| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alejandro Gugliucc. Angiopoietin-like Proteins and Lipoprotein Lipase: The Waltz Partners That Govern Triglyceride-Rich Lipoprotein Metabolism? Impact on Atherogenesis, Dietary Interventions, and Emerging Therapies. Journal of clinical medicine. vol 13. issue 17. 2024-09-14. PMID:39274442. |
conversely, lpl activity in adipocytes increases significantly after feeding, while its activity in oxidative tissues decreases concurrently. |
2024-09-14 |
2024-09-16 |
Not clear |
| Yiheng Huang, Liujun Chen, Lisha Li, Yadan Qi, Haibin Tong, Hong Wu, Jinjie Xu, Lin Leng, Sukhinder Cheema, Guang Sun, Zhengyuan Xia, John McGuire, Brian Rodrigues, Lawrence H Young, Richard Bucala, Dake Q. Downregulation of adipose LPL by PAR2 contributes to the development of hypertriglyceridemia. JCI insight. vol 9. issue 13. 2024-07-08. PMID:38973609. |
following pd feeding, adipose lpl expression and activity were significantly reduced, and this reduction was reversed in par2-/- mice. |
2024-07-08 |
2024-07-11 |
mouse |
| Sabine Stoltenberg Grove, Jacob Dall, Johannes Gulmann Madse. The Effect of Lysophospholipids and Sex on Growth Performance and Small Intestine Morphology in Weanling Pigs, 7-30 kg. Animals : an open access journal from MDPI. vol 14. issue 8. 2024-04-27. PMID:38672361. |
the aim of this study was to investigate the effect of feeding lpl in weanling pig diets on growth performance and intestinal morphology. |
2024-04-27 |
2024-04-29 |
Not clear |
| William Andrew Thompson, Jithine Jayakumar Rajeswari, Alison C Holloway, Mathilakath M Vijaya. Excess feeding increases adipogenesis but lowers leptin transcript abundance in zebrafish larvae. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023-12-07. PMID:38061616. |
the molecular markers of adipogenesis, including fas, elovl2, and dgat2, were upregulated, while the transcript abundance of lpl, a lipolytic gene, were transiently lower due to excess feeding. |
2023-12-07 |
2023-12-17 |
zebrafish |
| Yan Q Chen, Eugene Y Zhen, Anna M Russell, Mariam Ehsani, Robert W Siegel, Yuewei Qian, Robert J Konra. Decoding the role of angiopoietin-like protein 4/8 complex-mediated plasmin generation in the regulation of LPL activity. Journal of lipid research. 2023-09-04. PMID:37666362. |
after feeding, adipose tissue lipoprotein lipase (lpl) activity should be maximized, therefore the potent lpl-inhibitory activity of angiopoietin-like protein 4 (angptl4) must be blocked by angptl8 through formation of angptl4/8 complexes. |
2023-09-04 |
2023-09-07 |
human |
| Jaclyn E Welles, Holly Lacko, Yuka Imamura Kawasawa, Michael D Dennis, Leonard S Jefferson, Scot R Kimbal. An integrative approach to assessing effects of a short-term Western diet on gene expression in rat liver. Frontiers in endocrinology. vol 13. 2022-11-17. PMID:36387860. |
we found that feeding had a significant positive effect on ribosome occupancy of 49 mrnas associated with hepatic steatosis (e.g., lipe, lpl), but this effect was blunted in the liver of rats fed a wd. |
2022-11-17 |
2023-08-14 |
rat |
| Huitian Cai, Yi Zhang, Zhehan Qiu, Peihuan Lu. Gene Expression of Antioxidant Metabolic Enzymes in Grape Extracts. Cellular and molecular biology (Noisy-le-Grand, France). vol 67. issue 6. 2022-07-12. PMID:35818195. |
the results showed that grape extract could effectively enhance sod activity, lpl relative expression and fas relative expression in mice liver tissue; grape extract could effectively increase sod relative expression, trxr2 relative expression and cat relative expression in mice kidney tissue; grape extract could effectively reduce mda activity in mice liver tissue, and increase and decrease the extent of mda activity and the duration of feeding in mice. |
2022-07-12 |
2023-08-14 |
mouse |
| N Ma, J A Abaker, G Wei, H Chen, X Shen, G Chan. A high-concentrate diet induces an inflammatory response and oxidative stress and depresses milk fat synthesis in the mammary gland of dairy cows. Journal of dairy science. 2022-03-29. PMID:35346479. |
for milk fat metabolism, hc diet feeding reduced the milk fat content in milk samples and the triacylglycerol content in the mammary gland and inhibited the expression of de novo synthase (acaca and fasn), long-chain fatty acid converting enzymes (acsl1 and scd), fatty acid transporters (cd36, fatp, fabp3, and lpl), triacylglycerol synthase (agpat6, dgat1, and lpin1), lipid droplet releasing enzyme (plin1), and transcription factors sterol regulatory element binding protein (srebp1) and peroxisome proliferator activated receptor gamma (pparg). |
2022-03-29 |
2023-08-13 |
Not clear |
| Sander Kerste. Role and mechanism of action of angiopoietin-like protein ANGPTL4 in plasma lipid metabolism. Journal of lipid research. 2021-11-21. PMID:34801488. |
the inhibition of lpl by angptl4 is opposed by angptl8, which keeps lpl active after feeding. |
2021-11-21 |
2023-08-13 |
Not clear |
| Kathryn M Spitler, Shwetha K Shetty, Emily M Cushing, Kelli L Sylvers-Davie, Brandon S J Davie. Regulation of plasma triglyceride partitioning by adipose-derived ANGPTL4 in mice. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:33846453. |
moreover, despite higher adipose lpl activity levels, mice lacking adipocyte angptl4 no longer had increased triglyceride uptake into adipose compared to littermate controls after chronic high-fat feeding. |
2021-11-08 |
2023-08-13 |
mouse |
| Kathryn M Spitler, Shwetha K Shetty, Emily M Cushing, Kelli L Sylvers-Davie, Brandon S J Davie. Regulation of plasma triglyceride partitioning by adipose-derived ANGPTL4 in mice. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:33846453. |
these observations suggest that after chronic high-fat feeding lpl is no longer rate-limiting for triglyceride delivery to adipocytes. |
2021-11-08 |
2023-08-13 |
mouse |
| Jiao Li, Xu-Fang Liang, Muhammad Shoaib Alam, Haocan Luo, Yanpeng Zhang, Binbin Peng, Qianqian Xiao, Zhilu Zhang, Liwei Liu, Shan H. Adaptation of AMPK-mTOR-signal pathways and lipid metabolism in response to low- and high-level rapeseed meal diet in Chinese perch (Siniperca chuatsi). Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. vol 191. issue 5. 2021-11-03. PMID:34373935. |
fish fed with rsl diets showed decreased food intake, serum low density lipoprotein (ldl), phosphorylated grb10 (p < 0.05), inhibited fatty acid (fa) transport (lipoprotein lipase (lpl)), and glycerol synthesis (phosphoenol pyruvate carboxykinase (pepck)) in the liver. |
2021-11-03 |
2023-08-13 |
Not clear |
| Yan Q Chen, Thomas G Pottanat, Robert W Siegel, Mariam Ehsani, Yue-Wei Qian, Robert J Konra. Angiopoietin-like protein 4 (ANGPTL4) is an inhibitor of endothelial lipase (EL) while the ANGPTL4/8 complex has reduced EL-inhibitory activity. Heliyon. vol 7. issue 9. 2021-09-11. PMID:34504977. |
we previously demonstrated that angiopoietin-like protein 8 (angptl8) forms angptl3/8 and angptl4/8 complexes that increase with feeding to direct fatty acids (fa) toward adipose tissue through differential modulation of lipoprotein lipase (lpl) activity. |
2021-09-11 |
2023-08-13 |
human |
| Yan Q Chen, Thomas G Pottanat, Robert W Siegel, Mariam Ehsani, Yue-Wei Qian, Eugene Y Zhen, Ajit Regmi, William C Roell, Haihong Guo, M Jane Luo, Ruth E Gimeno, Ferdinand Van't Hooft, Robert J Konra. Angiopoietin-like protein 8 differentially regulates ANGPTL3 and ANGPTL4 during postprandial partitioning of fatty acids. Journal of lipid research. vol 61. issue 8. 2021-08-13. PMID:32487544. |
here, we studied how complex formation of angptl8 with angptl3 or angptl4 varies with feeding to regulate lpl. |
2021-08-13 |
2023-08-13 |
human |
| Yan Q Chen, Thomas G Pottanat, Robert W Siegel, Mariam Ehsani, Yue-Wei Qian, Eugene Y Zhen, Ajit Regmi, William C Roell, Haihong Guo, M Jane Luo, Ruth E Gimeno, Ferdinand Van't Hooft, Robert J Konra. Angiopoietin-like protein 8 differentially regulates ANGPTL3 and ANGPTL4 during postprandial partitioning of fatty acids. Journal of lipid research. vol 61. issue 8. 2021-08-13. PMID:32487544. |
during feeding, increased angptl8 increases angptl3 inhibition of lpl in muscle via circulating angptl3/8, while decreasing angptl4 inhibition of lpl in adipose tissue through localized angptl4/8, thereby increasing fa uptake into adipose tissue. |
2021-08-13 |
2023-08-13 |
human |
| Yuyu Wang, Suming Xie, Zhijuan Nie, Quanjie Li, Yi Sun, Nailin Shao, Jiancao Gao, Jiawen Hu, Pao Xu, Gangchun X. Optimum feeding frequency of juvenile largemouth bass (Micropterus salmoides) reared in in-pond raceway recirculating culture system. Fish physiology and biochemistry. vol 46. issue 6. 2021-05-07. PMID:32865717. |
this study was conducted to determine the effects of feeding frequency on the growth, serum biochemical parameters, antioxidant status and hepatic growth hormone (gh), insulin-like growth factor i (igf-i), lipoprotein lipase (lpl) and hepatic lipase (hl) gene expression levels of juvenile largemouth bass (micropterus salmoides) reared in an in-pond raceway recirculating culture system (iprs). |
2021-05-07 |
2023-08-13 |
cat |
| Jéssica Vicky Bernardo de Oliveira, Raquel Patrícia Ataíde Lima, Rafaella Cristhine Pordeus Luna, Alcides da Silva Diniz, Aléssio Tony Cavalcanti de Almeida, Naila Francis Paulo de Oliveira, Maria da Conceição Rodrigues Gonçalves, Roberto Texeira de Lima, Flávia Emília Leite de Lima Ferreira, Sônia Cristina Pereira de Oliveira Ramalho Diniz, Alexandre Sergio Silva, Ana Hermínia Andrade E Silva, Darlene Camati Persuhn, Maria José de Carvalho Cost. The direct correlation between oxidative stress and LDL-C levels in adults is maintained by the Friedewald and Martin equations, but the methylation levels in the MTHFR and ADRB3 genes differ. PloS one. vol 15. issue 12. 2021-01-19. PMID:33326437. |
this study compared the ldl-c concentrations estimated by two different equations and determined their associations with inflammatory status, oxidative stress, anthropometric variables, food intake and dna methylation levels in the lpl, adrb3 and mthfr genes. |
2021-01-19 |
2023-08-13 |
Not clear |
| Jiangbing Qiu, Ying Ji, Yuan Fang, Mingyue Zhao, Shuqin Wang, Qinghui Ai, Aifeng L. Response of fatty acids and lipid metabolism enzymes during accumulation, depuration and esterification of diarrhetic shellfish toxins in mussels (Mytilus galloprovincialis). Ecotoxicology and environmental safety. vol 206. 2020-12-04. PMID:32891913. |
enzymes involved in lipid metabolism, including acetyl-coenzyme a carboxylase (acc), fatty acid synthase (fas), lipoprotein lipase (lpl) and hepatic lipase (hl), were actively involved in the metabolism of fatty acids in the dg, whereas their activities were weak in muscle tissue during the feeding period. |
2020-12-04 |
2023-08-13 |
human |
| Pedro M Araújo, Ivan Viegas, Afonso D Rocha, Auxiliadora Villegas, John G Jones, Liliana Mendonça, Jaime A Ramos, José A Masero, José A Alve. Understanding how birds rebuild fat stores during migration: insights from an experimental study. Scientific reports. vol 9. issue 1. 2020-11-09. PMID:31296911. |
despite no significant differences found in enzymatic abundance (fasn, me1, acc and lpl) in stored fat, experimental godwits feeding on rice seeds presented high rates of dnl when compared to fly-larvae fed birds (~35 times more) and fasted godwits (no dnl activity). |
2020-11-09 |
2023-08-13 |
Not clear |
| Jie Gao, Gangqiang Ding, Qi Li, Lingxiao Gong, Jian Huang, Yaxin San. Tibet kefir milk decreases fat deposition by regulating the gut microbiota and gene expression of Lpl and Angptl4 in high fat diet-fed rats. Food research international (Ottawa, Ont.). vol 121. 2020-09-21. PMID:31108749. |
tkm feeding reduced abdominal fat mass from 33.9 g to 24.0 g and serum triglyceride (tg) from 0.75 mmol/l to 0.47 mmol/l, and caused lipoprotein lipase (lpl) to decrease from 395.8 ± 36.0 ng/l to 362.3 ± 64.4 ng/l in fat and increase from 287.3 ± 40.8 ng/l to 329.8 ± 48.5 ng/l and 312.5 ± 22.0 to 375.1 ± 30.8 ng/l in liver and serum, respectively. |
2020-09-21 |
2023-08-13 |
human |