Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Marc P Allard-Ratick, Bryan R Kindya, Jay Khambhati, Marc C Engels, Pratik B Sandesara, Robert S Rosenson, Laurence S Sperlin. HDL: Fact, fiction, or function? HDL cholesterol and cardiovascular risk. European journal of preventive cardiology. vol 28. issue 2. 2021-09-23. PMID:33838035. |
high-density lipoprotein plays key roles in important pathways related to the development of atherosclerotic disease including reverse cholesterol transport, oxidation and inflammation, and endothelial function as well as in other physiological systems including immune system modulation, cellular apoptosis, and endothelial progenitor cell homeostasis. |
2021-09-23 |
2023-08-13 |
Not clear |
Fen Cao, Kun Wu, Yong-Zhi Zhu, Zhong-Wu Ba. Roles and Mechanisms of Dipeptidyl Peptidase 4 Inhibitors in Vascular Aging. Frontiers in endocrinology. vol 12. 2021-09-08. PMID:34489872. |
dipeptidyl peptidase-4 (dpp4) inhibitors, as a hypoglycemic agent, play a protective role in reversing vascular aging regardless of their effects in meliorating glycemic control in humans and animal models of type 2 diabetes mellitus (t2dm) through complex cellular mechanisms, including improving ec dysfunction, promoting ec proliferation and migration, alleviating ec senescence, obstructing ec apoptosis, suppressing the proliferation and migration of vsmcs, increasing circulating endothelial progenitor cell (epc) levels, and preventing the infiltration of mononuclear macrophages. |
2021-09-08 |
2023-08-13 |
Not clear |
Xudong Yao, Shengnan Yu, Xingzhi Jing, Jiachao Guo, Kai Sun, Fengjing Guo, Yaping Y. PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway. Stem cell research & therapy. vol 11. issue 1. 2021-06-18. PMID:32228695. |
pten inhibitor vo-ohpic attenuates gc-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating nrf2 signaling and inhibiting mitochondrial apoptosis pathway. |
2021-06-18 |
2023-08-13 |
Not clear |
Baichuan Li, Yang Xu, Yong Quan, Qiyan Cai, Yifan Le, Teng Ma, Zhi Liu, Guangyan Wu, Fei Wang, Chuncha Bao, Hongli L. Inhibition of RhoA/ROCK Pathway in the Early Stage of Hypoxia Ameliorates Depression in Mice ACS chemical neuroscience. vol 11. issue 17. 2021-06-18. PMID:32667781. |
then, we demonstrated that demyelination was associated with failures of oligodendrocyte precursor cell proliferation and differentiation and increased apoptosis of oligodendrocytes. |
2021-06-18 |
2023-08-13 |
mouse |
Vasantha Kalaivani, Abdul Jalee. Apolipoprotein(a), an enigmatic anti-angiogenic glycoprotein in human plasma: A curse or cure? Pharmacological research. vol 158. 2021-06-04. PMID:32430285. |
besides this, apo(a) can also exert its anti-angiogenic effect indirectly by inducing endothelial cell apoptosis, by inhibiting endothelial progenitor cell functions or by upregulating nuclear factors in endothelial cells via apo(a)-bound oxpls. |
2021-06-04 |
2023-08-13 |
human |
Robert T Flemmer, Sarah P Connolly, Brittany A Geizer, Joseph T Opferman, Jacqueline L Vanderlui. The Role of Mcl-1 in Embryonic Neural Precursor Cell Apoptosis. Frontiers in cell and developmental biology. vol 9. 2021-05-08. PMID:33959612. |
the role of mcl-1 in embryonic neural precursor cell apoptosis. |
2021-05-08 |
2023-08-13 |
mouse |
Jing Li, Panpan Meng, Riyang Zhou, Yiyue Zhang, Qing Li. Famciclovir leads to failure of hematopoiesis, but may have the benefit of relieving myeloid expansion in MDS-like zebrafish. Toxicology and applied pharmacology. vol 410. 2021-01-14. PMID:33207248. |
here, by utilizing a zebrafish model, we found that fcv exposure led to hematopoietic failure by impairing the proliferation of hematopoietic stem and progenitor cell (hspc) and inducing hspc apoptosis. |
2021-01-14 |
2023-08-13 |
zebrafish |
Eve Helena Rogers, Vanja Pekovic-Vaughan, John Alan Hun. Mechanical stretch and chronotherapeutic techniques for progenitor cell transplantation and biomaterials. BioMedicine. vol 8. issue 3. 2021-01-09. PMID:30141401. |
tensile stress, or compression loading are just two of these forces, and here we examine the role of cyclical or dynamic mechanical loading on progenitor cell proliferation and differentiation, as well as on other cellular processes including cell morphology, apoptosis and matrix mineralisation. |
2021-01-09 |
2023-08-13 |
human |
Haojun Yang, Jie Zhu, Guangyao Wang, Hanyang Liu, Yan Zhou, Jun Qia. STK35 Is Ubiquitinated by NEDD4L and Promotes Glycolysis and Inhibits Apoptosis Through Regulating the AKT Signaling Pathway, Influencing Chemoresistance of Colorectal Cancer. Frontiers in cell and developmental biology. vol 8. 2020-10-30. PMID:33117809. |
furthermore, stk35 overexpression could promote glycolysis, suppress apoptosis, upregulate p-akt, and counteract the antitumor functions of 5-fu and neural precursor cell expressed developmentally downregulated gene 4-like (nedd4l) in crc cells. |
2020-10-30 |
2023-08-13 |
Not clear |
Paul Hasty, Judith Campisi, Z Dave Shar. Do p53 stress responses impact organismal aging? Translational cancer research. vol 5. issue 6. 2020-09-29. PMID:30984573. |
to accelerate aging, p53 induces apoptosis or cell cycle arrest as a prerequisite to cellular senescence; both can impair the mobilization of stem and progenitor cell populations. |
2020-09-29 |
2023-08-13 |
mouse |
Pere Gascón, Andriy Krendyukov, Nicola Mathieson, Matti Aapr. Epoetin alfa for the treatment of myelodysplastic syndrome-related anemia: A review of clinical data, clinical guidelines, and treatment protocols. Leukemia research. vol 81. 2020-05-21. PMID:31005849. |
myelodysplastic syndromes (mds) are characterized by ineffective hematopoiesis, leading to hematopoietic precursor cell apoptosis and peripheral blood cytopenias. |
2020-05-21 |
2023-08-13 |
Not clear |
Yihong Li, Fuqiang Yuan, Ting Wu, Lanhai Lu, Jie Liu, Wenke Feng, Shao-Yu Che. Sulforaphane protects against ethanol-induced apoptosis in neural crest cells through restoring epithelial-mesenchymal transition by epigenetically modulating the expression of Snail1. Biochimica et biophysica acta. Molecular basis of disease. vol 1865. issue 10. 2020-05-13. PMID:31295528. |
ethanol-induced apoptosis in neural crest cells (nccs), a multipotent progenitor cell population, is implicated in the fetal alcohol spectrum disorders (fasd). |
2020-05-13 |
2023-08-13 |
Not clear |
Xuming Wang, Jin Duan, Weiping Fu, Zhaowu Yin, Jianing Sheng, Zhuyun Lei, Han Wan. Decreased expression of NEDD4L contributes to NSCLC progression and metastasis. Biochemical and biophysical research communications. vol 513. issue 2. 2020-04-27. PMID:30967264. |
recent evidence indicated that neural precursor cell expressed, developmentally down-regulated 4-like (nedd4l) has a critical role in the regulation of cellular processes such as apoptosis, transport and metastasis, and is downregulated in several types of cancers. |
2020-04-27 |
2023-08-13 |
Not clear |
Alicia M McConnell, Bindu Konda, David G Kirsch, Barry R Strip. Distal airway epithelial progenitor cells are radiosensitive to High-LET radiation. Scientific reports. vol 6. 2019-11-20. PMID:27659946. |
clonal expansion following high-let radiation exposure was correlated with elevated progenitor cell apoptosis, persistent γ-h2ax foci, and defects in mitotic progression of distal airway progenitors. |
2019-11-20 |
2023-08-13 |
Not clear |
Meihui Wang, Liang Xia, Guosheng F. Lipopolysaccharide pretreatment inhibits oxidative stress-induced endothelial progenitor cell apoptosis via a TLR4-mediated PI3K/Akt/ NF-κB p65 signaling pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 65. issue 4. 2019-08-29. PMID:31078159. |
lipopolysaccharide pretreatment inhibits oxidative stress-induced endothelial progenitor cell apoptosis via a tlr4-mediated pi3k/akt/ nf-κb p65 signaling pathway. |
2019-08-29 |
2023-08-13 |
Not clear |
Haiming Jin, Zengjie Zhang, Chengui Wang, Qian Tang, Jianle Wang, Xueqin Bai, Qingqing Wang, Majid Nisar, Naifeng Tian, Quan Wang, Cong Mao, Xiaolei Zhang, Xiangyang Wan. Melatonin protects endothelial progenitor cells against AGE-induced apoptosis via autophagy flux stimulation and promotes wound healing in diabetic mice. Experimental & molecular medicine. vol 50. issue 11. 2019-06-04. PMID:30459300. |
increased apoptosis and endothelial progenitor cell (epc) dysfunction are implicated in delayed diabetic wound healing. |
2019-06-04 |
2023-08-13 |
mouse |
Svetlana Demyanenko, Anatoly Uzdensk. Profiling of Signaling Proteins in Penumbra After Focal Photothrombotic Infarct in the Rat Brain Cortex. Molecular neurobiology. vol 54. issue 9. 2019-05-23. PMID:27771897. |
these included over-expression of proteins initiating, regulating, or executing various apoptosis stages (caspases, smac/diablo, bcl-10, phosphatidylserine receptor (psr), prostate apoptosis response 4 (par4), e2f1, p75, p38, jnk, p53, growth arrest and dna damage inducible protein 153 (gadd153), glutamate decarboxylases (gad65/67), nmdar2a, c-myc) and antiapoptotic proteins (bcl-x, p63, mdm2, p21waf-1, erk1/2, erk5, map kinase-activated protein kinase-2 (makapk2), pkcα, pkcβ, pkcμ, raf1, protein phosphatases 1α and map kinase phosphatase-1 (mkp-1), neural precursor cell expressed, developmentally down-regulated 8 (nedd8), estrogen and egf receptors, calmodulin, camkiiα, camkiv, amyloid precursor protein (app), nicastrin). |
2019-05-23 |
2023-08-13 |
rat |
Alice Valentin-Torres, Carine Savarin, Joslyn Barnett, Cornelia C Bergman. Blockade of sustained tumor necrosis factor in a transgenic model of progressive autoimmune encephalomyelitis limits oligodendrocyte apoptosis and promotes oligodendrocyte maturation. Journal of neuroinflammation. vol 15. issue 1. 2019-04-08. PMID:29690885. |
using a mouse model of progressive ms, this study evaluates the effects of sustained tnf on oligodendrocyte (olg) apoptosis and olg precursor cell (opc) differentiation. |
2019-04-08 |
2023-08-13 |
mouse |
Geon A Kim, Yeonjae Lee, Hyun Jin Kim, Hyun Ju Oh, Sung Keun Kang, Jeong Chan Ra, Byeong Chun Le. Intravenous human endothelial progenitor cell administration into aged mice enhances embryo development and oocyte quality by reducing inflammation, endoplasmic reticulum stress and apoptosis. The Journal of veterinary medical science. vol 80. issue 12. 2019-01-17. PMID:30369585. |
intravenous human endothelial progenitor cell administration into aged mice enhances embryo development and oocyte quality by reducing inflammation, endoplasmic reticulum stress and apoptosis. |
2019-01-17 |
2023-08-13 |
mouse |
Mina Azimi, Tien T Le, Nadean L Brow. Presenilin gene function and Notch signaling feedback regulation in the developing mouse lens. Differentiation; research in biological diversity. vol 102. 2018-11-21. PMID:30059908. |
by directly comparing psen single and double mutant phenotypes during mouse lens development, we found a stronger requirement for psen1, although both genes are needed for progenitor cell growth and to prevent apoptosis. |
2018-11-21 |
2023-08-13 |
mouse |