| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Weishaupt, W Brück, T Hartung, K V Toyka, R Gol. Schwann cell apoptosis in experimental autoimmune neuritis of the Lewis rat and the functional role of tumor necrosis factor-alpha. Neuroscience letters. vol 306. issue 1-2. 2001-08-16. PMID:11403962. |
we found that the addition of a tnf-alpha neutralizing antiserum resulted in a significant decrease in the rate of sc apoptosis in vivo compared to animals treated with control antigen rhp0 or with rhp2 only. |
2001-08-16 |
2023-08-12 |
rat |
| R Chiesa, A Pestronk, R E Schmidt, W G Tourtellotte, B Ghetti, P Piccardo, D A Harri. Primary myopathy and accumulation of PrPSc-like molecules in peripheral tissues of transgenic mice expressing a prion protein insertional mutation. Neurobiology of disease. vol 8. issue 2. 2001-07-12. PMID:11300723. |
transgenic mice that express the mouse prp homologue of this mutation (designated pg14) under control of a prp promoter display a progressive neurological disorder characterized by ataxia, apoptosis of cerebellar granule cells, and accumulation in the brain of mutant prp molecules that display the biochemical hallmarks of prp(sc), the pathogenic isoform of prp. |
2001-07-12 |
2023-08-12 |
mouse |
| G Wohlleben, S M Ibrahim, J Schmidt, K V Toyka, H P Hartung, R Gol. Regulation of Fas and FasL expression on rat Schwann cells. Glia. vol 30. issue 4. 2000-07-07. PMID:10797617. |
to assess the possible involvement of the fas/fasl system in t-cell apoptosis in the pns of the rat, we characterized fas and fasl expression on neonatal rat schwann cells (sc) in vitro. |
2000-07-07 |
2023-08-12 |
human |
| L Xu, J Yang, Y Huang, P H van der Meide, M Levi, B Wahren, H Link, B Xia. Limitation of nitric oxide production: cells from lymph node and spleen exhibit distinct difference in nitric oxide production. Immunology letters. vol 71. issue 3. 2000-06-21. PMID:10722870. |
no derived from sc suppressed cell proliferation and induced apoptosis in vitro. |
2000-06-21 |
2023-08-12 |
rat |
| L Xu, J Yang, Y Huang, P H van der Meide, M Levi, B Wahren, H Link, B Xia. Limitation of nitric oxide production: cells from lymph node and spleen exhibit distinct difference in nitric oxide production. Immunology letters. vol 71. issue 3. 2000-06-21. PMID:10722870. |
the high levels of no derived from sc are involved in the self-limiting mechanisms of autoimmune responses by inhibiting cell expansion and promoting cell apoptosis. |
2000-06-21 |
2023-08-12 |
rat |
| B Bonetti, P Valdo, C Stegagno, R Tanel, G L Zanusso, D Ramarli, E Fiorini, S Turazzi, M Carner, G Morett. Tumor necrosis factor alpha and human Schwann cells: signalling and phenotype modulation without cell death. Journal of neuropathology and experimental neurology. vol 59. issue 1. 2000-04-07. PMID:10744037. |
by immunocytochemical and functional assays, we found that sc expressed tnf receptors and that tnfalpha promoted in sc cultures transient activation of transcription factors nfkappab and c-jun in the absence of apoptosis. |
2000-04-07 |
2023-08-12 |
human |
| B Bonetti, P Valdo, C Stegagno, R Tanel, G L Zanusso, D Ramarli, E Fiorini, S Turazzi, M Carner, G Morett. Tumor necrosis factor alpha and human Schwann cells: signalling and phenotype modulation without cell death. Journal of neuropathology and experimental neurology. vol 59. issue 1. 2000-04-07. PMID:10744037. |
irrespective of the presence of nerve inflammation, sc showed no evidence of apoptosis. |
2000-04-07 |
2023-08-12 |
human |
| C L Delaney, H L Cheng, E L Feldma. Insulin-like growth factor-I prevents caspase-mediated apoptosis in Schwann cells. Journal of neurobiology. vol 41. issue 4. 2000-01-11. PMID:10590177. |
to investigate whether igf-i can protect schwann cells (sc) from apoptosis, sc were harvested from postnatal day 3 rats and maintained in serum-containing media until confluency. |
2000-01-11 |
2023-08-12 |
rat |
| C L Delaney, H L Cheng, E L Feldma. Insulin-like growth factor-I prevents caspase-mediated apoptosis in Schwann cells. Journal of neurobiology. vol 41. issue 4. 2000-01-11. PMID:10590177. |
caspase-3 activity was rapidly activated upon serum withdrawal in sc, and the caspase inhibitor baf blocked apoptosis. |
2000-01-11 |
2023-08-12 |
rat |
| C L Delaney, H L Cheng, E L Feldma. Insulin-like growth factor-I prevents caspase-mediated apoptosis in Schwann cells. Journal of neurobiology. vol 41. issue 4. 2000-01-11. PMID:10590177. |
these results suggest that igf-i rescues sc from apoptosis via pi 3-k signaling which is upstream from caspase activation. |
2000-01-11 |
2023-08-12 |
rat |
| K Sasaki, H Ino, T Chiba, E Adachi-Usam. Light-induced apoptosis in the neonatal mouse retina and superior colliculus. Investigative ophthalmology & visual science. vol 40. issue 13. 1999-12-09. PMID:10586927. |
apoptosis occurs naturally in the rodent retina and superior colliculus (sc) during the neonatal period. |
1999-12-09 |
2023-08-12 |
mouse |
| H Ushijima, S Perovic, J Leuck, P G Rytik, W E Müller, H C Schröde. Suppression of PrP(Sc)- and HIV-1 gp120 induced neuronal cell death by sulfated colominic acid. Journal of neurovirology. vol 5. issue 3. 1999-09-03. PMID:10414519. |
the scrapie prion protein (prp(sc)) has been shown to induce apoptosis of rat cortical neurons in vitro. |
1999-09-03 |
2023-08-12 |
human |
| J A Weiner, J Chu. Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 9. 1999-06-10. PMID:10220449. |
overexpression of functional epitope-tagged lpa1/vzg-1 protein decreases sc apoptosis in response to serum withdrawal. |
1999-06-10 |
2023-08-12 |
Not clear |
| T Florio, S Thellung, C Amico, M Robello, M Salmona, O Bugiani, F Tagliavini, G Forloni, G Schettin. Prion protein fragment 106-126 induces apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in the GH3 cell line. Journal of neuroscience research. vol 54. issue 3. 1999-01-12. PMID:9819139. |
previous studies have shown that a synthetic peptide homologous to residues 106-126 of prp (prp 106-126) maintains many characteristics of prp(sc), i.e., the ability to form amyloid fibrils and to induce apoptosis in neurons. |
1999-01-12 |
2023-08-12 |
Not clear |
| H C Schröder, S Perovic, V Kavsan, H Ushijima, W E Mülle. Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death. Neurotoxicology. vol 19. issue 4-5. 1998-12-10. PMID:9745929. |
in vitro experiments revealed that the scrapie prion protein, prp(sc), as well as the prp fragment prp106-126, and the hiv-1 coat protein gp120 induce apoptosis of rat cortical neurons. |
1998-12-10 |
2023-08-12 |
rat |
| C T Montague, J B Prins, L Sanders, J Zhang, C P Sewter, J Digby, C D Byrne, S O'Rahill. Depot-related gene expression in human subcutaneous and omental adipocytes. Diabetes. vol 47. issue 9. 1998-09-16. PMID:9726225. |
no transcript that was unique to one or another depot was found, but cellular inhibitor of apoptosis protein-2 (ciap2) mrna, which has not previously been reported in adipocytes, was expressed at higher levels in om than sc adipocytes (om > sc in all eight subjects; mean om:sc ratio 1.9 +/- 0.2, p < 0.01). |
1998-09-16 |
2023-08-12 |
human |
| A Schwarz, K Mahnke, T A Luger, T Schwar. Pentoxifylline reduces the formation of sunburn cells. Experimental dermatology. vol 6. issue 1. 1997-07-18. PMID:9067700. |
recently, it was demonstrated that tumor necrosis factor alpha (tnf alpha) appears to be involved in the formation of sc since neutralization of tnf alpha both in vitro and in vivo reduced uvb-induced apoptosis of keratinocytes. |
1997-07-18 |
2023-08-12 |
mouse |
| A Schwarz, K Mahnke, T A Luger, T Schwar. Pentoxifylline reduces the formation of sunburn cells. Experimental dermatology. vol 6. issue 1. 1997-07-18. PMID:9067700. |
to prove whether ptx also reduces uvb-induced apoptosis in vivo, balb/c mice were exposed to uvb on their abdomens, skin biopsies performed 24 h later and sc counted. |
1997-07-18 |
2023-08-12 |
mouse |
| A Schwarz, K Mahnke, T A Luger, T Schwar. Pentoxifylline reduces the formation of sunburn cells. Experimental dermatology. vol 6. issue 1. 1997-07-18. PMID:9067700. |
in summary, the data demonstrate that ptx can reduce the formation of sc both in vitro and in vivo and thus further support that tnf alpha is involved in uvb-induced apoptosis of keratinocytes. |
1997-07-18 |
2023-08-12 |
mouse |
| P R Rhode, M Burkhardt, J Jiao, A H Siddiqui, G P Huang, H C Won. Single-chain MHC class II molecules induce T cell activation and apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 157. issue 11. 1996-12-27. PMID:8943392. |
both sc class ii molecules loaded the appropriate peptides and sc class ii/peptide fusions were effective in stimulating t cell responses, including cytokine release and apoptosis. |
1996-12-27 |
2023-08-12 |
Not clear |