| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuli Wang, Stuart J Decker, Judith Sebolt-Leopol. Knockdown of Chk1, Wee1 and Myt1 by RNA interference abrogates G2 checkpoint and induces apoptosis. Cancer biology & therapy. vol 3. issue 3. 2004-11-26. PMID:14726685. |
wee1 downregulation sensitized hela cells to adriamycin trade mark -induced apoptosis. |
2004-11-26 |
2023-08-12 |
human |
| Yuli Wang, Stuart J Decker, Judith Sebolt-Leopol. Knockdown of Chk1, Wee1 and Myt1 by RNA interference abrogates G2 checkpoint and induces apoptosis. Cancer biology & therapy. vol 3. issue 3. 2004-11-26. PMID:14726685. |
reduction in wee1, chk1, or myt1 levels did not sensitize normal human mammary epithelial cells (hmec) cells to adriamycin trade mark -induced apoptosis unlike the situation in hela cells. |
2004-11-26 |
2023-08-12 |
human |
| Sanaa M Nabha, Ramzi M Mohammad, Mahmoud H Dandashi, Brigitte Coupaye-Gerard, Amro Aboukameel, George R Pettit, Ayad M Al-Kati. Combretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukemia cell line independent of caspase activation and poly(ADP-ribose) polymerase cleavage. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 8. issue 8. 2003-02-26. PMID:12171907. |
for this we studied the effect of ca4p on selected markers of apoptosis [caspases 9 and 3, poly(adp-ribose) polymerase (parp), bcl-2, and bax] and g2-m protein regulators (p53, mdm2, 14-3-3sigma, gadd45, cdc2, cdc25, chk1, wee1, p21, and cyclin b1). |
2003-02-26 |
2023-08-12 |
human |
| Donald M Price, Zhigang Jin, Simon Rabinovitch, Shelagh D Campbel. Ectopic expression of the Drosophila Cdk1 inhibitory kinases, Wee1 and Myt1, interferes with the second mitotic wave and disrupts pattern formation during eye development. Genetics. vol 161. issue 2. 2003-01-10. PMID:12072468. |
we also observed interactions with p53, which suggest that wee1 and myt1 activity can block apoptosis. |
2003-01-10 |
2023-08-12 |
drosophila_melanogaster |
| G Tzivion, Y H Shen, J Zh. 14-3-3 proteins; bringing new definitions to scaffolding. Oncogene. vol 20. issue 44. 2001-11-01. PMID:11607836. |
cdc25, wee1, cdk2, centrosome), apoptosis (e.g. |
2001-11-01 |
2023-08-12 |
Not clear |
| J J Smith, E K Evans, M Murakami, M B Moyer, M A Moseley, G Vande Woude, S Kornblut. Wee1-regulated apoptosis mediated by the crk adaptor protein in Xenopus egg extracts. The Journal of cell biology. vol 151. issue 7. 2001-02-08. PMID:11134069. |
we have demonstrated a specific interaction between tyrosine-phosphorylated wee1 and the crk sh2 domain and have shown that recombinant wee1 can restore apoptosis to an extract depleted of sh2 interactors. |
2001-02-08 |
2023-08-12 |
xenopus_laevis |
| J J Smith, E K Evans, M Murakami, M B Moyer, M A Moseley, G Vande Woude, S Kornblut. Wee1-regulated apoptosis mediated by the crk adaptor protein in Xenopus egg extracts. The Journal of cell biology. vol 151. issue 7. 2001-02-08. PMID:11134069. |
moreover, exogenous wee1 accelerated apoptosis in egg extracts, and this acceleration was largely dependent on the presence of endogenous crk protein. |
2001-02-08 |
2023-08-12 |
xenopus_laevis |
| J J Smith, E K Evans, M Murakami, M B Moyer, M A Moseley, G Vande Woude, S Kornblut. Wee1-regulated apoptosis mediated by the crk adaptor protein in Xenopus egg extracts. The Journal of cell biology. vol 151. issue 7. 2001-02-08. PMID:11134069. |
as other cdk inhibitors, such as roscovitine and myt1, did not act like wee1 to accelerate apoptosis, we propose that wee1-crk complexes signal in a novel apoptotic pathway, which may be unrelated to wee1's role as a cell cycle regulator. |
2001-02-08 |
2023-08-12 |
xenopus_laevis |
| S D Leach, C D Scatena, C J Keefer, H A Goodman, S Y Song, L Yang, J A Pietenpo. Negative regulation of Wee1 expression and Cdc2 phosphorylation during p53-mediated growth arrest and apoptosis. Cancer research. vol 58. issue 15. 1998-08-27. PMID:9699647. |
negative regulation of wee1 expression and cdc2 phosphorylation during p53-mediated growth arrest and apoptosis. |
1998-08-27 |
2023-08-12 |
mouse |
| S D Leach, C D Scatena, C J Keefer, H A Goodman, S Y Song, L Yang, J A Pietenpo. Negative regulation of Wee1 expression and Cdc2 phosphorylation during p53-mediated growth arrest and apoptosis. Cancer research. vol 58. issue 15. 1998-08-27. PMID:9699647. |
under conditions of either growth arrest or apoptosis, p53 activation resulted in the down-regulation of wee1 expression and dephosphorylation of cdc2. |
1998-08-27 |
2023-08-12 |
mouse |
| B B Zhou, H Li, J Yuan, M W Kirschne. Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 12. 1998-07-09. PMID:9618490. |
instead, activation of these kinases seems to result from both a rapid cleavage of wee1 (an inhibitory kinase of cdc2 and cdk2) and inactivation of anaphase-promoting complex (the specific system for cyclin degradation), in which cdc27 homolog is cleaved during apoptosis. |
1998-07-09 |
2023-08-12 |
Not clear |
| S L Yao, K A McKenna, S J Sharkis, A Bed. Requirement of p34cdc2 kinase for apoptosis mediated by the Fas/APO-1 receptor and interleukin 1beta-converting enzyme-related proteases. Cancer research. vol 56. issue 20. 1996-11-04. PMID:8840958. |
inhibition of p34cdc2 activity by transient overexpression of a dominant-negative cdc2 construct or human wee1 kinase inhibited fas-mediated apoptosis. |
1996-11-04 |
2023-08-12 |
human |
| G Chen, L Shi, D W Litchfield, A H Greenber. Rescue from granzyme B-induced apoptosis by Wee1 kinase. The Journal of experimental medicine. vol 181. issue 6. 1995-06-23. PMID:7539047. |
rescue from granzyme b-induced apoptosis by wee1 kinase. |
1995-06-23 |
2023-08-12 |
Not clear |
| G Chen, L Shi, D W Litchfield, A H Greenber. Rescue from granzyme B-induced apoptosis by Wee1 kinase. The Journal of experimental medicine. vol 181. issue 6. 1995-06-23. PMID:7539047. |
cells that expressed wee1 in the nucleus became resistant to apoptosis induced by granzyme b and perforin. |
1995-06-23 |
2023-08-12 |
Not clear |
| G Chen, L Shi, D W Litchfield, A H Greenber. Rescue from granzyme B-induced apoptosis by Wee1 kinase. The Journal of experimental medicine. vol 181. issue 6. 1995-06-23. PMID:7539047. |
thus, wee1 can rescue cells from granzyme-induced apoptosis by preventing cdc2 dephosphorylation. |
1995-06-23 |
2023-08-12 |
Not clear |