suggested that the feeding associated with enhanced neuropeptide y (npy) activity within the hypothalamus may operate in part by interacting antagonistically with other neural processes responsive to serotonin (5-hydroxytryptamine or 5-ht). |
1995-10-19 |
2023-08-12 |
rat |
| C M Brown, D V Coscin. Ineffectiveness of hypothalamic serotonin to block neuropeptide Y-induced feeding. Pharmacology, biochemistry, and behavior. vol 51. issue 4. 1995-10-19. PMID:7675837. |
to test this possibility further, experiments were performed to determine if the magnitude of feeding produced by injecting npy into the paraventricular nucleus (pvn) or the perifornical hypothalamus (pfh) was diminished by coinjections of 5-ht into these two sites or peripheral injections of the 5-ht agonist, d-fenfluramine. |
1995-10-19 |
2023-08-12 |
rat |
| C M Brown, D V Coscin. Ineffectiveness of hypothalamic serotonin to block neuropeptide Y-induced feeding. Pharmacology, biochemistry, and behavior. vol 51. issue 4. 1995-10-19. PMID:7675837. |
in both studies, npy (235 pmol) produced significant feeding in both sites either 1 or 2 h after injection when compared to saline. |
1995-10-19 |
2023-08-12 |
rat |
| C M Brown, D V Coscin. Ineffectiveness of hypothalamic serotonin to block neuropeptide Y-induced feeding. Pharmacology, biochemistry, and behavior. vol 51. issue 4. 1995-10-19. PMID:7675837. |
however, peripherally injected d-fenfluramine (0.32, 0.63, or 1.25 mg/kg) produced strong dose-dependent attenuation both 1- and 2-h food intake elicited by 235 pmol npy in either site, with the pfh being proportionately more sensitive to this effect. |
1995-10-19 |
2023-08-12 |
rat |
| E S Hanson, M F Dallma. Neuropeptide Y (NPY) may integrate responses of hypothalamic feeding systems and the hypothalamo-pituitary-adrenal axis. Journal of neuroendocrinology. vol 7. issue 4. 1995-09-27. PMID:7647769. |
neuropeptide y (npy) may integrate responses of hypothalamic feeding systems and the hypothalamo-pituitary-adrenal axis. |
1995-09-27 |
2023-08-12 |
rat |
| E S Hanson, M F Dallma. Neuropeptide Y (NPY) may integrate responses of hypothalamic feeding systems and the hypothalamo-pituitary-adrenal axis. Journal of neuroendocrinology. vol 7. issue 4. 1995-09-27. PMID:7647769. |
neuropeptide y (npy) is a powerful stimulus to food intake in the rat. |
1995-09-27 |
2023-08-12 |
rat |
| R D Myers, M H Wooten, C D Ames, J W Nyc. Anorexic action of a new potential neuropeptide Y antagonist [D-Tyr27,36, D-Thr32]-NPY (27-36) infused into the hypothalamus of the rat. Brain research bulletin. vol 37. issue 3. 1995-09-07. PMID:7627566. |
neuropeptide y (npy) produces a vigorous feeding response in several species when it is injected into hypothalamic structures involved in eating behavior. |
1995-09-07 |
2023-08-12 |
rat |
| R D Myers, M H Wooten, C D Ames, J W Nyc. Anorexic action of a new potential neuropeptide Y antagonist [D-Tyr27,36, D-Thr32]-NPY (27-36) infused into the hypothalamus of the rat. Brain research bulletin. vol 37. issue 3. 1995-09-07. PMID:7627566. |
a mixture of the two doses of npy and d-npy27-36 injected at the same hypothalamic loci did not attenuate the intake of food but tended to enhance the feeding response in the rats. |
1995-09-07 |
2023-08-12 |
rat |
| S M Bouali, A Fournier, S St-Pierre, F B Jolicoeu. Influence of ambient temperature on the effects of NPY on body temperature and food intake. Pharmacology, biochemistry, and behavior. vol 50. issue 3. 1995-08-22. PMID:7617688. |
influence of ambient temperature on the effects of npy on body temperature and food intake. |
1995-08-22 |
2023-08-12 |
Not clear |
| S M Bouali, A Fournier, S St-Pierre, F B Jolicoeu. Influence of ambient temperature on the effects of NPY on body temperature and food intake. Pharmacology, biochemistry, and behavior. vol 50. issue 3. 1995-08-22. PMID:7617688. |
because thermoregulation and food consumption are interrelated, and because thermoregulation processes are influenced by ambient temperature, we examined the effects of neuropeptide y (npy) on both body temperature and food intake in various thermal environments after intracerebroventricular administration of 20 micrograms. |
1995-08-22 |
2023-08-12 |
Not clear |