| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N J Rothwel. Central effects of TNF alpha on thermogenesis and fever in the rat. Bioscience reports. vol 8. issue 4. 1989-01-03. PMID:3263887. |
intracerebroventricular (icv) injection of purified recombinant human tumour necrosis factor alpha (tnf alpha, 4-8 micrograms) in conscious rats, produced increases in colonic temperature (1.0 degrees c) and resting oxygen consumption (vo2, 14%) which were maximal after 80-90 minutes. |
1989-01-03 |
2023-08-11 |
human |
| B Persson, K Gradin, A Pettersson, T Hedne. Antihypertensive effects of ketanserin and ritanserin in the spontaneously hypertensive rat. Journal of cardiovascular pharmacology. vol 11 Suppl 1. 1988-11-17. PMID:2459509. |
this suggests that the 5-ht2- and alpha 1-blockade may complement each other in reducing the blood pressure, a conclusion supported by the observation that in the conscious rat, 5-ht2-receptor blockade by ritanserin enhanced the hypotensive response to prazosin. |
1988-11-17 |
2023-08-11 |
rat |
| C Stumpf, L Pichle. Synchronizing effect of the alpha 1-adrenoceptor agonist 2-(2-chloro-5-trifluoromethylphenylimino)imidazolidine on rabbit electroencephalogram. Arzneimittel-Forschung. vol 38. issue 6. 1988-11-03. PMID:3178916. |
the selective alpha 1-adrenoceptor agonist st 587 (2-(2-chloro-5-trifluoromethylphenylimino)imidazolidine) was tested in conscious rabbits in the dose range of 0.125 to 8 mg/kg cumulatively i.v. |
1988-11-03 |
2023-08-11 |
rabbit |
| J Moratinos, C Carpene, I de Pablos, M Revert. Role of alpha 1- and alpha 2-adrenoceptors in catecholamine-induced hyperglycaemia, lipolysis and insulin secretion in conscious fasted rabbits. British journal of pharmacology. vol 94. issue 2. 1988-08-29. PMID:2840157. |
role of alpha 1- and alpha 2-adrenoceptors in catecholamine-induced hyperglycaemia, lipolysis and insulin secretion in conscious fasted rabbits. |
1988-08-29 |
2023-08-11 |
Not clear |
| T Ahmed, J D'Brot, M Wasserman, R Muccitelli, M Robinson, S Tucker, B Marchett. Effect of verapamil on pulmonary and eicosanoid responses to endotoxin in awake sheep. Journal of applied physiology (Bethesda, Md. : 1985). vol 64. issue 4. 1988-07-15. PMID:3163996. |
in twelve conscious sheep, measurements of pulmonary vascular resistance (pvr), systemic vascular resistance (svr), lung resistance (rl), arterial po2 (pao2), leukocyte (wbc) count, arterial thromboxane b2 (txb2), prostaglandin (pg) f2 alpha, and 6-ketoprostaglandin f1 alpha (6-keto-pgf1 alpha) concentrations were obtained before and at predetermined intervals after a 10-min infusion of escherichia coli endotoxin (0.3 microgram/kg). |
1988-07-15 |
2023-08-11 |
Not clear |
| E J Austin, R J Wilkus, W T Longstret. Etiology and prognosis of alpha coma. Neurology. vol 38. issue 5. 1988-06-02. PMID:3362375. |
we reviewed our experience with alpha coma, the finding of predominantly alpha-frequency rhythms in the eegs of unconscious patients, and identified 50 patients. |
1988-06-02 |
2023-08-11 |
Not clear |
| E J Austin, R J Wilkus, W T Longstret. Etiology and prognosis of alpha coma. Neurology. vol 38. issue 5. 1988-06-02. PMID:3362375. |
after out-of-hospital cardiac arrest, the risk of never regaining consciousness or dying during hospitalization did not differ significantly between unconscious patients with (n = 24) and without (n = 69) alpha frequencies in their eegs. |
1988-06-02 |
2023-08-11 |
Not clear |
| G Katsuura, P E Gottschall, R R Dahl, A Arimur. Adrenocorticotropin release induced by intracerebroventricular injection of recombinant human interleukin-1 in rats: possible involvement of prostaglandin. Endocrinology. vol 122. issue 5. 1988-06-01. PMID:2834174. |
acth release induced by iv and intracerebroventricular (icv) injection of recombinant human interleukin-1 beta (il-1 beta) or alpha (il-1 alpha) was studied in conscious, unrestrained rats. |
1988-06-01 |
2023-08-11 |
human |
| Y Murakami, Y Kato, K Tojo, T Inoue, N Yanaihara, H Imur. Stimulation of growth hormone secretion by central administration of atrial natriuretic polypeptide in the rat. Endocrinology. vol 122. issue 5. 1988-06-01. PMID:2966063. |
intracerebroventricular (icv) injection of alpha-human atrial natriuretic polypeptide (alpha hanp) or alpha-rat anp (0.6 and 3 nmol/rat) elicited an increase in plasma gh levels both in conscious freely moving rats and in urethane-anesthetized rats when given at the trough of spontaneous gh secretion. |
1988-06-01 |
2023-08-11 |
rat |
| Y Murakami, Y Kato, K Tojo, T Inoue, N Yanaihara, H Imur. Stimulation of growth hormone secretion by central administration of atrial natriuretic polypeptide in the rat. Endocrinology. vol 122. issue 5. 1988-06-01. PMID:2966063. |
intracerebroventricular injection of alpha anp (3 nmol/rat) failed to stimulate gh secretion in conscious rats pretreated with cysteamine (30 mg/100 g bw, sc), a depletor of somatostatin (srif), and in conscious rats during constant iv infusion of srif (55 ng/ml). |
1988-06-01 |
2023-08-11 |
rat |
| Y Murakami, Y Kato, K Tojo, T Inoue, N Yanaihara, H Imur. Stimulation of growth hormone secretion by central administration of atrial natriuretic polypeptide in the rat. Endocrinology. vol 122. issue 5. 1988-06-01. PMID:2966063. |
gh release induced by iv injection of synthetic rat grf (200 ng/100 g bw) was exaggerated by alpha hanp (3 nmol/rat, icv) in conscious rats. |
1988-06-01 |
2023-08-11 |
rat |
| T Ahmed, B Weichman, M A Wasserman, R Muccitelli, S Tucker, B Marchett. Prevention and reversal of endotoxin-induced pulmonary hypertension by a leukotriene antagonist. The European respiratory journal. vol 1. issue 2. 1988-05-31. PMID:3282910. |
in six conscious sheep, haemodynamic measurements were obtained for the calculation of pulmonary vascular resistance (pvr), along with measurements of arterial oxygen tension (pao2), leucocyte count (wbc), thromboxane b2 (txb2), 6-keto-pgf1 alpha and pgf2 alpha, before and at predetermined intervals after a 10-min infusion of e. coli endotoxin (0.3 microgram/kg), with and without treatment with the leukotriene receptor antagonist, fpl-57231. |
1988-05-31 |
2023-08-11 |
Not clear |
| F Lefèvre-Borg, O Mathias, I Caver. Role of the sympathetic nervous system in blood pressure maintenance and in the antihypertensive effects of calcium antagonists in spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979). vol 11. issue 4. 1988-05-17. PMID:2451639. |
in conscious spontaneously hypertensive rats (shr), 2, 3, 6, 9, 12, and 16 months of age, the blockade of autonomic ganglia (with chlorisondamine) or postjunctional alpha 1-adrenergic receptors (with prazosin) or the depletion of peripheral norepinephrine stores (with syrosingopine), in contrast to the blockade of alpha 2-adrenergic receptors (with yohimbine, rauwolscine), produced a sustained decrease in the directly measured mean tail artery blood pressure. |
1988-05-17 |
2023-08-11 |
rat |
| F Lefèvre-Borg, O Mathias, I Caver. Role of the sympathetic nervous system in blood pressure maintenance and in the antihypertensive effects of calcium antagonists in spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979). vol 11. issue 4. 1988-05-17. PMID:2451639. |
these results indicate that, in conscious adult shr, norepinephrine released by peripheral sympathetic nervous terminals and humorally borne epinephrine stimulate almost exclusively post-junctional alpha 1-adrenergic receptors. |
1988-05-17 |
2023-08-11 |
rat |
| F Lefèvre-Borg, O Mathias, I Caver. Role of the sympathetic nervous system in blood pressure maintenance and in the antihypertensive effects of calcium antagonists in spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979). vol 11. issue 4. 1988-05-17. PMID:2451639. |
the latter findings may account for the lack of blood pressure-lowering effects of the studied calcium antagonists at doses that effectively antagonize alpha 2-adrenergic receptor-mediated vasoconstriction in conscious shr. |
1988-05-17 |
2023-08-11 |
rat |
| J P Koepke, S Jones, G F DiBon. Sodium responsiveness of central alpha 2-adrenergic receptors in spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979). vol 11. issue 4. 1988-05-17. PMID:2895735. |
the responsiveness of central nervous system alpha 2-adrenergic receptors in the neural control of renal function was compared in conscious spontaneously hypertensive rats (shr) and normotensive wistar-kyoto rats (wky) on normal or high sodium intake (3-4 weeks of 1% nacl for drinking). |
1988-05-17 |
2023-08-11 |
rat |
| J P Koepke, S Jones, G F DiBon. Sodium responsiveness of central alpha 2-adrenergic receptors in spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979). vol 11. issue 4. 1988-05-17. PMID:2895735. |
we conclude that the responsiveness of central nervous system alpha 2-adrenergic receptors regarding the neural control of renal function is increased by high sodium intake in conscious shr, but not in conscious normotensive wky. |
1988-05-17 |
2023-08-11 |
rat |
| A Waterman, A Livingston, O Bouchenaf. Analgesic effects of intrathecally-applied alpha 2-adrenoceptor agonists in conscious, unrestrained sheep. Neuropharmacology. vol 27. issue 2. 1988-05-06. PMID:2895432. |
analgesic effects of intrathecally-applied alpha 2-adrenoceptor agonists in conscious, unrestrained sheep. |
1988-05-06 |
2023-08-11 |
Not clear |
| A Waterman, A Livingston, O Bouchenaf. Analgesic effects of intrathecally-applied alpha 2-adrenoceptor agonists in conscious, unrestrained sheep. Neuropharmacology. vol 27. issue 2. 1988-05-06. PMID:2895432. |
intrathecal injections of small volumes of the alpha 2-adrenoceptor agonists, xylazine and clonidine, into the cervical region of the spinal cord of conscious unrestrained sheep produced a dose-dependent analgesia of the forelimbs as measured using a mechanical pressure device. |
1988-05-06 |
2023-08-11 |
Not clear |
| S M Gardiner, T Bennet. Involvement of beta 2-adrenoceptor-mediated mechanisms in the cardiovascular responses to alpha 1- and alpha 2-adrenoceptor antagonism in conscious, unrestrained, Long Evans and Brattleboro rats. British journal of pharmacology. vol 93. issue 1. 1988-04-28. PMID:2894880. |
involvement of beta 2-adrenoceptor-mediated mechanisms in the cardiovascular responses to alpha 1- and alpha 2-adrenoceptor antagonism in conscious, unrestrained, long evans and brattleboro rats. |
1988-04-28 |
2023-08-11 |
rat |