| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanyan Zhao, Jiaying Wang, Xuehui Li. TRPV4 induces apoptosis via p38 MAPK in human lung cancer cells. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 54. issue 12. 2021-10-22. PMID:34669779. |
collectively, our findings indicated that trpv4 induced apoptosis via p38 mapk in human lung cancer cells and suggested that trpv4 was a potential target for therapy of human lung cancers. |
2021-10-22 |
2023-08-13 |
human |
| Chunsong Yang, Mengqing Si, Jing Zho. Silencing TRPV4 partially reverses the neurotoxic effects caused by excess Ketamine. The Journal of toxicological sciences. vol 46. issue 2. 2021-07-12. PMID:33536391. |
after silencing trpv4, we tested cell viability and apoptosis. |
2021-07-12 |
2023-08-13 |
rat |
| Na Liu, Jinyu Liu, Xianbin Wen, Liping Bai, Ruifei Shao, Jie Ba. TRPV4 contributes to ER stress: Relation to apoptosis in the MPP Life sciences. vol 261. 2020-11-19. PMID:32961227. |
trpv4 contributes to er stress: relation to apoptosis in the mpp parkinson's disease (pd) is a multifactorial neurodegenerative disorder. |
2020-11-19 |
2023-08-13 |
Not clear |
| Jin-Zhuo Ning, Wei Li, Fan Cheng, Wei-Min Yu, Ting Rao, Yuan Ruan, Run Yuan, Xiao-Bin Zhang, Dong Zhuo, Yang Du, Cheng-Cheng Xia. MiR-29a Suppresses Spermatogenic Cell Apoptosis in Testicular Ischemia-Reperfusion Injury by Targeting TRPV4 Channels. Frontiers in physiology. vol 8. 2020-10-01. PMID:29238305. |
mir-29a suppresses spermatogenic cell apoptosis in testicular ischemia-reperfusion injury by targeting trpv4 channels. |
2020-10-01 |
2023-08-13 |
Not clear |
| N Pairet, S Mang, T Kiechle, N Laufhäger, P Dietl, D J Lam. Differential modulation of transendothelial electrical resistance by TRPV4 agonists is mediated by apoptosis and/or necrosis. Biochemistry and biophysics reports. vol 20. 2020-09-30. PMID:31650038. |
differential modulation of transendothelial electrical resistance by trpv4 agonists is mediated by apoptosis and/or necrosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jingjing Shen, Liu Tu, Di Chen, Ting Tan, Yan Wang, Shali Wan. TRPV4 channels stimulate Ca Brain research bulletin. vol 146. 2020-03-10. PMID:30508606. |
trpv4 channels stimulate ca individuals with intracerebral hemorrhage (ich) suffer varying degrees of neurological dysfunction as a result of neuronal apoptosis, and thus, maintenance of neuronal survival may be crucial to prevent ich brain injury. |
2020-03-10 |
2023-08-13 |
mouse |
| Bo Xu, Runlin Xing, Zhengquan Huang, Songjiang Yin, Xiaochen Li, Li Zhang, Liang Ding, Peimin Wan. Excessive mechanical stress induces chondrocyte apoptosis through TRPV4 in an anterior cruciate ligament-transected rat osteoarthritis model. Life sciences. vol 228. 2019-06-24. PMID:31055086. |
excessive mechanical stress induces chondrocyte apoptosis through trpv4 in an anterior cruciate ligament-transected rat osteoarthritis model. |
2019-06-24 |
2023-08-13 |
rat |
| Bo Xu, Runlin Xing, Zhengquan Huang, Songjiang Yin, Xiaochen Li, Li Zhang, Liang Ding, Peimin Wan. Excessive mechanical stress induces chondrocyte apoptosis through TRPV4 in an anterior cruciate ligament-transected rat osteoarthritis model. Life sciences. vol 228. 2019-06-24. PMID:31055086. |
here, we investigated the potential role of trpv4 in chondrocyte apoptosis induced by excessive mechanical stress. |
2019-06-24 |
2023-08-13 |
rat |
| Yu Fang, Guoxing Liu, Chengzhi Xie, Ke Qian, Xiaohua Lei, Qiang Liu, Gao Liu, Zhenyu Cao, Jie Fu, Huihui Du, Sushun Liu, Shengfu Huang, Jixiong Hu, Xundi X. Pharmacological inhibition of TRPV4 channel suppresses malignant biological behavior of hepatocellular carcinoma via modulation of ERK signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 101. 2018-10-02. PMID:29635900. |
pharmacological inhibition of trpv4 channels in hcc cells with the specific antagonist hc-067047 suppressed cell proliferation, induced apoptosis and decreased the migration capability by attenuating the epithelial-mesenchymal transition (emt) process in vitro. |
2018-10-02 |
2023-08-13 |
mouse |
| Yu Fang, Guoxing Liu, Chengzhi Xie, Ke Qian, Xiaohua Lei, Qiang Liu, Gao Liu, Zhenyu Cao, Jie Fu, Huihui Du, Sushun Liu, Shengfu Huang, Jixiong Hu, Xundi X. Pharmacological inhibition of TRPV4 channel suppresses malignant biological behavior of hepatocellular carcinoma via modulation of ERK signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 101. 2018-10-02. PMID:29635900. |
the p-erk expression was apparently repressed after treatment with the trpv4 antagonist, further blockade of the erk pathway with u0126 could significantly aggravate hcc cells apoptosis. |
2018-10-02 |
2023-08-13 |
mouse |
| Yu Fang, Guoxing Liu, Chengzhi Xie, Ke Qian, Xiaohua Lei, Qiang Liu, Gao Liu, Zhenyu Cao, Jie Fu, Huihui Du, Sushun Liu, Shengfu Huang, Jixiong Hu, Xundi X. Pharmacological inhibition of TRPV4 channel suppresses malignant biological behavior of hepatocellular carcinoma via modulation of ERK signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 101. 2018-10-02. PMID:29635900. |
together, our studies showed that the antitumor effects caused by trpv4 channel inhibition in hcc cell lines might be attributed to the suppression of emt process and inactivation of p-erk which induced subsequent cell apoptosis. |
2018-10-02 |
2023-08-13 |
mouse |
| Wei Li, Jin-Zhuo Ning, Fang Cheng, Wei-Min Yu, Ting Rao, Yuan Ruan, Run Yuan, Xiao-Bin Zhang, Yang Du, Cheng-Cheng Xia. MALAT1 Promotes Cell Apoptosis and Suppresses Cell Proliferation in Testicular Ischemia-Reperfusion Injury by Sponging MiR-214 to Modulate TRPV4 Expression. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 46. issue 2. 2018-07-19. PMID:29870987. |
malat1 promotes cell apoptosis and suppresses cell proliferation in testicular ischemia-reperfusion injury by sponging mir-214 to modulate trpv4 expression. |
2018-07-19 |
2023-08-13 |
Not clear |
| Aida Olivan-Viguera, Angel Luis Garcia-Otin, Javier Lozano-Gerona, Edgar Abarca-Lachen, Ana J Garcia-Malinis, Kirk L Hamilton, Yolanda Gilaberte, Esther Pueyo, Ralf Köhle. Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes. PloS one. vol 13. issue 1. 2018-02-15. PMID:29293584. |
pharmacological activation of trpv4 produces immediate cell damage and induction of apoptosis in human melanoma cells and hacat keratinocytes. |
2018-02-15 |
2023-08-13 |
human |
| Kuo-Feng Huang, Kuo-Hsing Ma, Pei-Shan Liu, Bo-Wei Chen, Sheau-Huei Chue. Baicalein increases keratin 1 and 10 expression in HaCaT keratinocytes via TRPV4 receptor activation. Experimental dermatology. vol 25. issue 8. 2018-01-25. PMID:27060689. |
removal of extracellular ca(2+) or blockade of ca(2+) influx by pharmacological inhibition or silencing of the trpv4 receptor did not affect growth arrest, ros generation or apoptosis, but inhibited baicalein-induced erk phosphorylation and k1/k10 expression. |
2018-01-25 |
2023-08-13 |
Not clear |
| A A Peters, S Y N Jamaludin, K T D S Yapa, S Chalmers, A P Wiegmans, H F Lim, M J G Milevskiy, I Azimi, F M Davis, K S Northwood, E Pera, D L Marcial, E Dray, N J Waterhouse, P J Cabot, T J Gonda, P A Kenny, M A Brown, K K Khanna, S J Roberts-Thomson, G R Monteit. Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells. Oncogene. vol 36. issue 46. 2017-12-01. PMID:28759041. |
pharmacological activation of trpv4 produced pronounced cell death through two mechanisms: apoptosis and oncosis in mda-mb-468 cells. |
2017-12-01 |
2023-08-13 |
Not clear |
| Herminia Pasantes-Morale. Channels and Volume Changes in the Life and Death of the Cell. Molecular pharmacology. vol 90. issue 3. 2017-05-09. PMID:27358231. |
the review also underlines the contribution of transient receptor potential (trp) channels, notably trpv4, in volume regulation after swelling and describes the role of other trps in volume changes linked to apoptosis and necrosis. |
2017-05-09 |
2023-08-13 |
Not clear |
| P Jie, Z Hong, Y Tian, Y Li, L Lin, L Zhou, Y Du, L Chen, L Che. Activation of transient receptor potential vanilloid 4 induces apoptosis in hippocampus through downregulating PI3K/Akt and upregulating p38 MAPK signaling pathways. Cell death & disease. vol 6. 2016-02-18. PMID:26043075. |
herein, we examined trpv4-induced neuronal apoptosis by intracerebroventricular (icv) injection of a trpv4 agonist (gsk1016790a) and assessed its involvement in cerebral ischemic injury. |
2016-02-18 |
2023-08-13 |
mouse |
| P Jie, Z Hong, Y Tian, Y Li, L Lin, L Zhou, Y Du, L Chen, L Che. Activation of transient receptor potential vanilloid 4 induces apoptosis in hippocampus through downregulating PI3K/Akt and upregulating p38 MAPK signaling pathways. Cell death & disease. vol 6. 2016-02-18. PMID:26043075. |
we conclude that activation of trpv4 induces apoptosis by downregulating pi3k/akt and upregulating p38 mapk signaling pathways, which is involved in cerebral ischemic injury. |
2016-02-18 |
2023-08-13 |
mouse |
| Lei Zhan, Yang Yang, Tao-Tao Ma, Cheng Huang, Xiao-Ming Meng, Lei Zhang, Jun L. Transient receptor potential vanilloid 4 inhibits rat HSC-T6 apoptosis through induction of autophagy. Molecular and cellular biochemistry. vol 402. issue 1-2. 2015-10-26. PMID:25600591. |
however, the precise mechanism of trpv4 on hsc apoptosis is still unclear. |
2015-10-26 |
2023-08-13 |
rat |
| Lei Zhan, Yang Yang, Tao-Tao Ma, Cheng Huang, Xiao-Ming Meng, Lei Zhang, Jun L. Transient receptor potential vanilloid 4 inhibits rat HSC-T6 apoptosis through induction of autophagy. Molecular and cellular biochemistry. vol 402. issue 1-2. 2015-10-26. PMID:25600591. |
here, we explored the role of trpv4 in regulating hsc-t6 cell apoptosis. |
2015-10-26 |
2023-08-13 |
rat |