| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rosaria Chilà, Alessandra Basana, Monica Lupi, Federica Guffanti, Eugenio Gaudio, Andrea Rinaldi, Luciano Cascione, Valentina Restelli, Chiara Tarantelli, Francesco Bertoni, Giovanna Damia, Laura Carrass. Combined inhibition of Chk1 and Wee1 as a new therapeutic strategy for mantle cell lymphoma. Oncotarget. vol 6. issue 5. 2016-03-28. PMID:25428911. |
the combined inhibition of chk1 and wee1 was strongly synergistic in mcl cells, leading to deregulation of the cell cycle, with increased activity of cdk2 and cdk1, and activation of apoptosis. |
2016-03-28 |
2023-08-13 |
mouse |
| Feng-Feng Xie, Shi-Shi Pan, Rong-Ying Ou, Zhen-Zhen Zheng, Xiao-Xiu Huang, Meng-Ting Jian, Jian-Ge Qiu, Wen-Ji Zhang, Qi-Wei Jiang, Yang Yang, Wen-Feng Li, Zhi Shi, Xiao-Jian Ya. Volasertib suppresses tumor growth and potentiates the activity of cisplatin in cervical cancer. American journal of cancer research. vol 5. issue 12. 2016-02-17. PMID:26885445. |
in the present study, we show that volasertib can markedly induce cell growth inhibition, cell cycle arrest at g2/m phase and apoptosis with the decreased protein expressions of plk1 substrates survivin and wee1 in human cervical cancer cells. |
2016-02-17 |
2023-08-13 |
human |
| Marieke Aarts, Ilirjana Bajrami, Maria T Herrera-Abreu, Richard Elliott, Rachel Brough, Alan Ashworth, Christopher J Lord, Nicholas C Turne. Functional Genetic Screen Identifies Increased Sensitivity to WEE1 Inhibition in Cells with Defects in Fanconi Anemia and HR Pathways. Molecular cancer therapeutics. vol 14. issue 4. 2016-01-26. PMID:25673822. |
wee1 inhibitors synergize with dna-damaging agents that arrest cells in s-phase by triggering direct mitotic entry without completing dna synthesis, resulting in catastrophic chromosome fragmentation and apoptosis. |
2016-01-26 |
2023-08-13 |
Not clear |
| Victoria C Silva, Melissa Plooster, Jessica C Leung, Lynne Cassimeri. A delay prior to mitotic entry triggers caspase 8-dependent cell death in p53-deficient Hela and HCT-116 cells. Cell cycle (Georgetown, Tex.). vol 14. issue 7. 2015-12-28. PMID:25602147. |
to test these possibilities, we abrogated the cell cycle delay by inhibiting wee1 in synchronized, stathmin-depleted cells and found that apoptosis was reduced to control levels. |
2015-12-28 |
2023-08-13 |
Not clear |
| Julio Vera, Yvonne Raatz, Olaf Wolkenhauer, Tina Kottek, Animesh Bhattacharya, Jan C Simon, Manfred Kun. Chk1 and Wee1 control genotoxic-stress induced G2-M arrest in melanoma cells. Cellular signalling. vol 27. issue 5. 2015-12-15. PMID:25683911. |
wee1 inhibition under doxorubicin pulse-treatment reduces g2-m arrest and induces apoptosis. |
2015-12-15 |
2023-08-13 |
Not clear |
| Joyce P Y Mak, Wing Yu Man, Hoi Tang Ma, Randy Y C Poo. Pharmacological targeting the ATR-CHK1-WEE1 axis involves balancing cell growth stimulation and apoptosis. Oncotarget. vol 5. issue 21. 2015-08-31. PMID:25301733. |
small-molecule inhibitors of chk1 (azd7762) or wee1 (mk-1775) induced mitotic catastrophe, as characterized by dephosphorylation of cdk1(tyr15), phosphorylation of histone h39(ser10), and apoptosis. |
2015-08-31 |
2023-08-13 |
Not clear |
| Joyce P Y Mak, Wing Yu Man, Hoi Tang Ma, Randy Y C Poo. Pharmacological targeting the ATR-CHK1-WEE1 axis involves balancing cell growth stimulation and apoptosis. Oncotarget. vol 5. issue 21. 2015-08-31. PMID:25301733. |
unexpectedly, partial inhibition of wee1 and chk1 had the opposite effect of accelerating the cell cycle without inducing apoptosis, thereby increasing the overall cell proliferation. |
2015-08-31 |
2023-08-13 |
Not clear |
| Radim Havelek, Jana Cmielova, Karel Kralovec, Lenka Bruckova, Zuzana Bilkova, Ivana Fousova, Zuzana Sinkorova, Jirina Vavrova, Martina Rezacov. Specific inhibition of Wee1 kinase and Rad51 recombinase: a strategy to enhance the sensitivity of leukemic T-cells to ionizing radiation-induced DNA double-strand breaks. Biochemical and biophysical research communications. vol 453. issue 3. 2015-07-08. PMID:25285634. |
the objectives of the current study were to investigate the effects of the small molecule inhibitors of wee1 kinase ii (681641) and rad51 (ri-1) on cell cycle progression, dna double-strand breaks repair and apoptosis following ionizing radiation exposure in human leukemic t-cells jurkat and molt-4. |
2015-07-08 |
2023-08-13 |
human |
| Radim Havelek, Jana Cmielova, Karel Kralovec, Lenka Bruckova, Zuzana Bilkova, Ivana Fousova, Zuzana Sinkorova, Jirina Vavrova, Martina Rezacov. Specific inhibition of Wee1 kinase and Rad51 recombinase: a strategy to enhance the sensitivity of leukemic T-cells to ionizing radiation-induced DNA double-strand breaks. Biochemical and biophysical research communications. vol 453. issue 3. 2015-07-08. PMID:25285634. |
pre-treatment with the wee1 681641 or rad51 ri-1 inhibitor alone increased the sensitivity of jurkat cells to irradiation, however combining both inhibitors together resulted in a further enhancement of apoptosis. |
2015-07-08 |
2023-08-13 |
human |
| Radim Havelek, Jana Cmielova, Karel Kralovec, Lenka Bruckova, Zuzana Bilkova, Ivana Fousova, Zuzana Sinkorova, Jirina Vavrova, Martina Rezacov. Specific inhibition of Wee1 kinase and Rad51 recombinase: a strategy to enhance the sensitivity of leukemic T-cells to ionizing radiation-induced DNA double-strand breaks. Biochemical and biophysical research communications. vol 453. issue 3. 2015-07-08. PMID:25285634. |
pre-treatment with rad51 ri-1 had no effect on apoptosis induction; however wee1 681641 increased ionizing radiation-induced cell death in molt-4 cells. |
2015-07-08 |
2023-08-13 |
human |
| Cara Horny, Muralimanoharan Sri Balasubashini, Krishna Komanduri, Manonmani Ganapathy, I-Tien Yeh, Rita Ghosh, Addanki P Kuma. 2-methoxyestradiol Prevents LNCaP Tumor Development in Nude Mice: Potential Role of G2/M Regulatory Proteins. Journal of cell death. vol 2. 2015-06-30. PMID:26124676. |
the observed tumor growth inhibition was associated with induction of apoptosis, increased expression of wee1 kinase and p34cdc2. |
2015-06-30 |
2023-08-13 |
mouse |
| Chin-Chih Ho, An-Cheng Huang, Chun-Shu Yu, Jin-Cherng Lien, Shin-Hwar Wu, Yi-Ping Huang, Hui-Ying Huang, Jehn-Hwa Kuo, Wen-Yen Liao, Jai-Sing Yang, Po-Yuan Chen, Jing-Gung Chun. Ellagic acid induces apoptosis in TSGH8301 human bladder cancer cells through the endoplasmic reticulum stress- and mitochondria-dependent signaling pathways. Environmental toxicology. vol 29. issue 11. 2015-04-07. PMID:23554011. |
western blotting assay showed that ellagic acid promoted p21, p53 and decreased cdc2 and wee1 for leading to g0/g1 phase arrest and promoting bad expression, aif and endo g, cytochrome c, caspase-9 and -3 for leading to apoptosis in tsgh8301 cells. |
2015-04-07 |
2023-08-12 |
human |
| Ellen Weisberg, Atsushi Nonami, Zhao Chen, Feiyang Liu, Jianming Zhang, Martin Sattler, Erik Nelson, Kristen Cowens, Amanda L Christie, Constantine Mitsiades, Kwok-Kin Wong, Qingsong Liu, Nathanael Gray, James D Griffi. Identification of Wee1 as a novel therapeutic target for mutant RAS-driven acute leukemia and other malignancies. Leukemia. vol 29. issue 1. 2015-03-24. PMID:24791855. |
the specificity of wee1 as the target of mk-1775 was validated by wee1 knockdown, as well as partial reversal of drug combination-induced apoptosis by a cyclin-dependent kinase 1 (cdk1) inhibitor. |
2015-03-24 |
2023-08-13 |
human |
| William N Pappano, Qian Zhang, Lora A Tucker, Chris Tse, Jieyi Wan. Genetic inhibition of the atypical kinase Wee1 selectively drives apoptosis of p53 inactive tumor cells. BMC cancer. vol 14. 2015-03-09. PMID:24927813. |
genetic inhibition of the atypical kinase wee1 selectively drives apoptosis of p53 inactive tumor cells. |
2015-03-09 |
2023-08-13 |
Not clear |
| Tomomi Kogiso, Hikaru Nagahara, Etsuko Hashimoto, Shunichi Ariizumi, Masakazu Yamamoto, Keiko Shirator. Efficient induction of apoptosis by wee1 kinase inhibition in hepatocellular carcinoma cells. PloS one. vol 9. issue 6. 2015-03-03. PMID:24960176. |
efficient induction of apoptosis by wee1 kinase inhibition in hepatocellular carcinoma cells. |
2015-03-03 |
2023-08-13 |
human |
| Tomomi Kogiso, Hikaru Nagahara, Etsuko Hashimoto, Shunichi Ariizumi, Masakazu Yamamoto, Keiko Shirator. Efficient induction of apoptosis by wee1 kinase inhibition in hepatocellular carcinoma cells. PloS one. vol 9. issue 6. 2015-03-03. PMID:24960176. |
here we demonstrated that tgf-β1-induced apoptosis is mediated by decreased phosphorylation of cdc2 at tyr15 accompanied by down-regulation of wee1 kinase expression. |
2015-03-03 |
2023-08-13 |
human |
| Tomomi Kogiso, Hikaru Nagahara, Etsuko Hashimoto, Shunichi Ariizumi, Masakazu Yamamoto, Keiko Shirator. Efficient induction of apoptosis by wee1 kinase inhibition in hepatocellular carcinoma cells. PloS one. vol 9. issue 6. 2015-03-03. PMID:24960176. |
as expected from these results, a wee1 kinase inhibitor efficiently induced apoptosis in hcc cells in the absence of tgf-β1 treatment. |
2015-03-03 |
2023-08-13 |
human |
| Annemie A Van Linden, Dmitry Baturin, James B Ford, Susan P Fosmire, Lori Gardner, Christopher Korch, Philip Reigan, Christopher C Porte. Inhibition of Wee1 sensitizes cancer cells to antimetabolite chemotherapeutics in vitro and in vivo, independent of p53 functionality. Molecular cancer therapeutics. vol 12. issue 12. 2014-08-04. PMID:24121103. |
mechanistic studies indicate that inhibition of wee1 abrogates the s-phase checkpoint and augments apoptosis induced by cytarabine. |
2014-08-04 |
2023-08-12 |
mouse |
| Duane H Hamilton, Bruce Huang, Romaine I Fernando, Kwong-Yok Tsang, Claudia Palen. WEE1 inhibition alleviates resistance to immune attack of tumor cells undergoing epithelial-mesenchymal transition. Cancer research. vol 74. issue 9. 2014-07-06. PMID:24626094. |
in support of a causal connection, pretreatment of tumor cells with a specific inhibitor of wee1, a negative regulator kinase of cdk1, could counter the defective apoptosis of tumor cells expressing high levels of brachyury. |
2014-07-06 |
2023-08-12 |
human |
| H Eirik Haarberg, Kim H T Paraiso, Elizabeth Wood, Vito W Rebecca, Vernon K Sondak, John M Koomen, Keiran S M Smalle. Inhibition of Wee1, AKT, and CDK4 underlies the efficacy of the HSP90 inhibitor XL888 in an in vivo model of NRAS-mutant melanoma. Molecular cancer therapeutics. vol 12. issue 6. 2014-02-24. PMID:23538902. |
blockade of wee1, using either sirna knockdown or the inhibitor mk1775, was associated with significant levels of growth inhibition and apoptosis induction. |
2014-02-24 |
2023-08-12 |
Not clear |